DK2227455T3 - Trisubstitueret 3,4-dihydro-1H-isoquinolinforbindelse, fremgangsmåde til fremstillingen og dens anvendelse - Google Patents

Trisubstitueret 3,4-dihydro-1H-isoquinolinforbindelse, fremgangsmåde til fremstillingen og dens anvendelse

Info

Publication number
DK2227455T3
DK2227455T3 DK08866627.6T DK08866627T DK2227455T3 DK 2227455 T3 DK2227455 T3 DK 2227455T3 DK 08866627 T DK08866627 T DK 08866627T DK 2227455 T3 DK2227455 T3 DK 2227455T3
Authority
DK
Denmark
Prior art keywords
preparation
trisubstituted
dihydro
isoquinoline compound
compound
Prior art date
Application number
DK08866627.6T
Other languages
English (en)
Inventor
Vries Andreas Hendrikus Maria De
Doris Domin
Matthias Helms
Christoph Imboden
Ralf Koberstein
Zarghun Nazir
Wolfgang Skranc
Michael Stanek
Wilhelm Tschebull
Gerardus Karel Maria Verzijl
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK2227455T3 publication Critical patent/DK2227455T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
DK08866627.6T 2007-12-28 2008-12-23 Trisubstitueret 3,4-dihydro-1H-isoquinolinforbindelse, fremgangsmåde til fremstillingen og dens anvendelse DK2227455T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2007055334 2007-12-28
PCT/IB2008/055509 WO2009083903A1 (en) 2007-12-28 2008-12-23 Trisubstituted 3,4-dihydro-1h-isoquinolin compound, process for its preparation, and its use

Publications (1)

Publication Number Publication Date
DK2227455T3 true DK2227455T3 (da) 2012-01-23

Family

ID=40394543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08866627.6T DK2227455T3 (da) 2007-12-28 2008-12-23 Trisubstitueret 3,4-dihydro-1H-isoquinolinforbindelse, fremgangsmåde til fremstillingen og dens anvendelse

Country Status (11)

Country Link
US (1) US8247560B2 (da)
EP (1) EP2227455B1 (da)
JP (1) JP5829399B2 (da)
KR (1) KR101579992B1 (da)
CN (1) CN102083796B (da)
AT (1) ATE528295T1 (da)
CA (1) CA2709694C (da)
DK (1) DK2227455T3 (da)
ES (1) ES2375334T3 (da)
IL (1) IL206570A (da)
WO (1) WO2009083903A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102026979B (zh) 2007-12-28 2013-05-08 埃科特莱茵药品有限公司 对映体三取代3，4-二氢-异喹啉衍生物的制备方法
WO2010095106A1 (en) * 2009-02-20 2010-08-26 Actelion Pharmaceuticals Ltd Solid forms of ( 2r) -2- { ( is ) -6, 7 -dimethoxy- 1- [2- (4-triflu0r0methyl-phenyl) -ethyl] -3, 4-dihydr0-1h -isoquinolin-2-yl} -n-methyl-2-phenyl-acetamide hydrochloride
WO2011001373A1 (en) 2009-06-30 2011-01-06 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480714A (en) * 1966-02-07 1969-11-25 Ciba Geigy Corp N-substituted isoquinolines as antiprotozoal agents
DD204917A1 (de) 1981-12-31 1983-12-14 Gerhard Kempter Verfahren zur herstellung phenylsubstituierter und benzkondensierter cycloalkylaminoacetanilide
JPS6153268A (ja) 1984-08-24 1986-03-17 Hokuriku Seiyaku Co Ltd アントラニルアミド誘導体
DD261158A1 (de) 1987-01-08 1988-10-19 Univ Halle Wittenberg Verfahren zur herstellung von 2-aminoalkyl-3,4-dihydro-4-oxo-7h-pyrrolo 2.3-d pyrimidinen
DD258817A1 (de) 1987-01-19 1988-08-03 Univ Halle Wittenberg Verfahren zur herstellung von 2-(aminoalkyl) -pyrimido-4,5'-5,4 pyrrolo 3,2-f 1,4 thiazepinderivaten
JPH07267961A (ja) 1994-03-30 1995-10-17 Taisho Pharmaceut Co Ltd ベンゾフロ［３，２−ｄピリミジン−４−オン誘導体
US6184381B1 (en) 1995-12-06 2001-02-06 Japan Science & Technology Corp. Process for preparing optically active compounds
JPH1095766A (ja) 1996-09-19 1998-04-14 Sanwa Kagaku Kenkyusho Co Ltd アセトアミド誘導体、及びその用途
DE19952348A1 (de) 1998-12-19 2000-06-21 Degussa Liganden und Komplexe zur enantioselektiven Hydrierung
HU227811B1 (en) 2000-03-14 2012-03-28 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes
WO2001085693A1 (fr) 2000-05-11 2001-11-15 Banyu Pharmaceutical Co., Ltd. Dérivés n-acyltétrahydroisoquinoline
WO2002051232A2 (en) * 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
GB0130388D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
DE602004021786D1 (de) * 2003-03-26 2009-08-13 Actelion Pharmaceuticals Ltd Tetrahydroisochinolylacetamidderivate zur verwendung als orexinrezeptorantagonisten
SI1751111T1 (sl) * 2004-03-01 2015-04-30 Actelion Pharmaceuticals Ltd. Substituirani 1,2,3,4-tetrahidroizokinolinski derivati
TW200609239A (en) 2004-07-05 2006-03-16 Solvias Ag Process for preparing amines and a carboxamide thereof
EA015256B1 (ru) * 2006-03-15 2011-06-30 Актелион Фармасьютикалз Лтд. Производные тетрагидроизохинолина для повышения функции памяти
US7834028B2 (en) 2006-04-26 2010-11-16 Actelion Pharmaceuticals Ltd. Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists

Also Published As

Publication number Publication date
US8247560B2 (en) 2012-08-21
US20100010226A1 (en) 2010-01-14
CN102083796A (zh) 2011-06-01
KR101579992B1 (ko) 2015-12-23
KR20100110347A (ko) 2010-10-12
ATE528295T1 (de) 2011-10-15
IL206570A0 (en) 2010-12-30
CN102083796B (zh) 2013-06-05
CA2709694A1 (en) 2009-07-09
EP2227455A1 (en) 2010-09-15
EP2227455B1 (en) 2011-10-12
ES2375334T3 (es) 2012-02-28
JP5829399B2 (ja) 2015-12-09
WO2009083903A1 (en) 2009-07-09
CA2709694C (en) 2016-04-05
IL206570A (en) 2014-07-31
JP2011507944A (ja) 2011-03-10

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