DK2508621T3 - Optimering og individualisering af valg og dosering af medikamenter - Google Patents

Optimering og individualisering af valg og dosering af medikamenter Download PDF

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Publication number
DK2508621T3
DK2508621T3 DK11185491.5T DK11185491T DK2508621T3 DK 2508621 T3 DK2508621 T3 DK 2508621T3 DK 11185491 T DK11185491 T DK 11185491T DK 2508621 T3 DK2508621 T3 DK 2508621T3
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drug
patient
functional
dose
specific
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DK11185491.5T
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Tracy A Glauser
Richard Wenstrup
Alexander A Vinks
John Pestian
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Childrens Hosp Medical Center
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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Claims (2)

1. Fremgangsmåde til bestemmelse af en startdosis af et etneuropsykiatrisk lægemiddel til indgivelse til en patient med behov herfor, hvilken fremgangsmåde omfatter (a) modtagelse af den normale lægemiddeldosis til populationen, som repræsenterer patienten (Dpop), på en processor; (b) modtagelse af patientens genotype for et panel af gener på en processor omfattende følgende cytochrom P450 (CYP) gener: CYP2D6, CYP2C19 og CYP2C9; (c) bestemmelse af antallet af funktionelle og ikke-funktionelle alleler for hvert gen på basis af genotypen; (d) placering af patienten i en metabolisme-fænotype-undergruppe på basis af antallet af funktionelle alleler for hvert af CYP-generne, hvor metabolismeundergruppen udvælges fra en af følgende: ekstensiv metabolisme (EM) = 2 funktionelle alleler, intermediær metabolisme (IM) = 1 funktionel allel og langsom metabolisme (PM) = 0 funktionelle alleler; (e) modtagelse af frekvensen af metabolisme-fænotype-undergrupperne i populationen på en processor; og (f) via en processor bestemmelse af startdosen af lægemidlet eksprimeret som en procentdel på basis af antallet af ikke-funktionelle alleler som følger: procentvis reduktion for en ikke-funktionel allel: (DRem% - DR!m%)/ DRem% procentvis reduktion for to ikke-funktionelle alleler: (DRem% - DRpM%)/ DRkm% hvor DRX% er dosisanbefalingen for metabolisme-undergruppen X eksprimeret som en procentdel af den normale lægemiddeldosis (DpoP), hvor Dpop = fpM(DpM) + fiM(Dim) + ίεινιφΕΜ), og hvor Dem reduceres med 20 % for hver ikke-funktionel CYP2D6 eller CYP2C19 allel og med 40 % for hver ikke-funktionel CYP2C9 allel.
2. Fremgangsmåde ifølge krav 1, hvorved den normale lægemiddeldosis (Dpop) reduceres med 20 % for hver ikke-funktionel CYP2D6 allel, som detekteres i patienten, og lægemidlet udvælges fra gruppen bestående af atomoxetin, imipramin, perp- henazin, doxepin, maprotilin, trimipramin, thioridazin, desipramin, clomipramin, zuclopenthixol, paroxetin, venlafaxin, flupentixol og mianserin; 20 % for hver ikke-funktionel CYP2C19 allel, der detekteres i patienten, og lægemidlet udvælges fra gruppen bestående af trimipramin, amitryptilin, moclobemid, imipramin, citalopram, clomipramin og fluoxetin; og 40 % for hver ikke-funktionel CYP2C9 allel, der detekteres i patienten, og lægemidlet udvælges fra gruppen bestående af amaryl, glipizid, diabeta, glu-covance, cozaar, hyzaar, diabinese, orinase, tolinase og warfarin.
DK11185491.5T 2005-11-29 2006-11-28 Optimering og individualisering af valg og dosering af medikamenter DK2508621T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74043005P 2005-11-29 2005-11-29
US78311806P 2006-03-16 2006-03-16
EP06838538A EP1958111A4 (en) 2005-11-29 2006-11-28 OPTIMIZATION AND PERSONALIZATION OF SELECTION AND DOSAGE OF DRUGS

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DK2508621T3 true DK2508621T3 (da) 2015-01-12

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US (4) US8589175B2 (da)
EP (4) EP3703058A1 (da)
JP (4) JP2009517186A (da)
AU (1) AU2006320633A1 (da)
CA (3) CA2911569C (da)
DK (1) DK2508621T3 (da)
ES (1) ES2529211T3 (da)
HK (2) HK1176093A1 (da)
WO (1) WO2007064675A2 (da)

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