DK3310919T3 - Vektorer til brug i et inducerbart samekspressionssystem - Google Patents
Vektorer til brug i et inducerbart samekspressionssystem Download PDFInfo
- Publication number
- DK3310919T3 DK3310919T3 DK16812476.6T DK16812476T DK3310919T3 DK 3310919 T3 DK3310919 T3 DK 3310919T3 DK 16812476 T DK16812476 T DK 16812476T DK 3310919 T3 DK3310919 T3 DK 3310919T3
- Authority
- DK
- Denmark
- Prior art keywords
- inducible
- vectors
- expression system
- expression
- Prior art date
Links
- 230000004186 co-expression Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- General Factory Administration (AREA)
- Preliminary Treatment Of Fibers (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Slot Machines And Peripheral Devices (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/740,475 US20150353940A1 (en) | 2013-08-05 | 2015-06-16 | Vectors for use in an inducible coexpression system |
| PCT/US2016/037942 WO2016205570A1 (en) | 2015-06-16 | 2016-06-16 | Vectors for use in an inducible coexpression system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3310919T3 true DK3310919T3 (da) | 2022-02-14 |
Family
ID=54769087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16812476.6T DK3310919T3 (da) | 2015-06-16 | 2016-06-16 | Vektorer til brug i et inducerbart samekspressionssystem |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20150353940A1 (enExample) |
| EP (2) | EP4039810A1 (enExample) |
| JP (2) | JP6976860B2 (enExample) |
| KR (1) | KR102716963B1 (enExample) |
| CN (1) | CN107849572A (enExample) |
| AU (2) | AU2016278242B2 (enExample) |
| CA (1) | CA2986443A1 (enExample) |
| DK (1) | DK3310919T3 (enExample) |
| ES (1) | ES2906725T3 (enExample) |
| IL (2) | IL307555A (enExample) |
| MX (1) | MX390195B (enExample) |
| WO (1) | WO2016205570A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017106583A1 (en) * | 2015-12-15 | 2017-06-22 | Absci, Llc | Cytoplasmic expression system |
| US12157766B2 (en) | 2012-08-05 | 2024-12-03 | Absci Corporation | Cytoplasmic expression system |
| CA3114395A1 (en) | 2018-09-25 | 2020-04-02 | Absci, Llc | Protein purification methods |
| KR20210090645A (ko) | 2018-11-05 | 2021-07-20 | 제넨테크, 인크. | 원핵 숙주 세포에서 2개의 사슬 단백질을 생산하는 방법 |
| CN111269294B (zh) * | 2018-12-05 | 2023-03-28 | 广州中国科学院先进技术研究所 | 纤维寡糖转运蛋白LacY的突变位点、突变转运蛋白LacY及其制备方法和应用 |
| CN111979206B (zh) * | 2019-05-24 | 2021-08-17 | 深圳瑞德林生物技术有限公司 | 固定化融合酶及用其制备谷胱甘肽的方法 |
| AU2021312935B2 (en) * | 2020-07-24 | 2024-11-28 | Duke University | Methods and compositions for the production of acetyl-CoA derived products |
| US20220380783A1 (en) * | 2021-05-06 | 2022-12-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and system of managing resource competition in synthetic gene circuits |
| CN113528410A (zh) * | 2021-06-23 | 2021-10-22 | 云舟生物科技（广州）有限公司 | 一种用于快速高效诱导表达外源蛋白的大肠杆菌工程菌及其制备方法与应用 |
| WO2023114905A1 (en) | 2021-12-16 | 2023-06-22 | Absci Corporation | Membrane-associated fusion proteins to increase the competency of cells |
| IL313521A (en) | 2021-12-17 | 2024-08-01 | Absci Corp | Solid-phase screening for high-throughput bacterial strains |
| CN118510902A (zh) | 2021-12-21 | 2024-08-16 | Absci公司 | 用于鉴定具有增加的可溶性靶蛋白表达的菌株的FolA选择测定 |
| EP4453198A1 (en) | 2021-12-23 | 2024-10-30 | ABSCI Corporation | Products and methods for heterologous expression of proteins in a host cell |
| WO2023129881A1 (en) * | 2021-12-30 | 2023-07-06 | Absci Corporation | Knockout of ptsp gene elevates active gene expression |
| US20230268026A1 (en) | 2022-01-07 | 2023-08-24 | Absci Corporation | Designing biomolecule sequence variants with pre-specified attributes |
| WO2024006269A1 (en) | 2022-06-29 | 2024-01-04 | Absci Corporation | Affinity screening method |
| WO2024040020A1 (en) | 2022-08-15 | 2024-02-22 | Absci Corporation | Quantitative affinity activity specific cell enrichment |
| WO2024254237A1 (en) | 2023-06-08 | 2024-12-12 | Absci Corporation | Solid-phase screening for high-performing bacterial strains |
| WO2025058962A1 (en) | 2023-09-11 | 2025-03-20 | Absci Corporation | High-throughput methods for kinetic characterization, quantifying and optimizing antibodies and antibody fragments expression in bacteria |
| WO2025076081A1 (en) | 2023-10-03 | 2025-04-10 | Absci Corporation | Tl1a associated antibody compositions and methods of use |
| WO2025122885A1 (en) | 2023-12-08 | 2025-06-12 | Absci Corporation | Anti-her2 associated antibody compositions designed by artificial intelligence and methods of use |
| WO2025144700A1 (en) | 2023-12-27 | 2025-07-03 | Absci Corporation | Nanobody library screening using bacterial surface display |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3344618B2 (ja) | 1997-06-20 | 2002-11-11 | 株式会社エイチ・エス・ピー研究所 | シャペロン発現プラスミド |
| ATE449844T1 (de) * | 1997-12-05 | 2009-12-15 | Europ Lab Molekularbiolog | Neue methode zur klonierung dns unter anwendung des e. coli rece/rect rekombinationssystems |
| US6780405B1 (en) | 2000-04-28 | 2004-08-24 | Avant Immunotherapeutics, Inc. | Regulated antigen delivery system (RADS) |
| US6979556B2 (en) * | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
| DE60135498D1 (de) * | 2000-12-14 | 2008-10-02 | Genentech Inc | Produktion von ganzen Antikörpern in prokaryontischen Zellen |
| JP4461210B2 (ja) * | 2001-08-27 | 2010-05-12 | ジェネンテック， インコーポレイテッド | 抗体発現系とその構築法 |
| WO2005040388A2 (en) * | 2003-08-22 | 2005-05-06 | Nucleonics Inc. | Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments |
| US8227241B2 (en) * | 2004-03-12 | 2012-07-24 | Unigene Laboratories, Inc. | Bacterial host cell for the direct expression of peptides |
| DE102004061846A1 (de) * | 2004-12-22 | 2006-07-13 | Basf Ag | Mehrfachpromotoren |
| CA2610405C (en) | 2005-06-06 | 2015-01-27 | Dow Global Technologies Inc. | Mannitol induced promoter systems in bacterial host cells |
| US8178338B2 (en) | 2005-07-01 | 2012-05-15 | The Regents Of The University Of California | Inducible expression vectors and methods of use thereof |
| EP2155789B1 (en) | 2007-05-01 | 2013-07-24 | Research Development Foundation | Immunoglobulin fc libraries |
| US8999668B2 (en) | 2008-01-03 | 2015-04-07 | Cornell Research Foundation, Inc. | Glycosylated protein expression in prokaryotes |
| KR100958096B1 (ko) * | 2008-02-11 | 2010-05-14 | 한국과학기술원 | 염색체 특정 부위 제거용 재조합 벡터 및 이를 이용한미생물 내 염색체 특정 부위의 제거방법 |
| DK2379722T3 (da) * | 2008-12-16 | 2017-01-02 | C-Lecta Gmbh | Ekspressionsvektor |
| CA2754928A1 (en) * | 2009-03-10 | 2010-09-16 | Athena Biotechnologies, Inc. | Reducing carbon dioxide production and increasing ethanol yield during microbial ethanol fermentation |
| US8623652B2 (en) * | 2009-04-06 | 2014-01-07 | Lucigen Corporation | Host-vector system for cloning and expressing genes |
| AU2010322454B2 (en) * | 2009-11-19 | 2016-05-19 | Glaxosmithkline Biologicals S.A. | Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells |
| US8603797B2 (en) * | 2010-03-17 | 2013-12-10 | Cornell University | Methods and compositions for targeted mutagenesis in bacteria |
| EP2386641A1 (en) | 2010-05-11 | 2011-11-16 | Université Catholique De Louvain | Method for extracellular production of recombinant biomolecules in a microorganism |
| DK2880168T3 (en) * | 2012-08-05 | 2017-04-18 | Absci Llc | INDUCERABLE CO EXPRESSION SYSTEM |
| EP3030651A4 (en) * | 2013-08-05 | 2017-02-22 | Aronora, Inc. | Coordinated coexpression of thrombin |
-
2015
- 2015-06-16 US US14/740,475 patent/US20150353940A1/en not_active Abandoned
-
2016
- 2016-06-16 WO PCT/US2016/037942 patent/WO2016205570A1/en not_active Ceased
- 2016-06-16 JP JP2017565149A patent/JP6976860B2/ja active Active
- 2016-06-16 IL IL307555A patent/IL307555A/en unknown
- 2016-06-16 KR KR1020187000942A patent/KR102716963B1/ko active Active
- 2016-06-16 IL IL256094A patent/IL256094B2/en unknown
- 2016-06-16 CA CA2986443A patent/CA2986443A1/en active Pending
- 2016-06-16 ES ES16812476T patent/ES2906725T3/es active Active
- 2016-06-16 CN CN201680035423.4A patent/CN107849572A/zh active Pending
- 2016-06-16 EP EP21214179.0A patent/EP4039810A1/en active Pending
- 2016-06-16 AU AU2016278242A patent/AU2016278242B2/en active Active
- 2016-06-16 MX MX2017016400A patent/MX390195B/es unknown
- 2016-06-16 EP EP16812476.6A patent/EP3310919B1/en active Active
- 2016-06-16 DK DK16812476.6T patent/DK3310919T3/da active
- 2016-09-11 US US15/261,984 patent/US11371048B2/en active Active
-
2021
- 2021-06-28 JP JP2021106797A patent/JP2021153600A/ja active Pending
-
2022
- 2022-09-08 AU AU2022228166A patent/AU2022228166A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2986443A1 (en) | 2016-12-22 |
| EP3310919A1 (en) | 2018-04-25 |
| AU2022228166A1 (en) | 2022-09-29 |
| US20150353940A1 (en) | 2015-12-10 |
| JP2018518957A (ja) | 2018-07-19 |
| IL256094A (en) | 2018-02-28 |
| US20160376602A1 (en) | 2016-12-29 |
| EP3310919B1 (en) | 2021-12-15 |
| IL256094B1 (en) | 2023-11-01 |
| AU2016278242B2 (en) | 2022-06-09 |
| JP2021153600A (ja) | 2021-10-07 |
| IL307555A (en) | 2023-12-01 |
| HK1253045A1 (zh) | 2019-06-06 |
| CN107849572A (zh) | 2018-03-27 |
| KR20180020213A (ko) | 2018-02-27 |
| JP6976860B2 (ja) | 2021-12-08 |
| US11371048B2 (en) | 2022-06-28 |
| EP3310919A4 (en) | 2019-01-09 |
| EP4039810A1 (en) | 2022-08-10 |
| ES2906725T3 (es) | 2022-04-20 |
| KR102716963B1 (ko) | 2024-10-11 |
| WO2016205570A1 (en) | 2016-12-22 |
| AU2016278242A1 (en) | 2018-01-18 |
| MX390195B (es) | 2025-03-20 |
| MX2017016400A (es) | 2018-03-02 |
| IL256094B2 (en) | 2024-03-01 |
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