AU2015243694B2 - (5,6-dihydro)pyrimido(4,5-e)indolizines - Google Patents

(5,6-dihydro)pyrimido(4,5-e)indolizines Download PDF

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Publication number
AU2015243694B2
AU2015243694B2 AU2015243694A AU2015243694A AU2015243694B2 AU 2015243694 B2 AU2015243694 B2 AU 2015243694B2 AU 2015243694 A AU2015243694 A AU 2015243694A AU 2015243694 A AU2015243694 A AU 2015243694A AU 2015243694 B2 AU2015243694 B2 AU 2015243694B2
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AU
Australia
Prior art keywords
carboxamide
indolizine
anilino
methoxy
dihydropyrimido
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AU2015243694A
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AU2015243694A1 (en
Inventor
Rogier Christian Buijsman
Adrianus Petrus Antonius De Man
Joeri Johannes Petrus DE WIT
Jan Gerard STERRENBURG
Joost Cornelis Marinus UITDEHAAG
Guido Jenny Rudolf Zaman
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Sillajen Inc
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SILLAJEN Inc
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Assigned to SillaJen Inc. reassignment SillaJen Inc. Request for Assignment Assignors: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015243694A 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido(4,5-e)indolizines Active AU2015243694B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14163734.8 2014-04-07
EP14163734 2014-04-07
EP15153207.4 2015-01-30
EP15153207 2015-01-30
PCT/EP2015/056839 WO2015155042A1 (en) 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido[4,5-e]indolizines

Publications (2)

Publication Number Publication Date
AU2015243694A1 AU2015243694A1 (en) 2016-11-03
AU2015243694B2 true AU2015243694B2 (en) 2019-01-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015243694A Active AU2015243694B2 (en) 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido(4,5-e)indolizines

Country Status (16)

Country Link
US (3) USRE48974E1 (cg-RX-API-DMAC7.html)
EP (1) EP3129374B1 (cg-RX-API-DMAC7.html)
JP (1) JP6518690B2 (cg-RX-API-DMAC7.html)
KR (1) KR102432420B1 (cg-RX-API-DMAC7.html)
CN (1) CN106132963B (cg-RX-API-DMAC7.html)
AU (1) AU2015243694B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016022342B1 (cg-RX-API-DMAC7.html)
CA (1) CA2944610C (cg-RX-API-DMAC7.html)
DK (1) DK3129374T3 (cg-RX-API-DMAC7.html)
ES (1) ES2716165T3 (cg-RX-API-DMAC7.html)
HU (1) HUE043108T2 (cg-RX-API-DMAC7.html)
MX (1) MX368767B (cg-RX-API-DMAC7.html)
PL (1) PL3129374T3 (cg-RX-API-DMAC7.html)
PT (1) PT3129374T (cg-RX-API-DMAC7.html)
RU (1) RU2692479C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015155042A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX368767B (es) * 2014-04-07 2019-10-15 Netherlands Translational Res Center B V (5,6-dihidro)pirimido[4,5-e]indolizinas.
AU2016247476B2 (en) 2015-04-17 2021-12-16 SillaJen Inc. Prognostic biomarkers for TTK inhibitor chemotherapy
PL3416964T3 (pl) * 2016-02-19 2021-10-18 Phoenix Molecular Designs Pochodne 6-okso-n-(1-(benzylo)-1h-pirazol-4-ilo)-6,7,8,9-tetrahydropirydo[3’,2’:4,5]pirolo[1,2-a]pirazyno-2-karboksyamidu jako inhibitory kinazy rybosomalnej s6 p90 (rsk) do leczenia nowotworu złośliwego
KR20230109185A (ko) 2016-06-07 2023-07-19 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
CN106551938B (zh) * 2016-11-26 2017-11-24 广东安诺药业股份有限公司 一种治疗非酒精性脂肪肝的药物及其应用
PT3601239T (pt) 2017-03-23 2024-10-24 Jacobio Pharmaceuticals Co Ltd Novos derivados heterocíclicos úteis como inibidores de shp2
CN112839935A (zh) 2018-09-26 2021-05-25 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
AU2020222056A1 (en) 2019-02-11 2021-10-07 Phoenix Molecular Designs Crystalline forms of an RSK inhibitor
JP2024546977A (ja) * 2021-12-15 2024-12-26 シルラジェン，インコーポレイテッド 新生物疾患の処置方法
AU2022415783A1 (en) * 2021-12-15 2024-06-27 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases
MX2024007452A (es) * 2021-12-15 2024-07-09 Sillajen Inc Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas.
KR20240144991A (ko) * 2022-03-04 2024-10-04 신라젠(주) 신생물성 질환 치료에 사용하기 위한 약제학적 병용물

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines
WO2012101032A1 (en) * 2011-01-26 2012-08-02 Nerviano Medical Sciences S.R.L. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors

Family Cites Families (11)

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BR0212760A (pt) * 2001-09-19 2004-12-07 Aventis Pharma Sa Compostos quìmicos
JP5043432B2 (ja) 2003-05-22 2012-10-10 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ピラゾロ−キナゾリン誘導体、その製造方法、およびキナーゼ阻害剤としてのその使用
JP5284973B2 (ja) 2006-11-28 2013-09-11 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 三環式インドールおよび（４，５−ジヒドロ）インドール
WO2010111406A2 (en) 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
WO2010125004A1 (en) 2009-04-29 2010-11-04 Nerviano Medical Sciences S.R.L. Cdk inhibitor salts
JP5851990B2 (ja) 2009-07-29 2016-02-03 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Ｐｌｋ阻害剤の塩
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
CA2821829A1 (en) 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
JP6523267B2 (ja) 2013-06-24 2019-05-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｆｓｈｒの調節剤としてのイミダゾール化合物及びその使用
MX368767B (es) * 2014-04-07 2019-10-15 Netherlands Translational Res Center B V (5,6-dihidro)pirimido[4,5-e]indolizinas.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines
WO2012101032A1 (en) * 2011-01-26 2012-08-02 Nerviano Medical Sciences S.R.L. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors

Also Published As

Publication number Publication date
JP2017510595A (ja) 2017-04-13
MX2016012997A (es) 2016-12-07
AU2015243694A1 (en) 2016-11-03
CA2944610A1 (en) 2015-10-15
BR112016022342A2 (pt) 2017-08-15
RU2016141405A (ru) 2018-05-07
CA2944610C (en) 2024-01-09
RU2692479C2 (ru) 2019-06-25
KR20170013866A (ko) 2017-02-07
US20170096432A1 (en) 2017-04-06
US9856258B2 (en) 2018-01-02
BR112016022342A8 (pt) 2021-07-20
DK3129374T3 (en) 2019-04-08
EP3129374A1 (en) 2017-02-15
BR112016022342B1 (pt) 2022-10-04
CN106132963B (zh) 2019-08-06
HUE043108T2 (hu) 2019-07-29
PT3129374T (pt) 2019-03-25
ES2716165T3 (es) 2019-06-10
RU2016141405A3 (cg-RX-API-DMAC7.html) 2018-10-02
KR102432420B1 (ko) 2022-08-17
CN106132963A (zh) 2016-11-16
WO2015155042A1 (en) 2015-10-15
USRE48974E1 (en) 2022-03-15
PL3129374T3 (pl) 2019-07-31
MX368767B (es) 2019-10-15
USRE50082E1 (en) 2024-08-20
JP6518690B2 (ja) 2019-05-22
EP3129374B1 (en) 2018-12-19

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PC Assignment registered

Owner name: SILLAJEN INC.

Free format text: FORMER OWNER(S): NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.