DK3129374T3 - (5,6-dihydro) pyrimido [4,5-e] INDOLIZINER - Google Patents

(5,6-dihydro) pyrimido [4,5-e] INDOLIZINER Download PDF

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Publication number
DK3129374T3
DK3129374T3 DK15712912.3T DK15712912T DK3129374T3 DK 3129374 T3 DK3129374 T3 DK 3129374T3 DK 15712912 T DK15712912 T DK 15712912T DK 3129374 T3 DK3129374 T3 DK 3129374T3
Authority
DK
Denmark
Prior art keywords
carboxamide
indolizine
dihydropyrimido
anilino
alkyl
Prior art date
Application number
DK15712912.3T
Other languages
Danish (da)
English (en)
Inventor
Man Adrianus Petrus Antonius De
Rogier Christian Buijsman
Jan Gerard Sterrenburg
Joost Cornelis Marinus Uitdehaag
Wit Joeri Johannes Petrus De
Guido Jenny Rudolf Zaman
Original Assignee
Netherlands Translational Res Center B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netherlands Translational Res Center B V filed Critical Netherlands Translational Res Center B V
Application granted granted Critical
Publication of DK3129374T3 publication Critical patent/DK3129374T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15712912.3T 2014-04-07 2015-03-30 (5,6-dihydro) pyrimido [4,5-e] INDOLIZINER DK3129374T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14163734 2014-04-07
EP15153207 2015-01-30
PCT/EP2015/056839 WO2015155042A1 (en) 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido[4,5-e]indolizines

Publications (1)

Publication Number Publication Date
DK3129374T3 true DK3129374T3 (en) 2019-04-08

Family

ID=52774240

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15712912.3T DK3129374T3 (en) 2014-04-07 2015-03-30 (5,6-dihydro) pyrimido [4,5-e] INDOLIZINER

Country Status (16)

Country Link
US (3) USRE48974E1 (cg-RX-API-DMAC7.html)
EP (1) EP3129374B1 (cg-RX-API-DMAC7.html)
JP (1) JP6518690B2 (cg-RX-API-DMAC7.html)
KR (1) KR102432420B1 (cg-RX-API-DMAC7.html)
CN (1) CN106132963B (cg-RX-API-DMAC7.html)
AU (1) AU2015243694B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016022342B1 (cg-RX-API-DMAC7.html)
CA (1) CA2944610C (cg-RX-API-DMAC7.html)
DK (1) DK3129374T3 (cg-RX-API-DMAC7.html)
ES (1) ES2716165T3 (cg-RX-API-DMAC7.html)
HU (1) HUE043108T2 (cg-RX-API-DMAC7.html)
MX (1) MX368767B (cg-RX-API-DMAC7.html)
PL (1) PL3129374T3 (cg-RX-API-DMAC7.html)
PT (1) PT3129374T (cg-RX-API-DMAC7.html)
RU (1) RU2692479C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015155042A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX368767B (es) * 2014-04-07 2019-10-15 Netherlands Translational Res Center B V (5,6-dihidro)pirimido[4,5-e]indolizinas.
AU2016247476B2 (en) 2015-04-17 2021-12-16 SillaJen Inc. Prognostic biomarkers for TTK inhibitor chemotherapy
PL3416964T3 (pl) * 2016-02-19 2021-10-18 Phoenix Molecular Designs Pochodne 6-okso-n-(1-(benzylo)-1h-pirazol-4-ilo)-6,7,8,9-tetrahydropirydo[3’,2’:4,5]pirolo[1,2-a]pirazyno-2-karboksyamidu jako inhibitory kinazy rybosomalnej s6 p90 (rsk) do leczenia nowotworu złośliwego
KR20230109185A (ko) 2016-06-07 2023-07-19 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
CN106551938B (zh) * 2016-11-26 2017-11-24 广东安诺药业股份有限公司 一种治疗非酒精性脂肪肝的药物及其应用
PT3601239T (pt) 2017-03-23 2024-10-24 Jacobio Pharmaceuticals Co Ltd Novos derivados heterocíclicos úteis como inibidores de shp2
CN112839935A (zh) 2018-09-26 2021-05-25 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
AU2020222056A1 (en) 2019-02-11 2021-10-07 Phoenix Molecular Designs Crystalline forms of an RSK inhibitor
JP2024546977A (ja) * 2021-12-15 2024-12-26 シルラジェン，インコーポレイテッド 新生物疾患の処置方法
AU2022415783A1 (en) * 2021-12-15 2024-06-27 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases
MX2024007452A (es) * 2021-12-15 2024-07-09 Sillajen Inc Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas.
KR20240144991A (ko) * 2022-03-04 2024-10-04 신라젠(주) 신생물성 질환 치료에 사용하기 위한 약제학적 병용물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0212760A (pt) * 2001-09-19 2004-12-07 Aventis Pharma Sa Compostos quìmicos
JP5043432B2 (ja) 2003-05-22 2012-10-10 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ピラゾロ−キナゾリン誘導体、その製造方法、およびキナーゼ阻害剤としてのその使用
JP5284973B2 (ja) 2006-11-28 2013-09-11 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 三環式インドールおよび（４，５−ジヒドロ）インドール
EA020703B9 (ru) * 2008-06-26 2015-12-30 Ле Лаборатуар Сервье Пиразолохиназолины
WO2010111406A2 (en) 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
WO2010125004A1 (en) 2009-04-29 2010-11-04 Nerviano Medical Sciences S.R.L. Cdk inhibitor salts
JP5851990B2 (ja) 2009-07-29 2016-02-03 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Ｐｌｋ阻害剤の塩
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
CA2821829A1 (en) 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
EP2668190B1 (en) * 2011-01-26 2016-08-17 Nerviano Medical Sciences S.r.l. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
JP6523267B2 (ja) 2013-06-24 2019-05-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｆｓｈｒの調節剤としてのイミダゾール化合物及びその使用
MX368767B (es) * 2014-04-07 2019-10-15 Netherlands Translational Res Center B V (5,6-dihidro)pirimido[4,5-e]indolizinas.

Also Published As

Publication number Publication date
JP2017510595A (ja) 2017-04-13
MX2016012997A (es) 2016-12-07
AU2015243694A1 (en) 2016-11-03
CA2944610A1 (en) 2015-10-15
BR112016022342A2 (pt) 2017-08-15
RU2016141405A (ru) 2018-05-07
CA2944610C (en) 2024-01-09
RU2692479C2 (ru) 2019-06-25
KR20170013866A (ko) 2017-02-07
US20170096432A1 (en) 2017-04-06
US9856258B2 (en) 2018-01-02
AU2015243694B2 (en) 2019-01-17
BR112016022342A8 (pt) 2021-07-20
EP3129374A1 (en) 2017-02-15
BR112016022342B1 (pt) 2022-10-04
CN106132963B (zh) 2019-08-06
HUE043108T2 (hu) 2019-07-29
PT3129374T (pt) 2019-03-25
ES2716165T3 (es) 2019-06-10
RU2016141405A3 (cg-RX-API-DMAC7.html) 2018-10-02
KR102432420B1 (ko) 2022-08-17
CN106132963A (zh) 2016-11-16
WO2015155042A1 (en) 2015-10-15
USRE48974E1 (en) 2022-03-15
PL3129374T3 (pl) 2019-07-31
MX368767B (es) 2019-10-15
USRE50082E1 (en) 2024-08-20
JP6518690B2 (ja) 2019-05-22
EP3129374B1 (en) 2018-12-19

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