DK2229947T3 - Biokompatible polymerer til et medicinsk præparat - Google Patents

Biokompatible polymerer til et medicinsk præparat Download PDF

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Publication number
DK2229947T3
DK2229947T3 DK10006666.1T DK10006666T DK2229947T3 DK 2229947 T3 DK2229947 T3 DK 2229947T3 DK 10006666 T DK10006666 T DK 10006666T DK 2229947 T3 DK2229947 T3 DK 2229947T3
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Prior art keywords
pain
biocompatible polymer
lesions
treatment
relief
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DK10006666.1T
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English (en)
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Denis Barritault
Véronique Barbier-Chassefiere
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Organes Tissus Régénération Réparation Remplacement
Denis Barritault
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Priority claimed from FR0312605A external-priority patent/FR2861308A1/fr
Priority claimed from FR0403550A external-priority patent/FR2868316A1/fr
Application filed by Organes Tissus Régénération Réparation Remplacement, Denis Barritault filed Critical Organes Tissus Régénération Réparation Remplacement
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Publication of DK2229947T3 publication Critical patent/DK2229947T3/da

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B3/00—Preparation of cellulose esters of organic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Physical Education & Sports Medicine (AREA)
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Claims (8)

  1. BIOKOMPATIBLE POLYMERER TIL ET MEDICINSK PRÆPARAT
    1. Farmaceutisk, dermatologisk eller kosmetisk præparat for sin anvendelse som lægemiddel beregnet til forebyggelse, lindring og/eller behandling af gener, ubehag såsom stikken, irritationer, kløe og stramhed af huden og/eller beskyttelse af vævene mod sidstnævnte, idet nævnte præparat omfatter en biokompatibel polymer med følgende generelle formel(I) AaXxYy (I) i hvilken: A glukose, X repræsenterer en RCOOR' gruppe, Y repræsenterer en 0 eller N-sulfonat gruppe bundet til A og svarende til en af følgende formler -R0S03R',-RNS03R' i hvilken: R repræsenterer en alifatisk kulbrintekæde, muligvis forgrenet og/eller umættet og som kan indeholde en eller flere aromatiske ringe og R' repræsenterer et hydrogenatom eller en kation, a repræsenterer antallet af monomerer og er således beskaffen, at massen af nævnte polymerer i formel (I) er større end cirka 2000 Dalton x repræsenterer substitutionsraten af A-monomerer med X-grupper, idet x er indbefattet mellem cirka 20 og 150%. y repræsenterer substitutionsraten af A-monomerer med Y-grupper, idet y er indbefattet mellem cirka 30 og 150%.
  2. 2. Præparat ifølge et hvilket som helst af de foregående krav, i hvilken radikalet R er valgt blandt en lineær eller forgrenet alkyl-, allyl-, arylgruppe.
  3. 3. Præparat ifølge et hvilket som helst af de foregående krav, i hvilken nævnte biokompatible polymer omfatter funktionelle kemiske Z-grupper, forskellige fra X og Y, som er i stand til at give nævnte polymer supplerende biologiske eller fysisk/kemiske egenskaber.
  4. 4. Præparat ifølge krav 3, i hvilken substitutionsraten for samtlige A-monomerer med Z-grupper repræsenteret ved"z"er indbefattet mellem 0 og 50%.
  5. 5. Præparat ifølge krav 3 eller 4, i hvilken Z-grupperne er identiske eller forskellige og er aminosyrer, fedtsyrer, fedtalkoholer, ceramider eller derivater heraf, eller nukleotide adresserende sekvenser.
  6. 6. Præparat ifølge et hvilket som helst af krav 3 eller 4, i hvilken Z-grupperne er identiske eller forskellige og er terapeutiske midler.
  7. 7. Præparat ifølge et hvilket som helst af de foregående krav, i hvilken det farmaceutiske eller dermatologiske præparat eller medicinske anordning er beregnet til at forebygge, lindre og/eller behandle kløe induceret af læsioner eller irritationer hos en person i et område i kontakt med et eksternt miljø.
  8. 8. Præparat ifølge krav 6, i hvilken de nævnte læsioner og irritationer er udvalgt blandt hudlæsioner, læsioner på hornhinden, læsioner på trommehinden, læsioner på fordøjelseskanalen, læsioner på åndedrætsvejene såsom læsioner på væv i luftvejene og lungerne og læsioner på det urogenitale system.
DK10006666.1T 2003-10-28 2004-10-28 Biokompatible polymerer til et medicinsk præparat DK2229947T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0312605A FR2861308A1 (fr) 2003-10-28 2003-10-28 Utilisation de polymeres biocompatibles pour la preparation d'une composition pharmaceutique, dermatologique ou cosmetique destinee a la prevention, au soulagement ou au traitement des genes, desagrements et douleurs
FR0403550A FR2868316A1 (fr) 2004-04-05 2004-04-05 Utilisation de polymeres biocompatibles pour la preparation d'une composition ou d'un dispositif medical destines a la prevention, au soulagement ou au traitement des genes et douleurs
EP04805335A EP1677807B1 (fr) 2003-10-28 2004-10-28 Utilisation de polymeres biocompatibles pour la preparation d'une composition ou d'un disositif medicale

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DK2229947T3 true DK2229947T3 (da) 2015-10-12

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DK10006666.1T DK2229947T3 (da) 2003-10-28 2004-10-28 Biokompatible polymerer til et medicinsk præparat
DK10184844.8T DK2260853T3 (da) 2003-10-28 2004-10-28 Biokompatible polymerer til en medicinsk sammensætning

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US (1) US20140301972A1 (da)
EP (3) EP2229947B1 (da)
JP (3) JP5026791B2 (da)
CN (1) CN102885849B (da)
AT (1) ATE480245T1 (da)
AU (1) AU2004285318B2 (da)
CA (1) CA2543530C (da)
DE (1) DE602004029068D1 (da)
DK (2) DK2229947T3 (da)
EA (1) EA010945B1 (da)
ES (2) ES2552106T3 (da)
IL (2) IL175235A (da)
PL (1) PL1677807T3 (da)
PT (1) PT1677807E (da)
WO (1) WO2005041986A2 (da)

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ATE480245T1 (de) * 2003-10-28 2010-09-15 Organes Tissus Regeneration Re Verwendung von biokompatiblen polymeren zur herstellung einer zusammenstzung oder eines medizinprodukts
CN101573030B (zh) * 2006-12-01 2015-01-28 巴斯夫欧洲公司 通过短期过热和快速干燥制备农药固溶体的方法
JP5740301B2 (ja) 2008-03-27 2015-06-24 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ コラーゲン結合性合成ペプチドグリカン、調製及び使用方法
JP6069307B2 (ja) 2011-05-24 2017-02-01 シミック・アイピー・リミテッド・ライアビリティー・カンパニーＳｙｍｉｃ Ｉｐ， Ｌｌｃ ヒアルロン酸結合合成ペプチドグリカン、その製造および使用方法
SG11201506966RA (en) 2013-03-15 2015-10-29 Symic Biomedical Inc Extracellular matrix-binding synthetic peptidoglycans
WO2015164822A1 (en) 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
CN110809478A (zh) 2017-07-07 2020-02-18 斯米克Ip有限公司 合成的生物缀合物
EP3685822A1 (fr) * 2019-01-24 2020-07-29 Organes Tissus Régénération Réparation Remplacement Composition cosmetique/dermatologique
FR3096579B1 (fr) 2019-05-27 2023-05-05 Organes Tissus Regeneration Reparation Remplacement composition pour la protection et la reparation de la barriere hematoencephalique (BHE)
WO2021181010A1 (fr) * 2020-03-09 2021-09-16 Organes Tissus Regeneration Reparation Remplacement Composition pour le traitement de lesions du système respiratoire
AU2021235223A1 (en) * 2020-03-09 2022-09-29 Denis Barritault Composition for the treatment of lesions of the respiratory system

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JP2014218503A (ja) 2014-11-20
JP5646446B2 (ja) 2014-12-24
EP2229947A2 (fr) 2010-09-22
CA2543530A1 (fr) 2005-05-12
EP2229947B1 (fr) 2015-07-01
EP1677807B1 (fr) 2010-09-08
ATE480245T1 (de) 2010-09-15
IL210249A0 (en) 2011-03-31
EP1677807A2 (fr) 2006-07-12
IL175235A (en) 2011-03-31
EP2260853A3 (fr) 2012-05-30
CN102885849A (zh) 2013-01-23
CA2543530C (fr) 2014-02-04
EP2260853A2 (fr) 2010-12-15
PL1677807T4 (pl) 2011-05-31
JP5026791B2 (ja) 2012-09-19
EA010945B1 (ru) 2008-12-30
DE602004029068D1 (de) 2010-10-21
EP2260853B1 (fr) 2015-10-21
ES2552106T3 (es) 2015-11-25
AU2004285318A1 (en) 2005-05-12
PT1677807E (pt) 2010-12-23
ES2558881T3 (es) 2016-02-09
PL1677807T3 (pl) 2011-05-31
JP2007514649A (ja) 2007-06-07
JP2012067127A (ja) 2012-04-05
IL175235A0 (en) 2008-04-13
EP2229947A3 (fr) 2011-01-05
CN102885849B (zh) 2017-09-22
AU2004285318B2 (en) 2009-11-19
IL210249A (en) 2014-07-31
US20140301972A1 (en) 2014-10-09
WO2005041986A2 (fr) 2005-05-12
WO2005041986A3 (fr) 2006-04-20
EA200600862A1 (ru) 2006-10-27

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