DK2997027T3 - Hidtil ukendte (cyano-dimethyl-methyl)-isoxazoler og -[1,3,4]thiadiazoler - Google Patents
Hidtil ukendte (cyano-dimethyl-methyl)-isoxazoler og -[1,3,4]thiadiazoler Download PDFInfo
- Publication number
- DK2997027T3 DK2997027T3 DK14728849.2T DK14728849T DK2997027T3 DK 2997027 T3 DK2997027 T3 DK 2997027T3 DK 14728849 T DK14728849 T DK 14728849T DK 2997027 T3 DK2997027 T3 DK 2997027T3
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- DK
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- Prior art keywords
- pain
- compound
- pharmaceutically acceptable
- acid
- methyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (21)
1. Forbindelse valgt fra gruppen bestående af
eller et farmaceutisk acceptabelt salt deraf.
2. Forbindelse ifølge krav 1, hvor forbindelsen er
eller et farmaceutisk acceptabelt salt deraf.
3. Forbindelse ifølge krav 1, hvor forbindelsen er
4. Forbindelse ifølge krav 1, hvor forbindelsen er
eller et farmaceutisk acceptabelt salt deraf.
5. Forbindelse ifølge et hvilket som helst af kravene 1 til 4 til anvendelse som lægemiddel.
6. Farmaceutisk sammensætning, som omfatter mindst én forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt deraf blandet med en farmaceutisk acceptabel adjuvans, et farmaceutisk acceptabelt fortyndingsmiddel og/eller en farmaceutisk acceptabel bærer.
7. Farmaceutisk sammensætning, som omfatter en forbindelse ifølge krav 2 blandet med en farmaceutisk acceptabel adjuvans, et farmaceutisk acceptabelt fortyndingsmiddel og/eller en farmaceutisk acceptabel bærer.
8. Farmaceutisk sammensætning, som omfatter en forbindelse ifølge krav 3 blandet med en farmaceutisk acceptabel adjuvans, et farmaceutisk acceptabelt fortyndingsmiddel og/elleren farmaceutisk acceptabel bærer.
9. Farmaceutisk sammensætning, som omfatter en forbindelse ifølge krav 4 blandet med en farmaceutisk acceptabel adjuvans, et farmaceutisk acceptabelt fortyndingsmiddel og/elleren farmaceutisk acceptabel bærer.
10. Forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt deraf til anvendelse ved behandling eller forebyggelse af smerter.
11. Forbindelse ifølge et hvilket som helst af kravene 2 til 4 til anvendelse ved behandling af smerter.
12. Forbindelse ifølge et hvilket som helst af kravene 2 til 4 til anvendelse ved forebyggelse af smerter.
13. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne er neuropatiske smerter.
14. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne er valgt fra gruppen bestående af perifere neuropatiske smerter, smerter forbundet med diabetisk perifer neuropati, smerter forbundet med lumbosakral radikulopati og smerter forbundet med postherpetisk neuralgi.
15. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne ertrigeminusneuralgi, komplekst regionalt smertesyndrom type I eller komplekst regionalt smertesyndrom type II.
16. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne er lænderygsmerter, hoftesmerter eller bensmerter.
17. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne er erhvervet immundefektsyndrom (aids)-relaterede neuropatiske smerter.
18. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne er kroniske rygsmerter eller fibromyalgi.
19. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 10 til 12, kendetegnet ved, at smerterne er tumorsmerter, smerter som følge af karpaltunnelsyndrom, smerter som følge af irritabel tarm, smerter som følge af osteoarthritis eller smerter som følge af diabetisk neuropati.
20. Forbindelse ifølge et eller flere af kravene 2 til 4 til anvendelse ved behandling af colon irritabile, osteoarthritis eller diabetisk neuropati.
21. Forbindelse til anvendelse ifølge krav 13, hvor de neuropatiske smerter er smerter efter apopleksi, smerter som følge af skade på centralnervesystemet eller smerter som følge af multipel sklerose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13168165.2A EP2803668A1 (en) | 2013-05-17 | 2013-05-17 | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
PCT/EP2014/060033 WO2014184327A1 (en) | 2013-05-17 | 2014-05-16 | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2997027T3 true DK2997027T3 (da) | 2017-06-06 |
Family
ID=48428381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14728849.2T DK2997027T3 (da) | 2013-05-17 | 2014-05-16 | Hidtil ukendte (cyano-dimethyl-methyl)-isoxazoler og -[1,3,4]thiadiazoler |
Country Status (25)
Country | Link |
---|---|
US (7) | US8865744B1 (da) |
EP (2) | EP2803668A1 (da) |
JP (1) | JP6309616B2 (da) |
KR (1) | KR102293386B1 (da) |
CN (1) | CN105229000B (da) |
AR (1) | AR096338A1 (da) |
AU (1) | AU2014267197B2 (da) |
BR (1) | BR112015028235A2 (da) |
CA (1) | CA2912463C (da) |
CL (1) | CL2015003286A1 (da) |
DK (1) | DK2997027T3 (da) |
EA (1) | EA031021B1 (da) |
ES (1) | ES2626396T3 (da) |
HK (1) | HK1222851A1 (da) |
IL (1) | IL242309B (da) |
MX (1) | MX350885B (da) |
NZ (1) | NZ713614A (da) |
PH (1) | PH12015502523A1 (da) |
PL (1) | PL2997027T3 (da) |
PT (1) | PT2997027T (da) |
TW (1) | TW201536762A (da) |
UA (1) | UA118031C2 (da) |
UY (1) | UY35571A (da) |
WO (1) | WO2014184327A1 (da) |
ZA (1) | ZA201507957B (da) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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PL3231801T3 (pl) | 2013-05-17 | 2019-07-31 | Incyte Corporation | Sol bipirazolu jako inhibitor jak |
EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
US20190343805A1 (en) * | 2017-01-06 | 2019-11-14 | Clexio Biosciences Ltd. | Topical detomidine formulations |
BR112020016628A2 (pt) | 2018-02-16 | 2020-12-15 | Incyte Corporation | Inibidores da via de jak1 para o tratamento de distúrbios relacionados a citocinas |
SI3773593T1 (sl) | 2018-03-30 | 2024-08-30 | Incyte Corporation | Zdravljenje hidradenitisa suppurative z zaviralci jak |
CR20220612A (es) | 2020-06-02 | 2023-04-11 | Incyte Corp | Procesos para preparar un inhibidor de jak1 |
KR20230118118A (ko) | 2020-12-08 | 2023-08-10 | 인사이트 코포레이션 | 백반증의 치료를 위한 jak1 경로 저해제 |
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