DK2173379T3 - Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer - Google Patents

Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer Download PDF

Info

Publication number
DK2173379T3
DK2173379T3 DK08779934.2T DK08779934T DK2173379T3 DK 2173379 T3 DK2173379 T3 DK 2173379T3 DK 08779934 T DK08779934 T DK 08779934T DK 2173379 T3 DK2173379 T3 DK 2173379T3
Authority
DK
Denmark
Prior art keywords
antibody
cancer
protein
human
lgr5
Prior art date
Application number
DK08779934.2T
Other languages
English (en)
Inventor
Austin Gurney
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40226729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2173379(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Application granted granted Critical
Publication of DK2173379T3 publication Critical patent/DK2173379T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (19)

1. Isoleret monoklonalt antistof, der binder specifikt til et humant R-spondin-protein (RSPO) og inhiberer vækst af en solid tumor omfattende solid tumorstamceller, hvor antistoffet forstyrrer binding af RSPO-proteinet til et leucin-rigt repeat-indeholdende G-protein-koblet receptor-protein (LGR), hvor LGR-proteinet er LGR5; og/eller forstyrrer RSPO-aktivering af LGR5-signalering.
2. Antistof ifølge krav 1, hvor RSPO-proteinet er RSPO-1, RSPO-2 eller RSPO-3.
3. Antistof ifølge krav 2, hvor RSPO-proteinet er RSPO-1.
4. Antistof ifølge krav 1, hvor RSPO-proteinet er RSPO-4.
5. Isoleret monoklonalt antistof, der binder specifikt til et ekstracellulært domæne af et humant leucin-rigt repeat-indeholdende G-protein-koblet receptor-protein (LGR), hvor LGR-proteinet er LGR5, og inhiberer vækst af en solid tumor omfattende solid tumor-stamceller, hvor antistoffet forstyrrer binding af RSPO til LGR5; og/eller forstyrrer RSPO-aktivering af LGR5-signalering.
6. Antistof ifølge krav 5, hvor det ekstracellulære domæne omfatter aminosyrer 22-564 af humant LGR5 (SEQ ID NO: 1).
7. Antistof ifølge krav 5, hvor antistoffet er (a) monoklonalt antistof 88M1 produceret af en hybridomcellelinje med ATCC-deponeringsnr. PTA-9342; eller (b) isoleret antistof omfattende tungkæde-CDR'erne og/eller letkæde-CDR'erne af et monoklonalt antistof 88M1 produceret af en hybridomcellelinje med ATCC-deponeringsnr. PTA-9342; eller (c) isoleret antistof, der konkurrerer med med et monoklonalt antistof 88M1 produceret af en hybridomcelle med ATCC-deponeringsnr. PTA-9342 i en kompetitiv bindingsassay.
8. Antistof ifølge et hvilket som helst af kravene 1 til 6, som er et kimært, humaniseret eller humant antistof, et bispecifikt antistof eller et antistoffragment.
9. Cellelinje, der producerer antistoffet ifølge et hvilket som helst af kravene 1 til 8.
10. Farmaceutisk sammensætning omfattende antistoffet ifølge et hvilket som helst af kravene 1 til 8 og et farmaceutisk acceptabelt bærestof.
11. Farmaceutisk sammensætning ifølge krav 10, yderligere omfattende et andet anticancermiddel.
12. Opløselig receptor omfattende et ekstracellulært domæne af et humant LGR5-protein til anvendelse i en fremgangsmåde til behandling af cancer omfattende cancerstamceller.
13. Opløselig receptor ifølge krav 12, hvor det ekstracellulære domæne omfatter aminosyrer 22-564 af humant LGR5 (SEQ ID NO: 1).
14. Opløselig receptor ifølge krav 13, som yderligere omfatter en ikke-LGR-proteinsekvens.
15. Opløselig receptor ifølge krav 14, hvor ikke-LGR-proteinsekvensen omfatter humant Fc.
16. Middel til anvendelse ved behandling af cancer omfattende cancerstamceller hos et menneske eller inhibering af vækst af en tumor hos et menneske, idet fremgangsmåden omfatter indgivelse af en terapeutisk virksom mængde af et middel, der (a) forstyrrer bindingen af et humant R-spondin-protein (RSPO) og en human leucin-rig repeat-indeholdende G-protein-koblet receptor (LGR), hvor LGR-proteinet er LGR5; og/eller (b) forstyrrer RSPO-aktivering af LGR5-signallering, hvor midlet er et antistof ifølge et hvilket som helst af kravene 1 til 8 eller en opløselig receptor ifølge et hvilket som helst af kravene 12 til 15.
17. Middel til anvendelse ifølge krav 16, som er antistoffet ifølge et af kravene 1 til 8.
18. Middel til anvendelse ifølge krav 16 eller krav 17, hvor mennesket har en tumor omfattende cancerstamceller eller har fået fjernet en tumor omfattende cancerstamceller.
19. Middel til anvendelse ifølge et hvilket som helst af kravene 16 til 18, hvor fremgangsmåden til behandling af en cancer og/eller inhibering af vækst af en tumor yderligere omfatter indgivelse af en virksom mængde af et andet anticancermiddel.
DK08779934.2T 2007-07-02 2008-07-02 Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer DK2173379T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94761107P 2007-07-02 2007-07-02
PCT/US2008/008210 WO2009005809A2 (en) 2007-07-02 2008-07-02 Compositions and methods for treating and diagnosing cancer

Publications (1)

Publication Number Publication Date
DK2173379T3 true DK2173379T3 (da) 2015-12-07

Family

ID=40226729

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08779934.2T DK2173379T3 (da) 2007-07-02 2008-07-02 Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer

Country Status (14)

Country Link
US (10) US8158757B2 (da)
EP (3) EP3424529A1 (da)
JP (3) JP5931336B2 (da)
AU (1) AU2008270972B2 (da)
CA (1) CA2691378A1 (da)
CY (1) CY1116967T1 (da)
DK (1) DK2173379T3 (da)
ES (2) ES2694018T3 (da)
HR (1) HRP20151261T1 (da)
HU (1) HUE027154T2 (da)
PL (2) PL3009148T3 (da)
PT (1) PT2173379E (da)
SI (1) SI2173379T1 (da)
WO (1) WO2009005809A2 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2157192E (pt) 2003-10-10 2013-11-28 Deutsches Krebsforsch Composições para diagnóstico e terapia de doenças associadas com a expressão aberrante de futrinas (r-espondinas)
PL2081586T5 (pl) 2006-10-20 2019-04-30 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Rspondyny jako modulatory angiogenezy i waskulogenezy
DK2173379T3 (da) 2007-07-02 2015-12-07 Oncomed Pharm Inc Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer
CN102112492B (zh) * 2007-11-14 2015-02-25 中外制药株式会社 使用抗gpr49抗体的癌症的诊断和治疗
WO2010016766A2 (en) * 2008-08-08 2010-02-11 Koninklijke Nederlandse Akademie Van Wetenschappen Antibodies recognizing endogenous human lgr5 and/or lgr6
US8652843B2 (en) 2008-08-12 2014-02-18 Oncomed Pharmaceuticals, Inc. DDR1-binding agents and methods of use thereof
US20110171650A1 (en) * 2008-09-16 2011-07-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Gene expression related to preeclampsia
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
AU2010211428B2 (en) 2009-02-03 2015-09-03 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells.
US8563307B2 (en) 2009-02-24 2013-10-22 James Wang Treatment of immunosuppression-related disorders
ES2617281T3 (es) 2009-10-28 2017-06-16 Janssen Biotech, Inc. Anticuerpos anti-glp-1r y sus usos
EP4190149A1 (en) 2009-12-25 2023-06-07 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
WO2012046797A1 (ja) 2010-10-06 2012-04-12 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞集団及びその作製方法
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
US9057096B2 (en) 2011-05-20 2015-06-16 Board Of Regents Of The University Of Texas System Regulation of Wnt/beta-catenin signaling
AU2013204484B2 (en) * 2011-07-15 2016-05-12 Oncomed Pharmaceuticals, Inc. RSPO binding agents and uses thereof
EP2731625B1 (en) 2011-07-15 2018-04-18 OncoMed Pharmaceuticals, Inc. Rspo binding agents and uses thereof
WO2013035824A1 (ja) 2011-09-07 2013-03-14 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞の分離
TWI614340B (zh) 2011-09-28 2018-02-11 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
CN104080471B (zh) 2011-10-14 2018-08-10 诺华股份有限公司 用于Wnt途径相关疾病的抗体和方法
EP2772268B8 (en) 2011-10-28 2020-01-08 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
AU2012332593B2 (en) * 2011-11-01 2016-11-17 Bionomics, Inc. Anti-GPR49 antibodies
CN104053671A (zh) * 2011-11-01 2014-09-17 生态学有限公司 治疗癌症的抗体和方法
AU2012332590B2 (en) * 2011-11-01 2016-10-20 Bionomics, Inc. Anti-GPR49 antibodies
AU2012332588B2 (en) * 2011-11-01 2017-09-07 Bionomics, Inc. Methods of blocking cancer stem cell growth
WO2013119923A1 (en) 2012-02-09 2013-08-15 The Regents Of The University Of Michigan Different states of cancer stem cells
JP6545959B2 (ja) 2012-02-11 2019-07-17 ジェネンテック， インコーポレイテッド Ｒスポンジン転位およびその使用方法
AR090549A1 (es) * 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados
CA2878868A1 (en) * 2012-07-13 2014-01-16 Austin L. Gurney Rspo3 binding agents and uses thereof
US20140017721A1 (en) * 2012-07-13 2014-01-16 The Research Foundation Of State University Of New York Spontaneously immortalized prostate cancer cell line
WO2014089268A2 (en) 2012-12-06 2014-06-12 StemBios Technologies, Inc. Lgr5+ somatic stem cells
EP2746769A1 (en) 2012-12-21 2014-06-25 Stembios Technologies, Inc. Method for evaluating effect of action on subject based on stem celldynamics
WO2014192974A1 (ja) 2013-05-30 2014-12-04 株式会社オーダーメードメディカルリサーチ 抗ｌｇｒ６抗体を含む癌の検出用又は診断用試薬
AR097685A1 (es) 2013-09-17 2016-04-06 Genentech Inc Métodos de uso de anticuerpos anti-lgr5
WO2015108203A1 (ja) 2014-01-15 2015-07-23 株式会社オーダーメードメディカルリサーチ 抗ｓｌｃ６ａ６抗体を用いたがん治療用医薬組成物
AU2015223566B2 (en) 2014-02-28 2020-10-08 Merus N.V. Antibodies that bind EGFR and ErbB3
SI3110849T1 (sl) 2014-02-28 2021-01-29 Merus N.V. Protitelo, ki veže ERBB-2 in ERBB-3
MX2016012873A (es) 2014-04-04 2017-03-07 Bionomics Inc Anticuerpos humanizados que se unen al receptor 5 acoplado a proteina g que contiene repeticion rica en leucina (lgr5).
CA3190408A1 (en) * 2014-05-05 2015-11-12 Synexis Llc Purified hydrogen peroxide gas generation methods and devices
KR20170010785A (ko) 2014-06-11 2017-02-01 제넨테크, 인크. 항-lgr5 항체 및 이의 용도
WO2016044295A1 (en) * 2014-09-16 2016-03-24 Oncomed Pharmaceuticals, Inc. Treatment of fibrotic diseases
WO2016057629A1 (en) * 2014-10-07 2016-04-14 Duke University Methods and therapeutics relating to human r-spondin protein and leucine-rich repeat-containing g protein-coupled receptor protein
MA41123A (fr) * 2014-12-02 2017-10-10 Oncomed Pharm Inc Polythérapie pour le traitement du cancer
WO2017040660A1 (en) * 2015-08-31 2017-03-09 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
SI3365373T1 (sl) 2015-10-23 2021-08-31 Merus N.V. Vezne molekule, ki zaviranjo rast raka
CN105274061A (zh) * 2015-10-26 2016-01-27 无锡傲锐东源生物科技有限公司 抗lgr5蛋白单克隆抗体杂交瘤细胞及其产生的抗lgr5单克隆抗体和应用
CN108697799A (zh) * 2016-03-22 2018-10-23 生态学有限公司 抗lgr5单克隆抗体的施用
KR20190053909A (ko) 2016-09-16 2019-05-20 바이오노믹스 리미티드 항체와 체크포인트 면역 억제제의 병용 요법
CA3045466A1 (en) 2016-12-01 2018-06-07 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
WO2018182422A1 (en) 2017-03-31 2018-10-04 Merus N.V. Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
SG11202001050PA (en) 2017-08-09 2020-03-30 Merus Nv Antibodies that bind egfr and cmet
EP4076497A1 (en) * 2019-12-19 2022-10-26 Deutsches Krebsforschungszentrum Leukemia treatment
WO2021247497A1 (en) * 2020-06-03 2021-12-09 Children's Hospital Medical Center Compositions and methods comprising r-spondins for treatment of tumors

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109496A (en) 1977-12-20 1978-08-29 Norris Industries Trapped key mechanism
US4323546A (en) 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US4981785A (en) 1988-06-06 1991-01-01 Ventrex Laboratories, Inc. Apparatus and method for performing immunoassays
US4968103A (en) 1988-07-22 1990-11-06 Photofinish Cosmetics Inc. Method of making a brush
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8901778D0 (en) 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
US5028205A (en) 1989-12-14 1991-07-02 Ingersoll-Rand Company Oil scavenger system for a seal for a rotary shaft
US5614396A (en) 1990-06-14 1997-03-25 Baylor College Of Medicine Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ATE164395T1 (de) 1990-12-03 1998-04-15 Genentech Inc Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
EP0552108B1 (en) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Energy transfer phase-modulation fluoro-immunoassay
US5376313A (en) 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
US20070124581A1 (en) 1992-05-17 2007-05-31 Reena Khare Cell adhesion and extracellular matrix proteins
EP0672131B1 (en) 1992-10-30 2003-12-17 The General Hospital Corporation A novel cell cycle control protein
ES2142934T3 (es) 1993-02-19 2000-05-01 Nippon Shinyaku Co Ltd Derivado del glicerol, dispositivo y composicion farmaceutica.
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5876978A (en) 1993-04-06 1999-03-02 Medical College Of Ohio Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5643765A (en) 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
JP2000502450A (ja) 1995-12-22 2000-02-29 アボツト・ラボラトリーズ 蛍光偏光免疫アッセイによる診断法
US5994316A (en) 1996-02-21 1999-11-30 The Immune Response Corporation Method of preparing polynucleotide-carrier complexes for delivery to cells
US5885529A (en) 1996-06-28 1999-03-23 Dpc Cirrus, Inc. Automated immunoassay analyzer
CA2283267A1 (en) 1997-03-07 1998-09-11 Clare Chemical Research Llc Fluorometric detection using visible light
US6080912A (en) 1997-03-20 2000-06-27 Wisconsin Alumni Research Foundation Methods for creating transgenic animals
JP2001527403A (ja) 1997-04-25 2001-12-25 ジェネティックス・インスチチュート・インコーポレーテッド 分泌蛋白およびそれらをコードするポリヌクレオチド
US6004528A (en) 1997-09-18 1999-12-21 Bergstein; Ivan Methods of cancer diagnosis and therapy targeted against the cancer stemline
US6083616A (en) 1997-09-19 2000-07-04 Seal Products, Inc. Nontack pressure activated adhesive
EP1017811A4 (en) 1997-09-24 2002-08-14 Merck & Co Inc HG38 GLYCOPROTEIN HORMONE RECEPTOR COUPLED WITH G-PROTEIN
US20020065394A1 (en) 1998-03-18 2002-05-30 Kenneth Jacobs Secreted proteins and polynucleotides encoding them
ATE440865T1 (de) * 1998-03-26 2009-09-15 Univ Leland Stanford Junior Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region
US6485972B1 (en) 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
US20030166047A1 (en) 1999-05-06 2003-09-04 Millennium Pharmaceuticals, Inc. Lgr6 nucleic acids and uses thereof
JP2003505082A (ja) 1999-07-26 2003-02-12 ジェネンテック・インコーポレーテッド 新規なポリヌクレオチドとその使用法
EP1572987A4 (en) 2000-02-03 2005-11-30 Nuvelo Inc NUCLEIC ACIDS AND POLYPEPTIDES
US6824973B2 (en) 2000-02-03 2004-11-30 Kirin Beer Kabushiki Kaisha Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide
EP1267616B1 (en) 2000-03-31 2007-08-08 The General Hospital Corporation Methods of increasing hair growth by wnt polypeptide
JP2003530124A (ja) 2000-04-05 2003-10-14 麒麟麦酒株式会社 新規幹細胞成長因子様ポリペプチドおよびポリヌクレオチドに関する方法および物質
EP1156062A1 (en) * 2000-05-12 2001-11-21 GPC Biotech AG Immunomodulatory human MHC class II antigen-binding peptides/proteins
AU2001263006A1 (en) 2000-05-18 2001-11-26 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001281791A1 (en) 2000-05-30 2001-12-11 Bayer Aktiengesellschaft Regulation of human lgr4-like g protein-coupled receptor
WO2003050502A2 (en) 2001-12-07 2003-06-19 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6768004B2 (en) 2001-01-11 2004-07-27 Mueller Sybille Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies
US20040077048A1 (en) 2002-01-30 2004-04-22 Warren Bridget A. Protein modification and maintenance molecules
US20030032034A1 (en) 2001-03-05 2003-02-13 Tang Y. Tom Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
US20100292155A1 (en) 2001-03-05 2010-11-18 Arca Biopharma, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
US7411052B2 (en) 2001-03-05 2008-08-12 Nuvelo, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
AU2002304249A1 (en) 2001-06-11 2002-12-23 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same
ATE440869T1 (de) * 2001-06-20 2009-09-15 Fibron Ltd Fgfr3 blockierende antikírper, verfahren zum screening darauf und verwendungen davon
US20030022217A1 (en) 2001-07-02 2003-01-30 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
CA2458818A1 (en) 2001-08-30 2003-04-10 Nuvelo, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
CA2462795A1 (en) 2001-10-03 2003-04-10 Incyte Genomics, Inc. Secreted proteins
US20070237770A1 (en) 2001-11-30 2007-10-11 Albert Lai Novel compositions and methods in cancer
US20040197778A1 (en) 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
EP1504099A4 (en) 2001-12-10 2006-05-10 Nuvelo Inc NEW NUCLEIC ACIDS AND POLYPEPTIDES
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
EP1499637A1 (en) 2002-04-26 2005-01-26 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same
EP1380644A1 (en) 2002-07-08 2004-01-14 Kylix B.V. The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role
CA2509568A1 (en) * 2002-12-26 2004-07-15 Applied Research Systems Ars Holding N.V. Spliced variants of lgr6
WO2004074436A2 (en) 2003-02-19 2004-09-02 Incyte Corporation Methods of use of a gpcr in the diagnosis and treatment of colon and lung cancer
US20050003405A1 (en) 2003-04-30 2005-01-06 Hua-Chien Chen Treatment and diagnostics of cancer
WO2005005601A2 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20050054829A1 (en) 2003-07-22 2005-03-10 Wiley Steven R. Compositions and methods relating to TSP-30a, b, c and d
DE10339820A1 (de) 2003-08-22 2005-03-17 Hinzmann, Bernd, Dr. Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
US9046537B2 (en) 2003-09-22 2015-06-02 Enzo Biochem, Inc. Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
PT2157192E (pt) * 2003-10-10 2013-11-28 Deutsches Krebsforsch Composições para diagnóstico e terapia de doenças associadas com a expressão aberrante de futrinas (r-espondinas)
WO2005040828A2 (en) 2003-10-24 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49)
CA2554403A1 (en) 2004-01-27 2005-08-11 Nuvelo, Inc. Gastrointestinal proliferative factor and uses thereof
WO2005074633A2 (en) * 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US7572456B2 (en) 2004-09-13 2009-08-11 Macrogenics, Inc. Humanized antibodies against West Nile Virus and therapeutic and prophylactic uses thereof
AU2005318171B2 (en) 2004-12-20 2011-09-29 Crucell Holland B.V. Binding molecules capable of neutralizing West Nile virus and uses thereof
US7439327B2 (en) 2005-01-18 2008-10-21 Nuvelo, Inc. Stem cell factor-like proteins and uses thereof
US20090220495A1 (en) 2005-04-07 2009-09-03 Abdallah Fanidi Cancer Related Genes (PRLR)
US20090036369A1 (en) 2005-07-26 2009-02-05 Kirin Pharma Kabushiki Kaisha Anti-tumor agents comprising r-spondins
WO2007030290A2 (en) * 2005-09-07 2007-03-15 Maine Medical Center Research Cristin/r-spondin ligands active in the wnt signaling pathway and methods, compositions and kits relating thereto
WO2007100357A2 (en) 2005-10-07 2007-09-07 Nuvelo, Inc. Stem cell factor-like protein scfa1 and uses thereof
US7723112B2 (en) * 2005-10-31 2010-05-25 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
GB0603683D0 (en) * 2006-02-23 2006-04-05 Novartis Ag Organic compounds
KR101196184B1 (ko) 2006-06-02 2012-11-01 아베오 파마슈티컬즈, 인크. 간세포 성장 인자 (ｈｇｆ) 결합 단백질
BRPI0712222B1 (pt) 2006-06-02 2021-10-13 Aveo Pharmaceuticals, Inc. Proteína de ligação isolada que se liga ao fator de crescimento de hepatócito humano (hgf), seu uso e método de produção, ácido nucléico, vetor de expressão, célula hospedeira, e métodos para produzir um polipeptídeo que compreende uma região variável da cadeia pesada de imunoglobulina e para produzir um polipeptídeo que compreende uma região variável da cadeia leve de imunoglobulina
ES2413087T3 (es) 2006-06-13 2013-07-15 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para el diagnóstico y tratamiento del cáncer
AU2007274738B2 (en) 2006-07-18 2013-11-28 Sanofi-Aventis Antagonist antibody against EphA2 for the treatment of cancer
JP2008044926A (ja) * 2006-08-14 2008-02-28 Trustees Of Columbia Univ In The City Of New York Ｗｎｔ信号伝達に関係した分泌タンパク質
WO2008042236A2 (en) 2006-09-29 2008-04-10 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PL2081586T5 (pl) 2006-10-20 2019-04-30 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Rspondyny jako modulatory angiogenezy i waskulogenezy
WO2008075796A1 (ja) 2006-12-21 2008-06-26 Kyowa Hakko Kirin Co., Ltd. 血球回復促進剤
WO2008088524A2 (en) 2006-12-28 2008-07-24 Nuvelo, Inc. Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor
BRPI0812562A2 (pt) 2007-06-12 2019-09-24 Trubion Pharmaceuticals Inc composições terapêuticas anti-cd20 e métodos
DK2173379T3 (da) 2007-07-02 2015-12-07 Oncomed Pharm Inc Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer
CA2700257A1 (en) 2007-10-02 2009-04-09 Hartmut Land Methods and compositions related to synergistic responses to oncogenic mutations
US20120082659A1 (en) 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
CN102112492B (zh) 2007-11-14 2015-02-25 中外制药株式会社 使用抗gpr49抗体的癌症的诊断和治疗
EP2313435A4 (en) 2008-07-01 2012-08-08 Aveo Pharmaceuticals Inc FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS
WO2010016766A2 (en) 2008-08-08 2010-02-11 Koninklijke Nederlandse Akademie Van Wetenschappen Antibodies recognizing endogenous human lgr5 and/or lgr6
JP5941615B2 (ja) 2008-10-31 2016-06-29 東レ株式会社 ヒトｃｘｃｌ１タンパク質の免疫学的測定方法
US20120039912A1 (en) 2009-04-15 2012-02-16 Galapagos Sasu Rspondin-3 inhibition in bone disorders
EP2424567B1 (en) 2009-04-27 2018-11-21 OncoMed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
US20120165270A1 (en) 2009-04-27 2012-06-28 Yeon Sook Choi Inhibition of hair follicle growth by the wnt inhibitor dkk1
KR20120027031A (ko) 2009-06-18 2012-03-20 와이어쓰 엘엘씨 소형 모듈 면역제약용 동결건조 제제
WO2011009090A1 (en) 2009-07-16 2011-01-20 Xoma Technology Ltd. Antibodies to high molecular weight melanoma associated antigen
EP2473531A4 (en) 2009-09-03 2013-05-01 Merck Sharp & Dohme ANTI-GITRANT ANTIBODIES
ES2573643T3 (es) 2009-12-23 2016-06-09 Deutsches Krebsforschungszentrum Receptores de Rspo2 y Rspo3
US8663950B2 (en) 2010-01-11 2014-03-04 Arizona Board Of Regents Production of a monoclonal antibody therapeutic against west nile virus in plants
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US20150024952A1 (en) 2010-12-28 2015-01-22 Arlet Alarcon Molecular profiling for cancer
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
ES2788183T3 (es) 2011-04-28 2020-10-20 Sbi Biotech Co Ltd Anticuerpo anti-proteína tirosina fosfatasa de tipo receptor humana
EP2731625B1 (en) 2011-07-15 2018-04-18 OncoMed Pharmaceuticals, Inc. Rspo binding agents and uses thereof
CN104080471B (zh) 2011-10-14 2018-08-10 诺华股份有限公司 用于Wnt途径相关疾病的抗体和方法
AU2012332588B2 (en) 2011-11-01 2017-09-07 Bionomics, Inc. Methods of blocking cancer stem cell growth
AU2012332590B2 (en) 2011-11-01 2016-10-20 Bionomics, Inc. Anti-GPR49 antibodies
JP6545959B2 (ja) 2012-02-11 2019-07-17 ジェネンテック， インコーポレイテッド Ｒスポンジン転位およびその使用方法
AR090549A1 (es) 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados
CA2878868A1 (en) 2012-07-13 2014-01-16 Austin L. Gurney Rspo3 binding agents and uses thereof
WO2014165232A1 (en) 2013-03-12 2014-10-09 Curegenix, Inc. Compounds for treatment of cancer
WO2014192974A1 (ja) 2013-05-30 2014-12-04 株式会社オーダーメードメディカルリサーチ 抗ｌｇｒ６抗体を含む癌の検出用又は診断用試薬
US20150147333A1 (en) 2013-10-18 2015-05-28 Genentech, Inc. Anti-rspo antibodies and methods of use
MA41123A (fr) 2014-12-02 2017-10-10 Oncomed Pharm Inc Polythérapie pour le traitement du cancer
US9777052B2 (en) 2014-12-02 2017-10-03 The Board Of Regents Of The University Of Oklahoma R-spondin variants, compositions, and methods of use

Also Published As

Publication number Publication date
WO2009005809A3 (en) 2009-04-02
US20130121993A1 (en) 2013-05-16
EP2173379B2 (en) 2023-07-05
US9040044B2 (en) 2015-05-26
US20130336970A1 (en) 2013-12-19
PL3009148T3 (pl) 2019-03-29
EP3424529A1 (en) 2019-01-09
EP2173379B1 (en) 2015-09-02
EP3009148A1 (en) 2016-04-20
HRP20151261T1 (hr) 2016-01-01
JP2014144016A (ja) 2014-08-14
ES2694018T3 (es) 2018-12-17
AU2008270972B2 (en) 2013-10-24
US20150337050A1 (en) 2015-11-26
CY1116967T1 (el) 2017-04-05
US20130115206A1 (en) 2013-05-09
US20180099047A1 (en) 2018-04-12
US20140134177A1 (en) 2014-05-15
US8883736B2 (en) 2014-11-11
US20170296658A1 (en) 2017-10-19
HUE027154T2 (en) 2016-08-29
US20150165024A1 (en) 2015-06-18
JP5931336B2 (ja) 2016-06-08
WO2009005809A2 (en) 2009-01-08
AU2008270972A1 (en) 2009-01-08
JP2010532169A (ja) 2010-10-07
US8158757B2 (en) 2012-04-17
US20090191205A1 (en) 2009-07-30
ES2553169T5 (es) 2023-11-30
PT2173379E (pt) 2015-11-24
SI2173379T1 (sl) 2015-12-31
EP3009148B1 (en) 2018-08-22
US9610348B2 (en) 2017-04-04
EP2173379A2 (en) 2010-04-14
US9717794B2 (en) 2017-08-01
US20090074782A1 (en) 2009-03-19
US8158758B2 (en) 2012-04-17
US8628774B2 (en) 2014-01-14
ES2553169T3 (es) 2015-12-04
US8540989B2 (en) 2013-09-24
JP2016187356A (ja) 2016-11-04
PL2173379T3 (pl) 2016-02-29
CA2691378A1 (en) 2009-01-08

Similar Documents

Publication Publication Date Title
US9717794B2 (en) Compositions and methods for treating and diagnosing cancer
US8501472B2 (en) Compositions and methods for treating and diagnosing pancreatic cancer
WO2009009114A2 (en) Compositions and methods for treating and diagnosing cancer
JP2014240384A (ja) ポリペプチド並びにポリヌクレオチド、並びに薬剤および生物製剤生産のための薬剤標的としてのその利用
AU2013203352B2 (en) Compositions and methods for treating and diagnosing cancer
WO2009111644A2 (en) Compositions and methods for diagnosing and treating pancreatic cancer