PT2989110T - Derivados de tamoxifeno para o tratamento de doenças neoplásicas, especialmente com nível elevado de proteína her2 - Google Patents

Derivados de tamoxifeno para o tratamento de doenças neoplásicas, especialmente com nível elevado de proteína her2

Info

Publication number
PT2989110T
PT2989110T PT14721738T PT14721738T PT2989110T PT 2989110 T PT2989110 T PT 2989110T PT 14721738 T PT14721738 T PT 14721738T PT 14721738 T PT14721738 T PT 14721738T PT 2989110 T PT2989110 T PT 2989110T
Authority
PT
Portugal
Prior art keywords
treatment
protein level
neoplastic diseases
her2 protein
high her2
Prior art date
Application number
PT14721738T
Other languages
English (en)
Portuguese (pt)
Inventor
Neuzil Jiri
Stursa Jan
Werner Lukás
Original Assignee
Jira­ Neuzil
Smart Brain Sro
Biotechnologicky Ustav Av Cr V V I
Kkcg Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50677895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2989110(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CZ2013-308A external-priority patent/CZ2013308A3/cs
Priority claimed from CZ2014-66A external-priority patent/CZ305571B6/cs
Application filed by Jira­ Neuzil, Smart Brain Sro, Biotechnologicky Ustav Av Cr V V I, Kkcg Ag filed Critical Jira­ Neuzil
Publication of PT2989110T publication Critical patent/PT2989110T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5449—Polyphosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/008—Dyes containing a substituent, which contains a silicium atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
PT14721738T 2013-04-24 2014-04-07 Derivados de tamoxifeno para o tratamento de doenças neoplásicas, especialmente com nível elevado de proteína her2 PT2989110T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2013-308A CZ2013308A3 (cs) 2013-04-24 2013-04-24 Deriváty tamoxifenu účinné proti nádorům, zejména s vyšší hladinou proteinu HER2
CZ2014-66A CZ305571B6 (cs) 2014-01-29 2014-01-29 Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2

Publications (1)

Publication Number Publication Date
PT2989110T true PT2989110T (pt) 2018-11-15

Family

ID=50677895

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14721738T PT2989110T (pt) 2013-04-24 2014-04-07 Derivados de tamoxifeno para o tratamento de doenças neoplásicas, especialmente com nível elevado de proteína her2

Country Status (21)

Country Link
US (1) US9896466B2 (enExample)
EP (1) EP2989110B1 (enExample)
JP (1) JP6375091B2 (enExample)
KR (1) KR101764991B1 (enExample)
CN (1) CN105452265B (enExample)
AU (1) AU2014256546B2 (enExample)
CA (1) CA2909994C (enExample)
CY (1) CY1120821T1 (enExample)
DK (1) DK2989110T3 (enExample)
EA (1) EA029881B1 (enExample)
ES (1) ES2699099T3 (enExample)
GE (1) GEP20186868B (enExample)
HR (1) HRP20181872T1 (enExample)
HU (1) HUE042239T2 (enExample)
MD (1) MD4626C1 (enExample)
NZ (1) NZ713589A (enExample)
PL (1) PL2989110T3 (enExample)
PT (1) PT2989110T (enExample)
SI (1) SI2989110T1 (enExample)
UA (1) UA116469C2 (enExample)
WO (1) WO2014173374A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10548318B2 (en) * 2015-07-03 2020-02-04 Bayer Cropscience Aktiengesellschaft N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamide derivatives with herbicidal action
WO2017005564A1 (de) * 2015-07-03 2017-01-12 Bayer Cropscience Aktiengesellschaft Herbizid wirksame n-(1,3,4-oxadiazol-2-yl)arylcarboxamid-derivate
WO2018013559A1 (en) * 2016-07-12 2018-01-18 Accutar Biotechnology Inc. Novel compounds and uses thereof
CA3032153A1 (en) 2016-08-19 2018-02-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration
EP3330274A1 (en) * 2016-12-01 2018-06-06 Springtide Ventures s.r.o. Compounds for treatment of senescence-related disorders
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
EP3612177A4 (en) 2017-04-21 2021-01-13 Lunella Biotech, Inc. TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
CA3063717C (en) 2017-05-19 2021-08-24 Lunella Biotech, Inc. Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
BR112020008022A2 (pt) 2017-10-24 2020-10-27 Lunella Biotech, Inc. mitoflavoscinas: o direcionamento de enzimas contendo flavina elimina as células-tronco de câncer (cscs) por meio da inibição da respiração mitocondrial
US10980821B2 (en) 2017-11-24 2021-04-20 Lunella Biotech, Inc. Triphenylphosphonium-derivative compounds for eradicating cancer stem cells
CA3083487A1 (en) 2017-12-01 2019-06-06 Lunella Biotech, Inc. Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2019113210A1 (en) 2017-12-05 2019-06-13 Anthos Partners, Lp Phosphonium-based ionic drug conjugates
WO2019126179A1 (en) 2017-12-20 2019-06-27 Lunella Biotech, Inc. Targeting mitochondrial fission through mdivi-1 derivatives
US20220211728A1 (en) * 2019-04-16 2022-07-07 Lunella Biotech, Inc. Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments
EP3753944A1 (en) 2019-06-17 2020-12-23 Institute Of Biotechnology Cas, V.V.I. 3,5-bis(phenyl)-1h-heteroaryl derivatives as medicaments

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0551434B1 (en) * 1990-10-01 1995-11-15 The Board Of Regents, The University Of Texas System High affinity tamoxifen derivatives and uses thereof
JP3635708B2 (ja) * 1995-03-06 2005-04-06 出光興産株式会社 有機エレクトロルミネッセンス素子
TWI309571B (en) * 2002-12-31 2009-05-11 Ind Tech Res Inst Delivery carrier for targeting cells haring over-expressed estrogen
IL173807A (en) * 2003-08-22 2014-02-27 Antipodean Pharmaceuticals Inc Antioxidant amphiphilic compounds, histoquinone history and pharmaceutical preparations containing them
JP2008506667A (ja) * 2004-07-13 2008-03-06 オリディス・ビオメド・フォルシュングス−ウント・エントヴィックルングス・ゲーエムベーハー 肝疾患及び上皮性癌の治療におけるミトコンドリアを標的とした酸化防止剤
JP5616798B2 (ja) * 2008-03-14 2014-10-29 スティーブン・ジョン・ラルフＳｔｅｐｈｅｎ Ｊｏｈｎ ＲＡＬＰＨ ミトコンドリア由来の抗ガン化合物
CA2756820A1 (en) * 2009-04-17 2010-10-21 Colby Pharmaceutical Company Pharmaceutically active compositions comprising oxidative stress modulators (osm), new chemical entities, compositions and uses
WO2011129837A1 (en) * 2010-04-16 2011-10-20 Olema Pharmaceuticals, Inc. Use of a 4-hydroxytoremifene prodrug for treatment of breast cancer

Also Published As

Publication number Publication date
EP2989110B1 (en) 2018-08-08
EA201591918A1 (ru) 2016-02-29
CA2909994C (en) 2018-06-26
WO2014173374A1 (en) 2014-10-30
MD4626C1 (ro) 2019-11-30
PL2989110T3 (pl) 2019-03-29
HK1216317A1 (zh) 2016-11-04
HRP20181872T1 (hr) 2019-02-08
EP2989110A1 (en) 2016-03-02
CA2909994A1 (en) 2014-10-30
NZ713589A (en) 2017-12-22
JP2016522179A (ja) 2016-07-28
MD20150117A2 (ro) 2016-08-31
JP6375091B2 (ja) 2018-08-15
KR101764991B1 (ko) 2017-08-10
HUE042239T2 (hu) 2019-06-28
MD4626B1 (ro) 2019-04-30
ES2699099T3 (es) 2019-02-07
AU2014256546B2 (en) 2017-03-30
UA116469C2 (uk) 2018-03-26
CN105452265A (zh) 2016-03-30
EA029881B1 (ru) 2018-05-31
CY1120821T1 (el) 2019-12-11
US20160075726A1 (en) 2016-03-17
US9896466B2 (en) 2018-02-20
GEP20186868B (en) 2018-06-25
KR20150144756A (ko) 2015-12-28
SI2989110T1 (sl) 2019-01-31
CN105452265B (zh) 2017-05-10
AU2014256546A1 (en) 2015-11-12
DK2989110T3 (en) 2018-12-03

Similar Documents

Publication Publication Date Title
HUE042239T2 (hu) Tamoxifen deriváltok neoplasztikus betegségek gyógyításához, fõként magasabb HER2 proteinszinttel
IL243976B (en) kdm1a inhibitors for disease treatment
EP3033079A4 (en) Methods for the treatment of her2 amplified cancer
LT3010910T (lt) Pirimidindiono junginiai, skirti širdies ligoms
HUE054397T2 (hu) Antitestkészítmények daganatkezelésre
IL240060A0 (en) Treatment involving antibodies against claudin 2. 18 for the treatment of cancer
SG11201507496UA (en) N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
HUE046702T2 (hu) Eljárások üvegcsontbetegség kezelésére
LT3390390T (lt) Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
HRP20190194T1 (hr) 17a,21-diesteri korteksolona, namijenjeni liječenju tumora
PL3089749T3 (pl) Preparaty skojarzone do leczenia raka
EP3007756A4 (en) Catheter-assisted tumor treatment
PL2959903T3 (pl) Lek do leczenia chorób oczu
PL3062790T3 (pl) Połączenia farmaceutyczne do leczenia raka
GB201314386D0 (en) Treatment system for aquaculture
HUE051295T2 (hu) Módosított fibroblaszt növekedési faktorok-1 szembetegségek kezelésére
IL244755B (en) process to create xanthohumol
HUE047920T2 (hu) GD2-pozitív rák kezelésére szolgáló készítmények
EP2991650A4 (en) Methods for the treatment of cancer
SG11201508061UA (en) Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency
HUE040536T2 (hu) Eljárás halogén-N,N-dimetilbenzilaminok elõállítására
EP3047857A4 (en) Treatment for hemorrhagic diseases by anti-protein-c antibody
HK40097140A (zh) 治疗线粒体疾病的方法
EP3016948B8 (en) 2-acylaminothiazoles for the treatment of cancer
HK40032828A (en) Methods for the treatment of mitochondrial disease