AR074482A1 - Derivados dimericos de avermectina y milbemicina - Google Patents

Derivados dimericos de avermectina y milbemicina

Info

Publication number
AR074482A1
AR074482A1 ARP090104711A ARP090104711A AR074482A1 AR 074482 A1 AR074482 A1 AR 074482A1 AR P090104711 A ARP090104711 A AR P090104711A AR P090104711 A ARP090104711 A AR P090104711A AR 074482 A1 AR074482 A1 AR 074482A1
Authority
AR
Argentina
Prior art keywords
independently
hydroxyl
onr11c
nr11c
alkoxyimino
Prior art date
Application number
ARP090104711A
Other languages
English (en)
Inventor
Charles Q Meng
Original Assignee
Merial Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd filed Critical Merial Ltd
Publication of AR074482A1 publication Critical patent/AR074482A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Derivados antiparasitarios y plaguicidas de compuestos basados en avermectina y milbemicina donde hay dos miembros de avermectina o milbemicina unidos por un conector químico. Los compuestos resultantes pueden usarse en composiciones veterinarias que se usan para tratar, controlar o prevenir las infecciones de endo y ectoparásitos en animales, o para combatir las plagas en plantas o en material propagativo vegetal. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) o una sal aceptable farmacéuticamente del mismo: donde: A es una unión simple o doble; B es una unión simple o doble; R1 y R5 son independientemente hidrógeno, hidroxilo, oxo, oximino o alcoxiimino, siempre que R1 es hidroxilo solamente cuando A es una unión simple, y que R5 es hidroxilo solamente cuando B es una unión simple; R2 y R6 son independientemente alquilo C1-8 lineal o ramificado, alquenilo C2-8, o cicloalquilo C3-8; R3 y R7 son independientemente hidroxilo, metoxi, oxo, hidroximino, o alcoxiimino; R4 y R8 son independientemente hidrógeno, hidroxilo, alcanoiloxi C1-8, benzoiloxi, di-alquilamino C1-8 benzoiloxi, (alcoxi C1-8)p, alquiltio C1-8, alquiltioalcoxi C1-8 o oleandrosiloxi; R9 y R10 son independientemente grupos diradicales seleccionados entre una unión, O, NR11, -NR11C(=O)-, -NR11C(=S)-, -NR11C(=O)O-, -ONR11C(=O)-, - ONR11C(=O)O-, -ONR11C(=O)NR11-, -OC(=O)O-, -N(R11)C(=O)N(R11)-, - N(R11)C(=S)N(R11)-, -N(R11)S(O)2N(R11)-, -N(R11)S(O)2-, -N(R11)S(O)N(R11)-, -N(R11)S(O)- , -C(=NR11)-, -C(=O)-, -C(=O)N(R11), y -C(=S)N(R11)-; R11 es H o R2; L es un ligando diradical seleccionado entre una unión, alquileno C1-20, alquenileno C2-20, alquinileno C2-20, cicloalquileno C3-8, arileno, ariloxi arileno, heteroarileno, o cualquier combinación de los mismos, el cual puede contener opcionalmente un átomo de N, O, S, P, o Si; y donde dicho ligando se puede sustituir opcionalmente con uno o más grupos seleccionados entre ciano, nitro, hidroxi, halógeno, O, N, S, alquilo C1-6, cicloalquilo C3-8, alcoxi C1-6, tioalquilo C1-6, oxo, oximino, y alcoxiimino; m y n son independientemente 0, 1, o 2; y p es 1-3.
ARP090104711A 2008-12-04 2009-12-04 Derivados dimericos de avermectina y milbemicina AR074482A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11976108P 2008-12-04 2008-12-04

Publications (1)

Publication Number Publication Date
AR074482A1 true AR074482A1 (es) 2011-01-19

Family

ID=41716681

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104711A AR074482A1 (es) 2008-12-04 2009-12-04 Derivados dimericos de avermectina y milbemicina

Country Status (16)

Country Link
US (1) US8426460B2 (es)
EP (1) EP2376513B1 (es)
JP (1) JP5595412B2 (es)
CN (1) CN102282154B (es)
AR (1) AR074482A1 (es)
AU (1) AU2009322206B2 (es)
BR (1) BRPI0922709B8 (es)
CA (1) CA2745434C (es)
EA (1) EA019126B1 (es)
ES (1) ES2537424T3 (es)
HK (1) HK1157790A1 (es)
MX (1) MX2011005726A (es)
NZ (1) NZ593184A (es)
TW (1) TWI457347B (es)
WO (1) WO2010065852A1 (es)
ZA (1) ZA201104100B (es)

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CN103360444B (zh) * 2012-04-03 2016-05-11 浙江海正药业股份有限公司 抗寄生虫药赛拉菌素的合成新工艺
AU2013245008B2 (en) 2012-04-04 2017-03-30 Intervet International B.V. Soft chewable pharmaceutical products
CN105017358B (zh) * 2015-07-31 2018-07-10 内蒙古嘉宝仕生物科技股份有限公司 一种合成甲胺基阿维菌素苯甲酸盐的方法
US11384032B2 (en) 2016-05-12 2022-07-12 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
CA3058394A1 (en) 2017-03-28 2018-10-04 Verdesian Life Sciences U.S., Llc Triarylmethane compounds for controlling enzyme-induced urea decomposition
RU2694546C1 (ru) * 2018-10-29 2019-07-16 Федеральное государственное бюджетное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. К.И. Скрябина и Я.Р. Коваленко" Способ лечения и профилактики паразитозов птиц с оптимизацией их обмена веществ и естественной резистентности
CN111838144A (zh) * 2020-07-31 2020-10-30 河南豫松环保科技有限公司 一种针对玉米螟和夜蛾的高效杀虫悬浮剂及其制备方法
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途
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AU2009322206A1 (en) 2011-06-23
CN102282154B (zh) 2015-07-01
JP2012511019A (ja) 2012-05-17
BRPI0922709B1 (pt) 2017-02-07
CA2745434C (en) 2017-06-20
CN102282154A (zh) 2011-12-14
EA019126B1 (ru) 2014-01-30
ZA201104100B (en) 2012-11-28
WO2010065852A1 (en) 2010-06-10
CA2745434A1 (en) 2010-06-10
EA201100899A1 (ru) 2011-12-30
JP5595412B2 (ja) 2014-09-24
TWI457347B (zh) 2014-10-21
NZ593184A (en) 2012-11-30
HK1157790A1 (en) 2012-07-06
MX2011005726A (es) 2011-07-29
EP2376513B1 (en) 2015-02-25
BRPI0922709B8 (pt) 2017-03-14
US20100144859A1 (en) 2010-06-10
TW201033228A (en) 2010-09-16
BRPI0922709A2 (pt) 2016-01-05
EP2376513A1 (en) 2011-10-19
US8426460B2 (en) 2013-04-23
ES2537424T3 (es) 2015-06-08
AU2009322206B2 (en) 2015-03-05

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