DK2173379T3 - Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer - Google Patents

Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer Download PDF

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DK2173379T3
DK2173379T3 DK08779934.2T DK08779934T DK2173379T3 DK 2173379 T3 DK2173379 T3 DK 2173379T3 DK 08779934 T DK08779934 T DK 08779934T DK 2173379 T3 DK2173379 T3 DK 2173379T3
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antibody
cancer
protein
human
lgr5
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DK08779934.2T
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Austin Gurney
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Oncomed Pharm Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Claims (19)

1. Isoleret monoklonalt antistof, der binder specifikt til et humant R-spondin-protein (RSPO) og inhiberer vækst af en solid tumor omfattende solid tumorstamceller, hvor antistoffet forstyrrer binding af RSPO-proteinet til et leucin-rigt repeat-indeholdende G-protein-koblet receptor-protein (LGR), hvor LGR-proteinet er LGR5; og/eller forstyrrer RSPO-aktivering af LGR5-signalering.
2. Antistof ifølge krav 1, hvor RSPO-proteinet er RSPO-1, RSPO-2 eller RSPO-3.
3. Antistof ifølge krav 2, hvor RSPO-proteinet er RSPO-1.
4. Antistof ifølge krav 1, hvor RSPO-proteinet er RSPO-4.
5. Isoleret monoklonalt antistof, der binder specifikt til et ekstracellulært domæne af et humant leucin-rigt repeat-indeholdende G-protein-koblet receptor-protein (LGR), hvor LGR-proteinet er LGR5, og inhiberer vækst af en solid tumor omfattende solid tumor-stamceller, hvor antistoffet forstyrrer binding af RSPO til LGR5; og/eller forstyrrer RSPO-aktivering af LGR5-signalering.
6. Antistof ifølge krav 5, hvor det ekstracellulære domæne omfatter aminosyrer 22-564 af humant LGR5 (SEQ ID NO: 1).
7. Antistof ifølge krav 5, hvor antistoffet er (a) monoklonalt antistof 88M1 produceret af en hybridomcellelinje med ATCC-deponeringsnr. PTA-9342; eller (b) isoleret antistof omfattende tungkæde-CDR'erne og/eller letkæde-CDR'erne af et monoklonalt antistof 88M1 produceret af en hybridomcellelinje med ATCC-deponeringsnr. PTA-9342; eller (c) isoleret antistof, der konkurrerer med med et monoklonalt antistof 88M1 produceret af en hybridomcelle med ATCC-deponeringsnr. PTA-9342 i en kompetitiv bindingsassay.
8. Antistof ifølge et hvilket som helst af kravene 1 til 6, som er et kimært, humaniseret eller humant antistof, et bispecifikt antistof eller et antistoffragment.
9. Cellelinje, der producerer antistoffet ifølge et hvilket som helst af kravene 1 til 8.
10. Farmaceutisk sammensætning omfattende antistoffet ifølge et hvilket som helst af kravene 1 til 8 og et farmaceutisk acceptabelt bærestof.
11. Farmaceutisk sammensætning ifølge krav 10, yderligere omfattende et andet anticancermiddel.
12. Opløselig receptor omfattende et ekstracellulært domæne af et humant LGR5-protein til anvendelse i en fremgangsmåde til behandling af cancer omfattende cancerstamceller.
13. Opløselig receptor ifølge krav 12, hvor det ekstracellulære domæne omfatter aminosyrer 22-564 af humant LGR5 (SEQ ID NO: 1).
14. Opløselig receptor ifølge krav 13, som yderligere omfatter en ikke-LGR-proteinsekvens.
15. Opløselig receptor ifølge krav 14, hvor ikke-LGR-proteinsekvensen omfatter humant Fc.
16. Middel til anvendelse ved behandling af cancer omfattende cancerstamceller hos et menneske eller inhibering af vækst af en tumor hos et menneske, idet fremgangsmåden omfatter indgivelse af en terapeutisk virksom mængde af et middel, der (a) forstyrrer bindingen af et humant R-spondin-protein (RSPO) og en human leucin-rig repeat-indeholdende G-protein-koblet receptor (LGR), hvor LGR-proteinet er LGR5; og/eller (b) forstyrrer RSPO-aktivering af LGR5-signallering, hvor midlet er et antistof ifølge et hvilket som helst af kravene 1 til 8 eller en opløselig receptor ifølge et hvilket som helst af kravene 12 til 15.
17. Middel til anvendelse ifølge krav 16, som er antistoffet ifølge et af kravene 1 til 8.
18. Middel til anvendelse ifølge krav 16 eller krav 17, hvor mennesket har en tumor omfattende cancerstamceller eller har fået fjernet en tumor omfattende cancerstamceller.
19. Middel til anvendelse ifølge et hvilket som helst af kravene 16 til 18, hvor fremgangsmåden til behandling af en cancer og/eller inhibering af vækst af en tumor yderligere omfatter indgivelse af en virksom mængde af et andet anticancermiddel.
DK08779934.2T 2007-07-02 2008-07-02 Sammensætninger og fremgangsmåder til behandling og diagnosticering af cancer DK2173379T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94761107P 2007-07-02 2007-07-02
PCT/US2008/008210 WO2009005809A2 (en) 2007-07-02 2008-07-02 Compositions and methods for treating and diagnosing cancer

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US (10) US8158758B2 (da)
EP (3) EP2173379B2 (da)
JP (3) JP5931336B2 (da)
AU (1) AU2008270972B2 (da)
CA (1) CA2691378A1 (da)
CY (1) CY1116967T1 (da)
DK (1) DK2173379T3 (da)
ES (2) ES2694018T3 (da)
HR (1) HRP20151261T1 (da)
HU (1) HUE027154T2 (da)
PL (2) PL2173379T3 (da)
PT (1) PT2173379E (da)
SI (1) SI2173379T1 (da)
WO (1) WO2009005809A2 (da)

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