RU2642314C2 - Способы избирательной количественной оценки агрегатов а-бета - Google Patents
Способы избирательной количественной оценки агрегатов а-бета Download PDFInfo
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- G01N33/552—Glass or silica
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
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- G01N2458/00—Labels used in chemical analysis of biological material
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- G01N2800/2814—Dementia; Cognitive disorders
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- Chemical Kinetics & Catalysis (AREA)
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- Neurology (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
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| PCT/EP2012/076552 WO2013092952A2 (de) | 2011-12-23 | 2012-12-21 | Verfahren zur selektiven quantifizierung von a-beta-aggregaten |
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| DE102013106713A1 (de) * | 2013-06-26 | 2014-12-31 | Forschungszentrum Jülich GmbH | Verfahren zur Ermittlung von Indikatoren zur Bestimmung von Krankheiten |
| WO2016053621A1 (en) * | 2014-09-16 | 2016-04-07 | Sri International | Affinity reagent and catalyst discovery though fiber-optic array scanning technology |
| DE102015003404B4 (de) * | 2015-03-18 | 2021-10-07 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung eines Standards für den Nachweis von Proteinaggregaten einer Proteinfehlfaltungserkrankung sowie Standard und dessen Verwendung |
| WO2017138497A1 (ja) * | 2016-02-08 | 2017-08-17 | シスメックス株式会社 | 被検物質の検出方法および被検物質の検出用試薬キット |
| JP6886854B2 (ja) * | 2017-04-13 | 2021-06-16 | シスメックス株式会社 | 被検物質の情報取得方法 |
| DE102017010455A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe |
| DE102017005543A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe |
| DE102017010842A1 (de) * | 2017-11-23 | 2019-05-23 | Forschungszentrum Jülich GmbH | Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe |
| US20200400687A1 (en) * | 2017-12-19 | 2020-12-24 | Chase Therapeutics Corporation | Methods for developing pharmaceuticals for treating neurodegenerative conditions |
| CN111518206B (zh) | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| DE102020114278A1 (de) | 2020-05-28 | 2021-12-02 | Forschungszentrum Jülich GmbH | Bestimmung krankheitsspezifischer Protein-Aggregate in Stuhlproben |
| DE102020003794A1 (de) * | 2020-06-25 | 2021-12-30 | Forschungszentrum Jülich GmbH | Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe |
| CN116879540B (zh) * | 2023-07-13 | 2024-04-05 | 香港中文大学（深圳） | 一种神经元蛋白聚集体特异性检测试剂盒 |
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| RU2432362C2 (ru) * | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
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| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
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| US7258990B2 (en) * | 2004-08-19 | 2007-08-21 | Biocept, Inc. | Alleviation of non-specific binding in microarray assays |
| CN101384279B (zh) * | 2006-02-24 | 2012-02-22 | 奇斯药制品公司 | 抗淀粉样蛋白免疫原性组合物、方法和用途 |
| WO2008070229A2 (en) * | 2006-08-28 | 2008-06-12 | Case Western Reserve University | Detection of pathogenic aggregates of protein in a sample by homologous elisa |
| SG185316A1 (en) * | 2007-10-19 | 2012-11-29 | Immunas Pharma Inc | ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO Aβ OLIGOMER, AND USE THEREOF |
| US20110104821A1 (en) * | 2008-05-08 | 2011-05-05 | Takahiko Tokuda | ABeta-OLIGOMER MEASUREMENT METHOD |
| JP5720248B2 (ja) * | 2008-12-24 | 2015-05-20 | コニカミノルタ株式会社 | 表面プラズモンおよび蛍光共鳴エネルギー転移を利用した免疫アッセイ |
| EP2534490B1 (en) * | 2010-02-09 | 2015-12-16 | Bristol-Myers Squibb Company | Immunoassay standards and measurement of clinical biomarkers using intra-assay calibration standards |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2432362C2 (ru) * | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
| WO2010129276A2 (en) * | 2009-04-27 | 2010-11-11 | Case Western Reserve University | PYRO-GLUTAMATE Aβ TARGETING AGENTS |
Non-Patent Citations (1)
| Title |
|---|
| FUNKE et al. "Single particle detection of Abeta aggregates associated with Alzheimer's disease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 364, 28.12.2007, pages 902-907. * |
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| ES2922201T3 (es) | 2022-09-09 |
| EP2794655A2 (de) | 2014-10-29 |
| JP6625709B2 (ja) | 2019-12-25 |
| CN104080807A (zh) | 2014-10-01 |
| DK2794655T3 (da) | 2022-07-18 |
| JP2015502551A (ja) | 2015-01-22 |
| RU2014130136A (ru) | 2016-02-10 |
| EP2794655B1 (de) | 2022-04-13 |
| BR112014015392A2 (pt) | 2019-09-24 |
| IL232870A0 (en) | 2014-07-31 |
| CA2858125A1 (en) | 2013-06-27 |
| IL232870B (en) | 2020-06-30 |
| DE102011057021A1 (de) | 2013-06-27 |
| WO2013092952A2 (de) | 2013-06-27 |
| US20150024512A1 (en) | 2015-01-22 |
| WO2013092952A3 (de) | 2013-08-29 |
| JP2019015738A (ja) | 2019-01-31 |
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