DK2823060T3 - Bestemmelse af forbundne immunreceptorkæder fra hyppighedsafstemte underenheder - Google Patents
Bestemmelse af forbundne immunreceptorkæder fra hyppighedsafstemte underenheder Download PDFInfo
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- DK2823060T3 DK2823060T3 DK13757482.8T DK13757482T DK2823060T3 DK 2823060 T3 DK2823060 T3 DK 2823060T3 DK 13757482 T DK13757482 T DK 13757482T DK 2823060 T3 DK2823060 T3 DK 2823060T3
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/1034—Isolating an individual clone by screening libraries
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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Claims (15)
1. Fremgangsmåde til bestemmelse af forbundne immunreceptorkæder i en prøve, hvilken fremgangsmåde omfatter trinnene: a. at opdele en prøve indeholdende lymfocytter, der udtrykker par af immunreceptorkæder i en flerhed af undergrupper; b. at bestemme nukleotidsekvenser af en første kæde af hvert par lymfocytimmunreceptorkæder, der har sådanne par i en del af flerheden af undergrupper; c. at bestemme nukleotidsekvenser af en anden kæde af hvert par lymfocytimmunreceptorkæde, der har sådanne par i den samme del af flerheden af undergrupper; d. at identificere som forbundne immunreceptorkæder de par af første kæder og anden kæder (i), som for hver undergruppe af delen enten forekommer sammen eller ikke forekommer, og (ii) der forekommer sammen i mindst en undergruppe af delen og ikke forekommer i mindst en undergruppe af delen.
2. Fremgangsmåde ifølge krav 1, der yderligere omfatter trinnet at gentage nævnte trin (a) - (d) for en anden flerhed af undergrupper, der er forskellige fra enhver tidligere flerhed, indtil et ønsket antal af nævnte forbundne immunreceptorer er opnået.
3. Fremgangsmåde ifølge krav 1, hvori nævnte flerhed er større end 100 og nævnte del af flerheden ligger i området fra 10 til 100.
4. Fremgangsmåde ifølge krav 1, hvori nævnte immunreceptorkæder er T-celle-receptor-a-kæder og T-celle-receptor-B-kæder.
5. Fremgangsmåde ifølge krav 1, hvori nævnte immunreceptorkæder er T-celle-receptor-y-kæder og T-celle-receptor-5-kæder.
6. Fremgangsmåde ifølge krav 1, hvori nævnte immunreceptorkæder er B-celle-receptor-tungkæde-variable regioner og B-celle-receptor-letkæde-variable regioner.
7. Fremgangsmåde ifølge krav 1, hvori nævnte prøve indeholder en population af nævnte lymfocytter, som udtrykker nævnte immunreceptorkædepar, og hvori populationen har en størrelse og hver forskellig lymfocyt af populationen har en hyppighed inden for populationen.
8. Fremgangsmåde ifølge krav 7, hvori nævnte flerhed af undergrupper afhænger af nævnte størrelse på nævnte population og nævnte hyppighed af nævnte lymfocytter, hvis forbundne immunreceptorkæder skal bestemmes.
9. Fremgangsmåde ifølge krav 1, hvori en størrelse af nævnte prøve og nævnte flerhed af undergrupper vælges således, at nævnte lymfocytter i nævnte prøve fordeles mellem nævnte undergrupper i overensstemmelse med en binomialmodel.
10. Fremgangsmåde ifølge ethvert af kravene 1 til 9, hvori prøven indeholder T-celler.
11. Fremgangsmåde ifølge ethvert af kravene 1 til 10, hvori prøven indeholder B-celler.
12. Fremgangsmåde ifølge ethvert af kravene 1 til 11, hvori de forbundne immunreceptorkæder, der er identificeret i trin (d), danner en klontypeprofil, og hvori hver klontype i klontypeprofilen er et nukleotidsekvenspar, som koder for et TCR-kædepar, der er udtrykt i den samme T-celle, eller hvori hver klontype i klontypeprofilen er et nukleotidsekvenspar, der koder for immunglobuliner med tung og let kæde, der er udtrykt i den samme B-celle.
13. Fremgangsmåde ifølge krav 12, hvori klontypeprofilen omfatter mindst 100 klontyper, og hvori hver nukleotidsekvens af hver klontype omfatter en sekvens på fra 30 til 300 nukleotider.
14. Fremgangsmåde ifølge krav 12, hvori klontypeprofilen omfatter mindst 500 klontyper, og hvori hver nukleotidsekvens af hver klontype omfatter en sekvens fra 30 til 300 nukleotider.
15. Fremgangsmåde ifølge krav 12, hvor klontypeprofilen omfatter mindst 1000 klontyper, og hvor hver nukleotidsekvens af hver klontype omfatter en sekvens på fra 30 til 300 nukleotider.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201261606617P | 2012-03-05 | 2012-03-05 | |
PCT/US2013/028942 WO2013134162A2 (en) | 2012-03-05 | 2013-03-04 | Determining paired immune receptor chains from frequency matched subunits |
Publications (1)
Publication Number | Publication Date |
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DK2823060T3 true DK2823060T3 (da) | 2018-05-28 |
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Application Number | Title | Priority Date | Filing Date |
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DK13757482.8T DK2823060T3 (da) | 2012-03-05 | 2013-03-04 | Bestemmelse af forbundne immunreceptorkæder fra hyppighedsafstemte underenheder |
Country Status (7)
Country | Link |
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US (1) | US10077478B2 (da) |
EP (2) | EP3372694A1 (da) |
JP (1) | JP6302847B2 (da) |
DK (1) | DK2823060T3 (da) |
ES (1) | ES2662128T3 (da) |
NO (1) | NO2935228T3 (da) |
WO (1) | WO2013134162A2 (da) |
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