DK2794655T3 - Fremgangsmåde til selektiv mængdebestemmelse af a-beta-aggregater - Google Patents
Fremgangsmåde til selektiv mængdebestemmelse af a-beta-aggregater Download PDFInfo
- Publication number
- DK2794655T3 DK2794655T3 DK12818996.6T DK12818996T DK2794655T3 DK 2794655 T3 DK2794655 T3 DK 2794655T3 DK 12818996 T DK12818996 T DK 12818996T DK 2794655 T3 DK2794655 T3 DK 2794655T3
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- beta aggregates
- selective quantification
- quantification
- selective
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 238000011002 quantification Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011057021A DE102011057021A1 (de) | 2011-12-23 | 2011-12-23 | Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten |
| PCT/EP2012/076552 WO2013092952A2 (de) | 2011-12-23 | 2012-12-21 | Verfahren zur selektiven quantifizierung von a-beta-aggregaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2794655T3 true DK2794655T3 (da) | 2022-07-18 |
Family
ID=47624003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12818996.6T DK2794655T3 (da) | 2011-12-23 | 2012-12-21 | Fremgangsmåde til selektiv mængdebestemmelse af a-beta-aggregater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150024512A1 (enExample) |
| EP (1) | EP2794655B1 (enExample) |
| JP (2) | JP2015502551A (enExample) |
| CN (1) | CN104080807A (enExample) |
| BR (1) | BR112014015392A2 (enExample) |
| CA (1) | CA2858125A1 (enExample) |
| DE (1) | DE102011057021A1 (enExample) |
| DK (1) | DK2794655T3 (enExample) |
| ES (1) | ES2922201T3 (enExample) |
| IL (1) | IL232870B (enExample) |
| RU (1) | RU2642314C2 (enExample) |
| WO (1) | WO2013092952A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013106713A1 (de) * | 2013-06-26 | 2014-12-31 | Forschungszentrum Jülich GmbH | Verfahren zur Ermittlung von Indikatoren zur Bestimmung von Krankheiten |
| WO2016053621A1 (en) * | 2014-09-16 | 2016-04-07 | Sri International | Affinity reagent and catalyst discovery though fiber-optic array scanning technology |
| DE102015003404B4 (de) * | 2015-03-18 | 2021-10-07 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung eines Standards für den Nachweis von Proteinaggregaten einer Proteinfehlfaltungserkrankung sowie Standard und dessen Verwendung |
| WO2017138497A1 (ja) * | 2016-02-08 | 2017-08-17 | シスメックス株式会社 | 被検物質の検出方法および被検物質の検出用試薬キット |
| JP6886854B2 (ja) * | 2017-04-13 | 2021-06-16 | シスメックス株式会社 | 被検物質の情報取得方法 |
| DE102017010455A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe |
| DE102017005543A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe |
| DE102017010842A1 (de) * | 2017-11-23 | 2019-05-23 | Forschungszentrum Jülich GmbH | Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe |
| US20200400687A1 (en) * | 2017-12-19 | 2020-12-24 | Chase Therapeutics Corporation | Methods for developing pharmaceuticals for treating neurodegenerative conditions |
| CN111518206B (zh) | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| DE102020114278A1 (de) | 2020-05-28 | 2021-12-02 | Forschungszentrum Jülich GmbH | Bestimmung krankheitsspezifischer Protein-Aggregate in Stuhlproben |
| DE102020003794A1 (de) * | 2020-06-25 | 2021-12-30 | Forschungszentrum Jülich GmbH | Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe |
| CN116879540B (zh) * | 2023-07-13 | 2024-04-05 | 香港中文大学（深圳） | 一种神经元蛋白聚集体特异性检测试剂盒 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE462454B (sv) * | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| WO2005018424A2 (en) * | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
| US7258990B2 (en) * | 2004-08-19 | 2007-08-21 | Biocept, Inc. | Alleviation of non-specific binding in microarray assays |
| SG10201706600VA (en) * | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| CN101384279B (zh) * | 2006-02-24 | 2012-02-22 | 奇斯药制品公司 | 抗淀粉样蛋白免疫原性组合物、方法和用途 |
| WO2008070229A2 (en) * | 2006-08-28 | 2008-06-12 | Case Western Reserve University | Detection of pathogenic aggregates of protein in a sample by homologous elisa |
| SG185316A1 (en) * | 2007-10-19 | 2012-11-29 | Immunas Pharma Inc | ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO Aβ OLIGOMER, AND USE THEREOF |
| US20110104821A1 (en) * | 2008-05-08 | 2011-05-05 | Takahiko Tokuda | ABeta-OLIGOMER MEASUREMENT METHOD |
| JP5720248B2 (ja) * | 2008-12-24 | 2015-05-20 | コニカミノルタ株式会社 | 表面プラズモンおよび蛍光共鳴エネルギー転移を利用した免疫アッセイ |
| US8512677B2 (en) * | 2009-04-27 | 2013-08-20 | Case Western Reserve University | Pyro-glutamate Aβ targeting agents |
| EP2534490B1 (en) * | 2010-02-09 | 2015-12-16 | Bristol-Myers Squibb Company | Immunoassay standards and measurement of clinical biomarkers using intra-assay calibration standards |
-
2011
- 2011-12-23 DE DE102011057021A patent/DE102011057021A1/de not_active Ceased
-
2012
- 2012-12-21 DK DK12818996.6T patent/DK2794655T3/da active
- 2012-12-21 CA CA2858125A patent/CA2858125A1/en not_active Abandoned
- 2012-12-21 BR BR112014015392A patent/BR112014015392A2/pt not_active IP Right Cessation
- 2012-12-21 WO PCT/EP2012/076552 patent/WO2013092952A2/de not_active Ceased
- 2012-12-21 EP EP12818996.6A patent/EP2794655B1/de active Active
- 2012-12-21 RU RU2014130136A patent/RU2642314C2/ru not_active IP Right Cessation
- 2012-12-21 ES ES12818996T patent/ES2922201T3/es active Active
- 2012-12-21 US US14/366,952 patent/US20150024512A1/en not_active Abandoned
- 2012-12-21 JP JP2014548051A patent/JP2015502551A/ja active Pending
- 2012-12-21 CN CN201280064163.5A patent/CN104080807A/zh active Pending
-
2014
- 2014-05-29 IL IL232870A patent/IL232870B/en active IP Right Grant
-
2018
- 2018-10-04 JP JP2018189249A patent/JP6625709B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2922201T3 (es) | 2022-09-09 |
| EP2794655A2 (de) | 2014-10-29 |
| JP6625709B2 (ja) | 2019-12-25 |
| CN104080807A (zh) | 2014-10-01 |
| JP2015502551A (ja) | 2015-01-22 |
| RU2014130136A (ru) | 2016-02-10 |
| EP2794655B1 (de) | 2022-04-13 |
| RU2642314C2 (ru) | 2018-01-24 |
| BR112014015392A2 (pt) | 2019-09-24 |
| IL232870A0 (en) | 2014-07-31 |
| CA2858125A1 (en) | 2013-06-27 |
| IL232870B (en) | 2020-06-30 |
| DE102011057021A1 (de) | 2013-06-27 |
| WO2013092952A2 (de) | 2013-06-27 |
| US20150024512A1 (en) | 2015-01-22 |
| WO2013092952A3 (de) | 2013-08-29 |
| JP2019015738A (ja) | 2019-01-31 |
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