DK2346874T3 - Fremgangsmåde til fremstilling af chloriner og deres farmaceutiske anvendelser - Google Patents
Fremgangsmåde til fremstilling af chloriner og deres farmaceutiske anvendelser Download PDFInfo
- Publication number
- DK2346874T3 DK2346874T3 DK09768255.3T DK09768255T DK2346874T3 DK 2346874 T3 DK2346874 T3 DK 2346874T3 DK 09768255 T DK09768255 T DK 09768255T DK 2346874 T3 DK2346874 T3 DK 2346874T3
- Authority
- DK
- Denmark
- Prior art keywords
- luzitin
- light
- cells
- laser
- irradiation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Claims (2)
1. En fremgangsmåde til fremstilling af et derivat af chlorin eller bakterio-chlorin med formlen:
Formel (I) hvor: ...... repræsenterer en carbon-carbon enkeltbinding eller en carbon-carbon dobbeltbinding; X1, X2, X3, X4, X5, X6, X7, er hver især uafhængigt valgt blandt halogen (F, Cl, Br) og hydrogenatomer, forudsat at enten alle X2, X4, X6 og X8 eller alle X1, X3, X5 og X7 er halogener, eller alle X er halogener; R-ι, R2, R3, R4, R5, Re, R7, Rs, er uafhængigt valgt blandt H, -OH og -S02R, hvor R er hver især uafhængigt valgt blandt -Cl, -OH, -aminosyre, -ORn, -NHRn og -NR2n hvor Rn er alkyl med 1 til 12 carbonatomer; Y er enten fluor eller hydrogen; der omfatter følgende: (i) den faste tilstandsreduktion af den tilsvarende substituerede porfyrin til derivat af chlorin eller bakteriochlorin, der bruger hydrazider i fravær af opløsningsmidler og eventuelt i fravær af baser, hvor den tilsvarende substituerede porfyrin har formlen:
Formel (II).
1. Patentkrav
2. En fremgangsmåde ifølge krav 1 til fremstilling af et derivat af chlorin eller bakteriochlorin med formlen:
Formel (III) hvor: ...... repræsenterer en carbon-carbon enkeltbinding eller en carbon-carbon dobbeltbinding; X2 er valgt blandt halogen (F, Cl, Br), X1 er valgt blandt hydrogen eller halogen (F, Cl, Br), og R’ er -S02R; R hver især uafhængigt valgt blandt -Cl, -OH, -aminosyre, -ORn, -NHRn og -NR2n hvor Rn er alkyl med 1 til 12 carbonatomer; der omfatter følgende: (i) den faste tilstandsreduktion af den tilsvarende substituerede porfyrin til derivat af chlorin eller bakteriochlorin, der bruger hydrazider i fravær af opløsningsmidler og eventuelt i fravær af baser, hvor den tilsvarende substituerede porfyrin har formlen:
Formel (IV).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819594.3A GB0819594D0 (en) | 2008-10-24 | 2008-10-24 | Process |
| PCT/PT2009/000057 WO2010047611A1 (en) | 2008-10-24 | 2009-10-22 | Process for preparing chlorins and their pharmaceutical uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2346874T3 true DK2346874T3 (da) | 2014-03-03 |
Family
ID=40133817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09768255.3T DK2346874T3 (da) | 2008-10-24 | 2009-10-22 | Fremgangsmåde til fremstilling af chloriner og deres farmaceutiske anvendelser |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9670217B2 (da) |
| EP (1) | EP2346874B1 (da) |
| JP (1) | JP5567024B2 (da) |
| CN (1) | CN102227432B (da) |
| AU (1) | AU2009307106B2 (da) |
| BR (1) | BRPI0919868B8 (da) |
| CA (1) | CA2741429C (da) |
| DK (1) | DK2346874T3 (da) |
| ES (1) | ES2450136T3 (da) |
| GB (1) | GB0819594D0 (da) |
| HK (1) | HK1160848A1 (da) |
| PL (1) | PL2346874T3 (da) |
| PT (1) | PT2346874E (da) |
| RU (1) | RU2513483C2 (da) |
| WO (1) | WO2010047611A1 (da) |
| ZA (1) | ZA201102760B (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8524239B2 (en) | 2010-07-09 | 2013-09-03 | The United States of America as represented by the Secrectary, Department of Health and Human Services | Photosensitizing antibody-fluorophore conjugates |
| CN107929733A (zh) * | 2011-07-11 | 2018-04-20 | 美国政府(由卫生和人类服务部的部长所代表) | 光敏抗体‑荧光团缀合物 |
| US9371555B2 (en) | 2012-06-01 | 2016-06-21 | Concordia Laboratories Inc. | Lighting systems and methods of using lighting systems for in vitro potency assay for photofrin |
| CN103721257B (zh) * | 2012-10-16 | 2016-12-21 | 无锡兆真辐射技术有限公司 | 光敏素催化分解过氧化氢系列药物 |
| GB201221125D0 (en) | 2012-11-23 | 2013-01-09 | Morex Dev Partners Llp | Pharmaceutial formulations |
| WO2014110149A2 (en) * | 2013-01-08 | 2014-07-17 | Stoneburner Jon F | Method of testing or treating the presence of live viruses |
| ES2743458T5 (es) | 2014-08-08 | 2023-06-08 | Us Health | Eliminación fotocontrolada de dianas in vitro e in vivo |
| US11484593B2 (en) * | 2015-03-20 | 2022-11-01 | Luzitin, S.A. | Atropisomers of halogenated tetraphenylbacteriochlorins and chlorins and their use in photodynamic therapy |
| CA2994822C (en) | 2015-08-07 | 2023-01-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer |
| EP3777978A1 (en) | 2015-08-18 | 2021-02-17 | Rakuten Medical, Inc. | Phthalocyanine dye conjugates and their storage |
| AU2016308290B2 (en) | 2015-08-18 | 2022-04-14 | Rakuten Medical, Inc. | Compositions, combinations and related methods for photoimmunotherapy |
| WO2017051435A1 (en) * | 2015-09-22 | 2017-03-30 | Council Of Scientific And Industrial Research | Chlorin based compounds, a process for preparation thereof and use as photodynamic therapeutic agents and fluorescent probes |
| US10744212B2 (en) | 2016-03-14 | 2020-08-18 | General Electric Company | Topical application of nerve labeling dyes for image-guided surgery |
| WO2018065384A1 (en) * | 2016-10-03 | 2018-04-12 | Galderma Research & Development | Expression profiles of abc and slc transporters in human and minipig skin, liver and kidney |
| JP7223218B2 (ja) * | 2017-05-22 | 2023-02-16 | 国立大学法人京都大学 | テトラフェニルポルフィリン誘導体 |
| CA3076008A1 (en) * | 2017-09-29 | 2019-04-04 | Duke University | Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same |
| CN109912607B (zh) * | 2018-12-11 | 2021-01-22 | 南华大学 | 一类卟啉-白杨素复合物及其抗肿瘤活性 |
| CN109651383B (zh) * | 2019-01-25 | 2021-11-16 | 华东理工大学 | 用于光敏剂的化合物及其应用 |
| JP2022532924A (ja) * | 2019-05-20 | 2022-07-20 | ニルバナ サイエンシーズ インク． | 発光波長の範囲が狭い発光染料、それを含む組成物及びそれを製造及び使用する方法 |
| RU2725876C1 (ru) * | 2019-07-15 | 2020-07-07 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | Производные фторсодержащих хлоринов, проявляющие противоопухолевую активность |
| CN114504551B (zh) * | 2020-11-16 | 2024-01-02 | 北京厚燊维康科技有限责任公司 | 可用于光动力治疗或诊断的制剂 |
| RU2759743C2 (ru) * | 2021-04-14 | 2021-11-17 | Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) | Способ комбинированного лечения локализованного t1-t2n0m0 рака гортани |
| EP4389755A1 (en) * | 2021-08-18 | 2024-06-26 | FUJIFILM Corporation | Fluorescent compound and fluorescence-labeled biosubstance obtained using same |
| WO2023059180A1 (en) * | 2021-10-06 | 2023-04-13 | Tunku Abdul Rahman University Of Management And Technology (Tar Umt) | Treating skin diseases using a photodynamic therapy (pdt) and a topical agent photosensitizer formulation |
| CN114813592A (zh) * | 2022-03-11 | 2022-07-29 | 华南理工大学 | 一种探究羟基氯喹在自然水体中降解机理的方法 |
| CN114870011B (zh) * | 2022-03-24 | 2023-06-06 | 深圳大学 | 一种增强实体瘤内原卟啉ix蓄积的微针贴片及其制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405616A (en) | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4562075A (en) | 1982-05-20 | 1985-12-31 | Nelson Research & Development Co. | Penetration enhancers for transdermal drug delivery of systemic agents |
| US4218803A (en) | 1979-05-25 | 1980-08-26 | Clifford Jack R | Implement for cleaning tubular culverts |
| US5171741A (en) | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| US5079262A (en) | 1989-07-28 | 1992-01-07 | Queen's University At Kingston | Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid |
| WO1994000118A1 (en) | 1992-06-19 | 1994-01-06 | The University Of Toledo | Production and use of imines of porphyrins |
| US5591847A (en) | 1994-05-23 | 1997-01-07 | Health Research, Inc. | Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages |
| RU2071320C1 (ru) * | 1994-09-29 | 1997-01-10 | Акционерное общество закрытого типа Научно-производственное предприятие "Мелодит" | Сенсибилизатор для фотодинамического разрушения клеток злокачественных новообразований |
| US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| US5770730A (en) | 1996-03-08 | 1998-06-23 | Health Research, Inc. | Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer |
| JP2000007693A (ja) * | 1998-06-26 | 2000-01-11 | Lederle Japan Ltd | クロリン誘導体 |
| BRPI9916096B8 (pt) | 1998-12-09 | 2021-05-25 | Yeda Res & Dev | derivados de bacterioclorofila substituídos com paládio, processos para sua preparação, composição compreendendo esses derivados e seu uso. |
| US6376483B1 (en) | 1999-05-27 | 2002-04-23 | Miravant Pharmaceuticals, Inc. | Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production |
| US6624187B1 (en) | 2000-06-12 | 2003-09-23 | Health Research, Inc. | Long wave length absorbing bacteriochlorin alkyl ether analogs |
| GB0121023D0 (en) * | 2001-08-30 | 2001-10-24 | Norwegian Radium Hospital Res | Compound |
| PT102721B (pt) * | 2002-02-01 | 2011-01-24 | Cipan Companhia Industr Prod De Antibioticos S A | Compostos macrocíclicos tetrapirrólicos com rendimento quântico de oxigénio singuleto adequado à terapia fotodinâmica e processos para a sua preparação |
| AU2003248747A1 (en) | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| FR2877943B1 (fr) | 2004-11-16 | 2008-09-05 | Univ De Coimbra | Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique |
| US7534807B2 (en) | 2005-02-18 | 2009-05-19 | North Carolina State University | De novo synthesis of bacteriochlorins |
| US20090318370A1 (en) * | 2007-02-19 | 2009-12-24 | Rei Medical Co., Ltd. | Novel glycoconjugated chlorin derivatives and method of producing the same |
-
2008
- 2008-10-24 GB GBGB0819594.3A patent/GB0819594D0/en not_active Ceased
-
2009
- 2009-10-22 DK DK09768255.3T patent/DK2346874T3/da active
- 2009-10-22 CN CN200980147426.7A patent/CN102227432B/zh active Active
- 2009-10-22 PT PT97682553T patent/PT2346874E/pt unknown
- 2009-10-22 AU AU2009307106A patent/AU2009307106B2/en not_active Ceased
- 2009-10-22 US US13/125,805 patent/US9670217B2/en active Active
- 2009-10-22 PL PL09768255T patent/PL2346874T3/pl unknown
- 2009-10-22 EP EP09768255.3A patent/EP2346874B1/en active Active
- 2009-10-22 JP JP2011533133A patent/JP5567024B2/ja active Active
- 2009-10-22 BR BRPI0919868A patent/BRPI0919868B8/pt not_active IP Right Cessation
- 2009-10-22 RU RU2011114878/04A patent/RU2513483C2/ru active
- 2009-10-22 CA CA2741429A patent/CA2741429C/en active Active
- 2009-10-22 WO PCT/PT2009/000057 patent/WO2010047611A1/en active Application Filing
- 2009-10-22 ES ES09768255.3T patent/ES2450136T3/es active Active
-
2011
- 2011-04-13 ZA ZA2011/02760A patent/ZA201102760B/en unknown
-
2012
- 2012-02-08 HK HK12101197.5A patent/HK1160848A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5567024B2 (ja) | 2014-08-06 |
| WO2010047611A9 (en) | 2010-07-22 |
| ZA201102760B (en) | 2012-07-25 |
| AU2009307106B2 (en) | 2015-05-07 |
| PT2346874E (pt) | 2014-03-06 |
| US20110250143A1 (en) | 2011-10-13 |
| EP2346874B1 (en) | 2013-12-04 |
| CN102227432B (zh) | 2015-04-22 |
| BRPI0919868A2 (pt) | 2015-12-15 |
| US9670217B2 (en) | 2017-06-06 |
| EP2346874A1 (en) | 2011-07-27 |
| CA2741429C (en) | 2017-04-18 |
| CA2741429A1 (en) | 2011-04-29 |
| ES2450136T3 (es) | 2014-03-24 |
| BRPI0919868B1 (pt) | 2020-10-27 |
| AU2009307106A1 (en) | 2010-04-29 |
| HK1160848A1 (en) | 2012-08-17 |
| CN102227432A (zh) | 2011-10-26 |
| BRPI0919868B8 (pt) | 2021-05-25 |
| PL2346874T3 (pl) | 2014-05-30 |
| JP2012506425A (ja) | 2012-03-15 |
| RU2513483C2 (ru) | 2014-04-20 |
| WO2010047611A1 (en) | 2010-04-29 |
| GB0819594D0 (en) | 2008-12-03 |
| RU2011114878A (ru) | 2012-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2346874T3 (da) | Fremgangsmåde til fremstilling af chloriner og deres farmaceutiske anvendelser | |
| Dąbrowski et al. | New halogenated water‐soluble chlorin and bacteriochlorin as photostable PDT sensitizers: synthesis, spectroscopy, photophysics, and in vitro photosensitizing efficacy | |
| AU2016259188B2 (en) | Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof | |
| WO2004002476A9 (en) | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy | |
| JP4976618B2 (ja) | 長波長吸収バクテリオクロリンアルキルエーテル類似体 | |
| AU746710B2 (en) | New porphyrins and their use | |
| CN107427580B (zh) | 卤代四苯基细菌卟吩和二氢卟吩的阻转异构体及它们在光动力学疗法中的应用 | |
| JPS625912A (ja) | 新規なテトラピロ−ル医薬用組成物 | |
| Cañete et al. | Photosensitizing properties of palladium-tetraphenylporphycene on cultured tumour cells | |
| RU2476218C1 (ru) | Фотосенсибилизаторы для фотодинамической терапии | |
| US7022843B1 (en) | β,β′-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins | |
| CN114409687B (zh) | 一种可在肿瘤内切换光治疗模式的光敏药物及其制备方法和应用 | |
| Wang et al. | Synthesis and evolution of S-Porphin sodium as a potential antitumor agent for photodynamic therapy against breast cancer | |
| Canyurt | EFFORTS TOWARDS SYNTHESIS OF HYDROGEN SULFIDE ACTIVATED BODIPY BASED PDT AGENT | |
| Robbins | Design, optimisation, and characterisation of two-and multi-photon absorption photosensitizers for their prospective use in photodynamic therapy | |
| RU2278119C1 (ru) | Тетраазахлорины как фотосенсибилизаторы для фотодинамической терапии | |
| Santos | Influence of light wavelength on cellular viability after photodynamic therapy | |
| Kılıç | Novel Near-Ir Photosensitizers for Photodynamic Therapy and Designing Heavy Atom Free Photosensitizers for the Photodynamic Therapy |