BRPI0816064B8 - composto inibidor da atividade de proteína tirosina quinase, seu uso, e composição farmacêutica - Google Patents

composto inibidor da atividade de proteína tirosina quinase, seu uso, e composição farmacêutica

Info

Publication number
BRPI0816064B8
BRPI0816064B8 BRPI0816064A BRPI0816064A BRPI0816064B8 BR PI0816064 B8 BRPI0816064 B8 BR PI0816064B8 BR PI0816064 A BRPI0816064 A BR PI0816064A BR PI0816064 A BRPI0816064 A BR PI0816064A BR PI0816064 B8 BRPI0816064 B8 BR PI0816064B8
Authority
BR
Brazil
Prior art keywords
tyrosine kinase
kinase activity
protein tyrosine
inhibitor compound
receptor signaling
Prior art date
Application number
BRPI0816064A
Other languages
English (en)
Portuguese (pt)
Inventor
Vaisburg Arkadii
Gaudette Frédéric
Raeppel Franck
Isakovic Ljubomir
Zhan Lijie
Mannion Michael
Z Zhou Nancy
Mario Saavedra Oscar
Deziel Robert
William Claridge Stephen
Raeppel Stéphane
Uno Tetsuyuki
Original Assignee
Methylgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc filed Critical Methylgene Inc
Publication of BRPI0816064A2 publication Critical patent/BRPI0816064A2/pt
Publication of BRPI0816064B1 publication Critical patent/BRPI0816064B1/pt
Publication of BRPI0816064B8 publication Critical patent/BRPI0816064B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
BRPI0816064A 2007-08-29 2008-08-28 composto inibidor da atividade de proteína tirosina quinase, seu uso, e composição farmacêutica BRPI0816064B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96867307P 2007-08-29 2007-08-29
US60/968,673 2007-08-29
PCT/CA2008/001538 WO2009026717A1 (en) 2007-08-29 2008-08-28 Inhibitors of protein tyrosine kinase activity

Publications (3)

Publication Number Publication Date
BRPI0816064A2 BRPI0816064A2 (pt) 2015-03-31
BRPI0816064B1 BRPI0816064B1 (pt) 2020-01-28
BRPI0816064B8 true BRPI0816064B8 (pt) 2021-05-25

Family

ID=40386626

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816064A BRPI0816064B8 (pt) 2007-08-29 2008-08-28 composto inibidor da atividade de proteína tirosina quinase, seu uso, e composição farmacêutica

Country Status (19)

Country Link
US (3) US8404846B2 (enExample)
EP (1) EP2183254B1 (enExample)
JP (1) JP5656634B2 (enExample)
KR (1) KR101556269B1 (enExample)
CN (3) CN101932586A (enExample)
AR (1) AR068066A1 (enExample)
AU (1) AU2008293038B2 (enExample)
BR (1) BRPI0816064B8 (enExample)
CA (1) CA2697795C (enExample)
DK (1) DK2183254T3 (enExample)
ES (1) ES2635131T3 (enExample)
IL (1) IL204192A (enExample)
MX (1) MX2010002427A (enExample)
MY (1) MY156536A (enExample)
PL (1) PL2183254T3 (enExample)
RU (1) RU2495044C2 (enExample)
TW (1) TWI571468B (enExample)
WO (1) WO2009026717A1 (enExample)
ZA (1) ZA201001512B (enExample)

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CN107207471B (zh) 2014-12-02 2020-06-26 伊尼塔公司 用于治疗神经母细胞瘤的组合
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GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
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BR112018012255A2 (pt) 2015-12-18 2018-12-04 Ignyta Inc método para tratar câncer
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
WO2019018570A1 (en) 2017-07-19 2019-01-24 Ignyta, Inc. PHARMACEUTICAL COMPOSITIONS CONTAINING ENTRECTINIB
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
WO2019077506A1 (en) 2017-10-17 2019-04-25 Ignyta, Inc. PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS
EP3762392B1 (en) 2018-03-08 2024-05-15 Wellmarker Bio Co., Ltd. Thienopyridine derivatives and pharmaceutical composition comprising same
CN112566935B (zh) 2018-05-23 2024-12-13 百济神州有限公司 抗ox40抗体和使用方法
CN109384799B (zh) * 2018-11-12 2020-07-14 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂化合物的晶型a及制备方法和含有其的药物组合物
JP2022554042A (ja) 2019-09-06 2022-12-28 ウェルマーカー・バイオ・カンパニー・リミテッド バイオマーカー型治療用組成物
WO2021050580A1 (en) * 2019-09-10 2021-03-18 Mirati Therapeutics, Inc. Crystalline form of a multi-tyrosine kinase inhibitor, method of preparation, and use thereof
WO2021098769A1 (en) * 2019-11-21 2021-05-27 Beigene, Ltd. Treatment of cancer with anti-ox40 antibodies and multi-kinase inhibitors
EP4089095A4 (en) * 2020-01-07 2024-03-27 Medshine Discovery Inc. DEUTERATED THIENOPYRIDINE COMPOUND
EP4213844A4 (en) 2020-09-17 2024-11-20 Mirati Therapeutics, Inc. POLYTHERAPIES
TW202302597A (zh) * 2021-03-10 2023-01-16 美商米拉蒂醫療公司 多重酪胺酸激酶抑制劑之結晶鹽、其製備方法及用途
WO2022240802A1 (en) 2021-05-10 2022-11-17 Teva Pharmaceuticals International Gmbh Solid state forms of sitravatinib salts and processes for preparation thereof
TW202342426A (zh) * 2022-02-15 2023-11-01 大陸商百濟神州（蘇州）生物科技有限公司 N-[(6-溴吡啶-3-基)甲基]-2-甲氧基乙烷-1-胺鹽及其製備方法
CN118846073B (zh) * 2024-06-25 2026-01-30 深圳海王医药科技研究院有限公司 一种酪氨酸激酶抑制剂的新应用
CN121281693B (zh) * 2025-12-08 2026-04-03 中国石油大学(华东) 一种构建稠油重组分平均分子结构的方法

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Also Published As

Publication number Publication date
EP2183254A1 (en) 2010-05-12
PL2183254T3 (pl) 2017-10-31
CA2697795A1 (en) 2009-03-05
JP2010536887A (ja) 2010-12-02
IL204192A (en) 2016-08-31
CN105777776A (zh) 2016-07-20
RU2010111729A (ru) 2011-10-10
CN101932586A (zh) 2010-12-29
MX2010002427A (es) 2010-03-30
CN109970759B (zh) 2026-08-04
US8389541B2 (en) 2013-03-05
AR068066A1 (es) 2009-11-04
BRPI0816064B1 (pt) 2020-01-28
US20130165477A1 (en) 2013-06-27
DK2183254T3 (en) 2017-09-11
KR20100075873A (ko) 2010-07-05
AU2008293038A1 (en) 2009-03-05
RU2495044C2 (ru) 2013-10-10
ZA201001512B (en) 2010-11-24
US8846927B2 (en) 2014-09-30
TW200914458A (en) 2009-04-01
ES2635131T3 (es) 2017-10-02
CN105777776B (zh) 2021-06-08
US20090264440A1 (en) 2009-10-22
US20120108628A1 (en) 2012-05-03
BRPI0816064A2 (pt) 2015-03-31
MY156536A (en) 2016-02-26
CA2697795C (en) 2016-08-16
WO2009026717A1 (en) 2009-03-05
EP2183254A4 (en) 2011-09-28
TWI571468B (zh) 2017-02-21
US8404846B2 (en) 2013-03-26
JP5656634B2 (ja) 2015-01-21
EP2183254B1 (en) 2017-06-21
AU2008293038B2 (en) 2013-08-29
KR101556269B1 (ko) 2015-09-30
CN109970759A (zh) 2019-07-05

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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