DK3356391T3 - Fremgangsmåde til oprensning af clostridial neurotoksin - Google Patents
Fremgangsmåde til oprensning af clostridial neurotoksin Download PDFInfo
- Publication number
- DK3356391T3 DK3356391T3 DK16784802.7T DK16784802T DK3356391T3 DK 3356391 T3 DK3356391 T3 DK 3356391T3 DK 16784802 T DK16784802 T DK 16784802T DK 3356391 T3 DK3356391 T3 DK 3356391T3
- Authority
- DK
- Denmark
- Prior art keywords
- cleaning
- procedure
- clostridial neurotoxin
- clostridial
- neurotoxin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24068—Tentoxilysin (3.4.24.68), i.e. tetanus neurotoxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1517450.1A GB201517450D0 (en) | 2015-10-02 | 2015-10-02 | Method |
| PCT/EP2016/072986 WO2017055274A1 (en) | 2015-10-02 | 2016-09-27 | Method for purifying clostridial neurotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3356391T3 true DK3356391T3 (da) | 2020-02-03 |
Family
ID=54606010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16784802.7T DK3356391T3 (da) | 2015-10-02 | 2016-09-27 | Fremgangsmåde til oprensning af clostridial neurotoksin |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11066451B2 (da) |
| EP (2) | EP3356391B1 (da) |
| JP (1) | JP2018537412A (da) |
| KR (1) | KR102675034B1 (da) |
| CN (1) | CN108137657A (da) |
| AU (1) | AU2016330322A1 (da) |
| BR (1) | BR112018006300A2 (da) |
| CA (1) | CA2996695A1 (da) |
| DK (1) | DK3356391T3 (da) |
| EA (1) | EA036610B1 (da) |
| ES (1) | ES2769775T3 (da) |
| GB (1) | GB201517450D0 (da) |
| HK (2) | HK1255471A1 (da) |
| HU (1) | HUE047489T2 (da) |
| MX (2) | MX2018003644A (da) |
| PL (1) | PL3356391T3 (da) |
| PT (1) | PT3356391T (da) |
| SG (1) | SG10202001084VA (da) |
| WO (1) | WO2017055274A1 (da) |
| ZA (1) | ZA201801755B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2490986T (pt) * | 2009-10-21 | 2018-11-13 | Revance Therapeutics Inc | Métodos e sistemas para purificar neurotoxina botulínica não complexada |
| EP3752128A1 (de) * | 2018-02-16 | 2020-12-23 | Bontana Therapies Gmbh | Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung |
| GB201914034D0 (en) * | 2019-09-30 | 2019-11-13 | Ipsen Biopharm Ltd | Treatment of neurological disorders |
| US20230248811A1 (en) | 2020-03-16 | 2023-08-10 | Ipsen Biopharm Limited | Treatment of Limb Spasticity |
| GB202003813D0 (en) | 2020-03-16 | 2020-04-29 | Ipsen Biopharm Ltd | Treatment of upper facial lines |
| CN113832069B (zh) * | 2020-11-30 | 2024-01-30 | 河南农业大学 | 丁酸梭菌及其应用 |
| JP2024513191A (ja) * | 2021-03-30 | 2024-03-22 | イプセン バイオファーム リミテッド | 疼痛及び炎症性障害の処置 |
| AU2022348206A1 (en) | 2021-09-16 | 2024-03-28 | Ipsen Biopharm Limited | Modified bont/a for use in the treatment of cervical dystonia |
| GB202113602D0 (en) | 2021-09-23 | 2021-11-10 | Ipsen Biopharm Ltd | Treatment of a disorder affecting an eyelid muscle of a subject |
| KR20240067100A (ko) | 2021-09-23 | 2024-05-16 | 입센 바이오팜 리미티드 | 대상체의 안검 근육에 이환된 장애의 치료에 사용하기 위한 변형된 bont/a |
| KR20240051355A (ko) * | 2022-10-12 | 2024-04-22 | 주식회사 알케미어 | 보툴리눔 독소의 경쇄 변이체 |
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| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| WO1993015766A1 (en) | 1992-02-10 | 1993-08-19 | Seragen, Inc. | Desensitization to specific allergens |
| GB9305735D0 (en) | 1993-03-19 | 1993-05-05 | North John R | Novel agent for controlling cell activity |
| DE122009000066I2 (de) | 1993-06-10 | 2010-12-30 | Allergan Inc | Behandlung von neuromuskulären Störungen und Zuständen mit verschiedenen botulinen Serotypen |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US6974578B1 (en) | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
| US20040126396A1 (en) | 1993-12-28 | 2004-07-01 | Allergan, Inc. | Botulinum toxin treatment for strabismus |
| US5670484A (en) | 1994-05-09 | 1997-09-23 | Binder; William J. | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders |
| US5714469A (en) | 1994-09-01 | 1998-02-03 | Smithkline Beecham Corporation | Method of treating sepsis |
| GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| US7192596B2 (en) | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| GB9721189D0 (en) | 1997-10-08 | 1997-12-03 | Speywood Lab The Limited | Analgesic conjugates |
| PL201879B1 (pl) | 1998-05-13 | 2009-05-29 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Białko hybrydowe i jego zastosowanie |
| EP1346731B1 (en) | 1998-07-22 | 2006-12-06 | Osprey Pharmaceuticals Limited | Conjugates for treating inflammatory disorders and associated tissue damage |
| GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| US6776990B2 (en) | 1999-04-08 | 2004-08-17 | Allergan, Inc. | Methods and compositions for the treatment of pancreatitis |
| US6358697B2 (en) | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
| US6767544B2 (en) | 2002-04-01 | 2004-07-27 | Allergan, Inc. | Methods for treating cardiovascular diseases with botulinum toxin |
| US6358917B1 (en) | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
| EP1206554B2 (en) | 1999-08-25 | 2010-10-20 | Allergan, Inc. | Activatable recombinant neurotoxins |
| GB9922554D0 (en) | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
| US6113915A (en) | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| US6265379B1 (en) | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
| US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
| US6139845A (en) | 1999-12-07 | 2000-10-31 | Allergan Sales, Inc. | Method for treating cancer with a neurotoxin |
| US6143306A (en) | 2000-01-11 | 2000-11-07 | Allergan Sales, Inc. | Methods for treating pancreatic disorders |
| US6261572B1 (en) | 2000-01-11 | 2001-07-17 | Allergan Sales, Inc. | Method for treating a pancreatic disorder with a neurotoxin |
| US6337075B1 (en) | 2000-01-11 | 2002-01-08 | Allergan Sales, Inc. | Methods for treating diabetes |
| US6641820B1 (en) | 2000-01-19 | 2003-11-04 | Allergan, Inc. | Clostridial toxin derivatives and methods to treat pain |
| US6524580B1 (en) | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US6464986B1 (en) | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
| US6299893B1 (en) | 2000-04-17 | 2001-10-09 | Marvin Schwartz | Method to reduce hair loss and stimulate hair regrowth |
| US6565870B1 (en) | 2000-04-28 | 2003-05-20 | Allergan, Inc. | Methods for treating bone tumors |
| US6306403B1 (en) | 2000-06-14 | 2001-10-23 | Allergan Sales, Inc. | Method for treating parkinson's disease with a botulinum toxin |
| US6903187B1 (en) | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
| US6423319B1 (en) | 2000-10-04 | 2002-07-23 | Allergan Sales, Inc. | Methods for treating muscle injuries |
| US6827931B1 (en) | 2000-10-20 | 2004-12-07 | Allergan, Inc. | Method for treating endocrine disorders |
| US7273722B2 (en) | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
| ITBO20010426A1 (it) * | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
| US7255866B2 (en) | 2001-09-17 | 2007-08-14 | Allergan, Inc. | Botulinum toxin therapy for fibromyalgia |
| US6623742B2 (en) | 2001-09-17 | 2003-09-23 | Allergan, Inc. | Methods for treating fibromyalgia |
| US6921538B2 (en) | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
| US20040115139A1 (en) | 2002-10-15 | 2004-06-17 | Allergan, Inc. | Botulinum toxin dental therapies and procedures |
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| DE102004043009A1 (de) | 2004-09-06 | 2006-03-23 | Toxogen Gmbh | Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen |
| CN1616489A (zh) * | 2004-09-30 | 2005-05-18 | 中国科学技术大学 | 纯化重组人白细胞介素12的方法 |
| WO2006059093A2 (en) | 2004-12-01 | 2006-06-08 | Health Protection Agency | Fusion proteins |
| BRPI0508374A (pt) | 2005-03-03 | 2007-07-31 | Allergan Inc | meios para bactéria clostrìdio e processo para obtenção de uma toxina clostrìdica |
| DE102005019302A1 (de) | 2005-04-26 | 2006-11-16 | Toxogen Gmbh | Carrier zum Targeting von Nervenzellen |
| DK1926744T4 (da) | 2005-09-19 | 2019-01-28 | Allergan Inc | Clostridium toksin-aktiverbare clostridiale toksiner |
| EP1834962A1 (de) | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
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| GB0903006D0 (en) | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
| CN101497909B (zh) * | 2009-03-05 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 制备抗a型肉毒毒素免疫球蛋白抗体的方法 |
| JP5764550B2 (ja) | 2009-04-14 | 2015-08-19 | エムシーダブリユー リサーチ フオンデーシヨン インコーポレーテツド | 遺伝子工学的ボツリヌス神経毒 |
| US8440204B2 (en) | 2009-04-30 | 2013-05-14 | Wisconsin Alumni Research Foundation | Subtype of Closteridium botulinum neurotoxin type A and uses thereof |
| US8129139B2 (en) * | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| PT2490986T (pt) * | 2009-10-21 | 2018-11-13 | Revance Therapeutics Inc | Métodos e sistemas para purificar neurotoxina botulínica não complexada |
| US8853360B2 (en) | 2010-06-23 | 2014-10-07 | Wisconsin Alumni Research Foundation | Engineered botulinum neurotoxin C1 with selective substrate specificity |
| US20140377248A1 (en) * | 2011-12-23 | 2014-12-25 | Merz Pharma Gmbh & Co. Kgaa | Method for the manufacturing of di-chain proteins for use in humans |
| JP6156954B2 (ja) | 2012-11-21 | 2017-07-05 | イプセン バイオイノベーション リミテッド | タンパク分解性にプロセシングされたポリペプチドの製造方法 |
| GB201312317D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| EP3822286A1 (en) | 2015-01-09 | 2021-05-19 | Ipsen Bioinnovation Limited | Cationic neurotoxins |
-
2015
- 2015-10-02 GB GBGB1517450.1A patent/GB201517450D0/en not_active Ceased
-
2016
- 2016-09-27 HU HUE16784802A patent/HUE047489T2/hu unknown
- 2016-09-27 AU AU2016330322A patent/AU2016330322A1/en not_active Abandoned
- 2016-09-27 CA CA2996695A patent/CA2996695A1/en not_active Abandoned
- 2016-09-27 DK DK16784802.7T patent/DK3356391T3/da active
- 2016-09-27 ES ES16784802T patent/ES2769775T3/es active Active
- 2016-09-27 MX MX2018003644A patent/MX2018003644A/es unknown
- 2016-09-27 US US15/765,427 patent/US11066451B2/en active Active
- 2016-09-27 EP EP16784802.7A patent/EP3356391B1/en active Active
- 2016-09-27 SG SG10202001084VA patent/SG10202001084VA/en unknown
- 2016-09-27 EA EA201890851A patent/EA036610B1/ru unknown
- 2016-09-27 JP JP2018517224A patent/JP2018537412A/ja active Pending
- 2016-09-27 CN CN201680055073.8A patent/CN108137657A/zh active Pending
- 2016-09-27 BR BR112018006300-2A patent/BR112018006300A2/pt not_active Application Discontinuation
- 2016-09-27 PL PL16784802T patent/PL3356391T3/pl unknown
- 2016-09-27 WO PCT/EP2016/072986 patent/WO2017055274A1/en active Application Filing
- 2016-09-27 KR KR1020187011891A patent/KR102675034B1/ko active IP Right Grant
- 2016-09-27 PT PT167848027T patent/PT3356391T/pt unknown
- 2016-09-27 EP EP19198429.3A patent/EP3650462A1/en active Pending
-
2018
- 2018-03-14 ZA ZA2018/01755A patent/ZA201801755B/en unknown
- 2018-03-23 MX MX2020011816A patent/MX2020011816A/es unknown
- 2018-11-15 HK HK18114645.0A patent/HK1255471A1/zh unknown
-
2019
- 2019-01-04 HK HK19100138.2A patent/HK1257762A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190100564A1 (en) | 2019-04-04 |
| US11066451B2 (en) | 2021-07-20 |
| EA036610B1 (ru) | 2020-11-30 |
| AU2016330322A1 (en) | 2018-04-26 |
| BR112018006300A2 (pt) | 2018-10-16 |
| KR20180080205A (ko) | 2018-07-11 |
| CN108137657A (zh) | 2018-06-08 |
| JP2018537412A (ja) | 2018-12-20 |
| ES2769775T3 (es) | 2020-06-29 |
| HUE047489T2 (hu) | 2020-04-28 |
| EP3650462A1 (en) | 2020-05-13 |
| WO2017055274A1 (en) | 2017-04-06 |
| PT3356391T (pt) | 2020-02-19 |
| PL3356391T3 (pl) | 2020-07-27 |
| GB201517450D0 (en) | 2015-11-18 |
| EA201890851A1 (ru) | 2018-08-31 |
| ZA201801755B (en) | 2019-01-30 |
| EP3356391B1 (en) | 2019-11-06 |
| SG10202001084VA (en) | 2020-03-30 |
| HK1257762A1 (zh) | 2019-10-25 |
| MX2020011816A (es) | 2021-01-15 |
| KR102675034B1 (ko) | 2024-06-14 |
| CA2996695A1 (en) | 2017-04-06 |
| EP3356391A1 (en) | 2018-08-08 |
| MX2018003644A (es) | 2018-04-30 |
| HK1255471A1 (zh) | 2019-08-16 |
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