CN104080807A - 选择性量化A-β聚集体的方法 - Google Patents

选择性量化A-β聚集体的方法 Download PDF

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Publication number
CN104080807A
CN104080807A CN201280064163.5A CN201280064163A CN104080807A CN 104080807 A CN104080807 A CN 104080807A CN 201280064163 A CN201280064163 A CN 201280064163A CN 104080807 A CN104080807 A CN 104080807A
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China
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aforementioned
beta
beta peptide
aggregates
probe
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Pending
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CN201280064163.5A
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English (en)
Chinese (zh)
Inventor
D·威尔伯尔德
S·A·丰克
L·旺-迪特里希
E·比克曼
O·班纳赫
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Forschungszentrum Juelich GmbH
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Forschungszentrum Juelich GmbH
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Publication of CN104080807A publication Critical patent/CN104080807A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201280064163.5A 2011-12-23 2012-12-21 选择性量化A-β聚集体的方法 Pending CN104080807A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011057021.7 2011-12-23
DE102011057021A DE102011057021A1 (de) 2011-12-23 2011-12-23 Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten
PCT/EP2012/076552 WO2013092952A2 (de) 2011-12-23 2012-12-21 Verfahren zur selektiven quantifizierung von a-beta-aggregaten

Publications (1)

Publication Number Publication Date
CN104080807A true CN104080807A (zh) 2014-10-01

Family

ID=47624003

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280064163.5A Pending CN104080807A (zh) 2011-12-23 2012-12-21 选择性量化A-β聚集体的方法

Country Status (12)

Country Link
US (1) US20150024512A1 (enExample)
EP (1) EP2794655B1 (enExample)
JP (2) JP2015502551A (enExample)
CN (1) CN104080807A (enExample)
BR (1) BR112014015392A2 (enExample)
CA (1) CA2858125A1 (enExample)
DE (1) DE102011057021A1 (enExample)
DK (1) DK2794655T3 (enExample)
ES (1) ES2922201T3 (enExample)
IL (1) IL232870B (enExample)
RU (1) RU2642314C2 (enExample)
WO (1) WO2013092952A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105358978A (zh) * 2013-06-26 2016-02-24 于利希研究中心有限公司 用于查明确定疾病的指示物的方法
CN108732145A (zh) * 2017-04-13 2018-11-02 希森美康株式会社 受检物质的信息获取方法
CN110832323A (zh) * 2017-06-13 2020-02-21 于利奇研究中心有限公司 用于检测样品中的生物治疗物质的聚集体的方法
CN110869764A (zh) * 2017-06-13 2020-03-06 于利奇研究中心有限公司 用于检测样品中的细胞外囊泡的方法
CN111527409A (zh) * 2017-11-23 2020-08-11 于利奇研究中心有限公司 将样品中蛋白错误折叠疾病的蛋白聚集体定量的方法

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WO2016053621A1 (en) * 2014-09-16 2016-04-07 Sri International Affinity reagent and catalyst discovery though fiber-optic array scanning technology
DE102015003404B4 (de) * 2015-03-18 2021-10-07 Forschungszentrum Jülich GmbH Verfahren zur Herstellung eines Standards für den Nachweis von Proteinaggregaten einer Proteinfehlfaltungserkrankung sowie Standard und dessen Verwendung
WO2017138497A1 (ja) * 2016-02-08 2017-08-17 シスメックス株式会社 被検物質の検出方法および被検物質の検出用試薬キット
US20200400687A1 (en) * 2017-12-19 2020-12-24 Chase Therapeutics Corporation Methods for developing pharmaceuticals for treating neurodegenerative conditions
CN111518206B (zh) 2019-02-01 2022-03-29 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
DE102020114278A1 (de) 2020-05-28 2021-12-02 Forschungszentrum Jülich GmbH Bestimmung krankheitsspezifischer Protein-Aggregate in Stuhlproben
DE102020003794A1 (de) * 2020-06-25 2021-12-30 Forschungszentrum Jülich GmbH Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe
CN116879540B (zh) * 2023-07-13 2024-04-05 香港中文大学（深圳） 一种神经元蛋白聚集体特异性检测试剂盒

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SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US7427392B1 (en) * 1994-11-14 2008-09-23 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
WO2005018424A2 (en) * 2003-08-18 2005-03-03 Research Foundation For Mental Hygiene, Inc. Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits
US7258990B2 (en) * 2004-08-19 2007-08-21 Biocept, Inc. Alleviation of non-specific binding in microarray assays
SG10201706600VA (en) * 2005-11-30 2017-09-28 Abbvie Inc Monoclonal antibodies and uses thereof
CN101384279B (zh) * 2006-02-24 2012-02-22 奇斯药制品公司 抗淀粉样蛋白免疫原性组合物、方法和用途
WO2008070229A2 (en) * 2006-08-28 2008-06-12 Case Western Reserve University Detection of pathogenic aggregates of protein in a sample by homologous elisa
SG185316A1 (en) * 2007-10-19 2012-11-29 Immunas Pharma Inc ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO Aβ OLIGOMER, AND USE THEREOF
US20110104821A1 (en) * 2008-05-08 2011-05-05 Takahiko Tokuda ABeta-OLIGOMER MEASUREMENT METHOD
JP5720248B2 (ja) * 2008-12-24 2015-05-20 コニカミノルタ株式会社 表面プラズモンおよび蛍光共鳴エネルギー転移を利用した免疫アッセイ
US8512677B2 (en) * 2009-04-27 2013-08-20 Case Western Reserve University Pyro-glutamate Aβ targeting agents
EP2534490B1 (en) * 2010-02-09 2015-12-16 Bristol-Myers Squibb Company Immunoassay standards and measurement of clinical biomarkers using intra-assay calibration standards

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JUNGKI RYU ET AL.: "Surface plasmon resonance analysis of Alzheimer"s [beta]-amyloid aggregation on a solid surface：from monomers to fully-grown fibrils", 《ANALYTICAL CHEMISTRY》 *
LEMERE ET AL.: "Developing novel immunogens for a safe and effective Alzheimer’s disease vaccine", 《PROGRESS IN BRAIN RESEARCH》 *
SUSANNE AILEEN FUNKE ET AL.: "Single particle detection of Ab aggregates associated with Alzheimer’s disease", 《BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105358978A (zh) * 2013-06-26 2016-02-24 于利希研究中心有限公司 用于查明确定疾病的指示物的方法
CN108732145A (zh) * 2017-04-13 2018-11-02 希森美康株式会社 受检物质的信息获取方法
US11112404B2 (en) 2017-04-13 2021-09-07 Sysmex Corporation Method for obtaining information of test substance
CN110832323A (zh) * 2017-06-13 2020-02-21 于利奇研究中心有限公司 用于检测样品中的生物治疗物质的聚集体的方法
CN110869764A (zh) * 2017-06-13 2020-03-06 于利奇研究中心有限公司 用于检测样品中的细胞外囊泡的方法
CN111527409A (zh) * 2017-11-23 2020-08-11 于利奇研究中心有限公司 将样品中蛋白错误折叠疾病的蛋白聚集体定量的方法

Also Published As

Publication number Publication date
ES2922201T3 (es) 2022-09-09
EP2794655A2 (de) 2014-10-29
JP6625709B2 (ja) 2019-12-25
DK2794655T3 (da) 2022-07-18
JP2015502551A (ja) 2015-01-22
RU2014130136A (ru) 2016-02-10
EP2794655B1 (de) 2022-04-13
RU2642314C2 (ru) 2018-01-24
BR112014015392A2 (pt) 2019-09-24
IL232870A0 (en) 2014-07-31
CA2858125A1 (en) 2013-06-27
IL232870B (en) 2020-06-30
DE102011057021A1 (de) 2013-06-27
WO2013092952A2 (de) 2013-06-27
US20150024512A1 (en) 2015-01-22
WO2013092952A3 (de) 2013-08-29
JP2019015738A (ja) 2019-01-31

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