DK2656859T3 - Topical application and transdermal delivery of the botulinum toxins - Google Patents

Topical application and transdermal delivery of the botulinum toxins Download PDF

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Publication number
DK2656859T3
DK2656859T3 DK13173674.6T DK13173674T DK2656859T3 DK 2656859 T3 DK2656859 T3 DK 2656859T3 DK 13173674 T DK13173674 T DK 13173674T DK 2656859 T3 DK2656859 T3 DK 2656859T3
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Prior art keywords
botulinum toxin
gly
positively charged
carrier
composition
Prior art date
Application number
DK13173674.6T
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Danish (da)
English (en)
Inventor
Michael D Dake
Jacob M Waugh
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Revance Therapeutics Inc
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Publication of DK2656859T3 publication Critical patent/DK2656859T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
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  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Virology (AREA)
DK13173674.6T 2004-03-03 2005-03-03 Topical application and transdermal delivery of the botulinum toxins DK2656859T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55001504P 2004-03-03 2004-03-03
EP05731866.9A EP1729821B1 (en) 2004-03-03 2005-03-03 Compositions and methods for topical application and transdermal delivery of botulinum toxins

Publications (1)

Publication Number Publication Date
DK2656859T3 true DK2656859T3 (en) 2016-01-11

Family

ID=34919562

Family Applications (3)

Application Number Title Priority Date Filing Date
DK13173674.6T DK2656859T3 (en) 2004-03-03 2005-03-03 Topical application and transdermal delivery of the botulinum toxins
DK15185714.1T DK2985039T3 (en) 2004-03-03 2005-03-03 Topical application and transdermal administration of botulinum toxins
DK05731866.9T DK1729821T3 (da) 2004-03-03 2005-03-03 Sammensætninger og fremgangsmåder til topisk påføring og transdermal afgivelse af botulinumtoksiner

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK15185714.1T DK2985039T3 (en) 2004-03-03 2005-03-03 Topical application and transdermal administration of botulinum toxins
DK05731866.9T DK1729821T3 (da) 2004-03-03 2005-03-03 Sammensætninger og fremgangsmåder til topisk påføring og transdermal afgivelse af botulinumtoksiner

Country Status (24)

Country Link
US (2) US8398997B2 (enExample)
EP (3) EP1729821B1 (enExample)
JP (1) JP5095388B2 (enExample)
KR (3) KR101322433B1 (enExample)
CN (2) CN102357062B (enExample)
AU (1) AU2005218665A1 (enExample)
BR (1) BRPI0508410B8 (enExample)
CA (1) CA2558408C (enExample)
CR (1) CR8602A (enExample)
CY (1) CY1120816T1 (enExample)
DK (3) DK2656859T3 (enExample)
ES (3) ES2691498T3 (enExample)
HU (1) HUE025656T2 (enExample)
IL (4) IL177816A (enExample)
LT (1) LT2985039T (enExample)
MX (2) MX345724B (enExample)
NO (1) NO20064490L (enExample)
NZ (1) NZ592041A (enExample)
PL (1) PL2985039T3 (enExample)
PT (3) PT1729821E (enExample)
SG (3) SG150568A1 (enExample)
SI (3) SI1729821T1 (enExample)
TR (1) TR201815364T4 (enExample)
WO (1) WO2005084410A2 (enExample)

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