DK3328888T3 - ANTI-PSMA-antistoffer, bispecifikke antigenbindingsmolekyler, der binder PSMA AND og CD3, samt anvendelser deraf - Google Patents

ANTI-PSMA-antistoffer, bispecifikke antigenbindingsmolekyler, der binder PSMA AND og CD3, samt anvendelser deraf Download PDF

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Publication number
DK3328888T3
DK3328888T3 DK16748023.5T DK16748023T DK3328888T3 DK 3328888 T3 DK3328888 T3 DK 3328888T3 DK 16748023 T DK16748023 T DK 16748023T DK 3328888 T3 DK3328888 T3 DK 3328888T3
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Prior art keywords
psma
antigen binding
binding molecules
bispecific antigen
bind
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DK16748023.5T
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English (en)
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DK3328888T5 (da
Inventor
Jessica R Kirshner
Alison Crawford
Gavin Thurston
Eric Smith
Lauric Haber
Drew Dudgeon
Ashique Rafique
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Regeneron Pharma
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK16748023.5T 2015-07-31 2016-07-29 ANTI-PSMA-antistoffer, bispecifikke antigenbindingsmolekyler, der binder PSMA AND og CD3, samt anvendelser deraf DK3328888T5 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562199823P 2015-07-31 2015-07-31
US201562222590P 2015-09-23 2015-09-23
US201662351823P 2016-06-17 2016-06-17
PCT/US2016/044732 WO2017023761A1 (en) 2015-07-31 2016-07-29 Anti-psma antibodies, bispecific antigen-binding molecules that bind psma and cd3, and uses thereof

Publications (2)

Publication Number Publication Date
DK3328888T3 true DK3328888T3 (da) 2023-01-23
DK3328888T5 DK3328888T5 (da) 2024-10-07

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DK16748023.5T DK3328888T5 (da) 2015-07-31 2016-07-29 ANTI-PSMA-antistoffer, bispecifikke antigenbindingsmolekyler, der binder PSMA AND og CD3, samt anvendelser deraf

Country Status (24)

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US (3) US10179819B2 (da)
EP (2) EP4183805A1 (da)
JP (2) JP6975707B2 (da)
KR (1) KR20180042272A (da)
CN (1) CN108137700B (da)
AR (1) AR106570A1 (da)
AU (1) AU2016302928B2 (da)
CA (1) CA2994245A1 (da)
DK (1) DK3328888T5 (da)
EA (1) EA038603B1 (da)
ES (1) ES2935120T3 (da)
FI (1) FI3328888T3 (da)
HK (1) HK1255971A1 (da)
HR (1) HRP20230237T1 (da)
HU (1) HUE061419T2 (da)
JO (1) JOP20160154B1 (da)
LT (1) LT3328888T (da)
MD (1) MD3328888T2 (da)
PL (1) PL3328888T3 (da)
PT (1) PT3328888T (da)
RS (1) RS63991B1 (da)
SI (1) SI3328888T1 (da)
TW (1) TWI728990B (da)
WO (1) WO2017023761A1 (da)

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JOP20160154B1 (ar) 2021-08-17
US20210403595A1 (en) 2021-12-30
FI3328888T3 (fi) 2023-02-22
HUE061419T2 (hu) 2023-06-28
TW201718649A (zh) 2017-06-01
PT3328888T (pt) 2023-01-05
AR106570A1 (es) 2018-01-31
EA038603B1 (ru) 2021-09-21
WO2017023761A1 (en) 2017-02-09
DK3328888T5 (da) 2024-10-07
MD3328888T2 (ro) 2023-04-30
CN108137700B (zh) 2021-11-19
RS63991B1 (sr) 2023-03-31
HK1255971A1 (zh) 2019-09-06
LT3328888T (lt) 2023-03-27
SI3328888T1 (sl) 2023-02-28
KR20180042272A (ko) 2018-04-25
TWI728990B (zh) 2021-06-01
JP2022025130A (ja) 2022-02-09
PL3328888T3 (pl) 2023-04-11
CN108137700A (zh) 2018-06-08
US20170051074A1 (en) 2017-02-23
EP3328888B1 (en) 2022-12-07
EP4183805A1 (en) 2023-05-24
CA2994245A1 (en) 2017-02-09
US11155633B2 (en) 2021-10-26
US20190127480A1 (en) 2019-05-02
ES2935120T3 (es) 2023-03-01
US10179819B2 (en) 2019-01-15
AU2016302928A1 (en) 2018-03-01
JP6975707B2 (ja) 2021-12-01
EA201890368A1 (ru) 2018-10-31
HRP20230237T1 (hr) 2023-04-14
EP3328888A1 (en) 2018-06-06
JP7271637B2 (ja) 2023-05-11
JP2018524396A (ja) 2018-08-30

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