DK3356391T3 - Fremgangsmåde til oprensning af clostridial neurotoksin - Google Patents

Fremgangsmåde til oprensning af clostridial neurotoksin Download PDF

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Publication number
DK3356391T3
DK3356391T3 DK16784802.7T DK16784802T DK3356391T3 DK 3356391 T3 DK3356391 T3 DK 3356391T3 DK 16784802 T DK16784802 T DK 16784802T DK 3356391 T3 DK3356391 T3 DK 3356391T3
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DK
Denmark
Prior art keywords
cleaning
procedure
clostridial neurotoxin
clostridial
neurotoxin
Prior art date
Application number
DK16784802.7T
Other languages
English (en)
Inventor
Stephen Gavin Hackett
Shilpa Palan
Dina Brady Anderson
Original Assignee
Ipsen Biopharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Biopharm Ltd filed Critical Ipsen Biopharm Ltd
Application granted granted Critical
Publication of DK3356391T3 publication Critical patent/DK3356391T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24068—Tentoxilysin (3.4.24.68), i.e. tetanus neurotoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16784802.7T 2015-10-02 2016-09-27 Fremgangsmåde til oprensning af clostridial neurotoksin DK3356391T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1517450.1A GB201517450D0 (en) 2015-10-02 2015-10-02 Method
PCT/EP2016/072986 WO2017055274A1 (en) 2015-10-02 2016-09-27 Method for purifying clostridial neurotoxin

Publications (1)

Publication Number Publication Date
DK3356391T3 true DK3356391T3 (da) 2020-02-03

Family

ID=54606010

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16784802.7T DK3356391T3 (da) 2015-10-02 2016-09-27 Fremgangsmåde til oprensning af clostridial neurotoksin

Country Status (20)

Country Link
US (1) US11066451B2 (da)
EP (2) EP3650462A1 (da)
JP (1) JP2018537412A (da)
KR (1) KR102675034B1 (da)
CN (1) CN108137657A (da)
AU (1) AU2016330322A1 (da)
BR (1) BR112018006300A2 (da)
CA (1) CA2996695A1 (da)
DK (1) DK3356391T3 (da)
EA (1) EA036610B1 (da)
ES (1) ES2769775T3 (da)
GB (1) GB201517450D0 (da)
HK (2) HK1255471A1 (da)
HU (1) HUE047489T2 (da)
MX (2) MX2018003644A (da)
PL (1) PL3356391T3 (da)
PT (1) PT3356391T (da)
SG (1) SG10202001084VA (da)
WO (1) WO2017055274A1 (da)
ZA (1) ZA201801755B (da)

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EP3752128A1 (de) * 2018-02-16 2020-12-23 Bontana Therapies Gmbh Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung
GB201914034D0 (en) * 2019-09-30 2019-11-13 Ipsen Biopharm Ltd Treatment of neurological disorders
GB202003813D0 (en) 2020-03-16 2020-04-29 Ipsen Biopharm Ltd Treatment of upper facial lines
BR112022018456A2 (pt) 2020-03-16 2022-11-01 Ipsen Biopharm Ltd Tratamento de espasticidade de membro
CN113832069B (zh) * 2020-11-30 2024-01-30 河南农业大学 丁酸梭菌及其应用
JP2024513191A (ja) * 2021-03-30 2024-03-22 イプセン バイオファーム リミテッド 疼痛及び炎症性障害の処置
EP4401759A1 (en) 2021-09-16 2024-07-24 Ipsen Biopharm Limited Modified bont/a for use in the treatment of cervical dystonia
KR20240067100A (ko) 2021-09-23 2024-05-16 입센 바이오팜 리미티드 대상체의 안검 근육에 이환된 장애의 치료에 사용하기 위한 변형된 bont/a
GB202113602D0 (en) 2021-09-23 2021-11-10 Ipsen Biopharm Ltd Treatment of a disorder affecting an eyelid muscle of a subject
KR20240051355A (ko) * 2022-10-12 2024-04-22 주식회사 알케미어 보툴리눔 독소의 경쇄 변이체

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Also Published As

Publication number Publication date
HK1255471A1 (zh) 2019-08-16
HUE047489T2 (hu) 2020-04-28
CN108137657A (zh) 2018-06-08
AU2016330322A1 (en) 2018-04-26
BR112018006300A2 (pt) 2018-10-16
KR20180080205A (ko) 2018-07-11
EP3356391B1 (en) 2019-11-06
EP3650462A1 (en) 2020-05-13
PL3356391T3 (pl) 2020-07-27
PT3356391T (pt) 2020-02-19
MX2018003644A (es) 2018-04-30
EA036610B1 (ru) 2020-11-30
EP3356391A1 (en) 2018-08-08
GB201517450D0 (en) 2015-11-18
HK1257762A1 (zh) 2019-10-25
EA201890851A1 (ru) 2018-08-31
ZA201801755B (en) 2019-01-30
MX2020011816A (es) 2021-01-15
US11066451B2 (en) 2021-07-20
US20190100564A1 (en) 2019-04-04
ES2769775T3 (es) 2020-06-29
CA2996695A1 (en) 2017-04-06
WO2017055274A1 (en) 2017-04-06
SG10202001084VA (en) 2020-03-30
KR102675034B1 (ko) 2024-06-14
JP2018537412A (ja) 2018-12-20

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