DK2254870T3 - 1-benzyl-3-hydroxymetylindazolderivater and their use in the treatment of diseases based on the expression of MCP-1, CX3CR1 - Google Patents

1-benzyl-3-hydroxymetylindazolderivater and their use in the treatment of diseases based on the expression of MCP-1, CX3CR1 Download PDF

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DK2254870T3
DK2254870T3 DK09718467.5T DK09718467T DK2254870T3 DK 2254870 T3 DK2254870 T3 DK 2254870T3 DK 09718467 T DK09718467 T DK 09718467T DK 2254870 T3 DK2254870 T3 DK 2254870T3
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carbon atoms
group
alkyl group
hydrogen
different
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DK09718467.5T
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Angelo Guglielmotti
Guido Furlotti
Giorgina Mangano
Nicola Cazzolla
Barbara Garofalo
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Acraf
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P17/00Drugs for dermatological disorders
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    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Obesity (AREA)
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  • Urology & Nephrology (AREA)
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  • Endocrinology (AREA)
  • Rheumatology (AREA)
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DK09718467.5T 2008-03-07 2009-03-05 1-benzyl-3-hydroxymetylindazolderivater and their use in the treatment of diseases based on the expression of MCP-1, CX3CR1 DK2254870T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08425139 2008-03-07
PCT/EP2009/052590 WO2009109618A2 (en) 2008-03-07 2009-03-05 Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40

Publications (1)

Publication Number Publication Date
DK2254870T3 true DK2254870T3 (en) 2016-05-17

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK09718467.5T DK2254870T3 (en) 2008-03-07 2009-03-05 1-benzyl-3-hydroxymetylindazolderivater and their use in the treatment of diseases based on the expression of MCP-1, CX3CR1
DK09717638.2T DK2254869T3 (en) 2008-03-07 2009-03-05 1-BENZYL-3-HYDROXYMETHYL INDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF CX3CR1 AND P40

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09717638.2T DK2254869T3 (en) 2008-03-07 2009-03-05 1-BENZYL-3-HYDROXYMETHYL INDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF CX3CR1 AND P40

Country Status (25)

Country Link
US (3) US7919518B2 (enExample)
EP (3) EP2254869B1 (enExample)
JP (2) JP5509101B2 (enExample)
KR (2) KR101581828B1 (enExample)
CN (2) CN101945855B (enExample)
AR (2) AR070810A1 (enExample)
AU (2) AU2009221083B2 (enExample)
BR (2) BRPI0907977A2 (enExample)
CA (2) CA2712703C (enExample)
CY (2) CY1117584T1 (enExample)
DK (2) DK2254870T3 (enExample)
EA (2) EA018241B1 (enExample)
ES (2) ES2637009T3 (enExample)
GE (2) GEP20135983B (enExample)
HR (2) HRP20160462T1 (enExample)
HU (1) HUE027098T2 (enExample)
IL (3) IL206893A0 (enExample)
LT (1) LT2254869T (enExample)
MX (2) MX2010009623A (enExample)
PL (2) PL2254869T3 (enExample)
PT (1) PT2254869T (enExample)
SG (1) SG188177A1 (enExample)
SI (2) SI2254869T1 (enExample)
UA (2) UA105170C2 (enExample)
WO (2) WO2009109613A2 (enExample)

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AU2009221063B2 (en) 2008-03-07 2013-03-21 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
LT2262778T (lt) * 2008-03-07 2019-11-11 Acraf 1-benzil-3-hidroksimetilindazolo dariniai ir jų panaudojimas gydant ligas, pagrįstas mcp-1, cxcr1 ir p40 raiška
LT2254869T (lt) * 2008-03-07 2017-08-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Nauji 1-benzil-3-hidroksimetilindazolo dariniai ir jų panaudojimas gydyme ligų, susijusių su cx3cr1 ir p40 raiška
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UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
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WO2015173786A1 (en) * 2014-05-15 2015-11-19 Boyd Shelley Romayne Compositions and methods for treating and diagnosing ocular disorders
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WO2016203313A1 (en) * 2015-06-16 2016-12-22 Translatum Medicus, Inc. Compositions and methods for treating and diagnosing ocular disorders
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GB201811169D0 (en) 2018-07-06 2018-08-29 Kancera Ab New compounds
JP6612004B1 (ja) * 2018-07-31 2019-11-27 株式会社親広産業 グルコース消費促進剤および解糖系促進剤
WO2020026471A1 (ja) * 2018-07-31 2020-02-06 株式会社親広産業 グルコース消費促進剤および解糖系促進剤
US11753382B2 (en) 2019-06-25 2023-09-12 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法
WO2024108386A1 (zh) * 2022-11-22 2024-05-30 中国科学院深圳先进技术研究院 抗mcp1中和抗体在制备治疗神经退行性疾病引起的系统性炎症药物中的应用
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LT2254869T (lt) 2008-03-07 2017-08-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Nauji 1-benzil-3-hidroksimetilindazolo dariniai ir jų panaudojimas gydyme ligų, susijusių su cx3cr1 ir p40 raiška
AU2009221063B2 (en) 2008-03-07 2013-03-21 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1

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IL207131A0 (en) 2010-12-30
PL2254870T3 (pl) 2016-07-29
US20110003874A1 (en) 2011-01-06
IL206893A0 (en) 2010-12-30
UA103605C2 (en) 2013-11-11
PT2254869T (pt) 2017-07-18
CA2712403C (en) 2017-06-06
US8283348B2 (en) 2012-10-09
CN101945855A (zh) 2011-01-12
HRP20171208T1 (hr) 2017-10-06
EA018241B1 (ru) 2013-06-28
ES2569330T3 (es) 2016-05-10
JP5509101B2 (ja) 2014-06-04
JP2011513367A (ja) 2011-04-28
CY1117584T1 (el) 2017-04-26
AR070811A1 (es) 2010-05-05
IL207131A (en) 2013-02-28
JP2011513365A (ja) 2011-04-28
KR20100133957A (ko) 2010-12-22
AU2009221083B2 (en) 2013-11-28
AU2009221083A1 (en) 2009-09-11
AR070810A1 (es) 2010-05-05
CA2712403A1 (en) 2009-09-11
CN101952256A (zh) 2011-01-19
ES2637009T3 (es) 2017-10-10
IL215579A0 (en) 2011-11-30
EA201071040A1 (ru) 2011-02-28
LT2254869T (lt) 2017-08-10
PL2254869T3 (pl) 2017-10-31
CN101945855B (zh) 2014-12-17
EP2254869B1 (en) 2017-05-31
MX2010009623A (es) 2010-09-28
HUE027098T2 (en) 2016-08-29
BRPI0907977A2 (pt) 2015-08-04
HRP20160462T1 (hr) 2016-06-03
AU2009221089B2 (en) 2013-12-05
CA2712703A1 (en) 2009-09-11
SI2254869T1 (sl) 2017-10-30
WO2009109613A3 (en) 2009-12-10
US20100311744A1 (en) 2010-12-09
BRPI0907976A2 (pt) 2015-08-04
WO2009109613A2 (en) 2009-09-11
EP2254869A2 (en) 2010-12-01
CA2712703C (en) 2016-10-11
JP5509099B2 (ja) 2014-06-04
UA105170C2 (en) 2014-04-25
EP2254870B1 (en) 2016-02-24
GEP20135912B (en) 2013-08-26
EP2254870A2 (en) 2010-12-01
EA019711B1 (ru) 2014-05-30
US20110160205A1 (en) 2011-06-30
KR101599867B1 (ko) 2016-03-04
AU2009221089A1 (en) 2009-09-11
CN101952256B (zh) 2016-03-16
SG188177A1 (en) 2013-03-28
IL215579A (en) 2015-06-30
EA201071038A1 (ru) 2011-02-28
KR20100131432A (ko) 2010-12-15
DK2254869T3 (en) 2017-09-04
EP3181551A1 (en) 2017-06-21
GEP20135983B (en) 2013-12-10
CY1119252T1 (el) 2018-02-14
US7919518B2 (en) 2011-04-05
KR101581828B1 (ko) 2015-12-31
MX2010009626A (es) 2010-12-20
US8835481B2 (en) 2014-09-16
WO2009109618A3 (en) 2009-12-10
SI2254870T1 (sl) 2016-05-31
WO2009109618A2 (en) 2009-09-11

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