DK2778233T3

DK2778233T3 - METHOD OF MEASURING ETHANOLAMINPHOSPHATE

METHOD OF MEASURING ETHANOLAMINPHOSPHATE Download PDF

Info

Publication number: DK2778233T3
Authority: DK; Denmark
Prior art keywords: gly; leu; ala; val; glu
Prior art date: 2011-11-10

Application number

DK12848737.8T

Other languages

Danish (da)

English (en)

Inventor

Takushi Ohga

Yoshiaki Ohashi

Original Assignee

Human Metabolome Tech Inc

Priority date

2011-11-10

Filing date

2012-11-06

Publication date

2017-03-20

2012-11-06 Application filed by Human Metabolome Tech Inc filed Critical Human Metabolome Tech Inc

2017-03-20 Application granted granted Critical

2017-03-20 Publication of DK2778233T3 publication Critical patent/DK2778233T3/en

Links

238000000034 method Methods 0.000 title claims description 22
108090000790 Enzymes Proteins 0.000 claims description 78
102000004190 Enzymes Human genes 0.000 claims description 78
IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 50
SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims description 48
238000005259 measurement Methods 0.000 claims description 38
238000006243 chemical reaction Methods 0.000 claims description 37
150000001413 amino acids Chemical class 0.000 claims description 31
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 26
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 26
NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical group CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims description 22
108090000623 proteins and genes Proteins 0.000 claims description 20
102000004169 proteins and genes Human genes 0.000 claims description 18
239000005515 coenzyme Substances 0.000 claims description 14
229910000147 aluminium phosphate Inorganic materials 0.000 claims description 13
229910021529 ammonia Inorganic materials 0.000 claims description 13
239000003153 chemical reaction reagent Substances 0.000 claims description 13
IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 claims description 12
235000007682 pyridoxal 5'-phosphate Nutrition 0.000 claims description 11
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238000000691 measurement method Methods 0.000 claims description 9
238000011002 quantification Methods 0.000 claims description 9
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238000006911 enzymatic reaction Methods 0.000 claims description 8
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BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 8
BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 claims description 5
230000003001 depressive effect Effects 0.000 claims description 5
238000000338 in vitro Methods 0.000 claims description 4
125000003275 alpha amino acid group Chemical group 0.000 claims 13
238000003556 assay Methods 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 52
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238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 12
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ZOTGXWMKUFSKEU-QXEWZRGKSA-N Gly-Ile-Met Chemical compound [H]NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O ZOTGXWMKUFSKEU-QXEWZRGKSA-N 0.000 description 4
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UQFYNFTYDHUIMI-WHFBIAKZSA-N Ser-Gly-Ala Chemical compound OC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)CO UQFYNFTYDHUIMI-WHFBIAKZSA-N 0.000 description 4
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