DK1978807T3 - Fremgangsmåde til at behandle kronisk nyresygdom - Google Patents
Fremgangsmåde til at behandle kronisk nyresygdom Download PDFInfo
- Publication number
- DK1978807T3 DK1978807T3 DK07717051.2T DK07717051T DK1978807T3 DK 1978807 T3 DK1978807 T3 DK 1978807T3 DK 07717051 T DK07717051 T DK 07717051T DK 1978807 T3 DK1978807 T3 DK 1978807T3
- Authority
- DK
- Denmark
- Prior art keywords
- ferric citrate
- ferric
- precipitate
- kidney disease
- chronic kidney
- Prior art date
Links
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Claims (12)
1. Ferricitrat til anvendelse i en fremgangsmåde til at forebygge, vende, opretholde eller forsinke progression af kronisk nyresygdom, hvori ferricitratet kan opnås med en fremgangsmåde omfattende trinnene at: a) opnå ferrichloridhexahydrat; b) tilsætte natriumhydroxid til ferrichloridhexahydratet under betingelser egnede til at producere en blanding omfattende polyjernoxid; c) isolere et bundfald fra blandingen; d) tilsætte krystallinsk citronsyre til bundfaldet; e) opvarme krystallinsk citronsyre og bundfaldet og derved danne en ferricitratopløsning; og f) bundfælde ferricitrat fra ferricitratopløsningen ved hjælp af et organisk opløsningsmiddel.
2. Ferricitrat til anvendelse ifølge krav 1 med en opløsningshastighed på mindst 2 mg/cm2/min.
3. Ferricitrat til anvendelse ifølge krav 1 med en opløsningshastighed fra 2 mg/cm2/min til 4 mg/cm2/min.
4. Ferricitrat til anvendelse ifølge ethvert af kravene 1 til 3, hvori ferricitratet administreres i en dosis på fra 2 til 20 g/dag.
5. Ferricitrat til anvendelse ifølge ethvert af kravene 1 til 4, hvori ferricitratet administreres oralt.
6. Anvendelse af en farmaceutisk sammensætning til fremstillingen af et medikament til at forebygge, vende, opretholde eller forsinke progression af kronisk nyresygdom, hvori sammensætningen omfatter ferricitrat, og ferricitratet kan opnås ved hjælp af en fremgangsmåde omfattende trinnene at: a) opnå ferrichloridhexahydrat; b) tilsætte natriumhydroxid til ferrichloridhexahydrat under betingelser egnede til at producere en blanding omfattende polyjernoxid; c) isolere et bundfald fra blandingen; d) tilsætte krystallinsk citronsyre til bundfaldet; e) opvarme krystallinsk citronsyre og bundfaldet og derved danne en ferricitratopløsning; og f) bundfælde ferricitrat fra ferricitratopløsningen ved hjælp af et organisk opløsningsmiddel.
7. Anvendelse ifølge krav 6, hvori sammensætningen er i en form egnet til oral administration.
8. Anvendelse ifølge krav 6 eller 7, hvori ferricitratet har en opløsningshastighed på mindst 2 mg/cm2/min.
9. Anvendelse ifølge krav 7 eller 8, hvori ferricitratet har en opløsningshastighed fra 2 mg/cm2/min til 4 mg/cm2/min.
10. Oral administrerbar form af ferricitrat til anvendelse til at forebygge, vende, opretholde eller forsinke progression af kronisk nyresygdom, den orale administrerbare form er fremstillet ud fra en farmaceutisk sammensætning omfattende en form af ferricitrat, som kan opnås ved hjælp af en fremgangsmåde omfattende trinnene: a) opnå ferrichloridhexahydrat; b) tilsætte natriumhydroxid til ferrichloridhexahydrat under betingelser egnede til at producere en blanding omfattende polyjernoxid; c) isolere et bundfald fra blandingen; d) tilsætte krystallinsk citronsyre til bundfaldet; e) opvarme krystallinsk citronsyre og bundfaldet og derved danne en ferricitratopløsning; og f) bundfælde ferricitrat fra ferricitratopløsningen ved hjælp af et organisk opløsningsmiddel.
11. Oral administrerbar form til anvendelse ifølge krav 10, hvori ferricitratet har en opløsningshastighed på mindst 2 mg/cm2/min.
12. Oral administrerbar form til anvendelse ifølge ethvert af kravene 10 til 11, hvori den orale administrerbare form er en tablet.
Applications Claiming Priority (3)
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| US76325306P | 2006-01-30 | 2006-01-30 | |
| PCT/US2006/032385 WO2007022435A2 (en) | 2005-08-18 | 2006-08-18 | Pharmaceutical-grade ferric organic compounds, uses thereof and methods of making same |
| PCT/US2007/002151 WO2007089571A2 (en) | 2006-01-30 | 2007-01-26 | Method of treating chronic kidney disease |
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| DK07717051.2T DK1978807T3 (da) | 2006-01-30 | 2007-01-26 | Fremgangsmåde til at behandle kronisk nyresygdom |
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| EP (3) | EP1978808B1 (da) |
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| US20220144872A1 (en) * | 2003-02-19 | 2022-05-12 | Panion & Bf Biotech Inc. | Pharmaceutical-Grade Ferric Organic Compounds, Uses Thereof and Methods of Making Same |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US8093423B2 (en) | 2003-02-19 | 2012-01-10 | Globoasia, Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and method of making same |
| CN105055446B (zh) * | 2006-01-30 | 2022-06-03 | 宝龄富锦生技股份有限公司 | 逆转、防止、延迟或稳定软组织钙化的方法 |
| US7658952B2 (en) | 2007-10-11 | 2010-02-09 | Baxter International Inc. | Dialysis solutions containing pyrophosphates |
| CN102164596A (zh) | 2008-10-27 | 2011-08-24 | Sbi5-Ala生物技术股份有限公司 | 以5-氨基乙酰丙酸或其衍生物、或它们的盐作为有效成分的成人病的预防、改善剂 |
| KR20140016438A (ko) | 2009-07-21 | 2014-02-07 | 케릭스 바이오파마슈티컬스 인코포레이티드 | 구연산철 투여형태 |
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| EP2594277A4 (en) * | 2010-07-07 | 2014-01-01 | Japan Tobacco Inc | TABLET WITH IRON CITRATE |
| JP2012112785A (ja) * | 2010-11-24 | 2012-06-14 | Tohoku Univ | 透析膜の評価方法 |
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| PL3730136T3 (pl) * | 2012-06-21 | 2024-03-25 | Keryx Biopharmaceuticals, Inc. | Zastosowanie cytrynianu żelaza(iii) w leczeniu pacjentów z przewlekłą chorobą nerek |
| JP6348495B2 (ja) * | 2012-09-04 | 2018-06-27 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | シトレートに富むカルシウム・マグネシウム補助剤およびその使用 |
| AU2014341975A1 (en) * | 2013-11-04 | 2016-05-19 | Keryx Biopharmaceuticals, Inc. | Ferric citrate for reducing cardiac failure in chronic kidney disease patients |
| US10172882B2 (en) | 2014-06-22 | 2019-01-08 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
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| WO2018193648A1 (ja) * | 2017-04-18 | 2018-10-25 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
| JP7578234B2 (ja) * | 2017-04-18 | 2024-11-06 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
| JP7219898B2 (ja) * | 2017-04-18 | 2023-02-09 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
| IT201700085412A1 (it) * | 2017-07-26 | 2019-01-26 | Pharmanutra S P A | Composizione per uso nella prevenzione e nel trattamento di patologie dell'apparato cardiovascolare |
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| KR102825650B1 (ko) | 2018-01-12 | 2025-06-26 | 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 | 체액 중의 암모니아 및 암모늄의 검출 및 정량화를 위한 시스템 및 방법 |
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