DK2423310T3 - Cancer antigen hjælperpeptid - Google Patents

Cancer antigen hjælperpeptid Download PDF

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DK2423310T3
DK2423310T3 DK10767122.4T DK10767122T DK2423310T3 DK 2423310 T3 DK2423310 T3 DK 2423310T3 DK 10767122 T DK10767122 T DK 10767122T DK 2423310 T3 DK2423310 T3 DK 2423310T3
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peptide
cells
drb1
helper
mhc class
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DK10767122.4T
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Haruo Sugiyama
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Int Inst Cancer Immunology Inc
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Claims (15)

1. Peptid der består af en aminosyresekvens bestående af sammenhængende aminosyrer afledt fra et WTl-protein og inducerer WTl-specifikke hjælper-T-celler ved at binde til et MHC-klasse-II-molekyle, hvor aminosyresekvensen er valgt fra: (a) aminosyresekvensen vist i SEQ ID NO:3; (b) aminosyresekvensen vist i SEQ ID NO:4; (c) aminosyresekvensen vist i SEQ ID NO:5; og (d) en aminosyresekvens i hvilken kun én aminosyre er substitueret, deleteret eller tilsat i aminosyresekvenserne vist i (a) til (c).
2. Peptidet ifølge krav 1, hvor aminosyresekvensen er aminosyresekvensen vist i SEQ ID NO:3.
3. Peptidet ifølge krav 1 eller 2, hvor (i) MHC-klasse-II-molekylet er valgt fra DRB1* 0101, DRB1*0405, DRB1*0802, DRB1*0803, DRB1*0901, DRB1*1201, DRB1*1403, DRB1*1501, DRB1*1502, DPB1*0201, DPB1*0202, DPB1*0402, DPB1*0501, DPB1*0901, DQB1*0301, DQB1*0302, DQB1*0401, DQB1*0501, DQB1*0601, DQB1*0602, og DRB5*0102; eller (ii) MHC-klasse-II-molekylet er valgt fra DRB1*0101, DRB1*0405, DRB1*1502, DPB1*0201, DPB1*0202, og DQB1*0601.
4. Polynukleotid der koder for peptidet ifølge et hvilket som helst af kravene 1 til 3.
5. Ekspressionsvektor omfattende polynukleotidet ifølge krav 4.
6. Antistof mod peptidet ifølge et hvilket som helst af kravene 1 til 3.
7. Farmaceutisk sammensætning til anvendelse i en fremgangsmåde til behandling eller forebyggelse af cancer, omfattende peptidet ifølge et hvilket som helst af kravene 1 til 3, polynukleotidet ifølge krav 4, eller vektoren ifølge krav 5.
8. Peptid ifølge et hvilket som helst af kravene 1 til 3, polynukleotid ifølge krav 4, eller en vektor ifølge krav 5, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af cancer.
9. Antigen-præsenterende celler der præsenterer peptidet ifølge et hvilket som helst af kravene 1 til 3 gennem MHC-klasse-II-molekylet ifølge krav 3.
10. Fremgangsmåde til at inducere antigen-præsenterende celler, som omfatter dyrkning af umodne antigen-præsenterende celler i tilstedeværelse af peptidet ifølge et hvilket som helst af kravene 1 til 3, og inducere antigen-præsenterende celler, der præsenterer peptidet gennem MHC-klasse-II-molekylet ifølge krav 3, fra de umodne antigenpræsenterende celler.
11. WT1-specifikke hjælper-T-celler som er induceret af peptidet ifølge et hvilket som helst af kravene 1 til 3.
12. Fremgangsmåde til at inducere WTl-specifikke hjælper-T-celler, som omfatter dyrkning af perifere blod-mononuklære celler i tilstedeværelse af peptidet ifølge et hvilket som helst af kravene 1 til 3, og inducere WTl-specifikke hjælper-T-celler fra de perifere blod-mononuklære celler.
13. Kit til at inducere WTl-specifikke hjælper-T-celler, omfattende, som en væsentlig bestanddel, peptidet ifølge et hvilket som helst af kravene 1 til 3.
14. Kit til forebyggelse eller behandling af cancer, omfattende, som en væsentlig bestanddel, peptidet ifølge et hvilket som helst af kravene 1 til 3, polynukleotidet ifølge krav 4, eller vektoren ifølge krav 5.
15. Fremgangsmåde til at bestemme tilstedeværelsen eller mængde af WTl-specifikke hjælper-T-celler i et individ der har MHC-klasse-II-molekyle ifølge krav 3, hvilken fremgangsmåde omfatter trinnene at: (a) omsætte peptidet ifølge et hvilket som helst af kravene 1 til 3 med en prøve afledt fra individet; og derefter (b) bestemme tilstedeværelsen eller mængde af et cytokin indeholdt i prøven.
DK10767122.4T 2009-04-23 2010-04-22 Cancer antigen hjælperpeptid DK2423310T3 (da)

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PCT/JP2010/057149 WO2010123065A1 (ja) 2009-04-23 2010-04-22 癌抗原ヘルパーペプチド

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US (4) US9266932B2 (da)
EP (1) EP2423310B1 (da)
JP (2) JP5730191B2 (da)
KR (2) KR20170046192A (da)
CN (3) CN113045636A (da)
AR (1) AR076349A1 (da)
AU (1) AU2010240099B2 (da)
BR (1) BRPI1014998A2 (da)
CA (1) CA2757764C (da)
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DK (1) DK2423310T3 (da)
ES (1) ES2528766T3 (da)
HK (1) HK1167427A1 (da)
IL (2) IL215668A0 (da)
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