DK2594272T3 - Aerosoliserede fluorquinoloner og anvendelser deraf - Google Patents

Aerosoliserede fluorquinoloner og anvendelser deraf Download PDF

Info

Publication number
DK2594272T3
DK2594272T3 DK12007354.9T DK12007354T DK2594272T3 DK 2594272 T3 DK2594272 T3 DK 2594272T3 DK 12007354 T DK12007354 T DK 12007354T DK 2594272 T3 DK2594272 T3 DK 2594272T3
Authority
DK
Denmark
Prior art keywords
levofloxacin
solution
aerosol
fluoroquinolone
mosmol
Prior art date
Application number
DK12007354.9T
Other languages
English (en)
Inventor
Keith A Bostian
Michael N Dudley
Mark Surber
David C Griffith
Olga Lomovskaya
Original Assignee
Horizon Orphan Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Horizon Orphan Llc filed Critical Horizon Orphan Llc
Application granted granted Critical
Publication of DK2594272T3 publication Critical patent/DK2594272T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Claims (16)

1. Fremgangsmåde til fremstilling afen aerosol afen opløsning omfattende levofloxacin eller ofloxacin og en divalent eller trivalent kation, hvor nævnte fremgangsmåde omfatter: opnåelse afen opløsning omfattende levofloxacin eller ofloxacin og en divalent eller trivalent kation; og aerosolisering af nævnte opløsning for at opnå en aerosol omfattende en aerodynamisk massemediandiameter på 5pm eller mindre, hvor nævnte aerosol er egnet til inhalering ind i en lunge.
2. Fremgangsmåden ifølge krav 1, hvor nævnte aerosolisering omfatter at forstøve nævnte opløsning med en forstøver, fortrinsvis en vibrerende netforstøver eller en kompressor-dreven forstøver.
3. Fremgangsmåden ifølge et hvilket som helst af kravene 1-2, hvor den divalente eller trivalente kation er valgt fra gruppen bestående af magnesium, calcium, aluminium, zink og jern.
4. Fremgangsmåden ifølge et hvilket som helst af kravene 1-3, hvor opløsningen har en permeabiliserende ionkoncentration fra omkring 25 mM til omkring 400 mM, fortrinsvis fra omkring 30 mM til omkring 300 mM, mere foretrukket fra omkring 40 mM til omkring 200 mM.
5. Fremgangsmåden ifølge krav 4, hvor den permeabiliserende ion er valgt fra chlorid og bromid.
6. Fremgangsmåden ifølge et hvilket som helst af kravene 1-5, hvor opløsningen har en koncentration af levofloxacin eller ofloxacin på omkring 1 mg/ml til omkring 700 mg/ml, fortrinsvis omkring 7 mg/ml til 700 mg/ml, fortrinsvis større end omkring 25 mg/ml, mere foretrukket større end omkring 35 mg/ml, endnu mere foretrukket større end omkring 40 mg/ml, yderst foretrukket større end omkring 50 mg/ml, og/eller eventuelt hvor opløsningen har en osmolalitet fra omkring 200 mOsmol/kg til omkring 1250 mOsmol/kg, fortrinsvis fra omkring 250 mOsmol/kg til omkring 1050 mOsmol/kg, mere foretrukket fra omkring 350 mOsmol/kg til omkring 750 mOsmol/kg; og/eller eventuelt hvor opløsningen har en pH fra omkring 4,5 til omkring 7,5, fortrinsvis fra omkring 5,5 til omkring 7,0, mere foretrukket fra omkring 5,5 til omkring 6,5.
7. Fremgangsmåden ifølge et hvilket som helst af kravene 1-6, hvor opløsningen omfatter magnesium og mere end omkring 50 mg/ml levofloxacin, og har en osmolalitet fra omkring 350 mOsmol/kg til omkring 750 mOsmol/kg, og en pH fra omkring 5,5 til omkring 6,5.
8. Fremgangsmåden ifølge et hvilket som helst af kravene 1-7, hvor aerosolen har en aerodynamisk massemediandiameter fra omkring 2 mikrometer til omkring 5 mikrometer med en geometrisk standardafvigelse mindre end eller lig med omkring 2,5 mikrometer, fortrinsvis fra omkring 2,5 mikrometer til omkring 4,5 mikrometer med en geometrisk standardafvigelse mindre end eller lig med omkring 1,8 mikrometer, mere foretrukket fra omkring 2,8 mikrometer til omkring 4,3 mikrometer med en geometrisk standardafvigelse mindre end eller lig med omkring 2 mikrometer.
9. Fremgangsmåden ifølge et hvilket som helst af kravene 1-8, hvor opløsningen yderligere omfatter en komponent valgt fra gruppen bestående af et sødemiddel, et andet antimikrobielt middel, dornasealpha, en hypertonisk formulering, mannitol og natriumchlorid.
10. Fremgangsmåden ifølge krav 9, hvor det andet antimikrobielle middel er valgt fra gruppen bestående af et aminoglycosid, polymyxin, monobactam, makrolid, ketolid, glycopeptid, og fluorquinolon.
11. Fremgangsmåden ifølge krav 9, hvor aminoglycosidet er tobramycin, polymyxinet er colistin, monobactammet er aztreonam, glycopeptidet er vancomycin eller fluorquinolonet er valgt fra gruppen bestående af lomefloxacin, pefloxacin, ciprofloxacin, gatifloxacin, gemifloxacin, moxifloxacin, tosufloxacin, pazufloxacin, rufloxacin, fleroxacin, balofloxacin, sparfloxacin, trovafloxacin, enoxacin, norfloxacin, clinafloxacin, grepafloxacin, sitafloxacin, temafloxacin, marbofloxacin, orbifloxacin, sarafloxacin, danofloxacin, difloxacin, enrofloxacin, garenoxacin, prulifloxacin, olamufloxacin, DX-619, TG-873870 og DW-286.
12. Farmaceutisk sammensætning, omfattende en vandig opløsning af levofloxacin eller ofloxacin og en divalent eller trivalent kation, hvor opløsningen er egnet til inhalering ind i en lunge.
13. Den farmaceutiske sammensætning ifølge krav 12, omfattende en vandig opløsning af levofloxacin og en divalent eller trivalent kation.
14. Den farmaceutiske sammensætning ifølge krav 13, hvor den divalente eller trivalente kation er valgt fra Mg2+, Ca2+, Zn2+, Fe2+ og Al3+.
15. Den farmaceutiske sammensætning ifølge krav 12 eller krav 13, hvor kationen er en divalent kation valgt fra magnesium eller calcium.
16. Den farmaceutiske sammensætning ifølge krav 13, hvor kationen er Mg2+.
DK12007354.9T 2005-05-18 2006-05-18 Aerosoliserede fluorquinoloner og anvendelser deraf DK2594272T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68253005P 2005-05-18 2005-05-18
US69616005P 2005-07-01 2005-07-01
US77330006P 2006-02-13 2006-02-13
EP06760146.8A EP1901749B1 (en) 2005-05-18 2006-05-18 Aerosolized fluoroquinolones and uses thereof

Publications (1)

Publication Number Publication Date
DK2594272T3 true DK2594272T3 (da) 2018-09-03

Family

ID=37056548

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12007354.9T DK2594272T3 (da) 2005-05-18 2006-05-18 Aerosoliserede fluorquinoloner og anvendelser deraf
DK06760146.8T DK1901749T3 (da) 2005-05-18 2006-05-18 Aerosoliserede fluorquinoloner og anvendelser heraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06760146.8T DK1901749T3 (da) 2005-05-18 2006-05-18 Aerosoliserede fluorquinoloner og anvendelser heraf

Country Status (23)

Country Link
EP (2) EP1901749B1 (da)
JP (2) JP5279487B2 (da)
KR (3) KR101488403B1 (da)
CN (2) CN104173323B (da)
AU (1) AU2006247053B2 (da)
CA (2) CA2900093C (da)
CY (2) CY1118137T1 (da)
DK (2) DK2594272T3 (da)
ES (2) ES2685315T3 (da)
HR (1) HRP20161230T2 (da)
HU (3) HUE030419T2 (da)
IL (3) IL187346A (da)
LT (2) LT1901749T (da)
LU (1) LUC00004I2 (da)
ME (1) ME02562B (da)
MX (1) MX359219B (da)
NZ (3) NZ591509A (da)
PL (2) PL2594272T3 (da)
PT (2) PT1901749T (da)
RS (1) RS55114B1 (da)
RU (2) RU2603638C2 (da)
SI (1) SI2594272T1 (da)
WO (1) WO2006125132A2 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
RU2008136460A (ru) * 2006-02-10 2010-03-20 Пари Фарма ГмбХ (DE) Фармацевтический аэрозоль
EP2030644A1 (en) 2007-08-31 2009-03-04 PARI Pharma GmbH Aerosols for sinunasal drug delivery
AU2008316794B2 (en) * 2007-10-25 2015-04-23 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
EP2098219A1 (en) 2008-03-05 2009-09-09 PARI Pharma GmbH Macrolide compositions having improved taste and stability
US8834930B2 (en) 2008-05-15 2014-09-16 Novartis Ag Pulmonary delivery of a fluoroquinolone
US8815838B2 (en) * 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
PL2346509T3 (pl) 2008-10-07 2021-03-08 Horizon Orphan Llc Lewofloksacyna w postaci aerozolu dla zmniejszania stanu zapalnego płuc
WO2010096242A1 (en) * 2009-02-18 2010-08-26 Aradigm Corporation Ph-modulated formulations for pulmonary delivery
SG10201811494SA (en) * 2009-04-24 2019-01-30 Horizon Orphan Llc Methods of treating a pulmonary bacterial infection using fluoroquinolones
US8536167B2 (en) * 2009-07-02 2013-09-17 Alcon Research, Ltd. Methods for treating ophthalmic, otic, or nasal infections
CN102711760A (zh) * 2009-08-19 2012-10-03 Mpex医药有限公司 雾化抗生素用于治疗慢性阻塞性肺病的用途
SI2470165T1 (en) 2009-08-28 2018-08-31 Hercules Llc Composition of film for coating from solid powdery compounds
AU2015275224C1 (en) * 2009-09-04 2017-11-16 Horizon Therapeutics U.S. Holding Llc Use of aerosolized levofloxacin for treating cystic fibrosis
MX353288B (es) 2009-09-04 2018-01-08 Raptor Pharmaceuticals Inc Uso de levofloxacina aerosolizada para el tratamiento de fibrosis quistica.
RU2597842C2 (ru) * 2010-07-12 2016-09-20 Кселлия Фармасьютикалз Апс Лечение легочных инфекций с помощью введения тобрамицина путем аэролизации
CN101914483B (zh) * 2010-09-02 2013-07-31 福建新大陆生物技术股份有限公司 一种液基薄层细胞保存处理液及其用途
MX354828B (es) 2010-09-29 2018-03-22 Pulmatrix Operating Co Inc Polvos secos de cationes metálicos monovalentes para inhalación.
ES2913095T3 (es) * 2011-01-31 2022-05-31 Avalyn Pharma Inc Compuestos de pirfenidona y análogos de piridona en aerosol y usos de los mismos
EP2491920A1 (en) * 2011-02-25 2012-08-29 Deva Holding Anonim Sirketi Effervescent tablet, sachet and dry syrup of gemifloxacin
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
SG11201407676VA (en) 2012-05-21 2015-03-30 Agency Science Tech & Res A dry powder formulation
PL2970244T3 (pl) * 2013-03-15 2020-01-31 Università Degli Studi Di Milano - Bicocca Nowe związki 1,2,4-oksadiazolu aktywne względem patogenów Gram-dodatnich
US11064913B2 (en) 2013-10-25 2021-07-20 Force Impact Technologies, Inc. Impact sensing wearable device and method
JP2016535774A (ja) * 2013-10-30 2016-11-17 インスピリックス, インコーポレーテッドInspirx, Inc. 多剤耐性結核治療のための噴霧吸入による免疫化学療法
CN103755730B (zh) * 2014-01-28 2016-05-04 广西师范大学 马波沙星-钙螯合物及其合成方法和应用
FR3020810B1 (fr) * 2014-05-06 2016-05-06 Servier Lab Nouveau sel de l'ivabradine et son procede de preparation.
EP3266445B1 (en) 2015-03-02 2022-05-11 Takeda Pharmaceutical Company Limited Suspension or composition containing nano-cocrystal and manufacturing method therefor
CN105534988B (zh) * 2015-12-21 2019-04-16 山东省蚕业研究所 一种蚕用增产、防治细菌病药物及其应用
WO2018011040A1 (en) * 2016-07-13 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Plga microparticles loaded with a fluoroquinolone for the treatment of respiratory diseases
CN109260180A (zh) * 2017-07-17 2019-01-25 北京盈科瑞创新药物研究有限公司 一种盐酸莫西沙星雾化吸入用溶液制剂及其制备方法
CN108414313A (zh) * 2018-02-27 2018-08-17 中国科学院北京基因组研究所 一种痰液液化试剂、含有其的试剂盒及其应用
US11510618B2 (en) 2018-12-20 2022-11-29 Force Impact Technologies, Inc. Method of manufacturing mouth guard having internal components for sensing impact forces
GB201900389D0 (en) * 2019-01-11 2019-02-27 Queens Univ Of Belfast Solvent and water-free lipid-based nanoparticles and their methods of manufacture
US20200253960A1 (en) * 2019-02-11 2020-08-13 Aradigm Corporation Antibiotic formulations for treating of cavity infections
KR102208837B1 (ko) * 2019-05-14 2021-02-01 경북대학교 산학협력단 메틸 갈레이트 및 플로로퀴놀론 계열 항균제를 포함하는 박테리아의 장 부착, 침입 억제, 또는 항생제 내성 억제용 조성물
CN112569211A (zh) * 2019-09-27 2021-03-30 盈科瑞（天津）创新医药研究有限公司 一种吸入用加替沙星溶液及其制备方法
CN110823876B (zh) * 2019-11-14 2022-06-28 东南大学 一种光学复合金属纳米材料的制备方法和应用
CN111053761B (zh) * 2020-01-16 2022-05-03 杭州旦承医药科技有限公司 一种吸入用双膦酸类药物及其制备方法及其在慢性阻塞性肺疾病的用途
WO2022020385A1 (en) * 2020-07-20 2022-01-27 Virushield, Inc. Improved antiviral compound with uv reflectivity
WO2022034226A1 (en) 2020-08-14 2022-02-17 Universidad De Navarra Avermectin and milbemycin compositions for inhalation
CN112322696B (zh) * 2020-11-19 2022-06-03 浙江省动物疫病预防控制中心 一种菌群耐药性强度评估方法
WO2022240897A1 (en) * 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
CN113952320B (zh) * 2021-09-18 2022-03-18 健康元药业集团股份有限公司 一种包含妥布霉素吸入溶液的药物组件及其用途

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2587215A (en) 1949-04-27 1952-02-26 Frank P Priestly Inhalator
BE555319A (da) 1956-03-21 1900-01-01
BE556587A (da) 1957-01-31 1957-04-11
US3669113A (en) 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3507277A (en) 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3456644A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456646A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456645A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
GB1268051A (en) 1968-06-07 1972-03-22 Fisons Pharmaceuticals Ltd Inhalation device
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3636949A (en) 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
BE758834A (fr) 1969-11-13 1971-05-12 Riker Laboratoires Inc Distributeur d'aerosol actionne par inhalation
GB1383761A (en) 1971-02-25 1974-02-12 Woodcraft Dc Inhalation device for use with an aerosol container
US3732864A (en) 1971-06-07 1973-05-15 Schering Corp Inhalation coordinated aerosol dispensing device
IT941426B (it) 1971-07-17 1973-03-01 Isf Spa Inalatore a camera di turbinio per sostanze medicamentose polveriformi
US3826255A (en) 1972-06-22 1974-07-30 Hudson Oxygen Therapy Sales Co Intermittent positive pressure breathing manifold
FR2224175B1 (da) 1973-04-04 1978-04-14 Isf Spa
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
IT1017153B (it) 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
SU628930A1 (ru) 1974-11-26 1978-10-25 Московский научно-исследовательский институт туберкулеза Устройство дл введени порошкообразного лекарственного вещества
US3948264A (en) 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US4147166A (en) 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
US4263907A (en) 1979-05-14 1981-04-28 Lindsey Joseph W Respirator nebulizer
BR8007911A (pt) 1979-12-06 1981-06-16 Glaxo Group Ltd Inalador aperfeicoado
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4688218A (en) 1981-07-15 1987-08-18 Etablissement Public De Diffusion Dit "Telediffusion De France" Multiplex channels for continuous flow for numerical signal
US4470412A (en) 1982-03-19 1984-09-11 Trutek Research, Inc. Inhalation valve
US4510929A (en) 1982-04-30 1985-04-16 Bordoni Maurice E Disposable radioactive aerosol inhalation apparatus
US4649911A (en) 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
GB8328808D0 (en) 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
US4624251A (en) 1984-09-13 1986-11-25 Riker Laboratories, Inc. Apparatus for administering a nebulized substance
US4648393A (en) 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
FR2575678B1 (fr) 1985-01-04 1988-06-03 Saint Gobain Vitrage Ejecteur pneumatique de poudre
US4805811A (en) 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
US4811731A (en) 1985-07-30 1989-03-14 Glaxo Group Limited Devices for administering medicaments to patients
US4809692A (en) 1986-01-31 1989-03-07 Trudell Medical Pediatric asthmatic medication inhaler
IT1204826B (it) 1986-03-04 1989-03-10 Chiesi Farma Spa Composizioni farmaceutiche per inalazione
US4790305A (en) 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
US5119806A (en) 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
KR910000142B1 (ko) 1987-05-29 1991-01-21 니혼 다바고 상교오 가부시기가이샤 담배용 필터
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US4907538A (en) 1988-05-09 1990-03-13 Little Suamico Products Inc. Multiple bin cow feeder
US4832015A (en) 1988-05-19 1989-05-23 Trudell Medical Pediatric asthmatic inhaler
IT1217890B (it) 1988-06-22 1990-03-30 Chiesi Farma Spa Dispositivo per l'inalazione di aerosol dosati
FR2636716B1 (fr) 1988-09-21 1990-12-07 Staubli Sa Ets Dispositif pour l'accouplement des platines porte-elements des raccords multiples
EP0363060B1 (en) 1988-10-04 1994-04-27 The Johns Hopkins University Aerosol inhaler
DK479189D0 (da) 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
US5012804A (en) 1989-03-06 1991-05-07 Trudell Medical Medication inhaler with adult mask
US5012803A (en) 1989-03-06 1991-05-07 Trudell Medical Modular medication inhaler
GB8908647D0 (en) 1989-04-17 1989-06-01 Glaxo Group Ltd Device
ES2087911T3 (es) 1989-04-28 1996-08-01 Riker Laboratories Inc Dispositivo de inhalacion de polvo seco.
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5113855A (en) 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5192548A (en) 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
GB9015077D0 (en) 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
IT1243344B (it) 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
US5060643A (en) 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
US5217004A (en) 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US5040527A (en) 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
AU651882B2 (en) 1991-05-14 1994-08-04 Visiomed Group Limited Aerosol inhalation device
ATE359842T1 (de) 1991-07-02 2007-05-15 Nektar Therapeutics Abgabevorrichtung für nebelförmige medikamente
ATE155695T1 (de) 1991-11-07 1997-08-15 Ritzau Pari Werk Gmbh Paul Vernebler insbesondere zur anwendung in geräten für die inhalationstherapie
DE4140689B4 (de) 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
DE4142238A1 (de) 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
DE9307115U1 (de) 1992-05-29 1993-09-02 Ggu Gesundheits Umweltforsch Vorrichtung zur Erzeugung inhalierbarer Wirkstoffe
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
NZ250105A (en) 1992-11-09 1996-07-26 Monaghan Canadian Ltd Inhalator mask; one-way valve opens upon exhalation
CZ287848B6 (en) 1992-12-18 2001-02-14 Schering Corp Inhalator of powder substances
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5642730A (en) 1994-06-17 1997-07-01 Trudell Medical Limited Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
WO1996025918A1 (en) 1995-02-24 1996-08-29 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US6427682B1 (en) 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
ATE209518T1 (de) 1995-06-21 2001-12-15 Asta Medica Ag Arzneipulverkartusche mit integrierter dosiereinrichtung, sowie pulverinhalator
AUPN417395A0 (en) 1995-07-14 1995-08-10 Techbase Pty. Ltd. An improved spacer
JP5042447B2 (ja) * 1995-07-21 2012-10-03 第一三共株式会社 混合製剤
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
SE9502799D0 (sv) 1995-08-10 1995-08-10 Astra Ab Device in inhalers
CZ293747B6 (cs) * 1995-12-21 2004-07-14 Pfizer Inc. Vodný farmaceutický roztok vhodný pro injekční podávání hostiteli a jeho použití
US6026809A (en) 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
US5694920A (en) 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US6083922A (en) 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
FR2747311B1 (fr) 1996-04-10 1998-08-14 Pf Medicament Inhalateur a poudre et a air comprime
AU743174B2 (en) 1997-10-08 2002-01-17 Sepracor, Inc. Dosage form for aerosol administration
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US6293279B1 (en) 1997-09-26 2001-09-25 Trudell Medical International Aerosol medication delivery apparatus and system
US6003512A (en) 1997-11-13 1999-12-21 Lovelace Respiratory Research Institute Dust gun-aerosol generator and generation
EP1149602B1 (en) 1997-11-19 2015-01-07 Aptar France SAS Spray device for an inhaler suitable for respiratory therapies
US6192876B1 (en) 1997-12-12 2001-02-27 Astra Aktiebolag Inhalation apparatus and method
US6223746B1 (en) 1998-02-12 2001-05-01 Iep Pharmaceutical Devices Inc. Metered dose inhaler pump
US6026807A (en) 1998-02-27 2000-02-22 Diemolding Corporation Metered dose inhaler cloud chamber
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
NZ509328A (en) 1998-07-24 2002-11-26 Jago Res A Medicinal aerosol formulations
GB2343122B (en) 1998-10-26 2003-01-08 Medic Aid Ltd Improvements in and relating to nebulisers
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6584971B1 (en) 1999-01-04 2003-07-01 Medic-Aid Limited Drug delivery apparatus
US6338443B1 (en) 1999-06-18 2002-01-15 Mercury Enterprises, Inc. High efficiency medical nebulizer
DK1223935T3 (da) * 1999-06-29 2008-02-04 Lg Life Sciences Ltd Anvendelse af gemifloxacinforbindelser mod bakterier
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
ATE313318T1 (de) 1999-10-29 2006-01-15 Nektar Therapeutics Trockenpulverzusammensetzungen mit verbesserter dispersität
MXPA02004349A (es) * 1999-11-01 2003-09-22 Alcon Inc Composiciones farmaceuticas que contienen un farmaco antibiotico de fluoroquinolona y goma de xantano.
US20010049366A1 (en) * 2000-02-09 2001-12-06 Alcon Universal Ltd. Topical solution formulations containing an antibiotic and a corticosteroid
CA2733850C (en) 2000-04-11 2013-10-22 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
WO2002018345A1 (en) * 2000-08-29 2002-03-07 Chiron Corporation Quinoline antibacterial compounds and methods of use thereof
TWI290053B (en) * 2000-09-19 2007-11-21 Daiichi Seiyaku Co Medicinal composition for preventing the generation of a disagreeable taste
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6626173B2 (en) 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
BR0207930A (pt) * 2001-03-05 2004-03-02 Ortho Mcneil Pharm Inc Composições farmacêuticas lìquidas com sabor mascarado
US6523536B2 (en) 2001-03-12 2003-02-25 Birdsong Medical Devices, Inc. Dual-canister inhaler having a spacer and easy to operate lever mechanism
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
JP2005507397A (ja) * 2001-10-09 2005-03-17 ブリストル−マイヤーズ　スクイブ　カンパニー 速溶性の経口製剤
EP1438019A1 (en) 2001-10-24 2004-07-21 PARI GmbH Spezialisten für effektive Inhalation Kit for the preparation of a pharmaceutical composition
US20030171340A1 (en) * 2002-02-07 2003-09-11 Jenefir Isbister Methods of disease treatment using metal-complexed tetracycline antibiotics
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
RU2373937C9 (ru) * 2003-02-10 2010-07-27 Байер Шеринг Фарма Акциенгезельшафт Лечение бактериальных заболеваний органов дыхания путем местного применения фторхинолонов
DE60318384T2 (de) * 2003-03-19 2009-02-19 The Jordanian Pharmaceutical Manufacturing Co. Ltd. Nicht-hygroskopische pharmazeutische Zusammensetzungen die nicht hydratisierte Quinolon-Carbonsäuren enthalten
RU2245134C1 (ru) * 2003-09-02 2005-01-27 Открытое акционерное общество "Красфарма" Состав офлоксацина для инъекций
JP2008500965A (ja) * 2004-03-17 2008-01-17 エムペックス・ファーマシューティカルズ・インコーポレーテッド 細菌の排出ポンプ阻害剤の使用および投与
KR101483297B1 (ko) * 2005-03-24 2015-01-21 다이이찌 산쿄 가부시키가이샤 의약용 조성물

Also Published As

Publication number Publication date
AU2006247053A2 (en) 2006-11-23
KR20140085605A (ko) 2014-07-07
IL239821A0 (en) 2015-08-31
NZ597290A (en) 2013-07-26
HUS1700005I1 (hu) 2017-02-28
RS55114B1 (sr) 2016-12-30
KR101488403B1 (ko) 2015-02-04
WO2006125132A3 (en) 2006-12-28
PT1901749T (pt) 2016-11-04
DK1901749T3 (da) 2016-10-24
AU2006247053B2 (en) 2013-05-23
MX359219B (es) 2018-09-19
CA2608273A1 (en) 2006-11-23
PL2594272T3 (pl) 2018-11-30
RU2603638C2 (ru) 2016-11-27
ES2685315T3 (es) 2018-10-08
LUC00004I1 (da) 2017-02-01
PL1901749T3 (pl) 2017-04-28
WO2006125132A2 (en) 2006-11-23
EP2594272A3 (en) 2013-12-04
PT2594272T (pt) 2018-07-31
SI2594272T1 (sl) 2018-10-30
JP5690853B2 (ja) 2015-03-25
JP5279487B2 (ja) 2013-09-04
CA2900093C (en) 2018-11-13
CN104173323B (zh) 2018-04-03
LTC1901749I2 (lt) 2019-01-10
KR101538677B1 (ko) 2015-07-22
CN101222927A (zh) 2008-07-16
KR20140021719A (ko) 2014-02-20
HUE038814T2 (hu) 2018-11-28
ME02562B (me) 2017-02-20
RU2016140347A3 (da) 2020-07-03
CN104173323A (zh) 2014-12-03
JP2008540676A (ja) 2008-11-20
LTPA2017002I1 (lt) 2017-03-10
JP2013082736A (ja) 2013-05-09
EP1901749A2 (en) 2008-03-26
NZ563417A (en) 2012-01-12
EP2594272B1 (en) 2018-07-11
CN101222927B (zh) 2016-08-24
AU2006247053A1 (en) 2006-11-23
EP1901749B1 (en) 2016-08-03
IL239821B (en) 2018-03-29
ES2599313T3 (es) 2017-02-01
RU2011118619A (ru) 2012-11-20
IL187346A (en) 2016-04-21
HUE030419T2 (en) 2017-05-29
EP2594272A2 (en) 2013-05-22
IL187346A0 (en) 2008-04-13
LT1901749T (lt) 2016-10-25
CA2900093A1 (en) 2006-11-23
CA2608273C (en) 2015-10-20
RU2016140347A (ru) 2018-04-13
HRP20161230T1 (hr) 2016-11-18
LUC00004I2 (da) 2017-05-02
NZ591509A (en) 2012-10-26
CY2017006I2 (el) 2017-06-28
KR20080052511A (ko) 2008-06-11
KR101488402B1 (ko) 2015-02-03
CY2017006I1 (el) 2017-06-28
HRP20161230T2 (hr) 2017-08-11
IL227521A (en) 2016-04-21
CY1118137T1 (el) 2017-06-28

Similar Documents

Publication Publication Date Title
DK2594272T3 (da) Aerosoliserede fluorquinoloner og anvendelser deraf
US10987357B2 (en) Aerosolized fluoroquinolones and uses thereof
US10722519B2 (en) Aerosol fluoroquinolone formulations for improved pharmacokinetics
US7838532B2 (en) Aerosolized fluoroquinolones and uses thereof
AU2013203605B2 (en) Aerosolized fluoroquinolones and uses thereof
US20220047604A1 (en) Aerosolized fluoroquinolones and uses thereof
RU2428986C2 (ru) Аэрозольные фторхинолоны и их применения