DK2417262T3 - Nanopartikelmedieret tilførsel af sekvensspecifikke nukleaser - Google Patents
Nanopartikelmedieret tilførsel af sekvensspecifikke nukleaserInfo
- Publication number
- DK2417262T3 DK2417262T3 DK10714403.2T DK10714403T DK2417262T3 DK 2417262 T3 DK2417262 T3 DK 2417262T3 DK 10714403 T DK10714403 T DK 10714403T DK 2417262 T3 DK2417262 T3 DK 2417262T3
- Authority
- DK
- Denmark
- Prior art keywords
- nanopartically
- medicated
- sequence
- supply
- specific nucleases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
- C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16738909P | 2009-04-07 | 2009-04-07 | |
PCT/US2010/030155 WO2010118077A1 (en) | 2009-04-07 | 2010-04-07 | Nanoparticle mediated delivery of sequence specific nucleases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2417262T3 true DK2417262T3 (da) | 2015-06-22 |
Family
ID=42173819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10714403.2T DK2417262T3 (da) | 2009-04-07 | 2010-04-07 | Nanopartikelmedieret tilførsel af sekvensspecifikke nukleaser |
Country Status (20)
Country | Link |
---|---|
US (2) | US9187755B2 (da) |
EP (1) | EP2417262B1 (da) |
JP (3) | JP5755636B2 (da) |
KR (1) | KR101701534B1 (da) |
CN (1) | CN102369287B (da) |
AR (1) | AR076225A1 (da) |
AU (1) | AU2010234539B2 (da) |
BR (1) | BRPI1015952B8 (da) |
CA (1) | CA2757831C (da) |
DK (1) | DK2417262T3 (da) |
ES (1) | ES2539327T3 (da) |
HR (1) | HRP20150564T1 (da) |
HU (1) | HUE026053T2 (da) |
IL (1) | IL214880A (da) |
PT (1) | PT2417262E (da) |
RU (3) | RU2612156C2 (da) |
SI (1) | SI2417262T1 (da) |
TW (1) | TWI576432B (da) |
WO (1) | WO2010118077A1 (da) |
ZA (1) | ZA201106262B (da) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9339539B2 (en) * | 2008-11-07 | 2016-05-17 | Hidaca Limited | Transfection with magnetic nanoparticles |
WO2012161764A1 (en) * | 2011-02-16 | 2012-11-29 | Fox Daniel N | Magnetic sorting of mammalian sperm having damaged membranes |
WO2012129443A2 (en) * | 2011-03-23 | 2012-09-27 | Dow Agrosciences Llc | Quantum dot carrier peptide conjugates suitable for imaging and delivery applications in plants |
CN102250944B (zh) * | 2011-06-02 | 2012-10-31 | 南京林业大学 | 一种CdSe/ZnS量子点与植物细胞的共孵育方法 |
AU2012325723A1 (en) * | 2011-10-21 | 2014-05-15 | Stemgenics, Inc | Functionalized nanoparticles for intracellular delivery of biologically active molecules |
EP2861737B1 (en) | 2012-06-19 | 2019-04-17 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses |
US20160145631A1 (en) * | 2013-06-14 | 2016-05-26 | Cellectis | Methods for non-transgenic genome editing in plants |
WO2014204725A1 (en) * | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
CA3109801C (en) | 2013-08-22 | 2024-01-09 | Andrew Cigan | Plant genome modification using guide rna/cas endonuclease systems and methods of use |
JP6595459B2 (ja) | 2013-09-23 | 2019-10-23 | レンセラール ポリテクニック インスティチュート | 種々の細胞集団におけるナノ粒子媒介遺伝子送達、ゲノム編集およびリガンド標的化修飾 |
KR20160089527A (ko) | 2013-12-12 | 2016-07-27 | 더 브로드 인스티튜트, 인코퍼레이티드 | 게놈 편집을 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료적 응용 |
WO2015089354A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
JP6455912B2 (ja) * | 2014-03-24 | 2019-01-23 | 国立研究開発法人産業技術総合研究所 | 人工ヌクレアーゼの細胞への導入方法 |
AU2015288157A1 (en) | 2014-07-11 | 2017-01-19 | E. I. Du Pont De Nemours And Company | Compositions and methods for producing plants resistant to glyphosate herbicide |
CN108064129A (zh) | 2014-09-12 | 2018-05-22 | 纳幕尔杜邦公司 | 玉米和大豆中复合性状基因座的位点特异性整合位点的产生和使用方法 |
EP3985115A1 (en) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
US20190024065A1 (en) * | 2015-02-06 | 2019-01-24 | Cellectis | Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles |
WO2016143223A1 (ja) * | 2015-03-09 | 2016-09-15 | 株式会社島津製作所 | 外部環境変化に対する耐性が向上した固定化プロテアーゼ |
KR102194612B1 (ko) * | 2015-03-16 | 2020-12-23 | 인스티튜트 오브 제네틱스 앤드 디벨롭멘털 바이오롤지, 차이니즈 아카데미 오브 사이언시스 | 비-유전성 물질을 이용한 식물 게놈의 부위-특이적인 변형 방법 |
CN107567499A (zh) | 2015-03-27 | 2018-01-09 | 纳幕尔杜邦公司 | 大豆u6核小rna基因启动子及其在植物小rna基因的组成型表达中的用途 |
WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
US20170000743A1 (en) * | 2015-07-02 | 2017-01-05 | Vindico NanoBio Technology Inc. | Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles |
US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
US11110168B2 (en) | 2016-03-15 | 2021-09-07 | North Carolina State University | Nanoparticles, controlled-release dosage forms, and methods for delivering an immunotherapeutic agent |
US11213594B2 (en) | 2016-04-29 | 2022-01-04 | Poseida Therapeutics, Inc. | Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids |
US20190233820A1 (en) * | 2016-10-11 | 2019-08-01 | Stemgenics, Inc. | Nanoparticles functionalized with gene editing tools and related methods |
EP4256951A3 (en) | 2016-11-04 | 2023-12-06 | Flagship Pioneering Innovations V. Inc. | Novel plant cells, plants, and seeds |
US10975388B2 (en) | 2016-12-14 | 2021-04-13 | Ligandal, Inc. | Methods and compositions for nucleic acid and protein payload delivery |
EP3392339A1 (en) | 2017-04-18 | 2018-10-24 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Improved genome editing in plant cells |
RU2663347C1 (ru) * | 2017-07-12 | 2018-08-03 | Общество с ограниченной ответственностью "Дока-Генные Технологии" | Способ доставки биологически активных макромолекул в клетки растений |
AU2019255725A1 (en) * | 2018-04-18 | 2020-12-10 | Ligandal, Inc. | Methods and compositions for genome editing |
US11518999B1 (en) | 2018-11-09 | 2022-12-06 | Inari Agriculture Technology, Inc. | Plant transformation |
JP2022514493A (ja) | 2018-12-14 | 2022-02-14 | パイオニア ハイ-ブレッド インターナショナル, インコーポレイテッド | ゲノム編集のための新規なcrispr-casシステム |
CN111363013B (zh) * | 2018-12-25 | 2021-11-19 | 深圳先进技术研究院 | 多组分纳米颗粒簇的构建方法 |
US11692197B2 (en) | 2019-05-06 | 2023-07-04 | Inari Agriculture Technology, Inc. | Delivery of biological molecules to plant cells |
KR20220052905A (ko) | 2019-06-25 | 2022-04-28 | 이나리 아그리컬쳐 테크놀로지, 인크. | 개선된 상동성 의존적 수선 게놈 편집 |
AU2022375817A1 (en) | 2021-11-01 | 2024-05-09 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
WO2023141540A2 (en) | 2022-01-20 | 2023-07-27 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
EP4299739A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
EP4299733A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
WO2024005863A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
WO2024005864A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050059031A1 (en) * | 2000-10-06 | 2005-03-17 | Quantum Dot Corporation | Method for enhancing transport of semiconductor nanocrystals across biological membranes |
DE10254166A1 (de) * | 2002-11-20 | 2004-06-03 | Icon Genetics Ag | Verfahren zur Kontrolle eines zellulären Prozesses in Pflanzen |
EP1639114A2 (en) * | 2003-07-01 | 2006-03-29 | Biolex, Inc. | Chloroplast transformation of duckweed |
CN1687427A (zh) * | 2005-03-30 | 2005-10-26 | 湖南大学 | 基于超声波介导的纳米颗粒作载体的基因转导方法 |
JP2008545621A (ja) * | 2005-04-20 | 2008-12-18 | デンドリティック ナノテクノロジーズ,インコーポレイテッド | 強化された拡大性と内部官能基性をもった樹枝状ポリマー |
US20070016985A1 (en) * | 2005-07-18 | 2007-01-18 | Pioneer Hi-Bred International, Inc. | Particle Preparation for Direct-Delivery Transformation |
AU2006288048A1 (en) | 2005-09-08 | 2007-03-15 | Biterials Co., Ltd. | Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof |
KR100821192B1 (ko) * | 2005-09-08 | 2008-04-11 | 주식회사바이테리얼즈 | 형광성을 가지는 자성 나노 입자 및 그 제조방법 |
WO2007050715A2 (en) * | 2005-10-26 | 2007-05-03 | Integrated Plant Genetics, Inc. | Compositions and methods for safe delivery of biologically-active plant transformation agents using non-fibrous silicon carbide powder |
EP2007435B1 (en) | 2006-03-31 | 2019-12-18 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
PL2049663T3 (pl) * | 2006-08-11 | 2015-08-31 | Dow Agrosciences Llc | Homologiczna rekombinacja za pośrednictwem nukleazy z palcami cynkowymi |
CN101889090B (zh) | 2007-10-05 | 2018-01-23 | 陶氏益农公司 | 用于将分子物质转移入植物细胞中的方法 |
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2010
- 2010-04-07 TW TW099110728A patent/TWI576432B/zh active
- 2010-04-07 KR KR1020117026339A patent/KR101701534B1/ko active IP Right Grant
- 2010-04-07 AR ARP100101171A patent/AR076225A1/es active IP Right Grant
- 2010-04-07 SI SI201030952T patent/SI2417262T1/sl unknown
- 2010-04-07 EP EP10714403.2A patent/EP2417262B1/en active Active
- 2010-04-07 RU RU2015120061A patent/RU2612156C2/ru active
- 2010-04-07 DK DK10714403.2T patent/DK2417262T3/da active
- 2010-04-07 ES ES10714403.2T patent/ES2539327T3/es active Active
- 2010-04-07 HU HUE10714403A patent/HUE026053T2/en unknown
- 2010-04-07 JP JP2012504794A patent/JP5755636B2/ja active Active
- 2010-04-07 CN CN201080015582.0A patent/CN102369287B/zh active Active
- 2010-04-07 WO PCT/US2010/030155 patent/WO2010118077A1/en active Application Filing
- 2010-04-07 BR BRPI1015952A patent/BRPI1015952B8/pt active IP Right Grant
- 2010-04-07 AU AU2010234539A patent/AU2010234539B2/en active Active
- 2010-04-07 PT PT107144032T patent/PT2417262E/pt unknown
- 2010-04-07 RU RU2011144872/10A patent/RU2556376C2/ru active
- 2010-04-07 US US12/755,447 patent/US9187755B2/en active Active
- 2010-04-07 CA CA2757831A patent/CA2757831C/en active Active
-
2011
- 2011-08-25 ZA ZA2011/06262A patent/ZA201106262B/en unknown
- 2011-08-29 IL IL214880A patent/IL214880A/en active IP Right Grant
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2015
- 2015-05-27 JP JP2015107100A patent/JP6275668B2/ja active Active
- 2015-05-27 HR HRP20150564TT patent/HRP20150564T1/hr unknown
- 2015-09-22 US US14/861,864 patent/US9719108B2/en active Active
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2017
- 2017-02-14 RU RU2017104660A patent/RU2664865C2/ru active
- 2017-05-17 JP JP2017098360A patent/JP6513127B2/ja active Active
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