DK2453895T3 - (+) - morfinaner som antagonister af toll-lignende receptor 9 og terapeutiske anvendelser deraf - Google Patents

(+) - morfinaner som antagonister af toll-lignende receptor 9 og terapeutiske anvendelser deraf Download PDF

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DK2453895T3
DK2453895T3 DK10736929.0T DK10736929T DK2453895T3 DK 2453895 T3 DK2453895 T3 DK 2453895T3 DK 10736929 T DK10736929 T DK 10736929T DK 2453895 T3 DK2453895 T3 DK 2453895T3
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cancer
pain
tlr9
cell
disease
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DK10736929.0T
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Bobby N Trawick
David W Berberich
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Mallinckrodt Llc
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    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
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  • Diabetes (AREA)
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  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Claims (3)

  1. 1» Forbindelse valgt fra følgende formler:
    5
    eller et farmaceutisk acceptabelt salt deraf.
  2. 2. Fremgangsmåde til inhlbering af TLR9-aktivering, hvilken fremgangsmåde omfatter at. bringe in vitro en celle der udtrykker TLR.9 i kontakt med en forbindelse vaigt fra følgende formler:
  3. 3. Fremgangsmåden ifølge krav 2, hvor cellen er valgt fra en g I ialcelle, en mikroglialælle, og en astrocyt.
DK10736929.0T 2009-07-16 2010-07-16 (+) - morfinaner som antagonister af toll-lignende receptor 9 og terapeutiske anvendelser deraf DK2453895T3 (da)

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US22601509P 2009-07-16 2009-07-16
US28687709P 2009-12-16 2009-12-16
PCT/US2010/042210 WO2011009015A1 (en) 2009-07-16 2010-07-16 (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

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DK2453895T3 true DK2453895T3 (da) 2018-08-27

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US (1) US20110015219A1 (da)
EP (1) EP2453895B1 (da)
JP (1) JP5864417B2 (da)
AU (1) AU2010273253B2 (da)
CA (1) CA2768236C (da)
DK (1) DK2453895T3 (da)
ES (1) ES2674018T3 (da)
NO (1) NO2453895T3 (da)
PL (1) PL2453895T3 (da)
TR (1) TR201809739T4 (da)
WO (1) WO2011009015A1 (da)

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PL2222642T3 (pl) * 2007-12-17 2014-07-31 SpecGx LLC Sposób i związki do wytwarzania (+) opiatów
WO2009078988A1 (en) 2007-12-17 2009-06-25 Mallinckrodt Inc. Sinomenine derivatives and processes for their synthesis
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
AU2010357625B2 (en) * 2010-07-16 2015-04-23 Mallinckrodt Llc (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
ES2586655T3 (es) * 2011-01-31 2016-10-18 Toray Industries, Inc. (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer
RU2573388C2 (ru) 2011-10-26 2016-01-20 Кемфарм Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты с гидроморфоном, пролекарства, способы получения и их применение
CN102617470A (zh) * 2012-03-07 2012-08-01 江苏大学 青藤碱4-羟基醚化和酯化衍生物、制备方法及用途
CN103387539A (zh) * 2012-05-08 2013-11-13 长沙理工大学 4-苄氧基-17-乙酰基吗啡喃-6-酮的合成
CN103387579A (zh) * 2012-05-08 2013-11-13 长沙理工大学 4-苄氧基-17-苯磺酰吗啡喃-6-酮的合成
TW201441199A (zh) 2012-12-28 2014-11-01 Purdue Pharma Lp 經取代之嗎啡喃類及其用途
GB201308440D0 (en) * 2013-05-10 2013-06-19 Dalgleish Angus Therapeutic
AU2014348256B2 (en) 2013-11-18 2018-06-07 SpecGx LLC Preparation of normorphinans
ES2784690T3 (es) 2013-12-05 2020-09-29 Univ Bath Nuevos compuestos opioides y sus usos
TWI601835B (zh) * 2014-09-05 2017-10-11 Furukawa Electric Co Ltd Copper foil, copper clad laminate, and substrate
RU2683274C2 (ru) 2014-12-02 2019-03-27 Кемфарм, Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты и оксиморфона, их пролекарства, способы получения и применение
US10351830B2 (en) * 2014-12-17 2019-07-16 Siemens Healthcare Diagnostics Inc. Conjugates for assays for oxycodone and oxymorphone
US9757372B2 (en) * 2015-03-25 2017-09-12 Taiwanj Pharmaceuticals Co., Ltd. Toll-like receptor 4 antagonists and use in autoimmune liver diseases
US11696594B2 (en) * 2015-12-10 2023-07-11 Dsm Ip Assets B.V. Vitamin formulation
SI3889145T1 (sl) 2015-12-17 2024-05-31 Merck Patent Gmbh 8-ciano-5-piperidino-kinolini kot antagonisti tlr7/8 in njihove uporabe za zdravljenje imunskih motenj
US10071079B2 (en) 2016-06-29 2018-09-11 Bristol-Myers Squibb Company [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
AU2017307208B2 (en) 2016-07-30 2021-01-21 Bristol-Myers Squibb Company Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors
DK3497094T3 (da) 2016-08-08 2023-05-15 Merck Patent Gmbh Tlr7/8-antagonister og anvendelser deraf
EP3510024B1 (en) 2016-09-09 2021-11-17 Bristol-Myers Squibb Company Pyridyl substituted indole compounds
CN110290792A (zh) * 2017-01-05 2019-09-27 景凯生物科技股份有限公司 吗啡喃衍生物和其用于治疗自体免疫、发炎或感染相关的障碍的组合物
WO2019020732A1 (en) 2017-07-27 2019-01-31 INSERM (Institut National de la Santé et de la Recherche Médicale) METHODS FOR DETERMINING WHETHER A PATIENT SUFFERING FROM RHABDOMYOLYSIS REACHES A RESPONSE WITH AN ANTAGONIST TLR9
EP3661926B1 (en) 2017-08-04 2022-02-23 Bristol-Myers Squibb Company Substituted indole compounds useful as inhibitors of tlr7/8/9
CN107325097B (zh) * 2017-08-04 2019-05-28 北京师范大学 青藤碱衍生物及其制备方法与应用
CN107337672B (zh) * 2017-08-04 2019-05-28 北京师范大学 一类青藤碱衍生物及其制备方法与应用
KR102688509B1 (ko) 2017-08-04 2024-07-24 브리스톨-마이어스 스큅 컴퍼니 [1,2,4]트리아졸로[4,3-a]피리디닐 치환된 인돌 화합물
JP7265554B2 (ja) 2017-11-14 2023-04-26 ブリストル－マイヤーズ スクイブ カンパニー 置換インドール化合物
ES2927960T3 (es) 2017-12-15 2022-11-14 Bristol Myers Squibb Co Compuestos de indol éter sustituidos
CA3085817A1 (en) 2017-12-18 2019-06-27 Bristol-Myers Squibb Company 4-azaindole compounds
EP3728253B1 (en) 2017-12-19 2024-03-27 Bristol-Myers Squibb Company 6-azaindole compounds
US11878975B2 (en) 2017-12-19 2024-01-23 Bristol-Myers Squibb Company Substituted indole compounds useful as TLR inhibitors
KR20200101398A (ko) 2017-12-19 2020-08-27 브리스톨-마이어스 스큅 컴퍼니 Tlr 억제제로서 유용한 아미드 치환된 인돌 화합물
ES2904676T3 (es) 2017-12-20 2022-04-05 Bristol Myers Squibb Co Compuestos de amino indol útiles como inhibidores de TLR
EP3728264B1 (en) 2017-12-20 2021-12-01 Bristol-Myers Squibb Company Diazaindole compounds
KR20200101400A (ko) 2017-12-20 2020-08-27 브리스톨-마이어스 스큅 컴퍼니 아릴 및 헤테로아릴 치환된 인돌 화합물
AU2019224127B2 (en) * 2018-02-23 2021-12-09 Rhodes Technologies Novel opioid compounds and uses thereof
WO2020086505A1 (en) 2018-10-24 2020-04-30 Bristol-Myers Squibb Company Substituted indole dimer compounds
WO2020205735A1 (en) * 2019-03-29 2020-10-08 Humanwell Pharmaceutical US Novel morphinans useful for treating medical disorders
CN115260098B (zh) * 2022-06-09 2024-06-04 澳门科技大学 Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3438989A (en) * 1967-03-10 1969-04-15 Warner Lambert Pharmaceutical Process for the production of ( ) dihydrothebainone
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
PT95069B (pt) * 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
CA2143864C (en) * 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
US5919826A (en) * 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
GB2392670A (en) * 2002-09-03 2004-03-10 Stylacats Ltd (+)-Morphine production
WO2007127624A1 (en) * 2006-04-26 2007-11-08 The Uab Research Foundation Reducing cancer cell invasion using an inhibitor of toll like receptor signaling
CN101066948B (zh) * 2007-05-30 2012-01-04 广东工业大学 青藤碱催化氢化还原制备氢化青藤碱的方法
NZ582668A (en) * 2007-07-17 2012-02-24 Mallinckrodt Llc Preparation of n-alkylated opiates by reductive amination
WO2009023819A2 (en) * 2007-08-15 2009-02-19 Idera Pharmaceuticals, Inc. Toll like receptor modulators
US20110251229A1 (en) * 2007-10-30 2011-10-13 The Regents Of The University Of Colorado (+)-opioids and methods of use
PL2222642T3 (pl) * 2007-12-17 2014-07-31 SpecGx LLC Sposób i związki do wytwarzania (+) opiatów
CA2709854A1 (en) * 2007-12-17 2009-06-25 Peter X. Wang Process for the preparation of buprenorphine and derivatives of buprenorphine
CN101265266B (zh) * 2008-04-23 2011-12-14 南京大学 青藤碱衍生物及其制备方法和应用
EP2331508B1 (en) * 2008-09-03 2014-11-12 Mallinckrodt LLC Substituted berbines and processes for their synthesis
US8080661B2 (en) * 2008-09-30 2011-12-20 Mallinckrodt Llc Processes for the synthesis of tertiary amines
KR20100090155A (ko) * 2009-02-05 2010-08-13 엘지전자 주식회사 이동 단말기 및 그의 프레즌스 정보 처리방법
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
CN102325775A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-6-羟基-吗啡喃或(+)-6-氨基-吗啡喃衍生物
PL2440562T3 (pl) * 2009-06-11 2017-07-31 Mallinckrodt Llc Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru
WO2011009020A2 (en) * 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
AU2010357625B2 (en) * 2010-07-16 2015-04-23 Mallinckrodt Llc (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof

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