DK2935601T3 - Rekombinante mikrobeceller, der fremstiller mindst 28 % eicosapentaensyre som tørvægt - Google Patents
Rekombinante mikrobeceller, der fremstiller mindst 28 % eicosapentaensyre som tørvægt Download PDFInfo
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6431—Linoleic acids [18:2[n-6]]
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01023—1-Acylglycerophosphocholine O-acyltransferase (2.3.1.23), i.e. lysophosphatidylcholine acyltransferase or LPCAT
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02P20/00—Technologies relating to chemical industry
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Claims (10)
- REKOMBINANTE MIKROBECELLER, DER FREMSTILLER MINDST 28 % EICOS APENTAENS YRE SOM T0RV7EGT E Rekombinant Yarrowia-celle, der fremstiller en olie, der indeholder mindst 28 % eicosapentaensyre (EPA) malt som en vsgtprocent af tprcellevsgt, hvor cellen omfatter: a) mindst én polynukleotidsekvens, der koder for en acyl-CoA:lysophosphatidylcholin-acyltransferase (LPCAT) med en aminosyresekvens, der er mindst 90 % identisk med sekvensen ifplge SEQ ID NO: 40 (YILPCAT), og b) LPCAT omfatter mutationer ved (i) aminosyreposition 136 ved asndring af methionin til en anden aminosyre, og (ii) aminosyreposition 389 ved asndring af threonin til en anden aminosyre, hvor LPCAT har LPCAT-aktivitet, og hvor polynukleotidet, der koder for LPCAT, er operativt forbundet med mindst én regulatorisk sekvens, og hvor cellen endvidere omfatter en nedregulering af en endogen polynukleotidsekvens, der koder for Sou2 sorbitol-anvendelsesprotein.
- 2. Rekombinant Yarrowia-celle ifplge krav 1, hvor LPCAT er en Yarrowia lipolytica LPCAT med en sekvens ifplge SEQ ID NO: 40.
- 3. Rekombinant Yarrowia-ce\\e ifplge krav 1, hvor nedreguleringen skyldes en mutation af den endogene polynukleotidsekvens, og hvor mutationer er udvalgt fra grappen bestaende af en substitution, deletion og insertion.
- 4. Rekombinant Yarrowia-ceïle ifplge krav 3, hvor Sou2 sorbitol-anvendelsesprotein omfatter en aminosyresekvens, der er mindst 95 % identisk med SEQ ID NO: 10.
- 5. Rekombinant Yarrowia-ce\\e ifplge krav 3 eller 4, hvor nedreguleringen reducerer den totale masngde sukkeralkoholer fremstillet af den mikrobielle celle.
- 6. Rekombinant Yarrowia-ce\\e ifplge et hvilket som helst af kravene 1 til 5, hvor cellen endvidere omfatter: (a) mindst én polynukleotidsekvens, der koder for phospholipid: diacylglycerol-acyltransferase (PDAT), (b) mindst én polynukleotidsekvens, der koder for delta-12-desaturase, og (c) mindst én polynukleotidsekvens, der koder for et dihomo-gamma-linolensyre-(DGLA) syntasemultizym; hvor hver af polynukleotidsekvenserne fra (a)-(c) er operativt forbundet med mindst én regulatorisk sekvens.
- 7. Rekombinant Yarrowia-ce\\e ifplge krav 6, hvor DGLA-syntasemultizymet omfatter en delta-9 elongase bundet til en delta-8-desaturase.
- 8. Rekombinant Yarrowia-ce\\e ifplge et hvilket som helst af kravene 1 til 7, hvor cellen endvidere omfatter: (a) mindst én polynukleotidsekvens, der koder for delta-8-desaturase, (b) mindst én polynukleotidsekvens, der koder for malonyl-CoA-syntetase (MCS), og (c) mindst én polynukleotidsekvens, der koder for acyl-CoA:lysophosphatidsyre-acyltransferase (LPAAT), hvor hver af polynukleotidsekvenserne fra (a)-(c) er operativt forbundet med mindst én regulatorisk sekvens.
- 9. Rekombinant Yarrowia-ce\\e ifplge et hvilket som helst af kravene 1 til 8, hvor oliën omfatter mindst 30 % EPA malt som et vsgtforhold af vasrtscellens tprvsgt.
- 10. Fremgangsmade til fremstilling af en mikrobiel olie, der omfatter eicosapentaensyre, hvilken fremgangsmade omfatter: a) dyrkning af den rekombinante Yarrowia-celle ifplge et hvilket som helst af kravene 1 til 9, hvor der fremstilles en mikrobiel olie, der omfatter eicosapentaensyre, og b) eventuel gen vinding af den mikrobielle olie fra trin (a).
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US201261740502P | 2012-12-21 | 2012-12-21 | |
PCT/US2013/075896 WO2014100062A1 (en) | 2012-12-21 | 2013-12-18 | Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight |
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DK13821271.7T DK2935601T3 (da) | 2012-12-21 | 2013-12-18 | Rekombinante mikrobeceller, der fremstiller mindst 28 % eicosapentaensyre som tørvægt |
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US (1) | US9701989B2 (da) |
EP (1) | EP2935601B1 (da) |
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CA (1) | CA2893409A1 (da) |
CL (1) | CL2015001673A1 (da) |
DK (1) | DK2935601T3 (da) |
NO (1) | NO2976143T3 (da) |
WO (1) | WO2014100062A1 (da) |
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US10513711B2 (en) | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease |
CN107406838A (zh) | 2014-11-06 | 2017-11-28 | 纳幕尔杜邦公司 | Rna引导的内切核酸酶向细胞中的肽介导的递送 |
KR102628801B1 (ko) | 2015-10-12 | 2024-01-25 | 이아이디피, 인크. | 세포내 유전자 변형 및 증가된 상동 재조합을 위한 보호 dna 주형 및 이용 방법 |
CN108330114B (zh) * | 2018-03-21 | 2020-11-03 | 北京大学 | 一种利用epa的甘油二酯酰基转移酶及其应用 |
KR102536297B1 (ko) * | 2021-02-08 | 2023-05-24 | 세종대학교산학협력단 | 식물체의 오메가 3 지방산 함량 증가 방법 |
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CA2517253C (en) | 2003-02-27 | 2018-07-03 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
EP2365063B1 (de) * | 2003-03-31 | 2015-10-14 | University Of Bristol | Neue pflanzliche Acyltransferase spezifisch für langkettige mehrfach ungesättigte Fettsäuren |
US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
US20110059496A1 (en) | 2003-06-25 | 2011-03-10 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
US7189559B2 (en) * | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
US20060094102A1 (en) | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
DE102004062294A1 (de) * | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
US7732155B2 (en) | 2006-12-13 | 2010-06-08 | National Research Council Of Canada | Methods for identifying lysophosphatidylcholine acyltransferases |
CN101970638B (zh) | 2007-10-03 | 2015-02-11 | 纳幕尔杜邦公司 | 用于高水平生产二十碳五烯酸的优化解脂耶氏酵母菌株 |
WO2010110375A1 (ja) * | 2009-03-26 | 2010-09-30 | サントリーホールディングス株式会社 | 新規なリゾリン脂質アシル基転移酵素 |
EP2821492A3 (en) * | 2009-05-13 | 2015-04-08 | BASF Plant Science Company GmbH | Acyltransferases and uses thereof in fatty acid production |
US8399226B2 (en) | 2009-06-16 | 2013-03-19 | E I Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
EP2516638A1 (en) * | 2009-12-24 | 2012-10-31 | E.I. Du Pont De Nemours And Company | Plant membrane bound o-acyl transferase (mboat) family protein sequences and their uses for altering fatty acid compositions |
CA2804925A1 (en) * | 2010-06-25 | 2011-12-29 | Basf Plant Science Company Gmbh | Acyltransferases from thraustochytrium species and uses thereof in fatty acid production |
JP2013535987A (ja) * | 2010-08-26 | 2013-09-19 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 高レベルのエイコサペンタエン酸生産のための組換え微生物宿主細胞 |
US8969049B2 (en) | 2011-03-31 | 2015-03-03 | E I Du Pont De Nemours And Company | Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast |
EP2694665A1 (en) | 2011-04-01 | 2014-02-12 | E. I. Du Pont de Nemours and Company | Yarrowia esterase/lipase promoter regions for gene expression in yeast |
WO2012138613A1 (en) | 2011-04-05 | 2012-10-11 | E. I. Du Pont De Nemours And Company | Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast |
EP2702148A1 (en) | 2011-04-07 | 2014-03-05 | E.I. Du Pont De Nemours And Company | Yarrowia peroxisomal 2,4-dienoyl-coa reductase promoter regions for gene expression in yeast |
HUE033766T2 (en) * | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Preparation of long chain polyunsaturated fatty acids in plant cells |
EP2861728B1 (en) * | 2012-06-19 | 2017-12-27 | E. I. du Pont de Nemours and Company | Improved production of polyunsaturated fatty acids by coexpression of acyl-coa: lysophosphatidylcholine acyltransferases and phospholipid: diacylglycerol acyltransferases |
US9005940B2 (en) * | 2012-12-21 | 2015-04-14 | E I Du Pont De Nemours And Company | Down-regulation of a polynucleotide encoding a Sou2 sorbitol utilization protein to modify lipid production in microbial cells |
-
2013
- 2013-12-18 DK DK13821271.7T patent/DK2935601T3/da active
- 2013-12-18 WO PCT/US2013/075896 patent/WO2014100062A1/en active Application Filing
- 2013-12-18 US US14/132,022 patent/US9701989B2/en active Active
- 2013-12-18 CA CA2893409A patent/CA2893409A1/en not_active Abandoned
- 2013-12-18 BR BR112015014781A patent/BR112015014781A2/pt not_active Application Discontinuation
- 2013-12-18 JP JP2015549594A patent/JP2016502852A/ja active Pending
- 2013-12-18 EP EP13821271.7A patent/EP2935601B1/en not_active Not-in-force
-
2014
- 2014-03-24 NO NO14712604A patent/NO2976143T3/no unknown
-
2015
- 2015-06-16 CL CL2015001673A patent/CL2015001673A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP2935601B1 (en) | 2018-03-21 |
US9701989B2 (en) | 2017-07-11 |
BR112015014781A2 (pt) | 2017-10-10 |
US20140186906A1 (en) | 2014-07-03 |
CL2015001673A1 (es) | 2015-10-23 |
CA2893409A1 (en) | 2014-06-26 |
WO2014100062A1 (en) | 2014-06-26 |
EP2935601A1 (en) | 2015-10-28 |
JP2016502852A (ja) | 2016-02-01 |
NO2976143T3 (da) | 2018-08-04 |
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