DK1988090T3 - Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse deraf - Google Patents
Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse derafInfo
- Publication number
- DK1988090T3 DK1988090T3 DK06775249.3T DK06775249T DK1988090T3 DK 1988090 T3 DK1988090 T3 DK 1988090T3 DK 06775249 T DK06775249 T DK 06775249T DK 1988090 T3 DK1988090 T3 DK 1988090T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazole
- procedures
- preparing
- carboxylic acid
- acid derivatives
- Prior art date
Links
- NKWCGTOZTHZDHB-UHFFFAOYSA-N 1h-imidazol-1-ium-4-carboxylate Chemical class OC(=O)C1=CNC=N1 NKWCGTOZTHZDHB-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100239910A CN101024643A (zh) | 2006-02-20 | 2006-02-20 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| PCT/CN2006/001914 WO2007095789A1 (en) | 2006-02-20 | 2006-07-31 | Imidazol-5-carboxylic acid derivatives, preparation methods and use therrof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1988090T3 true DK1988090T3 (da) | 2013-08-05 |
Family
ID=38436915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06775249.3T DK1988090T3 (da) | 2006-02-20 | 2006-07-31 | Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | USRE44873E1 (enExample) |
| EP (1) | EP1988090B1 (enExample) |
| JP (1) | JP5250760B2 (enExample) |
| KR (1) | KR101179110B1 (enExample) |
| CN (2) | CN101024643A (enExample) |
| AU (1) | AU2006338796B2 (enExample) |
| CA (1) | CA2643005C (enExample) |
| DK (1) | DK1988090T3 (enExample) |
| ES (1) | ES2424154T3 (enExample) |
| PL (1) | PL1988090T3 (enExample) |
| PT (1) | PT1988090E (enExample) |
| WO (1) | WO2007095789A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024643A (zh) | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| WO2008067687A1 (en) * | 2006-12-06 | 2008-06-12 | Shanghai Allist Pharmaceutical., Inc. | The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use therrof |
| CN101214242A (zh) * | 2007-01-05 | 2008-07-09 | 上海艾力斯医药科技有限公司 | 新的药用组合物 |
| CN101317842A (zh) * | 2007-06-07 | 2008-12-10 | 上海艾力斯医药科技有限公司 | 一种咪唑-5-羧酸衍生物的治疗用途 |
| CN101407511B (zh) * | 2007-10-11 | 2013-01-09 | 上海艾力斯生物医药有限公司 | 一种结晶型的咪唑-5-羧酸衍生物 |
| JP2011523941A (ja) * | 2008-05-15 | 2011-08-25 | メルク・シャープ・エンド・ドーム・コーポレイション | アンギオテンシンｉｉ受容体アンタゴニスト |
| CN101596189A (zh) * | 2008-06-05 | 2009-12-09 | 上海艾力斯生物医药有限公司 | 含有咪唑-5-羧酸类衍生物的药用组合物 |
| JP5575783B2 (ja) * | 2008-12-12 | 2014-08-20 | ファーマコステック カンパニー リミテッド | トリフェニルメタン保護基の除去方法 |
| KR101213467B1 (ko) * | 2010-04-30 | 2012-12-20 | 진양제약주식회사 | 로자탄 대사체 이엑스피-3174 이수화물의 신규한 제조 방법 |
| CN103012377A (zh) * | 2011-09-27 | 2013-04-03 | 江苏艾力斯生物医药有限公司 | 一种咪唑-5-羧酸酯的重结晶方法 |
| CN102558064B (zh) * | 2012-01-29 | 2014-04-16 | 安润医药科技（苏州）有限公司 | 抗高血压化合物及其制备方法和应用，以及其在药学上可接受的盐 |
| CN104610232B (zh) * | 2013-11-01 | 2019-09-20 | 深圳信立泰药业股份有限公司 | 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物 |
| CN103965171A (zh) * | 2014-04-30 | 2014-08-06 | 上海艾力斯医药科技有限公司 | 一种阿利沙坦酯的制备方法 |
| CN106188012B (zh) * | 2014-06-20 | 2018-11-30 | 深圳信立泰药业股份有限公司 | 一种阿利沙坦酯结晶及其制备方法及含有该结晶的药物组合物 |
| CN105218527B (zh) * | 2015-10-10 | 2018-04-24 | 江苏宝众宝达药业有限公司 | 一种exp-3174的制备方法 |
| US11026925B2 (en) | 2016-01-20 | 2021-06-08 | Shenzhen Salubris Pharmaceuticals Co. Ltd. | Angiotensin II receptor antagonist metabolite and NEP inhibitor composite and preparation method thereof |
| CN119371408B (zh) * | 2024-12-27 | 2025-04-22 | 安徽艾立德制药有限公司 | 一种无定形的阿利沙坦酯及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| AT398202B (de) * | 1991-10-04 | 1994-10-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| ES2155827T3 (es) * | 1992-06-02 | 2001-06-01 | Sankyo Co | 4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico. |
| JPH083162A (ja) * | 1994-04-19 | 1996-01-09 | Tanabe Seiyaku Co Ltd | イミダゾピリジン誘導体及びその製法 |
| ES2167571T3 (es) * | 1995-06-07 | 2002-05-16 | Searle & Co | Terapia de combinacion de antagonista de aldosterona epoxi-esteroideo y antagonista de angiotensina ii para el tratamiento del fallo cardiaco congestivo. |
| KR20060056352A (ko) | 2003-07-31 | 2006-05-24 | 니콕스 에스. 에이. | 안지오텐신ⅱ 수용체 차단제 유도체들 |
| US20070238740A1 (en) | 2003-08-28 | 2007-10-11 | Nitromed, Inc. | Nitrosated And Nitrosylated Cardiovascular Compounds, Compositions And Methods Of Use |
| DE602006010364D1 (de) | 2005-04-22 | 2009-12-24 | Daiichi Sankyo Co Ltd | Pharmazeutikum zur prävention oder behandlung von metabolischer knochenkrankheit |
| CN101024643A (zh) | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| WO2008067687A1 (en) | 2006-12-06 | 2008-06-12 | Shanghai Allist Pharmaceutical., Inc. | The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use therrof |
| CN101214242A (zh) | 2007-01-05 | 2008-07-09 | 上海艾力斯医药科技有限公司 | 新的药用组合物 |
| CN101317842A (zh) | 2007-06-07 | 2008-12-10 | 上海艾力斯医药科技有限公司 | 一种咪唑-5-羧酸衍生物的治疗用途 |
| CN101407511B (zh) | 2007-10-11 | 2013-01-09 | 上海艾力斯生物医药有限公司 | 一种结晶型的咪唑-5-羧酸衍生物 |
-
2006
- 2006-02-20 CN CNA2006100239910A patent/CN101024643A/zh active Pending
- 2006-07-31 EP EP06775249.3A patent/EP1988090B1/en not_active Not-in-force
- 2006-07-31 PL PL06775249T patent/PL1988090T3/pl unknown
- 2006-07-31 AU AU2006338796A patent/AU2006338796B2/en not_active Ceased
- 2006-07-31 CA CA2643005A patent/CA2643005C/en not_active Expired - Fee Related
- 2006-07-31 CN CNB2006800003978A patent/CN100506818C/zh active Active
- 2006-07-31 US US13/727,587 patent/USRE44873E1/en active Active
- 2006-07-31 WO PCT/CN2006/001914 patent/WO2007095789A1/zh not_active Ceased
- 2006-07-31 KR KR1020087022811A patent/KR101179110B1/ko not_active Expired - Fee Related
- 2006-07-31 PT PT67752493T patent/PT1988090E/pt unknown
- 2006-07-31 DK DK06775249.3T patent/DK1988090T3/da active
- 2006-07-31 US US11/576,094 patent/US7858651B2/en active Active
- 2006-07-31 ES ES06775249T patent/ES2424154T3/es active Active
- 2006-07-31 JP JP2008555597A patent/JP5250760B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| USRE44873E1 (en) | 2014-04-29 |
| CN101031562A (zh) | 2007-09-05 |
| ES2424154T3 (es) | 2013-09-27 |
| EP1988090A4 (en) | 2010-06-30 |
| US20090036505A1 (en) | 2009-02-05 |
| JP5250760B2 (ja) | 2013-07-31 |
| KR20080096707A (ko) | 2008-10-31 |
| EP1988090B1 (en) | 2013-05-01 |
| JP2009527509A (ja) | 2009-07-30 |
| WO2007095789A1 (en) | 2007-08-30 |
| EP1988090A1 (en) | 2008-11-05 |
| KR101179110B1 (ko) | 2012-09-07 |
| AU2006338796B2 (en) | 2011-05-12 |
| CN100506818C (zh) | 2009-07-01 |
| CA2643005C (en) | 2012-05-15 |
| CA2643005A1 (en) | 2007-08-30 |
| PL1988090T3 (pl) | 2013-10-31 |
| CN101024643A (zh) | 2007-08-29 |
| PT1988090E (pt) | 2013-08-05 |
| AU2006338796A1 (en) | 2007-08-30 |
| US7858651B2 (en) | 2010-12-28 |
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