DK338187A - 13beta-milbemycinderivater samt deres fremstillingog anvendelse - Google Patents
13beta-milbemycinderivater samt deres fremstillingog anvendelseInfo
- Publication number
- DK338187A DK338187A DK338187A DK338187A DK338187A DK 338187 A DK338187 A DK 338187A DK 338187 A DK338187 A DK 338187A DK 338187 A DK338187 A DK 338187A DK 338187 A DK338187 A DK 338187A
- Authority
- DK
- Denmark
- Prior art keywords
- unsubstituted
- substituted
- groups
- hydrogen
- milbemycine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH266886 | 1986-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK338187D0 DK338187D0 (da) | 1987-07-01 |
| DK338187A true DK338187A (da) | 1988-01-03 |
Family
ID=4238883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK338187A DK338187A (da) | 1986-07-02 | 1987-07-01 | 13beta-milbemycinderivater samt deres fremstillingog anvendelse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4859657A (OSRAM) |
| EP (1) | EP0252879B1 (OSRAM) |
| JP (1) | JP2528883B2 (OSRAM) |
| KR (1) | KR960001480B1 (OSRAM) |
| AT (1) | ATE75745T1 (OSRAM) |
| DE (1) | DE3778768D1 (OSRAM) |
| DK (1) | DK338187A (OSRAM) |
| ES (1) | ES2039258T3 (OSRAM) |
| GR (1) | GR3004535T3 (OSRAM) |
| IL (1) | IL83031A0 (OSRAM) |
| ZA (1) | ZA874752B (OSRAM) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001822A (en) * | 1989-04-11 | 1999-12-14 | Pfizer Inc. | Antiparasitic formulations |
| TW202452B (OSRAM) * | 1989-12-01 | 1993-03-21 | Ciba Geigy Ag | |
| US6514951B1 (en) | 1989-12-15 | 2003-02-04 | American Cyanamid Company | Pour-on formulations effective for the control of internal and external parasites of homothermic animals |
| US5208222A (en) * | 1991-03-28 | 1993-05-04 | Merck & Co., Inc. | 4"-and 4'-alkylthio avermectin derivatives |
| US5229415A (en) * | 1992-03-24 | 1993-07-20 | Merck & Co., Inc. | Alkylthio alkyl avermectins are active antiparasitic agents |
| CA2312898C (en) * | 1997-12-03 | 2004-05-11 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated castor oil |
| ES2359973T3 (es) | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
| AU748142B2 (en) * | 1999-04-02 | 2002-05-30 | Kwang-Suk Chung | Multi purpose fish-hook case including fishline binding device |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| US20060205681A1 (en) * | 2002-06-21 | 2006-09-14 | Maryam Moaddeb | Homogenous paste formulations |
| US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
| US7531186B2 (en) | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| US20080027011A1 (en) * | 2005-12-20 | 2008-01-31 | Hassan Nached | Homogeneous paste and gel formulations |
| CA2656617C (en) | 2006-07-05 | 2014-10-14 | Aventis Agriculture | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof |
| ES2714578T3 (es) | 2007-05-15 | 2019-05-29 | Merial Inc | Compuestos de ariloazol-2-il cianoetilamino, procedimiento de fabricación y procedimiento de utilización de los mismos |
| RU2497364C2 (ru) | 2007-11-26 | 2013-11-10 | Мериал Лимитед | Системы растворителей для жидких наружных композиций для борьбы с паразитами |
| AU2008340434B2 (en) | 2007-12-21 | 2014-02-06 | Boehringer Ingelheim Animal Health USA Inc. | The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals |
| US20100022469A1 (en) * | 2008-06-24 | 2010-01-28 | Majid Razzak | Anthelminthic formulations |
| SG10201703698QA (en) | 2008-11-14 | 2017-06-29 | Merial Inc | Enantiomerically enriched aryloazol- 2 -yl cyanoethylamino paraciticidal compounds |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| JP5755143B2 (ja) | 2008-11-19 | 2015-07-29 | メリアル リミテッド | アリールピラゾールおよび／またはホルムアミジンを含む組成物、それらの方法ならびに使用 |
| CA2745434C (en) | 2008-12-04 | 2017-06-20 | Merial Limited | Dimeric avermectin and milbemycin derivatives |
| EP2459569B1 (en) | 2009-07-30 | 2015-07-22 | Merial, Inc. | Insecticidal 4-amino-thieno[2,3-d]-pyrimidine compounds and methods of their use |
| EP2507209B1 (en) | 2009-12-04 | 2015-07-08 | Merial, Inc. | Pesticidal bis-organosulfur compounds |
| KR101920201B1 (ko) | 2009-12-17 | 2018-11-21 | 메리얼 인코포레이티드 | 구충성 디히드로아졸 화합물 및 이를 함유하는 조성물 |
| US8980896B2 (en) | 2009-12-17 | 2015-03-17 | Merial, Inc. | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| HRP20160103T1 (hr) | 2010-05-12 | 2016-02-26 | Merial, Inc. | Paraziticidne formulacije za injektiranje od levamisola i makrocikliäśkih laktona |
| AU2011328948B2 (en) | 2010-11-16 | 2016-08-04 | Centre National De La Recherche Scientifique (Cnrs) | Novel monensin derivatives for the treatment and prevention of protozoal infections |
| NZ612185A (en) | 2010-12-07 | 2015-10-30 | Merial Inc | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| US20120329832A1 (en) | 2011-06-27 | 2012-12-27 | Jean Delaveau | Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use |
| JP6041359B2 (ja) | 2011-06-27 | 2016-12-07 | メリアル インコーポレイテッド | アミドピリジルエーテル化合物及び組成物並びに寄生虫に対するそれらの使用 |
| LT2755473T (lt) | 2011-09-12 | 2019-03-12 | Merial, Inc. | Paraziticidinės kompozicijos, apimančios izoksazolino veiklųjį agentą, būdai ir jų panaudojimai |
| US20130079394A1 (en) | 2011-09-23 | 2013-03-28 | Cnrs (Centre National Recherche Scientifique) | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
| KR102066757B1 (ko) | 2011-11-17 | 2020-01-15 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 아릴 피라졸 및 치환된 이미다졸을 함유하는 조성물, 그의 방법 및 용도 |
| HUE067125T2 (hu) | 2011-12-02 | 2024-10-28 | Boehringer Ingelheim Vetmedica Gmbh | Hosszú hatású injektálható moxidektin formulációk |
| MD4577C1 (ro) | 2012-02-06 | 2019-02-28 | Merial Inc. | Compoziţii masticabile de uz veterinar care conţin agent activ izoxazolinic şi utilizarea acestora în tratamentul sau prevenirea unei infestări sau infecţii parazitare |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| MX351636B (es) | 2012-04-20 | 2017-10-23 | Merial Ltd | Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. |
| LT2922845T (lt) | 2012-11-20 | 2018-09-10 | Merial, Inc. | Antihelmintiniai junginiai ir kompozicijos ir jų naudojimo būdai |
| LT2950795T (lt) | 2013-01-31 | 2018-06-25 | Merial, Inc. | Leišmaniozės gydymo ir naikinimo būdas naudojant feksinidazolą |
| PL3063144T3 (pl) | 2013-11-01 | 2022-01-31 | Boehringer Ingelheim Animal Health USA Inc. | Przeciwpasożytnicze i szkodniczobójcze związki izoksazolinowe |
| JP6682719B2 (ja) | 2014-04-17 | 2020-04-15 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 寄生生物から動物を保護するためのマロノニトリル化合物の使用 |
| WO2015179414A1 (en) | 2014-05-19 | 2015-11-26 | Merial, Inc. | Anthelmintic compounds |
| ES2895826T3 (es) | 2014-06-19 | 2022-02-22 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones parasiticidas que comprenden derivados de indol, procedimientos y usos de las mismas |
| WO2016069983A1 (en) | 2014-10-31 | 2016-05-06 | Merial, Inc. | Parasiticidal composition comprising fipronil |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| KR102593069B1 (ko) | 2015-04-08 | 2023-10-23 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도 |
| MX395486B (es) | 2015-05-20 | 2025-03-25 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos depsipeptidicos como anthelminticos |
| US20160347829A1 (en) | 2015-05-27 | 2016-12-01 | Merial Inc. | Compositions containing antimicrobial IgY antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (OHC) microorganisms |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| BR112019007605A2 (pt) | 2016-10-14 | 2019-09-17 | Boehringer Ingelheim Animal Health Usa Inc | compostos pesticidas e parasiticidas de vinil isoxazolina |
| CN110167921A (zh) | 2016-11-16 | 2019-08-23 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫缩肽化合物 |
| UY37780A (es) | 2017-06-26 | 2019-01-31 | Merial Inc | Composiciones de gránulos parasiticidas con doble principio activo, sus métodos y usos |
| US11589586B2 (en) | 2017-08-14 | 2023-02-28 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal pyrazole-isoxazoline compounds |
| WO2019157241A1 (en) | 2018-02-08 | 2019-08-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| KR20250044476A (ko) | 2018-07-09 | 2025-03-31 | 베링거잉겔하임베트메디카게엠베하 | 구충성 헤테로시클릭 화합물 |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| AU2020208145B2 (en) | 2019-01-16 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| CA3129329A1 (en) | 2019-03-01 | 2020-09-10 | Boehringer Ingelheim Animal Health USA Inc. | Injectable clorsulon compositions, methods and uses thereof |
| CN113825543B (zh) | 2019-03-19 | 2024-09-06 | 勃林格殷格翰动物保健有限公司 | 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物 |
| CA3146043A1 (en) | 2019-07-22 | 2021-01-28 | Intervet International B.V. | Soft chewable veterinary dosage form |
| JP2023528822A (ja) | 2020-05-29 | 2023-07-06 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性複素環式化合物 |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093629A (en) * | 1977-04-11 | 1978-06-06 | Merck & Co., Inc. | Derivatives of antibiotic substance milbemycin and processes therefor |
| US4134973A (en) * | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
| US4203976A (en) * | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
| US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
| HUT39739A (en) * | 1984-12-04 | 1986-10-29 | Ciba Geigy Ag | Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof |
| GB2168345B (en) * | 1984-12-14 | 1988-05-25 | Ciba Geigy Ag | Pesticidal 13b-substituted milbemycin derivatives |
| US4778809A (en) * | 1985-08-23 | 1988-10-18 | Ciba-Geigy Corporation | 5-esters of milbemycins for controlling parasitic pests |
-
1987
- 1987-06-26 DE DE8787810369T patent/DE3778768D1/de not_active Expired - Lifetime
- 1987-06-26 ES ES198787810369T patent/ES2039258T3/es not_active Expired - Lifetime
- 1987-06-26 EP EP87810369A patent/EP0252879B1/de not_active Expired - Lifetime
- 1987-06-26 AT AT87810369T patent/ATE75745T1/de not_active IP Right Cessation
- 1987-06-30 US US07/068,692 patent/US4859657A/en not_active Expired - Fee Related
- 1987-06-30 IL IL83031A patent/IL83031A0/xx not_active IP Right Cessation
- 1987-07-01 DK DK338187A patent/DK338187A/da not_active Application Discontinuation
- 1987-07-01 ZA ZA874752A patent/ZA874752B/xx unknown
- 1987-07-02 JP JP62164112A patent/JP2528883B2/ja not_active Expired - Lifetime
- 1987-07-02 KR KR1019870007115A patent/KR960001480B1/ko not_active Expired - Fee Related
-
1992
- 1992-05-08 GR GR920400768T patent/GR3004535T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR880001661A (ko) | 1988-04-26 |
| IL83031A0 (en) | 1987-12-20 |
| GR3004535T3 (OSRAM) | 1993-04-28 |
| JP2528883B2 (ja) | 1996-08-28 |
| DK338187D0 (da) | 1987-07-01 |
| ZA874752B (en) | 1988-01-04 |
| US4859657A (en) | 1989-08-22 |
| JPS6333381A (ja) | 1988-02-13 |
| EP0252879A1 (de) | 1988-01-13 |
| DE3778768D1 (de) | 1992-06-11 |
| ES2039258T3 (es) | 1993-09-16 |
| EP0252879B1 (de) | 1992-05-06 |
| KR960001480B1 (ko) | 1996-01-31 |
| ATE75745T1 (de) | 1992-05-15 |
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