DK2119441T3 - Anvendelse af angiotensin-II-receptor-antagonister til forøgelse af insulinsensitivitet - Google Patents

Anvendelse af angiotensin-II-receptor-antagonister til forøgelse af insulinsensitivitet Download PDF

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Publication number
DK2119441T3
DK2119441T3 DK09160568.3T DK09160568T DK2119441T3 DK 2119441 T3 DK2119441 T3 DK 2119441T3 DK 09160568 T DK09160568 T DK 09160568T DK 2119441 T3 DK2119441 T3 DK 2119441T3
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Prior art keywords
telmisartan
glucose
value
diabetes
treated
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DK09160568.3T
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English (en)
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Stefan Kauschke
Michael Mark
Thomas Unger
Ulrich Kintscher
Michael Schupp
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Boehringer Ingelheim Int
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Publication of DK2119441T3 publication Critical patent/DK2119441T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)

Claims (10)

1. Farmaceutisk sammensætning, omfattende en angiotensin-II-receptor-antagonist valgt blandt irbesartan og telmisartan eller et salt deraf til anvendelse i en fremgangsmåde til behandling af personer hos hvilke der er diagnosticeret diabetes mellitus type 2 eller er mistanke om prædiabetes, eller til forebyggelse af diabetes.
2. Farmaceutisk sammensætning til anvendelse ifølge krav 1, kendetegnet ved, at hos personer der skal behandles, overstiger faste-blodsukkerværdien 125 mg glukose per dl plasma.
3. Farmaceutisk sammensætning til anvendelse ifølge krav 1, kendetegnet ved, at hos personer der skal behandles, er faste-blodsukkerværdien 110-125 mg glukose per dl plasma.
4. Farmaceutisk sammensætning til anvendelse ifølge krav 1, kendetegnet ved, at hos personer der skal behandles, måles en blodsukkerværdi over 200mg glukose per dl plasma, 2 timer efter fastende indtag af 75 g glukose.
5. Farmaceutisk sammensætning til anvendelse ifølge krav 1, kendetegnet ved, at hos personer der skal behandles, måles en blodsukkerværdi på 140-200mg glukose per dl plasma, 2 timer efter fastende indtag af 75 g glukose.
6. Farmaceutisk sammensætning til anvendelse ifølge krav 1, kendetegnet ved, at hos personer der skal behandles, overskrider blodværdien for triglycerid 150 mg/dl.
7. Farmaceutisk sammensætning til anvendelse ifølge krav 6, kendetegnet ved, at hos personer der skal behandles, underskrider blodværdien for HDL, 40 mg per dl plasma for kvinder, og 50 mg per dl plasma for mænd.
8. Farmaceutisk sammensætning til anvendelse ifølge kravene 6 og 7, kendeteg net ved, at hos personer der skal behandles, overskrider faste-blodsukkerværdien 110 mg glukose per dl plasma.
9. Farmaceutisk sammensætning til anvendelse ifølge kravene 1, 2 og 4, k e n d e t egnet ved, at hos personer der skal behandles, overstiger det systoliske blodtryk en værdi på 130 mm Hg, og det diastoliske blodtryk en værdi på 80 mm Hg.
10. Farmaceutisk sammensætning til anvendelse ifølge kravene 1-9, kendetegn e t ved, at hos personer der skal behandles, overskrider forholdet taljeomkreds til hofteomkreds for kvinder værdien 0,8 og for mænd værdien 1.
DK09160568.3T 2003-07-31 2004-07-24 Anvendelse af angiotensin-II-receptor-antagonister til forøgelse af insulinsensitivitet DK2119441T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10335027A DE10335027A1 (de) 2003-07-31 2003-07-31 Verwendung von Angiotensin II Rezeptor Antagonisten
DE10346260A DE10346260A1 (de) 2003-07-31 2003-10-06 Verwendung von Angiotensin II Rezeptor Antagonisten
DE10356815A DE10356815A1 (de) 2003-07-31 2003-12-05 Verwendung von Angiotensin II Rezeptor Antagonisten
EP04763484A EP1651213B2 (de) 2003-07-31 2004-07-24 Verwendung von angiotensin ii rezeptor antagonisten, insbesondere von telmisartan, zur steigerung der insulinsensitivität

Publications (1)

Publication Number Publication Date
DK2119441T3 true DK2119441T3 (da) 2015-08-10

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ID=34119379

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04763484.5T DK1651213T4 (da) 2003-07-31 2004-07-24 Anvendelse af angiotensin II-receptorantagonister, især af telmisartan, til forøgelse af insulinsensitivitet
DK09160568.3T DK2119441T3 (da) 2003-07-31 2004-07-24 Anvendelse af angiotensin-II-receptor-antagonister til forøgelse af insulinsensitivitet

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04763484.5T DK1651213T4 (da) 2003-07-31 2004-07-24 Anvendelse af angiotensin II-receptorantagonister, især af telmisartan, til forøgelse af insulinsensitivitet

Country Status (29)

Country Link
US (1) US20050070594A1 (da)
EP (3) EP2119441B1 (da)
JP (1) JP4833840B2 (da)
KR (1) KR20060054404A (da)
CN (3) CN102139110A (da)
AT (1) ATE443519T1 (da)
AU (1) AU2004260606B2 (da)
BR (1) BRPI0413165A (da)
CA (1) CA2534006C (da)
CY (1) CY1109560T1 (da)
DE (4) DE10335027A1 (da)
DK (2) DK1651213T4 (da)
EA (2) EA012600B1 (da)
EC (1) ECSP066303A (da)
ES (2) ES2543722T3 (da)
HK (1) HK1093305A1 (da)
HU (1) HUE027274T2 (da)
IL (1) IL172693A (da)
ME (1) MEP51108A (da)
MX (1) MXPA06001322A (da)
NO (1) NO335444B1 (da)
NZ (1) NZ544877A (da)
PL (2) PL2119441T3 (da)
PT (1) PT1651213E (da)
RS (1) RS50793B (da)
SI (1) SI1651213T2 (da)
UA (1) UA83854C2 (da)
WO (1) WO2005011680A1 (da)
ZA (1) ZA200509835B (da)

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