DK1983000T3 - Fremgangsmåde til behandling af multipel sklerose ved inhibering af IL-17-aktivitet - Google Patents

Fremgangsmåde til behandling af multipel sklerose ved inhibering af IL-17-aktivitet Download PDF

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Publication number
DK1983000T3
DK1983000T3 DK08008814.9T DK08008814T DK1983000T3 DK 1983000 T3 DK1983000 T3 DK 1983000T3 DK 08008814 T DK08008814 T DK 08008814T DK 1983000 T3 DK1983000 T3 DK 1983000T3
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Denmark
Prior art keywords
antibody
disease
ser
fab
antibodies
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DK08008814.9T
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English (en)
Inventor
Mark Ian Christie
Richard James Mead
Martyn Kim Robinson
Stephen Edward Rapecki
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Ucb Biopharma Sprl
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34635441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1983000(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0327181A external-priority patent/GB0327181D0/en
Priority claimed from GB0417115A external-priority patent/GB0417115D0/en
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Application granted granted Critical
Publication of DK1983000T3 publication Critical patent/DK1983000T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (4)

1. Inhibitor af IL-17-aktivitet til anvendelse i en fremgangsmåde til behandling og/eller forebyggelse af relapserende-remitterende multipel sklerose (MS), hvor inhibitoren er et IL-17R:Fc-fusionsprotein eller er et antistof eller funktionelt aktivt antistoffragment, som binder til IL-17 eller IL-17R.
2. Inhibitor til anvendelse ifølge krav 1, hvor antistoffet eller antistoffragmentet er monoklonalt, polyklonalt, kimærisk, humaniseret eller bispecifikt.
3. Inhibitor til anvendelse ifølge krav 1 eller krav 2, hvor antistoffragmentet er et Fab, Fab', F(ab')2, scFv eller et epitop-bindende fragment deraf.
4. Inhibitor til anvendelse ifølge et hvilket som helst af krav 1 til 3, hvor antistoffet eller antistoffragmentet er konjugeret til polyethylenglycol (PEG).
DK08008814.9T 2003-11-21 2004-11-16 Fremgangsmåde til behandling af multipel sklerose ved inhibering af IL-17-aktivitet DK1983000T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0327181A GB0327181D0 (en) 2003-11-21 2003-11-21 Biological products
GB0417115A GB0417115D0 (en) 2004-07-30 2004-07-30 Biological products
EP04798568A EP1687026B1 (en) 2003-11-21 2004-11-16 Method for the treatment of multiple sclerosis by inhibiting il-17 activity

Publications (1)

Publication Number Publication Date
DK1983000T3 true DK1983000T3 (da) 2015-12-07

Family

ID=34635441

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Application Number Title Priority Date Filing Date
DK08008814.9T DK1983000T3 (da) 2003-11-21 2004-11-16 Fremgangsmåde til behandling af multipel sklerose ved inhibering af IL-17-aktivitet

Country Status (16)

Country Link
US (2) US20070269428A1 (da)
EP (3) EP1983000B1 (da)
JP (1) JP4833850B2 (da)
AT (1) ATE395083T1 (da)
AU (1) AU2004292393C1 (da)
CA (1) CA2544920C (da)
CY (1) CY1116992T1 (da)
DE (1) DE602004013825D1 (da)
DK (1) DK1983000T3 (da)
ES (2) ES2305879T3 (da)
HR (1) HRP20151210T1 (da)
HU (1) HUE026260T2 (da)
PL (1) PL1983000T3 (da)
PT (1) PT1983000E (da)
SI (1) SI1983000T1 (da)
WO (1) WO2005051422A1 (da)

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Also Published As

Publication number Publication date
ES2554645T3 (es) 2015-12-22
JP2007511593A (ja) 2007-05-10
WO2005051422A1 (en) 2005-06-09
HRP20151210T1 (hr) 2015-12-04
CA2544920A1 (en) 2005-06-09
ATE395083T1 (de) 2008-05-15
EP1983000A3 (en) 2011-07-27
EP2974742A1 (en) 2016-01-20
EP1983000B1 (en) 2015-09-02
EP1983000A2 (en) 2008-10-22
SI1983000T1 (sl) 2015-12-31
US20070269428A1 (en) 2007-11-22
JP4833850B2 (ja) 2011-12-07
HUE026260T2 (en) 2016-06-28
AU2004292393C1 (en) 2011-08-04
US7931900B2 (en) 2011-04-26
AU2004292393B2 (en) 2009-10-08
US20090191200A1 (en) 2009-07-30
EP1687026A1 (en) 2006-08-09
ES2305879T3 (es) 2008-11-01
AU2004292393A1 (en) 2005-06-09
CY1116992T1 (el) 2017-04-05
PT1983000E (pt) 2015-12-30
DE602004013825D1 (de) 2008-06-26
PL1983000T3 (pl) 2016-02-29
EP1687026B1 (en) 2008-05-14
CA2544920C (en) 2012-09-11

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