DK3079719T3 - ANTI-SIGLEC-8-antistoffer og fremgangsmåder til anvendelse deraf - Google Patents
ANTI-SIGLEC-8-antistoffer og fremgangsmåder til anvendelse deraf Download PDFInfo
- Publication number
- DK3079719T3 DK3079719T3 DK14869424T DK14869424T DK3079719T3 DK 3079719 T3 DK3079719 T3 DK 3079719T3 DK 14869424 T DK14869424 T DK 14869424T DK 14869424 T DK14869424 T DK 14869424T DK 3079719 T3 DK3079719 T3 DK 3079719T3
- Authority
- DK
- Denmark
- Prior art keywords
- siglec
- antibodies
- methods
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361913891P | 2013-12-09 | 2013-12-09 | |
| PCT/US2014/069409 WO2015089117A1 (en) | 2013-12-09 | 2014-12-09 | Anti-siglec-8 antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3079719T3 true DK3079719T3 (da) | 2019-11-18 |
Family
ID=53371783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14869424T DK3079719T3 (da) | 2013-12-09 | 2014-12-09 | ANTI-SIGLEC-8-antistoffer og fremgangsmåder til anvendelse deraf |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9546215B2 (enExample) |
| EP (2) | EP3611191A1 (enExample) |
| JP (4) | JP6549143B2 (enExample) |
| KR (3) | KR20210125114A (enExample) |
| CN (3) | CN105916519B (enExample) |
| AU (2) | AU2014363944B2 (enExample) |
| BR (1) | BR112016013109B1 (enExample) |
| CA (1) | CA2930886C (enExample) |
| CY (1) | CY1122329T1 (enExample) |
| DK (1) | DK3079719T3 (enExample) |
| ES (1) | ES2758508T3 (enExample) |
| HR (1) | HRP20192052T1 (enExample) |
| HU (1) | HUE047283T2 (enExample) |
| IL (3) | IL298470A (enExample) |
| LT (1) | LT3079719T (enExample) |
| NZ (1) | NZ720769A (enExample) |
| PL (1) | PL3079719T3 (enExample) |
| PT (1) | PT3079719T (enExample) |
| RS (1) | RS59567B1 (enExample) |
| SG (2) | SG11201604632PA (enExample) |
| SI (1) | SI3079719T1 (enExample) |
| SM (1) | SMT201900714T1 (enExample) |
| WO (1) | WO2015089117A1 (enExample) |
| ZA (1) | ZA201603435B (enExample) |
Families Citing this family (25)
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| JP6825909B2 (ja) | 2014-02-28 | 2021-02-03 | アラコス インコーポレイテッド | シグレック−８関連疾患を処置するための方法および組成物 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| HK1254432A1 (zh) | 2015-06-17 | 2019-07-19 | Allakos Inc. | 用於治疗纤维性疾病的方法和组合物 |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2018129400A1 (en) * | 2017-01-06 | 2018-07-12 | Allakos Inc. | Methods and compositions for treating chronic obstructive pulmonary disorder |
| MX2019013136A (es) * | 2017-05-05 | 2020-07-14 | Allakos Inc | Metodos y composiciones para tratar trastornos gastrointestinales inflamatorios. |
| BR112019022912A2 (pt) * | 2017-05-05 | 2020-05-26 | Allakos Inc. | Métodos e composições para tratar doenças oculares alérgicas |
| CA3087063A1 (en) | 2017-12-29 | 2019-07-04 | Cornell University | Gene therapy for eosinophilic disorders |
| EP3788078A4 (en) * | 2018-05-04 | 2022-03-02 | Allakos Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CHRONIC URTICARIA |
| BR112021015009A2 (pt) * | 2019-02-15 | 2021-10-05 | Allakos Inc. | Métodos e composições para o tratamento da gastrite mastocística, esofagite mastocística, enterite mastocística, duodenite mastocística e/ou gastroenterite mastocística |
| MX2022001403A (es) * | 2019-08-02 | 2022-03-25 | Allakos Inc | Metodos de administracion de anticuerpos anti-siglec-8 y corticosteroides. |
| WO2021081411A1 (en) * | 2019-10-24 | 2021-04-29 | Allakos Inc. | Methods and compositions for treating irritable bowel syndrome and functional dyspepsia |
| IL293108A (en) * | 2019-11-19 | 2022-07-01 | Univ Pennsylvania | Monoclonal antibodies against alpha-synuclein, and methods of using them |
| US20230210989A1 (en) * | 2020-06-03 | 2023-07-06 | Kar Muthumani | Monoclonal Antibody Against Human Siglec-9 and Use For Immunotherapy |
| WO2022061032A1 (en) * | 2020-09-17 | 2022-03-24 | Allakos Inc. | Methods and compositions for treating viral infection |
| AU2021365008A1 (en) * | 2020-10-22 | 2023-06-08 | Allakos Inc. | Anti-siglec-8 antibody formulations |
| JP7873001B2 (ja) * | 2021-04-05 | 2026-06-11 | 国立大学法人 筑波大学 | アレルギー性疾患の予防又は治療剤 |
| EP4518897A4 (en) * | 2022-05-06 | 2026-05-20 | Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute | INHIBITION OF MAST CELL ACTIVATION BY BINDING TO SIALIC ACID-BINDING IMMUNOGLOBULIN-TYPE LECTIN-9 (SIGLEC-9) |
| WO2024043940A1 (en) * | 2022-08-25 | 2024-02-29 | Allakos Inc. | Methods and compositions for treating atopic dermatitis |
| WO2024254441A1 (en) * | 2023-06-08 | 2024-12-12 | Allakos Inc. | Bispecific antibodies to siglec-6 and siglec-8 and methods of use thereof |
| WO2026138939A1 (zh) * | 2024-12-25 | 2026-07-02 | 百奥泰生物制药股份有限公司 | 抗siglec-8抗体及其应用 |
| KR102974376B1 (ko) | 2025-04-08 | 2026-06-10 | 연세대학교 산학협력단 | 신규한 항-Siglec-8 나노바디 및 이의 용도 |
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