DK3024468T3 - T-cellereceptorer - Google Patents

T-cellereceptorer Download PDF

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Publication number
DK3024468T3
DK3024468T3 DK14748262.4T DK14748262T DK3024468T3 DK 3024468 T3 DK3024468 T3 DK 3024468T3 DK 14748262 T DK14748262 T DK 14748262T DK 3024468 T3 DK3024468 T3 DK 3024468T3
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Prior art keywords
cell receptors
receptors
cell
Prior art date
Application number
DK14748262.4T
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English (en)
Inventor
Peter Molloy
Nicholas Jonathan Pumphrey
Original Assignee
Adaptimmune Ltd
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Publication of DK3024468T3 publication Critical patent/DK3024468T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00118Cancer antigens from embryonic or fetal origin
    • A61K39/001181Alpha-feto protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/463Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632T-cell receptors [TCR]; antibody T-cell receptor constructs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46448Cancer antigens from embryonic or fetal origin
    • A61K39/464481Alpha-feto protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
DK14748262.4T 2013-07-26 2014-07-18 T-cellereceptorer DK3024468T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1313377.2A GB201313377D0 (en) 2013-07-26 2013-07-26 T cell receptors
PCT/GB2014/052199 WO2015011450A1 (en) 2013-07-26 2014-07-18 T cell receptors

Publications (1)

Publication Number Publication Date
DK3024468T3 true DK3024468T3 (da) 2019-07-22

Family

ID=49166992

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19172518.3T DK3578188T3 (da) 2013-07-26 2014-07-18 T-cellereceptorer
DK14748262.4T DK3024468T3 (da) 2013-07-26 2014-07-18 T-cellereceptorer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK19172518.3T DK3578188T3 (da) 2013-07-26 2014-07-18 T-cellereceptorer

Country Status (22)

Country Link
US (3) US10344074B2 (da)
EP (2) EP3578188B1 (da)
JP (3) JP6635311B2 (da)
KR (2) KR20210073612A (da)
CN (2) CN111153984A (da)
AU (2) AU2014294830B2 (da)
CA (1) CA2916027C (da)
CY (1) CY1121962T1 (da)
DK (2) DK3578188T3 (da)
ES (2) ES2734190T3 (da)
GB (1) GB201313377D0 (da)
HK (1) HK1222338A1 (da)
HR (1) HRP20191371T1 (da)
HU (1) HUE045399T2 (da)
LT (1) LT3024468T (da)
NZ (1) NZ715038A (da)
PL (1) PL3024468T3 (da)
PT (1) PT3024468T (da)
RS (1) RS59177B1 (da)
SG (1) SG11201510157YA (da)
SI (1) SI3024468T1 (da)
WO (1) WO2015011450A1 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201313377D0 (en) * 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
SG10201913158PA (en) 2015-04-03 2020-02-27 Eureka Therapeutics Inc Constructs targeting afp peptide/mhc complexes and uses thereof
CN106279404A (zh) * 2015-05-20 2017-01-04 广州市香雪制药股份有限公司 一种可溶且稳定的异质二聚tcr
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
WO2017059557A1 (en) * 2015-10-09 2017-04-13 Peking University Methods for enhancing in vivo persistence and efficacy of exogenously administered t cells, genetically modified t cells and method and method of use
AU2016342041B2 (en) 2015-10-23 2021-12-02 Eureka Therapeutics, Inc. Antibody/T-cell receptor chimeric constructs and uses thereof
JP6777841B2 (ja) * 2015-10-23 2020-10-28 国立大学法人金沢大学 細胞傷害性t細胞の作製方法
JP6970417B2 (ja) * 2015-10-23 2021-11-24 国立大学法人金沢大学 細胞傷害性t細胞の作製方法
LT3494133T (lt) 2016-08-02 2022-12-12 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Anti-kras-g12d t ląstelės receptoriai
CN110741016A (zh) 2017-04-26 2020-01-31 优瑞科生物技术公司 嵌合抗体/t-细胞受体构筑体及其用途
SG11201909751TA (en) 2017-05-12 2019-11-28 Augusta University Research Institute Inc Human alpha fetoprotein-specific t cell receptors and uses thereof
CA3091143A1 (en) 2018-02-15 2019-08-22 Memorial Sloan-Kettering Cancer Center Foxp3 targeting agent compositions and methods of use for adoptive cell therapy
CN110407927B (zh) * 2018-04-26 2022-09-09 香雪生命科学技术(广东)有限公司 一种识别afp抗原的tcr
CN110776562B (zh) * 2018-07-30 2022-06-17 香雪生命科学技术(广东)有限公司 一种识别afp抗原的t细胞受体
EP3854802A4 (en) * 2018-09-21 2022-10-12 XLifeSc, Ltd. HIGH AFFINITY T-LYMPHOCYTE RECEPTOR RECOGNIZING AFP ANTIGEN
CN110950949B (zh) * 2018-09-26 2022-04-05 香雪生命科学技术(广东)有限公司 一种识别ssx2抗原的t细胞受体
CA3119911A1 (en) * 2018-11-14 2020-05-22 Xlifesc, Ltd. High affinity tcr for afp recognition
CN111662374B (zh) * 2019-03-08 2023-01-24 香雪生命科学技术(广东)有限公司 一种识别afp抗原的高亲和力tcr
CN111748027A (zh) * 2019-03-29 2020-10-09 天津亨佳生物科技发展有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
CA3142513A1 (en) 2019-06-25 2020-12-30 Gilead Sciences, Inc. Flt3l-fc fusion proteins and methods of use
US20220275044A1 (en) * 2019-07-30 2022-09-01 Xlifesc, Ltd. T cell receptor for recognizing ssx2 antigen short peptide
WO2021022447A1 (zh) * 2019-08-05 2021-02-11 广东香雪精准医疗技术有限公司 识别afp抗原短肽的t细胞受体
CA3150818A1 (en) 2019-08-13 2021-02-18 King's College London Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily
CN112390875B (zh) * 2019-08-16 2023-01-24 香雪生命科学技术(广东)有限公司 一种识别afp的高亲和力t细胞受体
CN113072636A (zh) * 2020-01-06 2021-07-06 香雪生命科学技术(广东)有限公司 一种识别afp的t细胞受体及其编码序列
BR112022014623A2 (pt) 2020-02-14 2022-09-13 Jounce Therapeutics Inc Anticorpos e proteínas de fusão que se ligam a ccr8 e usos dos mesmos
US20230390334A1 (en) * 2020-02-14 2023-12-07 Adaptimmune Limited Method of treatment of cancer or tumour
CN113321727B (zh) * 2020-02-28 2024-04-09 香雪生命科学技术(广东)有限公司 一种识别afp抗原短肽的t细胞受体及其编码序列
CN113321725A (zh) * 2020-02-28 2021-08-31 香雪生命科学技术(广东)有限公司 一种识别afp的t细胞受体
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
CN115181177A (zh) * 2021-04-02 2022-10-14 香雪生命科学技术(广东)有限公司 针对afp的t细胞受体
CN115160432A (zh) * 2021-04-02 2022-10-11 香雪生命科学技术(广东)有限公司 识别afp的t细胞受体
TW202313094A (zh) 2021-05-18 2023-04-01 美商基利科學股份有限公司 使用FLT3L—Fc融合蛋白之方法
WO2023076983A1 (en) 2021-10-28 2023-05-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
US20230242508A1 (en) 2021-12-22 2023-08-03 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023122581A2 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023137471A1 (en) 2022-01-14 2023-07-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
WO2023137472A2 (en) 2022-01-14 2023-07-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
TW202346277A (zh) 2022-03-17 2023-12-01 美商基利科學股份有限公司 Ikaros鋅指家族降解劑及其用途
TW202400138A (zh) 2022-04-21 2024-01-01 美商基利科學股份有限公司 Kras g12d調節化合物
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
WO2024064642A2 (en) 2022-09-19 2024-03-28 Tune Therapeutics, Inc. Compositions, systems, and methods for modulating t cell function

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1421115E (pt) 2001-08-31 2005-07-29 Avidex Ltd Receptor de celulas t soluvel
US7569664B2 (en) 2002-10-09 2009-08-04 Immunocore Limited Single chain recombinant T cell receptors
GB0223399D0 (en) * 2002-10-09 2002-11-13 Avidex Ltd Receptors
JP5563194B2 (ja) 2004-06-29 2014-07-30 イムノコア リミテッド 改変t細胞レセプターを発現する細胞
ATE550356T1 (de) * 2006-05-03 2012-04-15 Us Gov Health & Human Serv Chimäre t-zellen-rezeptoren sowie entsprechende materialien und verwendungsverfahren
WO2008038002A2 (en) 2006-09-29 2008-04-03 Medigene Limited T cell therapies
JP5292550B2 (ja) * 2007-03-23 2013-09-18 静岡県 T細胞レセプターβ鎖遺伝子及びα鎖遺伝子
CN102083979B (zh) * 2008-05-09 2015-01-07 新加坡科技研究局 Hbv表位反应性外源t细胞受体(tcr)及其用途
GB0908613D0 (en) * 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
CN105524176B (zh) * 2010-05-21 2021-03-19 银溪制药股份有限公司 双特异性融合蛋白
GB201313377D0 (en) * 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors

Also Published As

Publication number Publication date
EP3578188A1 (en) 2019-12-11
JP2016525537A (ja) 2016-08-25
SI3024468T1 (sl) 2019-10-30
PT3024468T (pt) 2019-08-01
US20210324036A1 (en) 2021-10-21
HRP20191371T1 (hr) 2019-11-01
JP6635311B2 (ja) 2020-01-22
CN105408353A (zh) 2016-03-16
AU2020202538A1 (en) 2020-05-07
US10344074B2 (en) 2019-07-09
RS59177B1 (sr) 2019-10-31
WO2015011450A1 (en) 2015-01-29
NZ715038A (en) 2021-12-24
JP6956164B2 (ja) 2021-10-27
AU2014294830B2 (en) 2020-01-16
JP2021151248A (ja) 2021-09-30
HUE045399T2 (hu) 2019-12-30
KR102267345B1 (ko) 2021-06-22
SG11201510157YA (en) 2016-02-26
US20190330301A1 (en) 2019-10-31
HK1222338A1 (zh) 2017-06-30
EP3024468A1 (en) 2016-06-01
ES2912743T3 (es) 2022-05-27
DK3578188T3 (da) 2022-05-02
AU2014294830A1 (en) 2016-01-21
JP2020054364A (ja) 2020-04-09
ES2734190T3 (es) 2019-12-04
LT3024468T (lt) 2019-09-25
EP3578188B1 (en) 2022-02-23
KR20160034329A (ko) 2016-03-29
US11084862B2 (en) 2021-08-10
CA2916027C (en) 2022-11-29
CN105408353B (zh) 2020-05-19
CY1121962T1 (el) 2020-10-14
KR20210073612A (ko) 2021-06-18
EP3024468B1 (en) 2019-05-08
CN111153984A (zh) 2020-05-15
CA2916027A1 (en) 2015-01-29
GB201313377D0 (en) 2013-09-11
US20160137715A1 (en) 2016-05-19
PL3024468T3 (pl) 2019-12-31

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