DK2139477T3 - Pyrazolopyridinderivater som NADPH-oxidaseinhibitorer - Google Patents
Pyrazolopyridinderivater som NADPH-oxidaseinhibitorerInfo
- Publication number
- DK2139477T3 DK2139477T3 DK08718102.0T DK08718102T DK2139477T3 DK 2139477 T3 DK2139477 T3 DK 2139477T3 DK 08718102 T DK08718102 T DK 08718102T DK 2139477 T3 DK2139477 T3 DK 2139477T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxidase inhibitors
- nadph oxidase
- pyrazolopyridine derivatives
- pyrazolopyridine
- derivatives
- Prior art date
Links
- 102000004722 NADPH Oxidases Human genes 0.000 title 1
- 108010002998 NADPH Oxidases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000005229 pyrazolopyridines Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
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- Molecular Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89628407P | 2007-03-22 | 2007-03-22 | |
| EP07109555A EP2002835A1 (en) | 2007-06-04 | 2007-06-04 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| PCT/EP2008/053390 WO2008113856A1 (en) | 2007-03-22 | 2008-03-20 | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2139477T3 true DK2139477T3 (da) | 2013-03-11 |
Family
ID=38653574
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08718102.0T DK2139477T3 (da) | 2007-03-22 | 2008-03-20 | Pyrazolopyridinderivater som NADPH-oxidaseinhibitorer |
| DK12187254.3T DK2545918T3 (da) | 2007-03-22 | 2008-03-20 | Pyrazolopyridinderivater som NADPH-oxidaseinhibitorer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12187254.3T DK2545918T3 (da) | 2007-03-22 | 2008-03-20 | Pyrazolopyridinderivater som NADPH-oxidaseinhibitorer |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8389518B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2002835A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5715340B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105061422B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008228186C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0808824B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2676954C (cg-RX-API-DMAC7.html) |
| CY (2) | CY1113556T1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK2139477T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2398994T3 (cg-RX-API-DMAC7.html) |
| HR (2) | HRP20130143T1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL201009A (cg-RX-API-DMAC7.html) |
| PL (2) | PL2139477T3 (cg-RX-API-DMAC7.html) |
| PT (2) | PT2545918E (cg-RX-API-DMAC7.html) |
| RS (2) | RS52640B (cg-RX-API-DMAC7.html) |
| SI (2) | SI2545918T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008113856A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2002835A1 (en) * | 2007-06-04 | 2008-12-17 | GenKyo Tex | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2000176A1 (en) | 2007-06-04 | 2008-12-10 | GenKyo Tex | Tetrahydroindole derivatives as NADPH Oxidase inhibitors |
| EP2166008A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2166010A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2165707A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2166009A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
| US20120141461A1 (en) * | 2009-07-17 | 2012-06-07 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating fibrotic disorders |
| EP2305679A1 (en) | 2009-09-28 | 2011-04-06 | GenKyoTex SA | Pyrazoline dione derivatives as nadph oxidase inhibitors |
| EP2512242B8 (en) * | 2009-12-18 | 2015-12-09 | GlaxoSmithKline Intellectual Property Limited | Novel compounds |
| EP2361911A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
| EP2361912A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
| US9428478B2 (en) | 2011-06-13 | 2016-08-30 | Emory University | Piperazine derivatives, compositions, and uses related thereto |
| GB2494679A (en) * | 2011-09-15 | 2013-03-20 | Univ Jw Goethe Frankfurt Main | Treatment of neuropathic pain and nerve injury by Nox4 inhibition |
| EP2591782A1 (en) * | 2011-11-11 | 2013-05-15 | Johann Wolfgang Goethe-Universität | Nadph oxidase 4 inhibitors and use thereof |
| WO2014153227A1 (en) * | 2013-03-14 | 2014-09-25 | Eastern Virginia Medical School | Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting nox-1 |
| EP2857399A1 (en) | 2013-10-03 | 2015-04-08 | GenKyoTex SA | Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction |
| EP3098220A1 (en) | 2015-05-28 | 2016-11-30 | GenKyoTex SA | Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof |
| CN107743483B (zh) | 2015-06-22 | 2022-01-28 | 埃科特莱茵药品有限公司 | Nadph氧化酶4抑制剂 |
| WO2017196982A1 (en) | 2016-05-10 | 2017-11-16 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of rsv |
| CA3023922C (en) | 2016-05-10 | 2023-04-18 | Georgia State University Research Foundation, Inc. | Heterocyclic derivatives for the treatment of rsv |
| EP3510032B1 (en) | 2016-09-09 | 2022-07-06 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018049152A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2018203298A1 (en) | 2017-05-04 | 2018-11-08 | Glenmark Pharmaceuticals S.A. | Substituted bicyclic heterocyclic compounds as nadph oxidase inhibitors |
| US11236053B2 (en) | 2017-07-26 | 2022-02-01 | Emory University | NADPH oxidase inhibitors and uses thereof |
| WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
| EP3479843A1 (en) | 2017-11-01 | 2019-05-08 | GenKyoTex Suisse SA | Use of nox inhibitors for treatment of cancer |
| BR112020016927A2 (pt) | 2018-02-20 | 2020-12-15 | Incyte Corporation | Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida e compostos relacionados como inibidores de hpk1 para tratar câncer |
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