DK2774621T3 - Behandling af immunsygdom ved mukosal indgivelse af antigener - Google Patents
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- DK2774621T3 DK2774621T3 DK14169790.4T DK14169790T DK2774621T3 DK 2774621 T3 DK2774621 T3 DK 2774621T3 DK 14169790 T DK14169790 T DK 14169790T DK 2774621 T3 DK2774621 T3 DK 2774621T3
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Claims (21)
1. Mikroorganisme omfattende en nukleinsyre, der koder for et antigen til anvendelse i behandlingen afen immunrespons-relateret sygdom valgt fra en autoimmunsygdom, en allergisygdom og graft-versus-host-sygdom, hos et menneskeligt individ, hvor nævnte antigen er konstitutivt udtrykt og sekreteret af nævnte mikroorganisme, hvor nævnte mikroorganisme er en Lactococcus sp. bakterie, og nævnte antigen skal administreres via mukosal indgivelse, og hvor nævnte menneskelige individ har udviklet hypersensitivitet overfor nævnte antigen.
2. Mikroorganismen til anvendelsen ifølge krav 1, hvor den immunrespons-relaterede sygdom er en autoimmunsygdom.
3. Mikroorganismen til anvendelsen ifølge krav 1, hvor den immunrespons-relaterede sygdom er en allergisygdom.
4. Mikroorganismen til anvendelsen ifølge krav 1, hvor den immunrespons-relaterede sygdom er graft-versus-host-sygdom.
5. Mikroorganismen til anvendelsen ifølge krav 1 eller krav 3, hvor nævnte allergisygdom er valgt fra allergisk astma og en fødevareallergi.
6. Mikroorganismen til anvendelsen ifølge krav 1 eller krav 2, hvor nævnte autoimmunsygdom er valgt fra type 1 diabetes, cøliaki, multipel sklerose, autoimmun uveitis, autoimmun thyroiditis, autoimmun myasthenia gravis, og rheumatoid arthritis.
7. Mikroorganismen til anvendelsen ifølge krav 1 eller krav 2, hvor nævnte autoimmunsygdom er type 1 diabetes.
8. Mikroorganismen til anvendelsen ifølge krav 1 eller krav 2, hvor nævnte autoimmunsygdom er cøliaki.
9. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 8, hvor nævnte mikroorganisme er: - administreret dagligt; - indgivet i løbet af mindst 1 uge; - indgivet mindst én gang om dagen; - indgivet i en dosis på mindst 10 femtogram til 100 mg per dag; og/eller - indgivet i en formulering valgt fra spray, kapsel, aerosol, pastil, bolus, tablet, små poser, væske, suspension, emulsion, og sugetabletter.
10. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 9, hvor nævnte mukosale indgivelse er valgt fra rektal indgivelse, bukkal indgivelse, pulmonær indgivelse, okulær indgivelse, nasal indgivelse, vaginal indgivelse, og oral indgivelse.
11. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 10, hvor - nævnte antigen inducerer regulatoriske T-celler (Treg); - nævnte antigen reducerer proliferation af milt- og lyskelymfeknudeceller; og/eller - nævnte antigen undertrykker et inflammatorisk antigen-specifikt T-cellerespons.
12. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 11, hvor nævnte mikroorganisme er formuleret som et medikament, medicinsk næringsmiddel, nutraceutikum eller drik.
13. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 12, hvor et genetisk konstrukt, der koder for nævnte antigen er integreret i genomet af nævnte mikroorganisme.
14. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 13, hvor nævnte mikroorganisme er mukosalt indgivet til nævnte individ dagligt.
15. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 14, hvor nævnte Lactococcus sp. bakterie er Lactococcus lactis.
16. Farmaceutisk sammensætning omfattende en mikroorganisme og en eller flere farmaceutisk acceptable bærere, til anvendelse i behandlingen afen immunrespons-relateret sygdom valgt fra en autoimmunsygdom, en allergisygdom og graft-versus-host-sygdom, hos et menneskeligt individ, hvor nævnte mikroorganisme konstitutivt sekreterer et antigen, der er involveret i induktionen af en immunrespons-relateret sygdom, hvor mikroorganismen er en Lactococcus sp. bakterie, og hvor nævnte menneskelige individ har udviklet hypersensitivitet over for nævnte antigen.
17. Den farmaceutiske sammensætning til anvendelsen ifølge krav 16, hvor nævnte immunrespons-relaterede sygdom er valgt fra allergisk astma, en fødevareallergi, en autoimmunsygdom og graft-versus-host-sygdom.
18. Den farmaceutiske sammensætning til anvendelsen ifølge krav 16 eller krav 17, hvor nævnte mikroorganisme er Lactococcus lactis (LL).
19. Den farmaceutiske sammensætning til anvendelsen ifølge et hvilket som helst af kravene 16 til 18, hvor: - nævnte mikroorganisme er til stede i en dosis på mindst 10 femtogram (fg) til 100 mg; og/eller - nævnte farmaceutiske sammensætning er i en formulering valgt fra sprays, kapsler, aerosoler, pastil, bolus, tabletter, små poser, væsker, suspensioner, emulsioner, og sugetabletter.
20. Den farmaceutiske sammensætning til anvendelsen ifølge et hvilket som helst af kravene 16 til 19, hvor: - nævnte antigen inducerer regulatoriske T-celler (Treg); - nævnte antigen reducerer proliferation af milt- og lyskelymfeknudeceller; og - nævnte antigen undertrykker et inflammatorisk antigen-specifikt T-cellerespons.
21. Mikroorganismen til anvendelsen ifølge et hvilket som helst af kravene 1 til 15, eller den farmaceutiske sammensætning til anvendelsen ifølge et hvilket som helst af kravene 16 til 19, hvor nævnte antigen er et gliadin-afledt peptid.
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EP08708224.4A EP2125010B1 (en) | 2007-01-25 | 2008-01-25 | Treatment of immune disease by mucosal delivery of antigens using genetically modified lactobacillus |
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EP2774621A2 (en) | 2014-09-10 |
CN101605559A (zh) | 2009-12-16 |
US10143729B2 (en) | 2018-12-04 |
EP3351268A1 (en) | 2018-07-25 |
WO2008090223A2 (en) | 2008-07-31 |
ES2666658T3 (es) | 2018-05-07 |
CA3037889C (en) | 2022-09-13 |
US20190076511A1 (en) | 2019-03-14 |
CA3037889A1 (en) | 2008-07-31 |
WO2008090223A3 (en) | 2009-01-15 |
US20130330374A1 (en) | 2013-12-12 |
CA2675297C (en) | 2019-05-07 |
CN103933563B (zh) | 2016-09-28 |
HK1258000A1 (zh) | 2019-11-01 |
EP2774621B1 (en) | 2018-01-24 |
US20100104601A1 (en) | 2010-04-29 |
CN103933563A (zh) | 2014-07-23 |
ES2492468T3 (es) | 2014-09-09 |
EP2125010B1 (en) | 2014-06-04 |
EP3351268B1 (en) | 2020-08-05 |
US20130095129A1 (en) | 2013-04-18 |
DK2125010T3 (da) | 2014-08-25 |
EP2125010A2 (en) | 2009-12-02 |
US8524246B2 (en) | 2013-09-03 |
JP2010516269A (ja) | 2010-05-20 |
EP2774621A3 (en) | 2014-11-26 |
BRPI0807857A2 (pt) | 2014-05-27 |
DK3351268T3 (da) | 2020-11-02 |
CA2675297A1 (en) | 2008-07-31 |
US10668136B2 (en) | 2020-06-02 |
CN101605559B (zh) | 2014-04-23 |
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