DK2796466T3 - Humaniserede antistofmolekyler, der er specifikke for il-31 - Google Patents
Humaniserede antistofmolekyler, der er specifikke for il-31 Download PDFInfo
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- DK2796466T3 DK2796466T3 DK14175301.2T DK14175301T DK2796466T3 DK 2796466 T3 DK2796466 T3 DK 2796466T3 DK 14175301 T DK14175301 T DK 14175301T DK 2796466 T3 DK2796466 T3 DK 2796466T3
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- General Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
- Mycology (AREA)
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- Cell Biology (AREA)
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- Plant Pathology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (8)
- HUMANISEREDE ANTISTOFMOLEKYLER, DER ER SPECIFIKKE FOR IL-31 PATENTKRAV1. Isoleret, monoklonalt antistof eller antigenbindende fragment deraf, der specifikt binder til human IL-31, og som omfatter et humaniseret, variabelt tungkædcdomænc og et humaniseret, variabelt letkædedomæne, hvor det humaniserede, variable tungkædedomæne omfatter en CDR1, CDR2 og CDR3, der henholdsvis består af aminosyresekvenserne ifølge SEQ ID NO: 1, 2 og 3, og framework-regioner FRI, FR2, FR3 og FR4 med en aminosyresekvens, der er mindst 90 % identisk med aminosyresekvensen henholdsvis ifølge SEQ ID NO: 12 (FRI), SEQ ID NO: 13 (FR2), SEQ ID NO: 14 (FR3) og SEQ ID NO: 15 (FR4), og hvor det humaniserede, variable letkædedomæne omfatter en CDR1, CDR2 og CDR3, der består af aminosyresekvenserne ifølge henholdsvis SEQ ID NO: 5, 6 og 7, og framework-regionerne FR5, FR6, FR7 og FR8 med en aminosyresekvens, der er mindst 90 % identisk med aminosyresekvensen ifølge henholdsvis SEQ ID NO: 17 (FR5), SEQ ID NO: 18 (ER6), SEQ ID NO: 19 (FR7) og SEQ ID NO: 20 (FR8); hvor aminosyreresten ved position 29 af SEQ ID NO: 12 (FRI) er leucin, aminosyreresten ved position 8 af SEQ ID NO: 14 (FR3) er lysin, aminosyreresten ved position 32 af SEQ ID NO: 14 (FR3) er phenylalanin og aminosyreresten ved position 15 of SEQ ID NO: 19 (FR7) er tyrosin.
- 2. Isoleret, monoklonalt antigenbindende fragment ifølge krav 1, hvor det antigenbindende fragment endvidere omfatter et Fc-domæne.
- 3. Isoleret, monoklonalt antistof eller antigenbindende fragment deraf ifølge krav 1 eller 2, hvor antistoffet eller antigenbindende fragment endvidere omfatter et konstant tungkædeimmunoglobulindomæne, der er udvalgt fra gruppen bestående af: a) et humant, konstant IgGl-domæne; b) et humant, konstant IgG2-domæne; c) et humant, konstant IgG3-domæne og d) et humant, konstant IgG4-domæne.
- 4. Isoleret, monoklonalt antistof eller antigenbindende fragment deraf ifølge krav 3, hvor det konstante tungkædeimmunoglobulindomæne er et humant, konstant IgG4-domæne.
- 5. Isoleret, monoklonalt antistof eller antigenbindende fragment deraf ifølge krav 4, hvor det humane, konstante IgG4-domæne har serin- til prolinmutation ved position 241 bestemt ved Kabat.
- 6. Anvendelse af det isolerede monoklonale antistof eller antigenbindende fragment ifølge et hvilket som helst af kravene 1-5 til fremstilling af et medikament til behandling af atopisk dermatitis, dermatitis, prurigo nodularis, eksem, pruritus, vitiligo, alopecia aerata, acne rosacea, acne vulgaris, bulløs pemphigoid eller kontaktdermatitis.
- 7. Isoleret, monoklonalt antistof eller antigenbindende fragment ifølge et hvilket som helst af kravene 1-5 til anvendelse i behandling af atopisk dermatitis, dermatitis, prurigo nodularis, eksem, pruritus, vitiligo, alopecia aerata, acne rosacea, acne vulgaris, bulløs pemphigoid eller kontaktdermatitis.
- 8. Anvendelse ifølge krav 6, eller isoleret monoklonalt antistof eller antigenbindende fragment til anvendelse ifølge krav 7 i kombination med en farmaceutisk acceptabel bærer.
Applications Claiming Priority (2)
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US1236207P | 2007-12-07 | 2007-12-07 | |
EP12161272.5A EP2471817B1 (en) | 2007-12-07 | 2008-12-08 | Humanized antibody molecules specific for IL-31 |
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DK2796466T3 true DK2796466T3 (da) | 2018-02-05 |
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DK14175301.2T DK2796466T3 (da) | 2007-12-07 | 2008-12-08 | Humaniserede antistofmolekyler, der er specifikke for il-31 |
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US (8) | US8470979B2 (da) |
EP (3) | EP2471817B1 (da) |
JP (2) | JP5744522B2 (da) |
KR (1) | KR101603109B1 (da) |
CN (1) | CN101970488B (da) |
AU (1) | AU2008333131B2 (da) |
BR (1) | BRPI0820099A2 (da) |
CA (1) | CA2708251C (da) |
CY (1) | CY1120412T1 (da) |
DK (1) | DK2796466T3 (da) |
EA (1) | EA020457B1 (da) |
ES (2) | ES2570853T3 (da) |
HK (2) | HK1154020A1 (da) |
HR (1) | HRP20180252T1 (da) |
HU (1) | HUE036548T2 (da) |
IL (1) | IL206147A (da) |
LT (1) | LT2796466T (da) |
ME (1) | ME03057B (da) |
NO (1) | NO2796466T3 (da) |
PL (1) | PL2796466T3 (da) |
PT (1) | PT2796466T (da) |
RS (1) | RS56930B1 (da) |
SI (1) | SI2796466T1 (da) |
TR (1) | TR201802202T4 (da) |
WO (1) | WO2009071696A2 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003225525B2 (en) | 2002-01-18 | 2008-07-24 | Zymogenetics, Inc. | Novel cytokine zcytor17 ligand |
MX2007009577A (es) * | 2005-02-14 | 2008-01-30 | Zymogenetics Inc | Metodos para predecir respuesta terapeutica en dermatitis atopica a antagonistas del il-31. |
US7531637B2 (en) * | 2005-05-06 | 2009-05-12 | Zymogenetics, Inc. | IL-31 monoclonal antibodies |
US8101183B2 (en) * | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
EP2001906A2 (en) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
SI2594586T1 (sl) * | 2006-09-01 | 2014-11-28 | Zymogenetics, Inc. | IL-31 monoklonska protitelesa in metode uporabe |
ME03057B (me) | 2007-12-07 | 2019-01-20 | Zymogenetics Inc | Molekuli humanizovanih antitela specifični za il-31 |
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