DK267489A - 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler - Google Patents

1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler Download PDF

Info

Publication number
DK267489A
DK267489A DK267489A DK267489A DK267489A DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A
Authority
DK
Denmark
Prior art keywords
deoxy
preparation
medicinal products
nojirimycin derivatives
nojirimycin
Prior art date
Application number
DK267489A
Other languages
Danish (da)
English (en)
Other versions
DK267489D0 (da
Inventor
Jean-Bernard Ducep
Charles Danzin
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK267489D0 publication Critical patent/DK267489D0/da
Publication of DK267489A publication Critical patent/DK267489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK267489A 1988-06-02 1989-06-01 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler DK267489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88401340A EP0344383A1 (fr) 1988-06-02 1988-06-02 Inhibiteurs d'alpha-glucosidase

Publications (2)

Publication Number Publication Date
DK267489D0 DK267489D0 (da) 1989-06-01
DK267489A true DK267489A (da) 1989-12-03

Family

ID=8200392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK267489A DK267489A (da) 1988-06-02 1989-06-01 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler

Country Status (22)

Country Link
US (1) US5157116A (fr)
EP (1) EP0344383A1 (fr)
JP (1) JP2791419B2 (fr)
KR (1) KR0155541B1 (fr)
CN (1) CN1023803C (fr)
AR (1) AR247890A1 (fr)
AT (1) ATE129716T1 (fr)
AU (1) AU608711B2 (fr)
CA (1) CA1339740C (fr)
DE (1) DE68924670T2 (fr)
DK (1) DK267489A (fr)
ES (1) ES2081857T3 (fr)
FI (1) FI92934C (fr)
GR (1) GR3018354T3 (fr)
HU (1) HU203559B (fr)
IE (1) IE68455B1 (fr)
IL (1) IL90463A0 (fr)
NO (1) NO170023C (fr)
NZ (1) NZ229337A (fr)
PH (1) PH25908A (fr)
PT (1) PT90713B (fr)
ZA (1) ZA894068B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3936295A1 (de) * 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
US5844102A (en) * 1994-07-07 1998-12-01 University Of Maryland Baltimore County Glycohydrolase inhibitors, their preparation and use thereof
JP3580900B2 (ja) * 1995-04-20 2004-10-27 ホクレン農業協同組合連合会 α−グルコシダーゼ阻害剤を含む糖を主体とする組成物を有効成分とする食品及び飼料
AU4335997A (en) * 1996-09-09 1998-03-26 Wisconsin Alumni Research Foundation Human salivary proteins and fragments thereof having alpha-glucosidase inhibitory activity
NZ525021A (en) * 1997-04-15 2004-05-28 Csir Pharmaceutical compositions having appetite suppressant activity
EP0983239A1 (fr) * 1997-05-06 2000-03-08 Novo Nordisk A/S Nouveaux composes heterocycliques
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
JP4486792B2 (ja) * 2003-06-12 2010-06-23 学校法人近畿大学 環状オニウム化合物およびグルコシダーゼ阻害剤
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
WO2005092334A2 (fr) * 2004-03-25 2005-10-06 David Priestman Utilisation d'iminosucres anorexigenes n-substitues
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
KR20070084455A (ko) * 2004-11-23 2007-08-24 워너-램버트 캄파니 엘엘씨 지질혈증 치료용 ｈｍｇ ｃｏ-ａ 환원효소 억제제로서의7-(2ｈ-피라졸-3-일)-3,5-디히드록시-헵탄산 유도체
EP2027137B1 (fr) * 2005-06-08 2015-02-18 Amicus Therapeutics, Inc. Purification d'imino- et amino-sucre
BRPI0613224A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc método para estabilizar um açúcar triflatado, método para aumentar o rendimento da reação de um produto de açúcar e composição de açúcar triflatado estabilizada
JP2008543784A (ja) * 2005-06-08 2008-12-04 アミカス セラピューティックス インコーポレイテッド 結晶性糖組成物および作製方法
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
ATE518544T1 (de) 2007-03-12 2011-08-15 Zadec Aps Rotbusch-extrakt gegen diabetes
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (fr) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク ２−フェニルベンゾイルアミド
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012120414A2 (fr) 2011-03-04 2012-09-13 Pfizer Inc. Peptides de type edn3 et utilisations associées
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
WO2014151206A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
EP3004138B1 (fr) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Agonistes ultra-purs de guanylate cyclase c, leur procédé de production et d'utilisation
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
WO2018069532A1 (fr) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibiteurs de la semialdéhyde décarboxylase de l'acide alpha-amino-bêta-carboxymuconique
CN113302189A (zh) 2018-11-20 2021-08-24 Tes制药有限责任公司 α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
EP3911648A4 (fr) 2019-01-18 2022-10-26 Astrazeneca AB Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2922760A1 (de) * 1979-06-05 1980-12-11 Bayer Ag Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
JPS61115093A (ja) * 1984-11-09 1986-06-02 Nippon Shinyaku Co Ltd モラノリン誘導体の製法
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
DE3737523A1 (de) * 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel

Also Published As

Publication number Publication date
AU3580189A (en) 1990-02-01
EP0344383A1 (fr) 1989-12-06
DK267489D0 (da) 1989-06-01
DE68924670T2 (de) 1996-05-23
JP2791419B2 (ja) 1998-08-27
IL90463A0 (en) 1990-01-18
JPH0225498A (ja) 1990-01-26
GR3018354T3 (en) 1996-03-31
CA1339740C (fr) 1998-03-17
NZ229337A (en) 1990-12-21
KR910000776A (ko) 1991-01-30
AR247890A1 (es) 1995-04-28
KR0155541B1 (ko) 1998-10-15
NO170023B (no) 1992-05-25
NO892230L (no) 1989-12-04
PH25908A (en) 1991-12-19
ZA894068B (en) 1990-09-26
ATE129716T1 (de) 1995-11-15
HUT50191A (en) 1989-12-28
FI92934B (fi) 1994-10-14
CN1040032A (zh) 1990-02-28
IE68455B1 (en) 1996-06-26
DE68924670D1 (de) 1995-12-07
HU203559B (en) 1991-08-28
AU608711B2 (en) 1991-04-11
IE891798L (en) 1989-12-02
FI92934C (fi) 1995-01-25
CN1023803C (zh) 1994-02-16
FI892682A0 (fi) 1989-06-01
ES2081857T3 (es) 1996-03-16
US5157116A (en) 1992-10-20
NO170023C (no) 1992-09-02
FI892682A (fi) 1989-12-03
NO892230D0 (no) 1989-06-01
PT90713B (pt) 1993-09-30
PT90713A (pt) 1989-12-29

Similar Documents

Publication Publication Date Title
DK267489A (da) 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler
DK143588D0 (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK658688A (da) 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler
DK609489D0 (da) Imidazolderivater, deres fremstilling og anvendelse
DK166590A (da) Substituerede allylaminderivater, deres fremstilling og anvendelse som laegemidler
DK55088D0 (da) 3,4-dihydro-2h-benzo(b)pyraner, deres fremstilling og anvendelse som laegemidler
DK219685A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK366888A (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
DK581586A (da) N-(pyrrol-l-yl)-pyridinaminer, deres fremstilling og anvendelse som laegemidler
DK103987A (da) Substituerede 1,3,4,9-tetrahydropyranooe3,4-baaindol-l-eddikesyrer, deres fremstilling og anvendelse som laegemidler
DK284688A (da) Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler
DK144885A (da) Substituerede 4-hydroxybenzopyraner eller farmaceutisk acceptable additionssalte deraf, deres fremstilling og anvendelse som laegemidler
DK648389A (da) Anthracylin-derivater, deres fremstilling og anvendelse som laegemidler
DK619989D0 (da) Dipeptidderivater, deres fremstilling og anvendelse som laegemidler
NO921908D0 (no) Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter
DK469389D0 (da) Piperidinyl-imidazol-derivater, deres fremstilling og anvendelse
DK501888D0 (da) 6-mercaptopurin-derivater, deres fremstilling og anvendelse som laegemidler
DK42888A (da) Arylthiadiazolylsulfonamider og derivater deraf, deres fremstilling og anvendelse som laegemiddel
DK568289A (da) 1-aminoalkyl-3-oxy-substituerede-4-aryl-1,3,4,5-tetrahydro-2h-1,3-benzodiazepin-2-oner, deres fremstilling og anvendelse som laegemidler
DK602184D0 (da) Imidazoquinoliner, deres fremstilling og anvendelse som laegemidler
DK278290D0 (da) Substituerede 6h-pyridooe4,3-baacarbazoler og deres anvendelse som laegemidler
DK111887D0 (da) Aromatiske omega-alkylimino-tetrahydro-6h-1,3-thiazin-6-on-derivater, deres fremstilling og anvendelse som laegemidler
DK37787D0 (da) 2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler
DK116787A (da) Diarylsulfidderivater, deres fremstilling og anvendelse som laegemidler
DK288989D0 (da) Cholestadienderivater, deres fremstilling og anvendelse som laegemidler

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment