SG10201913959WA - Anti-kras-g12d t cell receptors - Google Patents
Anti-kras-g12d t cell receptorsInfo
- Publication number
- SG10201913959WA SG10201913959WA SG10201913959WA SG10201913959WA SG10201913959WA SG 10201913959W A SG10201913959W A SG 10201913959WA SG 10201913959W A SG10201913959W A SG 10201913959WA SG 10201913959W A SG10201913959W A SG 10201913959WA SG 10201913959W A SG10201913959W A SG 10201913959WA
- Authority
- SG
- Singapore
- Prior art keywords
- kras
- cell receptors
- receptors
- cell
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369883P | 2016-08-02 | 2016-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913959WA true SG10201913959WA (en) | 2020-03-30 |
Family
ID=59564253
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900654QA SG11201900654QA (en) | 2016-08-02 | 2017-07-31 | Anti-kras-g12d t cell receptors |
| SG10201913959WA SG10201913959WA (en) | 2016-08-02 | 2017-07-31 | Anti-kras-g12d t cell receptors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900654QA SG11201900654QA (en) | 2016-08-02 | 2017-07-31 | Anti-kras-g12d t cell receptors |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US10611816B2 (en) |
| EP (2) | EP3494133B1 (en) |
| JP (3) | JP6993402B2 (en) |
| KR (1) | KR102527052B1 (en) |
| CN (2) | CN109790211B (en) |
| AU (2) | AU2017306038B2 (en) |
| CA (1) | CA3032870A1 (en) |
| DK (1) | DK3494133T3 (en) |
| ES (1) | ES2928051T3 (en) |
| HR (1) | HRP20221183T1 (en) |
| HU (1) | HUE060121T2 (en) |
| IL (2) | IL301894A (en) |
| LT (1) | LT3494133T (en) |
| PL (1) | PL3494133T3 (en) |
| PT (1) | PT3494133T (en) |
| RS (1) | RS63615B1 (en) |
| SG (2) | SG11201900654QA (en) |
| SI (1) | SI3494133T1 (en) |
| WO (1) | WO2018026691A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE060121T2 (en) * | 2016-08-02 | 2023-01-28 | The U S A As Represented By The Secretary | Anti-kras-g12d t cell receptors |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| US11306132B2 (en) | 2017-09-20 | 2022-04-19 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | HLA class II-restricted T cell receptors against mutated RAS |
| KR20210032393A (en) * | 2018-06-19 | 2021-03-24 | 바이오엔테크 유에스 인크. | Neoantigen and its use |
| JP2022523052A (en) * | 2019-01-25 | 2022-04-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Compositions and Methods for Targeting Mutant RAS |
| KR20210130189A (en) * | 2019-02-20 | 2021-10-29 | 프레드 헛친슨 켄서 리서치 센터 | Binding protein specific for RAS neoantigen and uses thereof |
| CN110172089B (en) * | 2019-06-11 | 2020-01-07 | 北京鼎成肽源生物技术有限公司 | KRAS mutant multi-antigen combination, targeting KRAS mutant tumor CTL and application thereof |
| CN112110995A (en) * | 2019-06-19 | 2020-12-22 | 上海交通大学医学院 | Tumor neoantigen polypeptide and application thereof |
| CN112760290A (en) * | 2019-10-21 | 2021-05-07 | 郑州大学 | Stem cells carrying mutated tumor driver genes and uses thereof |
| CN112759641B (en) * | 2019-11-01 | 2023-01-20 | 香雪生命科学技术（广东）有限公司 | High-affinity TCR for recognizing Kras G12V |
| JP2022554349A (en) * | 2019-11-05 | 2022-12-28 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | HLA-restricted HORMAD1 T cell receptor and its uses |
| MX2022007598A (en) | 2019-12-20 | 2022-09-23 | Instil Bio Uk Ltd | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof. |
| EP4086281A4 (en) * | 2019-12-30 | 2024-02-14 | China Immunotech (Beijing) Biotechnology Co., Ltd | Enhanced t-cell receptor star and application thereof |
| CN116322734A (en) * | 2020-07-13 | 2023-06-23 | 美国卫生和人力服务部 | HLA class II restricted DRB T cell receptor for RAS with G12D mutation |
| US20240000935A1 (en) * | 2020-11-25 | 2024-01-04 | Geneius Biotechnology, Inc. | Antigen specific t cells and methods of making and using same |
| WO2022183167A1 (en) | 2021-02-25 | 2022-09-01 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| US20220372165A1 (en) | 2021-05-05 | 2022-11-24 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| WO2023150562A1 (en) | 2022-02-01 | 2023-08-10 | Alaunos Therapeutics, Inc. | Methods for activation and expansion of t cells |
| CN114920823B (en) * | 2022-05-27 | 2023-10-17 | 重庆医科大学 | TCR or antigen binding fragment thereof and uses thereof |
| WO2024020537A2 (en) * | 2022-07-22 | 2024-01-25 | Board Of Regents, The University Of Texas System | Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy |
| CN115850444A (en) * | 2022-09-15 | 2023-03-28 | 重庆医科大学 | TCR or antigen binding fragment thereof and uses thereof |
| CN117777270A (en) * | 2022-09-29 | 2024-03-29 | 广州医科大学 | T Cell Receptor (TCR) and application thereof |
| WO2024129720A2 (en) * | 2022-12-13 | 2024-06-20 | Biontech Us Inc. | T cell receptor constructs and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776459A (en) * | 1989-07-19 | 1998-07-07 | Connetics Corporation | TCR V beta 5 peptides |
| US20020150891A1 (en) * | 1994-09-19 | 2002-10-17 | Leroy E. Hood | Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region |
| US7709002B1 (en) | 1996-04-19 | 2010-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes |
| GB2328689A (en) | 1997-08-27 | 1999-03-03 | Norsk Hydro As | Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer |
| WO2004021995A2 (en) | 2002-09-06 | 2004-03-18 | The Government Of The United States Of America, Represented By The Secretary, Departement Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| AU2008206442B2 (en) | 2007-01-12 | 2012-10-18 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | gp100-specific T cell receptors and related materials and methods of use |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| RS56339B1 (en) | 2010-09-20 | 2017-12-29 | Biontech Cell & Gene Therapies Gmbh | Antigen-specific t cell receptors and t cell epitopes |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| US20140378389A1 (en) | 2011-09-15 | 2014-12-25 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | T cell receptors recognizing hla-a1- or hla-cw7-restricted mage |
| CN104080907A (en) * | 2011-11-30 | 2014-10-01 | 日本国立癌症研究中心 | Induced malignant stem cells |
| AU2014276440A1 (en) * | 2013-06-03 | 2015-11-05 | Novartis Ag | Combinations of an anti-PD-L1 antibody and a MEK inhibitor and/or a BRaf inhibitor |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| GB201314404D0 (en) * | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
| CN107223134B (en) * | 2014-11-26 | 2021-11-16 | 美国卫生和人力服务部 | T cell receptor for anti-mutated KRAS |
| US10556940B2 (en) | 2015-09-15 | 2020-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing HLA-Cw8 restricted mutated KRAS |
| HUE060121T2 (en) * | 2016-08-02 | 2023-01-28 | The U S A As Represented By The Secretary | Anti-kras-g12d t cell receptors |
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2017
- 2017-07-31 HU HUE17749580A patent/HUE060121T2/en unknown
- 2017-07-31 KR KR1020197005837A patent/KR102527052B1/en active IP Right Grant
- 2017-07-31 RS RS20220894A patent/RS63615B1/en unknown
- 2017-07-31 SI SI201731231T patent/SI3494133T1/en unknown
- 2017-07-31 CA CA3032870A patent/CA3032870A1/en active Pending
- 2017-07-31 SG SG11201900654QA patent/SG11201900654QA/en unknown
- 2017-07-31 AU AU2017306038A patent/AU2017306038B2/en active Active
- 2017-07-31 EP EP17749580.1A patent/EP3494133B1/en active Active
- 2017-07-31 IL IL301894A patent/IL301894A/en unknown
- 2017-07-31 IL IL264425A patent/IL264425B2/en unknown
- 2017-07-31 EP EP22182473.3A patent/EP4159751A1/en active Pending
- 2017-07-31 US US16/321,899 patent/US10611816B2/en active Active
- 2017-07-31 PL PL17749580.1T patent/PL3494133T3/en unknown
- 2017-07-31 CN CN201780059356.4A patent/CN109790211B/en active Active
- 2017-07-31 JP JP2019505220A patent/JP6993402B2/en active Active
- 2017-07-31 LT LTEPPCT/US2017/044615T patent/LT3494133T/en unknown
- 2017-07-31 WO PCT/US2017/044615 patent/WO2018026691A1/en unknown
- 2017-07-31 DK DK17749580.1T patent/DK3494133T3/en active
- 2017-07-31 CN CN202410214235.4A patent/CN118063591A/en active Pending
- 2017-07-31 SG SG10201913959WA patent/SG10201913959WA/en unknown
- 2017-07-31 ES ES17749580T patent/ES2928051T3/en active Active
- 2017-07-31 HR HRP20221183TT patent/HRP20221183T1/en unknown
- 2017-07-31 PT PT177495801T patent/PT3494133T/en unknown
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2020
- 2020-04-02 US US16/838,395 patent/US11208456B2/en active Active
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2021
- 2021-06-11 US US17/345,390 patent/US11897933B2/en active Active
- 2021-12-03 US US17/541,619 patent/US11840561B2/en active Active
- 2021-12-09 JP JP2021199878A patent/JP7413338B2/en active Active
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2023
- 2023-09-21 AU AU2023233125A patent/AU2023233125A1/en active Pending
- 2023-12-27 JP JP2023221526A patent/JP2024045139A/en active Pending
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2024
- 2024-01-25 US US18/423,020 patent/US20240209059A1/en active Pending
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