DK3384005T3 - Arginin som eneste nitrogenkilde til C1-fikserende mikroorganisme - Google Patents
Arginin som eneste nitrogenkilde til C1-fikserende mikroorganisme Download PDFInfo
- Publication number
- DK3384005T3 DK3384005T3 DK16871684.3T DK16871684T DK3384005T3 DK 3384005 T3 DK3384005 T3 DK 3384005T3 DK 16871684 T DK16871684 T DK 16871684T DK 3384005 T3 DK3384005 T3 DK 3384005T3
- Authority
- DK
- Denmark
- Prior art keywords
- arginine
- nitrogen source
- sole nitrogen
- fixing microorganism
- microorganism
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1018—Carboxy- and carbamoyl transferases (2.1.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/54—Acetic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/01—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
- C12Y104/01012—2,4-Diaminopentanoate dehydrogenase (1.4.1.12)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/01—Racemaces and epimerases (5.1) acting on amino acids and derivatives (5.1.1)
- C12Y501/01012—Ornithine racemase (5.1.1.12)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/03—Intramolecular transferases (5.4) transferring amino groups (5.4.3)
- C12Y504/03005—D-Ornithine 4,5-aminomutase (5.4.3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02002—Carbamate kinase (2.7.2.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
- C12Y305/03006—Arginine deiminase (3.5.3.6)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562262888P | 2015-12-03 | 2015-12-03 | |
US201562262886P | 2015-12-03 | 2015-12-03 | |
PCT/US2016/064855 WO2017096324A1 (en) | 2015-12-03 | 2016-12-02 | Arginine supplementation to improve efficiency in gas fermenting acetogens |
Publications (1)
Publication Number | Publication Date |
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DK3384005T3 true DK3384005T3 (da) | 2022-04-11 |
Family
ID=58798000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16871684.3T DK3384005T3 (da) | 2015-12-03 | 2016-12-02 | Arginin som eneste nitrogenkilde til C1-fikserende mikroorganisme |
Country Status (12)
Country | Link |
---|---|
US (2) | US10995347B2 (da) |
EP (2) | EP3384005B1 (da) |
KR (1) | KR20180127632A (da) |
CN (1) | CN108431208A (da) |
CA (1) | CA3010412C (da) |
DK (1) | DK3384005T3 (da) |
EA (1) | EA201891335A1 (da) |
ES (1) | ES2909579T3 (da) |
PT (1) | PT3384005T (da) |
TW (1) | TWI824995B (da) |
WO (1) | WO2017096324A1 (da) |
ZA (1) | ZA201804358B (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3074292C (en) * | 2017-09-08 | 2021-08-24 | Lanzatech, Inc. | Processes and systems for metabolite production using hydrogen rich c1-containing substrates |
KR20210092691A (ko) | 2020-01-16 | 2021-07-26 | 광주과학기술원 | 개선된 대사 활성을 갖는 혐기성 균주 |
US11788092B2 (en) | 2021-02-08 | 2023-10-17 | Lanzatech, Inc. | Recombinant microorganisms and uses therefor |
CN114438138A (zh) * | 2022-02-24 | 2022-05-06 | 重庆市畜牧科学院 | 用生孢梭菌制备的代谢组合物及其生产方法、检测方法和应用 |
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US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
US7160705B2 (en) * | 2000-04-28 | 2007-01-09 | Ajinomoto Co., Inc. | Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine |
US6645739B2 (en) * | 2001-07-26 | 2003-11-11 | Phoenix Pharmacologies, Inc. | Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same |
NZ546496A (en) | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
NZ553984A (en) | 2007-03-19 | 2009-07-31 | Lanzatech New Zealand Ltd | Alcohol production process |
CN102016052B (zh) * | 2007-08-15 | 2015-04-29 | 朗泽科技新西兰有限公司 | 生产醇的工艺 |
EA022710B1 (ru) | 2007-11-13 | 2016-02-29 | Ланзатек Нью Зиленд Лимитед | Штамм бактерии clostridium autoethanogenum, способный продуцировать этанол и ацетат путем анаэробной ферментации субстрата, содержащего co |
EA018720B1 (ru) | 2008-06-09 | 2013-10-30 | Ланзатек Нью Зиленд Лимитед | Способ получения бутандиола с помощью анаэробной микробной ферментации |
WO2010064932A1 (en) * | 2008-12-01 | 2010-06-10 | Lanzatech New Zealand Limited | Optimised fermentation media |
US20110275053A1 (en) * | 2009-01-29 | 2011-11-10 | Lanza Tech New Zealand Limited | Alcohol production process |
US8655630B2 (en) | 2009-02-17 | 2014-02-18 | Osaka University | Apparatus, system, and method for construction of a design workflow |
CN102791869B (zh) | 2010-03-10 | 2015-08-19 | 朗泽科技新西兰有限公司 | 通过发酵的酸产生 |
US20130217096A1 (en) | 2010-07-28 | 2013-08-22 | Lanzatech New Zealand Limited | Novel bacteria and methods of use thereof |
CN103415618A (zh) | 2010-08-19 | 2013-11-27 | 新西兰郎泽科技公司 | 使用对含一氧化碳的底物的微生物发酵来生产化学物质的方法 |
CN103282505A (zh) | 2010-08-26 | 2013-09-04 | 新西兰郎泽科技公司 | 通过发酵产生乙醇和乙烯的方法 |
FR2964116B1 (fr) * | 2010-09-01 | 2017-06-02 | Biomerieux Sa | Utilisation d'un activateur de beta-glucosidase pour la detection et/ou l'identification de c.difficile |
US20110236941A1 (en) | 2010-10-22 | 2011-09-29 | Lanzatech New Zealand Limited | Recombinant microorganism and methods of production thereof |
US20110256600A1 (en) | 2011-02-02 | 2011-10-20 | Lanzatech New Zealand Limited | Recombinant Microorganisms and Methods of Use Thereof |
US20130224839A1 (en) | 2011-02-02 | 2013-08-29 | Lanzatech New Zealand Limited | Recombinant Microorganism and Methods of Production Thereof |
CN103502435B (zh) | 2011-02-25 | 2018-05-18 | 朗泽科技新西兰有限公司 | 重组微生物及其用途 |
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PL2753700T3 (pl) | 2011-09-08 | 2020-07-27 | Lanzatech New Zealand Limited | Sposób fermentacji |
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JP6862349B2 (ja) | 2014-12-08 | 2021-04-21 | ランザテク・ニュージーランド・リミテッド | 発酵経路を経由するフラックスの増大を示す組み換え微生物体 |
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2016
- 2016-12-02 KR KR1020187018999A patent/KR20180127632A/ko active Search and Examination
- 2016-12-02 EP EP16871684.3A patent/EP3384005B1/en active Active
- 2016-12-02 US US15/368,521 patent/US10995347B2/en active Active
- 2016-12-02 ES ES16871684T patent/ES2909579T3/es active Active
- 2016-12-02 EP EP21198918.1A patent/EP3981869A1/en active Pending
- 2016-12-02 CA CA3010412A patent/CA3010412C/en active Active
- 2016-12-02 EA EA201891335A patent/EA201891335A1/ru unknown
- 2016-12-02 CN CN201680078415.8A patent/CN108431208A/zh active Pending
- 2016-12-02 DK DK16871684.3T patent/DK3384005T3/da active
- 2016-12-02 WO PCT/US2016/064855 patent/WO2017096324A1/en active Application Filing
- 2016-12-02 PT PT168716843T patent/PT3384005T/pt unknown
- 2016-12-05 TW TW105140133A patent/TWI824995B/zh active
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2018
- 2018-06-28 ZA ZA2018/04358A patent/ZA201804358B/en unknown
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2021
- 2021-03-16 US US17/203,617 patent/US11965201B2/en active Active
Also Published As
Publication number | Publication date |
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ZA201804358B (en) | 2020-09-30 |
EP3981869A1 (en) | 2022-04-13 |
TW201723170A (zh) | 2017-07-01 |
US11965201B2 (en) | 2024-04-23 |
CN108431208A (zh) | 2018-08-21 |
KR20180127632A (ko) | 2018-11-29 |
CA3010412A1 (en) | 2017-06-08 |
EP3384005A1 (en) | 2018-10-10 |
CA3010412C (en) | 2020-04-14 |
US20170159083A1 (en) | 2017-06-08 |
US20210230648A1 (en) | 2021-07-29 |
EP3384005A4 (en) | 2019-05-08 |
EA201891335A1 (ru) | 2018-11-30 |
US10995347B2 (en) | 2021-05-04 |
PT3384005T (pt) | 2022-04-05 |
WO2017096324A1 (en) | 2017-06-08 |
EP3384005B1 (en) | 2022-02-02 |
ES2909579T3 (es) | 2022-05-09 |
TWI824995B (zh) | 2023-12-11 |
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