DK2489662T3 - Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivater - Google Patents

Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivater

Info

Publication number
DK2489662T3
DK2489662T3 DK12000613.5T DK12000613T DK2489662T3 DK 2489662 T3 DK2489662 T3 DK 2489662T3 DK 12000613 T DK12000613 T DK 12000613T DK 2489662 T3 DK2489662 T3 DK 2489662T3
Authority
DK
Denmark
Prior art keywords
phenylthiazolidin
alkylimino
benzylidene
intermediates
derivatives
Prior art date
Application number
DK12000613.5T
Other languages
Danish (da)
English (en)
Inventor
Stefan Abele
Martin Bolli
Gunther Schmidt
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK2489662T3 publication Critical patent/DK2489662T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK12000613.5T 2006-11-23 2007-11-22 Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivater DK2489662T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006054409 2006-11-23
EP07849225.3A EP2094676B1 (en) 2006-11-23 2007-11-22 New process for the preparation of 2-iminothiazolidin-4-one derivatives

Publications (1)

Publication Number Publication Date
DK2489662T3 true DK2489662T3 (da) 2014-10-20

Family

ID=39316391

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12000613.5T DK2489662T3 (da) 2006-11-23 2007-11-22 Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivater
DK07849225.3T DK2094676T3 (da) 2006-11-23 2007-11-22 Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK07849225.3T DK2094676T3 (da) 2006-11-23 2007-11-22 Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater

Country Status (13)

Country Link
US (1) US8263780B2 (esLanguage)
EP (2) EP2489662B1 (esLanguage)
JP (1) JP4669564B2 (esLanguage)
KR (1) KR101255879B1 (esLanguage)
CN (2) CN103087004A (esLanguage)
AU (1) AU2007323042B2 (esLanguage)
CA (1) CA2669069C (esLanguage)
DK (2) DK2489662T3 (esLanguage)
ES (2) ES2410793T3 (esLanguage)
IL (1) IL198847A (esLanguage)
MX (1) MX2009005048A (esLanguage)
TW (1) TWI460166B (esLanguage)
WO (1) WO2008062376A2 (esLanguage)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
CN100567275C (zh) 2003-11-21 2009-12-09 埃科特莱茵药品有限公司 作为免疫抑制剂的5-(苯基-(z)-亚基)-噻唑烷-4-酮衍生物
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
KR101718639B1 (ko) * 2008-03-17 2017-03-21 액테리온 파마슈티칼 리미티드 선별적 ｓ1ｐ₁ 수용체 작동약에 대한 투약 섭생
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
US9340518B2 (en) * 2012-08-17 2016-05-17 Actelion Pharmaceuticals Ltd. Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process
PL3256125T3 (pl) 2014-12-11 2022-05-09 Actelion Pharmaceuticals Ltd Schemat dawkowania ponesimodu, selektywnego agonisty receptora s1p1
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11220488B2 (en) 2017-09-19 2022-01-11 Teva Pharmaceuticals International Gmbh Crystalline polymorph of Ponesimod
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US20220315545A1 (en) * 2019-07-10 2022-10-06 Bayer Aktiengesellschaft Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones
EP3997076A1 (de) * 2019-07-10 2022-05-18 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-(phenylimino)-1,3-thiazolidin-4-onen
CA3156298A1 (en) 2019-10-31 2021-05-06 Laetitia POUZOL Combination of a cxcr7 antagonist with an s1p1 receptor modulator
KR20200019639A (ko) 2020-01-30 2020-02-24 전대연 만남의 스마트 도착시스템
BR112022014704A2 (pt) * 2020-02-18 2022-10-11 Bayer Ag Processo para a preparação de 2-(fenilimino)-3-alquil-1,3-tiazolidin-4-onas
WO2023022896A1 (en) 2021-08-17 2023-02-23 Teva Czech Industries S.R.O Polymorphs of ponesimod
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152691A1 (en) * 2022-02-10 2023-08-17 Metrochem Api Pvt Ltd Process for the preparation of ponesimod and its intermediates thereof
CN117924210A (zh) * 2024-01-22 2024-04-26 赣南师范大学 一种2-亚氨基噻唑烷-4-酮类化合物的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077402A (en) * 1954-12-06 1963-02-12 Polaroid Corp Photographic color processes, products, and compositions
NL270002A (esLanguage) 1960-10-08
OA03835A (fr) * 1970-07-17 1971-12-24 Rhone Poulenc Sa Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent.
DE69123738T2 (de) 1990-04-27 1997-07-03 Orion-Yhtymae Oy, Espoo Pharmakologisch aktive catecholderivate
TW221689B (esLanguage) * 1991-08-27 1994-03-11 Otsuka Pharma Co Ltd
WO1994019335A1 (en) * 1993-02-26 1994-09-01 Otsuka Pharmaceutical Co., Ltd. Thiazole or imidazole derivatives as maillard reaction inhibitors
KR960022486A (ko) 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
US6353006B1 (en) * 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
DE60038687T2 (de) 1999-09-14 2009-05-28 Shionogi & Co., Ltd. 2-imino-1,3-thiazin-derivate
PT1142885E (pt) * 1999-11-12 2007-02-28 Fujimoto Brothers Co Ltd Derivados de 2-(n-cianoimino)tiazolidin-4-ona
US20050019825A9 (en) * 2002-03-15 2005-01-27 Qing Dong Common ligand mimics: pseudothiohydantoins
RS115904A (sr) 2002-07-10 2006-12-15 Applied Research Systems Ars Holding N.V. Derivati benzena fuzionisani sa azolidinon vinilom
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
CA2507256A1 (en) * 2002-11-22 2004-06-10 Smithkline Beecham Corporation Thiazolidine compounds in the treatment of anemic conditions
US20040167192A1 (en) * 2003-01-16 2004-08-26 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
CN100567275C (zh) * 2003-11-21 2009-12-09 埃科特莱茵药品有限公司 作为免疫抑制剂的5-(苯基-(z)-亚基)-噻唑烷-4-酮衍生物
JP2007523957A (ja) * 2004-02-25 2007-08-23 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
WO2006094233A1 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N,n'-dicyclic isothiourea sirtuin modulators
KR101718639B1 (ko) * 2008-03-17 2017-03-21 액테리온 파마슈티칼 리미티드 선별적 ｓ1ｐ₁ 수용체 작동약에 대한 투약 섭생
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms

Also Published As

Publication number Publication date
EP2094676A2 (en) 2009-09-02
IL198847A (en) 2015-07-30
EP2094676B1 (en) 2013-04-10
WO2008062376A3 (en) 2008-07-10
ES2523401T3 (es) 2014-11-25
CN101541772B (zh) 2013-04-17
DK2094676T3 (da) 2013-06-10
WO2008062376A2 (en) 2008-05-29
US20110201821A2 (en) 2011-08-18
US20100317867A1 (en) 2010-12-16
AU2007323042B2 (en) 2012-12-20
CN103087004A (zh) 2013-05-08
CA2669069C (en) 2015-02-17
TWI460166B (zh) 2014-11-11
MX2009005048A (es) 2009-05-25
KR20090081009A (ko) 2009-07-27
EP2489662B1 (en) 2014-08-06
AU2007323042A1 (en) 2008-05-29
CN101541772A (zh) 2009-09-23
US8263780B2 (en) 2012-09-11
JP2010510976A (ja) 2010-04-08
BRPI0718986A2 (pt) 2014-02-11
TW200831474A (en) 2008-08-01
EP2489662A1 (en) 2012-08-22
JP4669564B2 (ja) 2011-04-13
CA2669069A1 (en) 2008-05-29
KR101255879B1 (ko) 2013-04-17
ES2410793T3 (es) 2013-07-03
IL198847A0 (en) 2010-02-17

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