DK2989110T3 - Tamoxifen derivatives for the treatment of neoplastic diseases, especially with high HER2 protein levels - Google Patents
Tamoxifen derivatives for the treatment of neoplastic diseases, especially with high HER2 protein levels Download PDFInfo
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- DK2989110T3 DK2989110T3 DK14721738.4T DK14721738T DK2989110T3 DK 2989110 T3 DK2989110 T3 DK 2989110T3 DK 14721738 T DK14721738 T DK 14721738T DK 2989110 T3 DK2989110 T3 DK 2989110T3
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- tamoxifen
- triphenylphosphonium
- cancer
- mitochondrial
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- C—CHEMISTRY; METALLURGY
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- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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- C07F9/54—Quaternary phosphonium compounds
- C07F9/5449—Polyphosphonium compounds
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
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- C—CHEMISTRY; METALLURGY
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- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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- C09B69/00—Dyes not provided for by a single group of this subclass
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Landscapes
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| CZ2014-66A CZ305571B6 (cs) | 2014-01-29 | 2014-01-29 | Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2 |
| PCT/CZ2014/000035 WO2014173374A1 (en) | 2013-04-24 | 2014-04-07 | Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level |
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| WO2017005564A1 (de) * | 2015-07-03 | 2017-01-12 | Bayer Cropscience Aktiengesellschaft | Herbizid wirksame n-(1,3,4-oxadiazol-2-yl)arylcarboxamid-derivate |
| WO2018013559A1 (en) * | 2016-07-12 | 2018-01-18 | Accutar Biotechnology Inc. | Novel compounds and uses thereof |
| CA3032153A1 (en) | 2016-08-19 | 2018-02-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration |
| EP3330274A1 (en) * | 2016-12-01 | 2018-06-06 | Springtide Ventures s.r.o. | Compounds for treatment of senescence-related disorders |
| WO2018195434A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| EP3612177A4 (en) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY |
| CA3063717C (en) | 2017-05-19 | 2021-08-24 | Lunella Biotech, Inc. | Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| BR112020008022A2 (pt) | 2017-10-24 | 2020-10-27 | Lunella Biotech, Inc. | mitoflavoscinas: o direcionamento de enzimas contendo flavina elimina as células-tronco de câncer (cscs) por meio da inibição da respiração mitocondrial |
| US10980821B2 (en) | 2017-11-24 | 2021-04-20 | Lunella Biotech, Inc. | Triphenylphosphonium-derivative compounds for eradicating cancer stem cells |
| CA3083487A1 (en) | 2017-12-01 | 2019-06-06 | Lunella Biotech, Inc. | Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| WO2019113210A1 (en) | 2017-12-05 | 2019-06-13 | Anthos Partners, Lp | Phosphonium-based ionic drug conjugates |
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| US20220211728A1 (en) * | 2019-04-16 | 2022-07-07 | Lunella Biotech, Inc. | Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments |
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| TWI309571B (en) * | 2002-12-31 | 2009-05-11 | Ind Tech Res Inst | Delivery carrier for targeting cells haring over-expressed estrogen |
| IL173807A (en) * | 2003-08-22 | 2014-02-27 | Antipodean Pharmaceuticals Inc | Antioxidant amphiphilic compounds, histoquinone history and pharmaceutical preparations containing them |
| JP2008506667A (ja) * | 2004-07-13 | 2008-03-06 | オリディス・ビオメド・フォルシュングス−ウント・エントヴィックルングス・ゲーエムベーハー | 肝疾患及び上皮性癌の治療におけるミトコンドリアを標的とした酸化防止剤 |
| JP5616798B2 (ja) * | 2008-03-14 | 2014-10-29 | スティーブン・ジョン・ラルフＳｔｅｐｈｅｎ Ｊｏｈｎ ＲＡＬＰＨ | ミトコンドリア由来の抗ガン化合物 |
| CA2756820A1 (en) * | 2009-04-17 | 2010-10-21 | Colby Pharmaceutical Company | Pharmaceutically active compositions comprising oxidative stress modulators (osm), new chemical entities, compositions and uses |
| WO2011129837A1 (en) * | 2010-04-16 | 2011-10-20 | Olema Pharmaceuticals, Inc. | Use of a 4-hydroxytoremifene prodrug for treatment of breast cancer |
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- 2014-04-07 KR KR1020157030376A patent/KR101764991B1/ko not_active Expired - Fee Related
- 2014-04-07 US US14/786,710 patent/US9896466B2/en active Active
- 2014-04-07 EP EP14721738.4A patent/EP2989110B1/en active Active
- 2014-04-07 SI SI201430928T patent/SI2989110T1/sl unknown
- 2014-04-07 ES ES14721738T patent/ES2699099T3/es active Active
- 2014-04-07 NZ NZ713589A patent/NZ713589A/en not_active IP Right Cessation
- 2014-04-07 PL PL14721738T patent/PL2989110T3/pl unknown
- 2014-04-07 EA EA201591918A patent/EA029881B1/ru unknown
- 2014-04-07 CN CN201480033316.9A patent/CN105452265B/zh not_active Expired - Fee Related
- 2014-04-07 DK DK14721738.4T patent/DK2989110T3/en active
- 2014-04-07 CA CA2909994A patent/CA2909994C/en active Active
- 2014-04-07 PT PT14721738T patent/PT2989110T/pt unknown
- 2014-04-07 HR HRP20181872TT patent/HRP20181872T1/hr unknown
- 2014-04-07 JP JP2016509298A patent/JP6375091B2/ja active Active
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2015
- 2015-04-07 GE GEAP201513996A patent/GEP20186868B/en unknown
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- 2018-11-06 CY CY181101155T patent/CY1120821T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2989110B1 (en) | 2018-08-08 |
| EA201591918A1 (ru) | 2016-02-29 |
| CA2909994C (en) | 2018-06-26 |
| WO2014173374A1 (en) | 2014-10-30 |
| MD4626C1 (ro) | 2019-11-30 |
| PL2989110T3 (pl) | 2019-03-29 |
| HK1216317A1 (zh) | 2016-11-04 |
| HRP20181872T1 (hr) | 2019-02-08 |
| EP2989110A1 (en) | 2016-03-02 |
| CA2909994A1 (en) | 2014-10-30 |
| NZ713589A (en) | 2017-12-22 |
| JP2016522179A (ja) | 2016-07-28 |
| MD20150117A2 (ro) | 2016-08-31 |
| JP6375091B2 (ja) | 2018-08-15 |
| KR101764991B1 (ko) | 2017-08-10 |
| HUE042239T2 (hu) | 2019-06-28 |
| MD4626B1 (ro) | 2019-04-30 |
| ES2699099T3 (es) | 2019-02-07 |
| AU2014256546B2 (en) | 2017-03-30 |
| UA116469C2 (uk) | 2018-03-26 |
| CN105452265A (zh) | 2016-03-30 |
| EA029881B1 (ru) | 2018-05-31 |
| CY1120821T1 (el) | 2019-12-11 |
| PT2989110T (pt) | 2018-11-15 |
| US20160075726A1 (en) | 2016-03-17 |
| US9896466B2 (en) | 2018-02-20 |
| GEP20186868B (en) | 2018-06-25 |
| KR20150144756A (ko) | 2015-12-28 |
| SI2989110T1 (sl) | 2019-01-31 |
| CN105452265B (zh) | 2017-05-10 |
| AU2014256546A1 (en) | 2015-11-12 |
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