DK2183254T3 - INHIBITORS OF PROTEINTYROSINKINASE ACTIVITY - Google Patents

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Publication number

DK2183254T3

DK2183254T3 DK08800252.2T DK08800252T DK2183254T3 DK 2183254 T3 DK2183254 T3 DK 2183254T3 DK 08800252 T DK08800252 T DK 08800252T DK 2183254 T3 DK2183254 T3 DK 2183254T3

Authority

DK

Denmark

Prior art keywords

alkyl

group

alternatively

mmol

aryl

Prior art date

2007-08-29

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• 230000000694 effects Effects 0.000 title claims description 43
• 239000003112 inhibitor Substances 0.000 title claims description 23
• 150000001875 compounds Chemical class 0.000 claims description 197
• -1 (2) imidazolyl Chemical group 0.000 claims description 93
• 239000000203 mixture Substances 0.000 claims description 91
• 125000000623 heterocyclic group Chemical group 0.000 claims description 80
• 125000003118 aryl group Chemical group 0.000 claims description 76
• 125000000217 alkyl group Chemical group 0.000 claims description 57
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 55
• 238000000034 method Methods 0.000 claims description 46
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 44
• 150000003839 salts Chemical class 0.000 claims description 44
• 125000001072 heteroaryl group Chemical group 0.000 claims description 38
• 150000002367 halogens Chemical class 0.000 claims description 36
• 229910052736 halogen Inorganic materials 0.000 claims description 35
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
• 229910052757 nitrogen Inorganic materials 0.000 claims description 29
• 229910052739 hydrogen Inorganic materials 0.000 claims description 28
• 229920006395 saturated elastomer Polymers 0.000 claims description 26
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 22
• 125000004076 pyridyl group Chemical group 0.000 claims description 20
• 229910052760 oxygen Inorganic materials 0.000 claims description 18
• 125000003342 alkenyl group Chemical group 0.000 claims description 15
• 125000005843 halogen group Chemical group 0.000 claims description 15
• 229910052717 sulfur Inorganic materials 0.000 claims description 15
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 14
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 13
• 125000004429 atom Chemical group 0.000 claims description 13
• 125000005842 heteroatom Chemical group 0.000 claims description 13
• 125000004953 trihalomethyl group Chemical group 0.000 claims description 12
• 125000003545 alkoxy group Chemical group 0.000 claims description 10
• 125000004122 cyclic group Chemical group 0.000 claims description 10
• 125000004043 oxo group Chemical group O=* 0.000 claims description 10
• 125000001544 thienyl group Chemical group 0.000 claims description 10
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 9
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 9
• 125000004414 alkyl thio group Chemical group 0.000 claims description 9
• 125000002837 carbocyclic group Chemical group 0.000 claims description 9
• 229910052799 carbon Inorganic materials 0.000 claims description 9
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
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• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
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• 241001465754 Metazoa Species 0.000 description 19
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• 239000012267 brine Substances 0.000 description 17
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 17
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 14
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