DK3177670T3 - Hyperforgrenet poly(beta-aminoester) til genterapi - Google Patents
Hyperforgrenet poly(beta-aminoester) til genterapi Download PDFInfo
- Publication number
- DK3177670T3 DK3177670T3 DK15745509.8T DK15745509T DK3177670T3 DK 3177670 T3 DK3177670 T3 DK 3177670T3 DK 15745509 T DK15745509 T DK 15745509T DK 3177670 T3 DK3177670 T3 DK 3177670T3
- Authority
- DK
- Denmark
- Prior art keywords
- hyperforched
- gentherapy
- aminoester
- beta
- poly
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
- C08G83/005—Hyperbranched macromolecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1413907.5A GB201413907D0 (en) | 2014-08-06 | 2014-08-06 | Hyberbranched poly(beta-amino ester) for gene therapy |
PCT/EP2015/068153 WO2016020474A1 (en) | 2014-08-06 | 2015-08-06 | HYPERBRANCHED POLY( ß -AMINO ESTER) FOR GENE THERAPY |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3177670T3 true DK3177670T3 (da) | 2020-04-27 |
Family
ID=51587799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15745509.8T DK3177670T3 (da) | 2014-08-06 | 2015-08-06 | Hyperforgrenet poly(beta-aminoester) til genterapi |
Country Status (14)
Country | Link |
---|---|
US (1) | US20170216455A1 (da) |
EP (2) | EP3738992A1 (da) |
CY (1) | CY1122850T1 (da) |
DK (1) | DK3177670T3 (da) |
ES (1) | ES2785248T3 (da) |
GB (1) | GB201413907D0 (da) |
HR (1) | HRP20200633T1 (da) |
HU (1) | HUE049704T2 (da) |
LT (1) | LT3177670T (da) |
PL (1) | PL3177670T3 (da) |
PT (1) | PT3177670T (da) |
RS (1) | RS60335B1 (da) |
SI (1) | SI3177670T1 (da) |
WO (1) | WO2016020474A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019084229A1 (en) * | 2017-10-27 | 2019-05-02 | Massachusetts Institute Of Technology | POLY (BETA-AMINO ESTERS) AND USES THEREOF |
MX2021004169A (es) | 2018-10-12 | 2021-08-05 | Amryt Genetics Ltd | Composiciones y metodos para la transfeccion de celulas. |
AU2019366996A1 (en) | 2018-10-26 | 2021-05-27 | Massachusetts Institute Of Technology | Polymer-lipids and compositions |
WO2020140116A1 (en) * | 2018-12-28 | 2020-07-02 | Amryt Genetics Ltd | Methods for forming polyplexes |
AU2020353221A1 (en) | 2019-09-25 | 2022-03-31 | University College Dublin | Nanoparticle compositions for gene therapy |
EP3798250A1 (en) * | 2019-09-25 | 2021-03-31 | University College Dublin | Hyperbranched cationic polymers useful as nucleic acid delivery vectors for transfecting |
CN110746599B (zh) * | 2019-09-30 | 2021-06-18 | 苏州大学 | 具有高效基因递送能力的UV光响应性超支化聚β-氨基酯及其制备方法与应用 |
CN111135306B (zh) * | 2020-01-19 | 2023-03-10 | 安阳师范学院 | 基于叶酸靶向聚乙二醇修饰型超支化聚胺制备叶酸和磁性双靶向型非病毒基因载体的方法 |
WO2022192176A1 (en) * | 2021-03-09 | 2022-09-15 | Massachusetts Institute Of Technology | Branched poly(-amino esters) for the delivery of nucleic acids |
CN114106348B (zh) * | 2021-11-12 | 2023-07-07 | 西安交通大学 | 苯硼酸修饰的胞内可降解超支化聚(β-氨基酯)及其制备方法和蛋白递送应用 |
EP4183884A1 (en) * | 2021-11-19 | 2023-05-24 | Branca Bunus Limited | A method of preparing a fraction of a starting polymer vector for gene therapy |
WO2023131648A1 (en) | 2022-01-05 | 2023-07-13 | Branca Bunus Limited | Nanoparticulate compositions for gene therapy |
EP4324485A1 (en) | 2022-08-15 | 2024-02-21 | Branca Banus Ltd | A method for the production of pegylated hyperbranched poly( -amino ester)s, pegylated hyperbranched poly( -amino ester)s produced by those methods and their use in enhanced nucleic acid delivery |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180424A (en) * | 1991-10-07 | 1993-01-19 | Westvaco Corporation | Michael addition aminopolyester resins as dilution extenders for zinc-containing metal resinate inks |
US6998115B2 (en) | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
WO2006118547A1 (en) * | 2005-04-29 | 2006-11-09 | Agency For Science, Technology And Research | Hyperbranched polymers and their applications |
CA2658768C (en) * | 2006-07-21 | 2016-05-17 | Massachusetts Institute Of Technology | End-modified poly(beta-amino esters) and uses thereof |
-
2014
- 2014-08-06 GB GBGB1413907.5A patent/GB201413907D0/en not_active Ceased
-
2015
- 2015-08-06 ES ES15745509T patent/ES2785248T3/es active Active
- 2015-08-06 EP EP20162334.5A patent/EP3738992A1/en active Pending
- 2015-08-06 EP EP15745509.8A patent/EP3177670B1/en active Active
- 2015-08-06 PT PT157455098T patent/PT3177670T/pt unknown
- 2015-08-06 US US15/500,470 patent/US20170216455A1/en active Pending
- 2015-08-06 WO PCT/EP2015/068153 patent/WO2016020474A1/en active Application Filing
- 2015-08-06 DK DK15745509.8T patent/DK3177670T3/da active
- 2015-08-06 SI SI201531166T patent/SI3177670T1/sl unknown
- 2015-08-06 HU HUE15745509A patent/HUE049704T2/hu unknown
- 2015-08-06 RS RS20200441A patent/RS60335B1/sr unknown
- 2015-08-06 PL PL15745509T patent/PL3177670T3/pl unknown
- 2015-08-06 LT LTEP15745509.8T patent/LT3177670T/lt unknown
-
2020
- 2020-04-16 CY CY20201100361T patent/CY1122850T1/el unknown
- 2020-04-21 HR HRP20200633TT patent/HRP20200633T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20200633T1 (hr) | 2020-08-07 |
ES2785248T3 (es) | 2020-10-06 |
EP3738992A1 (en) | 2020-11-18 |
PT3177670T (pt) | 2020-04-24 |
HUE049704T2 (hu) | 2020-10-28 |
US20170216455A1 (en) | 2017-08-03 |
EP3177670A1 (en) | 2017-06-14 |
LT3177670T (lt) | 2020-06-25 |
GB201413907D0 (en) | 2014-09-17 |
RS60335B1 (sr) | 2020-07-31 |
WO2016020474A1 (en) | 2016-02-11 |
EP3177670B1 (en) | 2020-03-18 |
SI3177670T1 (sl) | 2020-07-31 |
PL3177670T3 (pl) | 2020-07-13 |
CY1122850T1 (el) | 2021-05-05 |
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