MX2020011816A - Metodo para purificar la neurotoxina clostridial. - Google Patents
Metodo para purificar la neurotoxina clostridial.Info
- Publication number
- MX2020011816A MX2020011816A MX2020011816A MX2020011816A MX2020011816A MX 2020011816 A MX2020011816 A MX 2020011816A MX 2020011816 A MX2020011816 A MX 2020011816A MX 2020011816 A MX2020011816 A MX 2020011816A MX 2020011816 A MX2020011816 A MX 2020011816A
- Authority
- MX
- Mexico
- Prior art keywords
- clostridial neurotoxin
- contacting
- clostridial
- purifying
- neurotoxin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24068—Tentoxilysin (3.4.24.68), i.e. tetanus neurotoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe un método para purificar una neurotoxina clostridial que comprende poner en contacto una resina de intercambio catiónico con una composición que comprende una neurotoxina clostridial, donde la etapa de contacto se realiza al menos pH 7.3, donde se produce la etapa de poner en contacto una resina de intercambio catiónico con una composición que comprende la neurotoxina clostridial antes de la conversión de la neurotoxina clostridial de una forma monocatenaria en una forma bicatenaria. También se proporcionan usos de una solución amortiguadora que tiene un valor de pH que es -1 unidad de pH o superior al pI calculado de una neurotoxina clostridial, intermediarios de purificación y neurotoxinas clostridiales obtenibles por la invención, en donde la neurotoxina clostridial está en una forma monocatenaria.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1517450.1A GB201517450D0 (en) | 2015-10-02 | 2015-10-02 | Method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020011816A true MX2020011816A (es) | 2021-01-15 |
Family
ID=54606010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003644A MX2018003644A (es) | 2015-10-02 | 2016-09-27 | Metodo para purificar la neurotoxina clostridial. |
| MX2020011816A MX2020011816A (es) | 2015-10-02 | 2018-03-23 | Metodo para purificar la neurotoxina clostridial. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003644A MX2018003644A (es) | 2015-10-02 | 2016-09-27 | Metodo para purificar la neurotoxina clostridial. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11066451B2 (es) |
| EP (2) | EP3356391B1 (es) |
| JP (1) | JP2018537412A (es) |
| KR (1) | KR20180080205A (es) |
| CN (1) | CN108137657A (es) |
| AU (1) | AU2016330322A1 (es) |
| BR (1) | BR112018006300A2 (es) |
| CA (1) | CA2996695A1 (es) |
| DK (1) | DK3356391T3 (es) |
| EA (1) | EA036610B1 (es) |
| ES (1) | ES2769775T3 (es) |
| GB (1) | GB201517450D0 (es) |
| HK (2) | HK1255471A1 (es) |
| HU (1) | HUE047489T2 (es) |
| MX (2) | MX2018003644A (es) |
| PL (1) | PL3356391T3 (es) |
| PT (1) | PT3356391T (es) |
| SG (1) | SG10202001084VA (es) |
| WO (1) | WO2017055274A1 (es) |
| ZA (1) | ZA201801755B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2490986T (pt) * | 2009-10-21 | 2018-11-13 | Revance Therapeutics Inc | Métodos e sistemas para purificar neurotoxina botulínica não complexada |
| US11707510B2 (en) * | 2018-02-16 | 2023-07-25 | Preclinics Discovery Gmbh | Nucleic acid-based botulinum neurotoxin for therapeutic use |
| GB201914034D0 (en) * | 2019-09-30 | 2019-11-13 | Ipsen Biopharm Ltd | Treatment of neurological disorders |
| GB202003813D0 (en) | 2020-03-16 | 2020-04-29 | Ipsen Biopharm Ltd | Treatment of upper facial lines |
| AU2021238924A1 (en) | 2020-03-16 | 2022-08-25 | Ipsen Biopharm Limited | Modified botulinum neurotoxin for treating limb spasticity |
| CN113832069B (zh) * | 2020-11-30 | 2024-01-30 | 河南农业大学 | 丁酸梭菌及其应用 |
| KR20230163470A (ko) * | 2021-03-30 | 2023-11-30 | 입센 바이오팜 리미티드 | 통증 ＆ 염증성 장애의 치료 |
| WO2023041934A1 (en) | 2021-09-16 | 2023-03-23 | Ipsen Biopharm Limited | Modified bont/a for use in the treatment of cervical dystonia |
| GB202113602D0 (en) | 2021-09-23 | 2021-11-10 | Ipsen Biopharm Ltd | Treatment of a disorder affecting an eyelid muscle of a subject |
| CA3228712A1 (en) | 2021-09-23 | 2023-03-30 | Nicolae GRIGORE | Modified bont/a for use in the treatment of a disorder affecting an eyelid muscle of a subject |
| KR20240051355A (ko) * | 2022-10-12 | 2024-04-22 | 주식회사 알케미어 | 보툴리눔 독소의 경쇄 변이체 |
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-
2015
- 2015-10-02 GB GBGB1517450.1A patent/GB201517450D0/en not_active Ceased
-
2016
- 2016-09-27 HU HUE16784802A patent/HUE047489T2/hu unknown
- 2016-09-27 AU AU2016330322A patent/AU2016330322A1/en not_active Abandoned
- 2016-09-27 JP JP2018517224A patent/JP2018537412A/ja active Pending
- 2016-09-27 ES ES16784802T patent/ES2769775T3/es active Active
- 2016-09-27 MX MX2018003644A patent/MX2018003644A/es unknown
- 2016-09-27 CN CN201680055073.8A patent/CN108137657A/zh active Pending
- 2016-09-27 SG SG10202001084VA patent/SG10202001084VA/en unknown
- 2016-09-27 EP EP16784802.7A patent/EP3356391B1/en active Active
- 2016-09-27 PL PL16784802T patent/PL3356391T3/pl unknown
- 2016-09-27 CA CA2996695A patent/CA2996695A1/en not_active Abandoned
- 2016-09-27 KR KR1020187011891A patent/KR20180080205A/ko not_active Application Discontinuation
- 2016-09-27 WO PCT/EP2016/072986 patent/WO2017055274A1/en active Application Filing
- 2016-09-27 BR BR112018006300-2A patent/BR112018006300A2/pt not_active Application Discontinuation
- 2016-09-27 DK DK16784802.7T patent/DK3356391T3/da active
- 2016-09-27 US US15/765,427 patent/US11066451B2/en active Active
- 2016-09-27 EA EA201890851A patent/EA036610B1/ru unknown
- 2016-09-27 PT PT167848027T patent/PT3356391T/pt unknown
- 2016-09-27 EP EP19198429.3A patent/EP3650462A1/en active Pending
-
2018
- 2018-03-14 ZA ZA2018/01755A patent/ZA201801755B/en unknown
- 2018-03-23 MX MX2020011816A patent/MX2020011816A/es unknown
- 2018-11-15 HK HK18114645.0A patent/HK1255471A1/zh unknown
-
2019
- 2019-01-04 HK HK19100138.2A patent/HK1257762A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016330322A1 (en) | 2018-04-26 |
| CA2996695A1 (en) | 2017-04-06 |
| EP3650462A1 (en) | 2020-05-13 |
| EP3356391A1 (en) | 2018-08-08 |
| HUE047489T2 (hu) | 2020-04-28 |
| ZA201801755B (en) | 2019-01-30 |
| ES2769775T3 (es) | 2020-06-29 |
| HK1257762A1 (zh) | 2019-10-25 |
| EA201890851A1 (ru) | 2018-08-31 |
| GB201517450D0 (en) | 2015-11-18 |
| EA036610B1 (ru) | 2020-11-30 |
| JP2018537412A (ja) | 2018-12-20 |
| HK1255471A1 (zh) | 2019-08-16 |
| CN108137657A (zh) | 2018-06-08 |
| WO2017055274A1 (en) | 2017-04-06 |
| DK3356391T3 (da) | 2020-02-03 |
| US20190100564A1 (en) | 2019-04-04 |
| BR112018006300A2 (pt) | 2018-10-16 |
| EP3356391B1 (en) | 2019-11-06 |
| KR20180080205A (ko) | 2018-07-11 |
| PT3356391T (pt) | 2020-02-19 |
| PL3356391T3 (pl) | 2020-07-27 |
| SG10202001084VA (en) | 2020-03-30 |
| US11066451B2 (en) | 2021-07-20 |
| MX2018003644A (es) | 2018-04-30 |
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