DK2077867T3 - Blodposesystem og fremgangsmåde til inaktivering af patogener i blodpladekoncentrater ved anvendelse af blodposesystemet - Google Patents
Blodposesystem og fremgangsmåde til inaktivering af patogener i blodpladekoncentrater ved anvendelse af blodposesystemet Download PDFInfo
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- DK2077867T3 DK2077867T3 DK07726129.5T DK07726129T DK2077867T3 DK 2077867 T3 DK2077867 T3 DK 2077867T3 DK 07726129 T DK07726129 T DK 07726129T DK 2077867 T3 DK2077867 T3 DK 2077867T3
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Claims (19)
1. Blodposesystem omfattende et biologisk fluid såsom blodpladekoncentrat og yderligere omfattende: - en opbevaringspose (4) lavet af et plastmateriale, - en bestrålingspose (2) lavet af et fleksibelt plastmateriale, som er i det væsentlige gennemsigtigt for UV-stråling og har en volumenkapacitet på mindst 10 gange rumfanget af det biologiske fluid indeholdt i bestrålingsposen, og omfattende et eller flere indløbsrør (1) og/eller udløbsrør (3), og - opbevaringsposen (4) og bestrålingsposen (2) er en og samme pose eller mindst to forskellige, der kan forbindes med hinanden, - hvor bestrålingsposen (2) omfatter en forsegling (16, 17), der tilvejebringer et rum indeholdende det biologiske fluid, der skal behandles, og et separat rum adskilt derfra omfattende den/de indre ende/ender af de et eller flere indløbsrør (1) og/eller udløbsrør (3), hvilken forsegling (16, 17) er placeret ved et hjørne af bestrålingsposen (2) og tilvejebringer et afskæringshjørne, kendetegnet ved, at indersiden af bestrålingsposen (2) omfatter afskårne eller runde hjørner, og at forseglingen har form som et afrundet hjørne.
2. Blodposesystem ifølge krav 1, hvori indløbsrørene (1) og/eller udløbsrørene (3) omfatter mindst en afklemningsdel, prop (18) eller afbrækningsdel (15) som lukke for røret og forløbende ind i bestrålingsposen, fortrinsvis placeret ved rørets, især udløbsrørets (3), indvendige ende, i hvilket tilfælde lukket kan åbnes.
3. Blodposesystem ifølge krav 1 eller 2, hvori forseglingen er symmetrisk med mindst en anden kant, som derved tilvejebringer en symmetrisk bestrålingspose.
4. Blodposesystem ifølge ethvert af de foregående krav, hvori det separate rum kun omfatter et eller flere indløbsrør.
5. Blodposesystem ifølge ethvert af de foregående krav, kendetegnet ved, at det biologiske fluid indeholdt i bestrålingsposen ikke indeholder en fotosensibilisa-tor med et absorptionsmaksimum i området 200 til 270 nm, især 200 til 350 nm, og som fortrinsvis er frit for pafogeninaktiverende stof tilført det biologiske fluid og frit for fotosensibilisator.
6. Blodposesystem ifølge ethvert af de foregående krav, kendetegnet ved, at det biologiske fluid er opslemmet blodpladekoncentrat omfattende plasma, hvori mindst 20 vægt-% af plasmaet indeholdt i blodpladekoncentratet er byttet mod en blodpladeopbevaringsopløsning til dannelse af et opslemmet blodpladekoncen-trat, og at blodpladeopbevaringsopløsningen omfatter vand og opløselige salte.
7. Blodposesystem ifølge krav 6, kendetegnet ved, at blodpladeopbevaringsop-løsningen indeholder mindst et af følgende salte: citrat, fosfat og/eller acetat.
8. Blodposesystem ifølge ethvert af de foregående krav, kendetegnet ved, at det biologiske fluid omfatter 0,2 til 2,5 x 109 blodplader pr. ml biologisk fluid indeholdt i blodposesystem et.
9. Blodposesystem ifølge ethvert af de foregående krav, kendetegnet ved, at - bestrålingsposen (2) er forskellig fra opbevaringsposen (4), hvori opbevaringsposen (4) valgfrit har halvdelen eller mindre af volumenkapaciteten af bestrålingsposen (2), og - blodpladeposesystemet omfatter en rørføring (3) til indbyrdes at forbinde bestrålingsposen (2) og opbevaringsposen (4), og som eventuelt er aftagelig.
10. Blodposesystem ifølge ethvert af de foregående krav, hvori opbevaringsposen (4) er gennemtrængelig for mindst en gas valgt fra gruppen bestående af luft, ilt og kuldioxid.
11. Blodposesystem ifølge ethvert af de foregående krav, hvori bestrålingsposen (2) uafhængigt af hinanden er kendetegnet ved et eller flere indbyrdes uafhængige træk: a) bestrålingsposen (2) består af EVA, b) bestrålingsposen (2) er lavet af materiale, som ikke har noget absorptionsmaksimum i området fra 200 til 350 nm, fortrinsvis 250 til 300 nm, og c) bestrålingsposen (2) har en flad inderside, hvilken inderside har begrænsninger betragtet fra oven, der har mindst 4, fortrinsvis 6 eller 8 hjørner eller danner en cirkel eller oval, når den er fyldt med det biologiske fluid.
12. Blodposesystem ifølge ethvert af de foregående krav, yderligere omfattende et leukocytfilter (8).
13. Fremgangsmåde til inaktivering af patogener og reduktion af leukocytter i blodpladekoncentrater i et blodpladesystem ifølge ethvert af krav 1 til 12, omfattende følgende trin: - fremskaffelse af et blodpladekoncentrat fra menneskebloddonation ved aferese-teknikker eller ved ”buffy-coat pooling”-teknikker, - indføring af blodpladekoncentratet i bestrålingsposen (2), sådan at bestrålingsposen er mindre en 20 volumen-% fyldt, fortrinsvis fra 10 til 1 volumen-% fyldt, - bestråling af bestrålingsposen (2) omfattende blodpladekoncentratet med en bestrålingskilde omfattende UV-C-lys med en bølgelængde på 200 til 270 nm, mens bestrålingsposen holdes i bevægelse, - indføring af det bestrålede blodpladekoncentrat i opbevaringsposen (4) til opbevaring eller forbliven af det bestrålede blodpladekoncentrat i bestrålingsposen (2) for opbevaring i bestrålingsposen.
14. Fremgangsmåde ifølge krav 13, omfattende følgende yderligere trin: - bytning af mindst 20 vægt-%, fortrinsvis mindst 50 vægt-%, af plasmaet indeholdt i blodpladekoncentratet mod en blodpladeopbevaringsopløsning til dannelse af et opslemmet blodpladekoncentrat, hvilken blodpladeopbevaringsopløsning omfatter vand og et eller flere opløselige salte, før blodpladekoncentratet udsættes for UV-bestråling.
15. Fremgangsmåde ifølge krav 13, hvori fremgangsmåden er yderligere kendetegnet ved et eller flere indbyrdes uafhængige træk: a) bestrålingsposen (2) placeres på en stiv plade lavet valgfrit af glas/kvartsmateriale, mens den bestråles og bevæges, b) den fyldte bestrålingspose (2) har en gennemsnitlig tykkelse mindre end 5 mm, fortrinsvis mindre end 2,5 mm når den bestråles, c) bestrålingsposen (2) bevæges for at blande det flydende indhold homogent og/eller fremskaffe en fluidprofil med bølgelignende overfladeområder i bestrålingsposen (2), omfattende en flerhed af bevægende eller stående bølgedale og -kamme, hvori bølgedalene ved deres laveste punkt fortrinsvis har en lagtykkelse mindre en 2,5 mm, og d) hvori lysdosis til bestråling af bestrålingsposen er mellem 0,1 og 2 J/cm2.
16. Fremgangsmåde ifølge krav 13, hvori blodpladekoncentratet/det opslemmede blodpladekoncentrat opbevares a) ved stuetemperatur fortrinsvis i mindst 8 dage, eller b) ved stuetemperatur under let bevægelse, fortrinsvis mindst 8 dage.
17. Fremgangsmåde ifølge krav 13, hvori bestrålingsposen (2) bevæges under bestråling med en regelmæssig bevægelse med en amplitude fra 0,2 til 8 cm i planets x- og y-retninger, hvori x og y fortrinsvis er samme størrelse, og en frekvens af amplituden er fra 10 til 200 Hz.
18. Fremgangsmåde ifølge ethvert af krav 13 til 17, hvori bestrålingsposen (2) bestråles og bevæges, mens den er fladt udstrakt og vandret på en i det væsentlige plan plade uden fastspænding af bestrålingsposens (2) øverste lag, så det øverste lag tillades at bevæge sig frit som reaktion på posens bevægelse.
19. Fremgangsmåde til fremstilling af et blodpladesystem ifølge ethvert af krav 1 til 12, omfattende følgende trin: - tilvejebringelse af et bestrålingspose (2) lavet af et fleksibelt plastmateriale, som er i det væsentlige gennemsigtigt for UV-bestråling, og omfattende mindst et indløbsrør (1) placeret ved et hjørne af posen (2), - indføring af det biologiske fluid i bestrålingsposen (2) via indløbsrøret, så bestrålingsposen (2) er mindre end 20 volumen-% fyldt, - forsegling af posen, så der derved skabes et første forseglet rum, i hvilket indløbsrøret (1) udmunder, og en andet forseglet rum omfattende det biologiske fluid.
Applications Claiming Priority (2)
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| EP06019589A EP1902740A1 (en) | 2006-09-19 | 2006-09-19 | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
| PCT/EP2007/005538 WO2008034476A1 (en) | 2006-09-19 | 2007-06-22 | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
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| PL (1) | PL2077867T3 (da) |
| PT (1) | PT2077867E (da) |
| WO (1) | WO2008034476A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005062410A1 (de) | 2005-12-23 | 2007-08-09 | Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. | Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht |
| DE102005062634A1 (de) | 2005-12-23 | 2007-06-28 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung |
| EP1902740A1 (en) | 2006-09-19 | 2008-03-26 | Maco Pharma S.A. | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
| EP2008669A1 (en) | 2007-06-22 | 2008-12-31 | Maco Pharma S.A. | Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process |
| USD627527S1 (en) * | 2008-07-08 | 2010-11-16 | Radio Systems Corporation | Pet bed heating pad |
| DE102008051123A1 (de) | 2008-10-09 | 2010-04-15 | Fresenius Kabi Deutschland Gmbh | Beutel, Beutelset, Verfahren und Behandlungsvorrichtung zum Behandeln wenigstens einer Blutkomponente |
| DE102008053131A1 (de) | 2008-10-24 | 2010-04-29 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Anordnung zum Sterilisieren, insbesondere zum Sterilisieren eines Adsorbers |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US9005343B2 (en) | 2010-05-05 | 2015-04-14 | New Health Sciences, Inc. | Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device |
| DE102010030370A1 (de) * | 2010-06-22 | 2011-12-22 | Terumo Europe N.V. | Kassette, Arbeitsstation und Verfahren zur Kennzeichnung von eine Flüssigkeit enthaltenden Behältern |
| JP5930483B2 (ja) | 2010-08-25 | 2016-06-08 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 保存中の赤血球の品質及び生存を高める方法 |
| EP3539381B1 (en) * | 2010-11-05 | 2023-05-24 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US8591486B2 (en) | 2010-11-17 | 2013-11-26 | Kci Licensing, Inc. | Reduced-pressure systems and methods employing an ultraviolet light source for reducing bioburden |
| EP2685815A4 (en) | 2011-03-16 | 2014-09-17 | Mayo Foundation | METHODS AND MATERIALS FOR EXTENDING USEFUL STORAGE OF PREPARATIONS OF HEMATIES AND PLATELET PREPARATIONS |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| ITMI20120643A1 (it) * | 2012-04-18 | 2013-10-19 | Frattini Paolo Giuseppe Gobbi | Sacca per soluzioni liquide miscelabili con sostanze attive disponibili in forma separata, in particolare in polvere o gel, per la formazione di sostanze medicinali o nutrizionali liquide somministrabili a pazienti per instillazione interna. |
| WO2014011499A1 (en) * | 2012-07-12 | 2014-01-16 | Terumo Bct, Inc. | Hybrid blood component storage bag and method of making such bag |
| US20140127077A1 (en) * | 2012-11-05 | 2014-05-08 | Gail Rock | Device and method for sterilization of instruments and surfaces |
| US9877476B2 (en) | 2013-02-28 | 2018-01-30 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
| US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
| US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
| US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
| CN107530377B (zh) | 2015-03-10 | 2021-09-03 | 新健康科学股份有限公司 | 氧减少一次性套件、装置及其使用方法 |
| KR102661405B1 (ko) | 2015-04-23 | 2024-04-25 | 헤마넥스트 인코포레이티드 | 혐기성 혈액 저장 용기 |
| CN107735095B (zh) | 2015-05-18 | 2022-06-14 | 希玛奈克斯特股份有限公司 | 储存全血的方法及其组合物 |
| US10180248B2 (en) | 2015-09-02 | 2019-01-15 | ProPhotonix Limited | LED lamp with sensing capabilities |
| US10730058B2 (en) * | 2015-09-14 | 2020-08-04 | Fenwal, Inc. | Apparatus, systems and methods for storing, treating and/or processing blood and blood components |
| AU2017271545C1 (en) | 2016-05-27 | 2023-06-15 | Hemanext Inc. | Anaerobic blood storage and pathogen inactivation method |
| CN106492245A (zh) * | 2016-12-23 | 2017-03-15 | 中国人民解放军南京军区南京总医院 | 血液病原体灭活装置 |
| FR3077824B1 (fr) * | 2018-02-15 | 2022-01-14 | Maco Pharma Sa | Procede de preparation d'un lysat plaquettaire irradie |
| CN111544296B (zh) * | 2020-06-18 | 2024-03-12 | 四川省人民医院 | 一种血液制品光能保藏袋 |
| FR3112985B1 (fr) | 2020-08-03 | 2023-11-17 | Maco Pharma Sa | Appareil pour souder une poche |
| CN113459593B (zh) * | 2021-07-29 | 2022-11-22 | 山东中保康医疗器具有限公司 | 用于一次性去白细胞塑料血袋生产的充气方法 |
| CN114084514B (zh) * | 2021-11-24 | 2022-10-25 | 百林科制药装备科技(江苏)有限公司 | 一次性使用容器及其制备、检测方法 |
| CN114366831A (zh) * | 2022-01-10 | 2022-04-19 | 南京双威生物医学科技有限公司 | 一种基于核黄素光化学法的血浆病原体灭活处理方法 |
| CN114366840B (zh) * | 2022-01-12 | 2023-06-09 | 山东中保康医疗器具有限公司 | 基于血袋管理的病毒灭活装置 |
| FR3133134A1 (fr) | 2022-03-04 | 2023-09-08 | Maco Pharma | Système à poches pour le traitement par irradiation électromagnétique d’un fluide biologique |
| FR3133135A1 (fr) | 2022-03-04 | 2023-09-08 | Maco Pharma | Système à poches pour le traitement par irradiation électromagnétique d’un fluide biologique |
| FR3138040A1 (fr) | 2022-07-21 | 2024-01-26 | Maco Pharma | Appareil et procédé pour irradier un fluide biologique |
| USD1043970S1 (en) | 2023-09-28 | 2024-09-24 | Sai Yuvan Gudavalli | IV bag |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US202395A (en) * | 1878-04-16 | Improvement in shaft-journals and boxes therefor | ||
| US178200A (en) * | 1876-05-30 | Improvement in grain separators | ||
| US164233A (en) * | 1875-06-08 | Improvement in roofing compositions | ||
| US155121A (en) * | 1874-09-15 | Improvement in shaft-couplings | ||
| US722676A (en) * | 1901-01-04 | 1903-03-17 | Peete B Clarke | Compensating valve for hydraulic rams. |
| US4469227A (en) | 1983-08-17 | 1984-09-04 | Clifford Faust | Package for cryogenically frozen liquids |
| US4586928A (en) * | 1984-10-09 | 1986-05-06 | Miles Laboratories, Inc. | Pivoting frangible valve for plastic bags |
| US4630448A (en) * | 1985-10-25 | 1986-12-23 | Baxter Travenol Laboratories, Inc. | Container for storing solid living tissue portions |
| US4952812A (en) * | 1986-08-26 | 1990-08-28 | Baxter International Inc. | Irradiation of blood products |
| US4878891A (en) * | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
| GB8807380D0 (en) | 1988-03-29 | 1988-05-05 | Gunn A | Blood processing apparatus |
| US4952818A (en) * | 1989-05-17 | 1990-08-28 | International Business Machines Corporation | Transmission line driver circuits |
| JP3182145B2 (ja) * | 1990-04-16 | 2001-07-03 | 日本赤十字社 | 血小板保存液 |
| JPH05131018A (ja) * | 1991-11-11 | 1993-05-28 | Terumo Corp | バツグ連結体およびその製造方法 |
| US6420570B1 (en) * | 1993-06-28 | 2002-07-16 | Cerus Corporation | Psoralen compounds |
| US5556993A (en) * | 1993-06-28 | 1996-09-17 | Steritech, Inc. | Compounds for the photodecontamination of pathogens in blood |
| ATE242960T1 (de) | 1993-11-10 | 2003-07-15 | Cerus Corp | Vorrichtung und verfahren zur photoaktivierung |
| DE69637181T2 (de) | 1995-07-14 | 2008-04-17 | Caf - Dcf Cvba - Scrl | Vorrichtung zur inaktivierung von viralen verunreinigungen in blutprodukten |
| JP3282952B2 (ja) * | 1995-10-16 | 2002-05-20 | テルモ株式会社 | バッグ加圧装置 |
| EP0874635B1 (en) * | 1995-12-04 | 2003-03-19 | Puget Sound Blood Center | Nonimmunogenic platelet and red blood cell compositions |
| DE29801590U1 (de) | 1998-01-30 | 1998-04-16 | Maco Pharma Int Gmbh | Blutbeutelsystem zur Virusinaktivierung von Blut, Blutkomponenten und Plasma |
| US6139878A (en) * | 1998-04-27 | 2000-10-31 | Aventis Behring, Llc | Method for preparing a diafiltered stabilized blood product |
| EP1002512A3 (en) * | 1998-11-19 | 2001-01-24 | Bracco International B.V. | Flexible container for the containment and delivery of fluids |
| US7445756B2 (en) * | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
| US7025877B1 (en) * | 1999-06-03 | 2006-04-11 | Baxter International Inc. | Processing set for processing and treating a biological fluid |
| US7094378B1 (en) | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US6268120B1 (en) * | 1999-10-19 | 2001-07-31 | Gambro, Inc. | Isoalloxazine derivatives to neutralize biological contaminants |
| US6596230B1 (en) | 2000-01-28 | 2003-07-22 | Baxter International Inc. | Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation |
| US6576201B1 (en) | 2000-01-28 | 2003-06-10 | Baxter International Inc. | Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation |
| WO2002026270A2 (en) | 2000-09-27 | 2002-04-04 | Gambro, Inc. | Inactivation of contaminants using photosensitizers and pulsed light |
| US20020043051A1 (en) * | 2000-10-17 | 2002-04-18 | Gambro, Inc | Container and method of sealing |
| US20020138066A1 (en) | 2001-03-23 | 2002-09-26 | Gambro, Inc. | Multiple compartment bag with openable closure assembly |
| US20030127603A1 (en) | 2001-05-15 | 2003-07-10 | Bernard Horowitz | Apparatus for the inactivation of pathogens in protein-containing fluids and uses thereof |
| US20030064001A1 (en) * | 2001-05-17 | 2003-04-03 | Fries William M. | System for the decontamination of fluid products using light |
| US20030228564A1 (en) * | 2001-05-30 | 2003-12-11 | Edrich Richard Alan | Nitric oxide in a pathogen inactivation process |
| WO2003026724A1 (en) | 2001-09-27 | 2003-04-03 | Gambro, Inc. | Radio frequency or electromagnetic information systems and methods for use in extracorporeal blood processing |
| DE10152159A1 (de) | 2001-10-25 | 2003-05-15 | Aventis Behring Gmbh | Verfahren zur proteinschonenden Reinigung von kontaminierten biologischen Flüssigkeiten |
| US7185087B2 (en) | 2001-10-26 | 2007-02-27 | Telefonaktiebolaget Lm Ericsson (Publ) | Maintenance of third party service's subscription information |
| DE60327166D1 (de) * | 2002-02-01 | 2009-05-28 | Caridianbct Biotechnologies Ll | Reduzierung von verunreinigungen in blut und blutprodukten durch verwendung von photoaktiven substanzen und bestrahlung mit licht eines engen wellelängenbereichs |
| JP2005524683A (ja) * | 2002-04-12 | 2005-08-18 | スロウレイ・テクノロジーズ・エルエルシー | 流体を除染するための方法および装置 |
| JP2005523746A (ja) | 2002-04-26 | 2005-08-11 | ガンブロ インコーポレーテッド | コンテナ内の流体を照射及び混合するための装置並びに方法 |
| JP2004041711A (ja) * | 2002-05-21 | 2004-02-12 | Mariusu:Kk | 血液保存バッグ |
| ATE340098T1 (de) | 2003-03-17 | 2006-10-15 | Oshkosh Truck Corp | Drehbare und gelenkige materialhandhabungsvorrichtung |
| US7207964B2 (en) * | 2003-03-17 | 2007-04-24 | Hemavation, Llc | Apparatus and method for down-regulating immune system mediators in blood |
| JP4272477B2 (ja) * | 2003-08-08 | 2009-06-03 | テルモ株式会社 | 血液成分採取装置 |
| JP4473221B2 (ja) * | 2004-01-16 | 2010-06-02 | テルモ株式会社 | 包材および医療器具セット包装体 |
| US8296071B2 (en) | 2004-03-15 | 2012-10-23 | Terumo Bct Biotechnologies, Llc | Methods for uniformly treating biological samples with electromagnetic radiation |
| FR2887335B1 (fr) | 2005-06-21 | 2007-08-10 | Maco Pharma Sa | Procede pour la determination d'une contamination pathogene dans un fluide contenant des plaquettes sanguines |
| DE102005062410A1 (de) | 2005-12-23 | 2007-08-09 | Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. | Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht |
| DE102005062634A1 (de) | 2005-12-23 | 2007-06-28 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung |
| EP1902740A1 (en) | 2006-09-19 | 2008-03-26 | Maco Pharma S.A. | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
| EP2008669A1 (en) | 2007-06-22 | 2008-12-31 | Maco Pharma S.A. | Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process |
-
2006
- 2006-09-19 EP EP06019589A patent/EP1902740A1/en not_active Withdrawn
-
2007
- 2007-06-22 JP JP2009528604A patent/JP5868570B2/ja active Active
- 2007-06-22 ES ES07726129.5T patent/ES2550638T3/es active Active
- 2007-06-22 US US12/311,033 patent/US20100133203A1/en not_active Abandoned
- 2007-06-22 DK DK07726129.5T patent/DK2077867T3/da active
- 2007-06-22 CA CA2663443A patent/CA2663443C/en active Active
- 2007-06-22 WO PCT/EP2007/005538 patent/WO2008034476A1/en active Application Filing
- 2007-06-22 PL PL07726129T patent/PL2077867T3/pl unknown
- 2007-06-22 EP EP07726129.5A patent/EP2077867B1/en active Active
- 2007-06-22 PT PT77261295T patent/PT2077867E/pt unknown
- 2007-06-22 AU AU2007299317A patent/AU2007299317B2/en active Active
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2015
- 2015-10-15 JP JP2015203434A patent/JP2016027899A/ja active Pending
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2017
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| AU2007299317B2 (en) | 2013-09-12 |
| US20170232163A1 (en) | 2017-08-17 |
| AU2007299317A1 (en) | 2008-03-27 |
| US20100133203A1 (en) | 2010-06-03 |
| EP2077867B1 (en) | 2015-08-12 |
| JP2010503501A (ja) | 2010-02-04 |
| CA2663443C (en) | 2015-01-20 |
| JP2016027899A (ja) | 2016-02-25 |
| PT2077867E (pt) | 2015-11-17 |
| EP1902740A1 (en) | 2008-03-26 |
| CA2663443A1 (en) | 2008-03-27 |
| ES2550638T3 (es) | 2015-11-11 |
| EP2077867A1 (en) | 2009-07-15 |
| US10058646B2 (en) | 2018-08-28 |
| PL2077867T3 (pl) | 2016-01-29 |
| JP5868570B2 (ja) | 2016-02-24 |
| WO2008034476A1 (en) | 2008-03-27 |
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