DK1923073T3 - Kombinationsmedicin med PDE-5-inhibitor - Google Patents

Kombinationsmedicin med PDE-5-inhibitor

Info

Publication number
DK1923073T3
DK1923073T3 DK06025229.3T DK06025229T DK1923073T3 DK 1923073 T3 DK1923073 T3 DK 1923073T3 DK 06025229 T DK06025229 T DK 06025229T DK 1923073 T3 DK1923073 T3 DK 1923073T3
Authority
DK
Denmark
Prior art keywords
inhibitor
portal hypertension
prevent
portal
treat
Prior art date
Application number
DK06025229.3T
Other languages
English (en)
Inventor
Wolfgang Kreisel
Deibert Peter
Original Assignee
Universitaetsklinikum Freiburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaetsklinikum Freiburg filed Critical Universitaetsklinikum Freiburg
Application granted granted Critical
Publication of DK1923073T3 publication Critical patent/DK1923073T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK06025229.3T 2003-06-06 2004-06-03 Kombinationsmedicin med PDE-5-inhibitor DK1923073T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10325813A DE10325813B4 (de) 2003-06-06 2003-06-06 Prophylaxe und/oder Therapie bei der portalen Hypertonie
EP04739573A EP1635838B1 (de) 2003-06-06 2004-06-03 Phosphodiesterase-5-inhibitoren zur prophylaxe und/oder therapie der portalen hypertonie

Publications (1)

Publication Number Publication Date
DK1923073T3 true DK1923073T3 (da) 2011-10-17

Family

ID=33494881

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06025229.3T DK1923073T3 (da) 2003-06-06 2004-06-03 Kombinationsmedicin med PDE-5-inhibitor
DK04739573T DK1635838T3 (da) 2003-06-06 2004-06-03 Phosphodiesterase 5 inhibitorer til profylakse og/eller behandling af portal hypertension

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK04739573T DK1635838T3 (da) 2003-06-06 2004-06-03 Phosphodiesterase 5 inhibitorer til profylakse og/eller behandling af portal hypertension

Country Status (14)

Country Link
US (1) US9278097B2 (da)
EP (2) EP1923073B1 (da)
JP (3) JP4557970B2 (da)
KR (2) KR101233828B1 (da)
CN (1) CN1871010B (da)
AT (2) ATE525074T1 (da)
CY (2) CY1107707T1 (da)
DE (2) DE10325813B4 (da)
DK (2) DK1923073T3 (da)
ES (2) ES2287740T3 (da)
PL (2) PL1635838T3 (da)
PT (2) PT1923073E (da)
SI (2) SI1635838T1 (da)
WO (1) WO2004108062A2 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4540295B2 (ja) * 2001-05-09 2010-09-08 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ２−フェニル置換イミダゾトリアジノンの新しい用途
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE102004023069A1 (de) * 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
DE102004038328A1 (de) * 2004-08-06 2006-03-16 Bayer Healthcare Ag Neue Verwendungen von 2-Phenyl-substituierten Imidazotriazinon-Derivaten
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
CA2611638C (en) * 2005-06-10 2010-08-24 Dong A Pharm. Co. Ltd. Agent for the prevention and treatment of liver diseases containing pyrazolopyrimidinone derivative
SG166106A1 (en) * 2005-09-29 2010-11-29 Bayer Schering Pharma Ag Pde inhibitors and combinations thereof for the treatment of urological disorders
US8512258B2 (en) * 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
WO2008151734A1 (en) * 2007-06-13 2008-12-18 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
EP2929886B1 (en) 2012-12-04 2021-11-24 Aribio Inc. Composition comprising phosphodiesterase type 5 inhibitor for inhibiting apoptosis of nerve cells
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
EP3644841A4 (en) 2017-06-30 2021-03-31 Georgia State University Research Foundation, Inc. NON-INVASIVE METHODS OF DETECTING LIVER FIBROSIS
CA3023014C (en) * 2017-11-06 2023-09-26 Stalicla Sa Pharmaceutical composition for treatment of autism
CN110811593A (zh) * 2019-11-07 2020-02-21 天津中医药大学第二附属医院 一种高血压中医证型采取肝血流动力学特点的判别方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2882843B2 (ja) * 1990-03-28 1999-04-12 日本化薬株式会社 門脈圧亢進症改善剤
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5973011A (en) * 1994-03-30 1999-10-26 Isis Pharma Gmbh Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
AU2291200A (en) 1999-01-20 2000-08-07 Arzneimittelwerk Dresden Gmbh Use of imidazo(1,5-a)-pyrido(3,2-e)-pyrazinones as medicaments
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
AU3210500A (en) * 1999-01-22 2000-08-07 Selectus Pharmaceuticals, Inc. Controlling heart rate or blood pressure in patients co-medicated with phosphodiesterase inhibitors for treatment of impotence
US6087362A (en) 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
US20010003120A1 (en) * 1999-05-14 2001-06-07 M. D. Robert Hines Method for treating erectile dysfunction
FR2796945B1 (fr) 1999-07-30 2002-06-28 Sod Conseils Rech Applic Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments
IL139073A0 (en) * 1999-10-21 2001-11-25 Pfizer Treatment of neuropathy
TWI224966B (en) 1999-11-02 2004-12-11 Pfizer Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient
US20020103117A1 (en) 2000-02-03 2002-08-01 Ralph Knoell Use of protein kinase-inhibitor-alpha
DE10004858A1 (de) * 2000-02-03 2001-08-16 Schering Ag Verwendung von Proteinkinase-Inhibitor-alpha
US6476037B1 (en) 2000-03-23 2002-11-05 The Regents Of The University Of California L-arginine and phosphodiesterase (PDE) inhibitor synergism
WO2002019213A2 (en) 2000-08-30 2002-03-07 Lilly Icos Llc Method for treatment of migraine using pde5 inhibitors
US20020028764A1 (en) * 2000-09-04 2002-03-07 Aarhus Amt. Treatment of acute and chronic liver disease
JP2002201128A (ja) * 2000-10-25 2002-07-16 Takeda Chem Ind Ltd 門脈圧亢進症予防・治療剤
US20040102502A1 (en) 2000-10-25 2004-05-27 Toshifumi Watanabe Preventing/remedies for portal hypertension
CZ20032339A3 (cs) * 2001-01-31 2004-09-15 Merck Patent Gmbh Farmaceutický prostředek obsahující parazolo [4,3-d]pyrimidiny a nitráty nebo thienopyrimidiny a nitráty
AU2002226633A1 (en) * 2001-02-02 2002-08-12 Pfizer Limited Treatment of diabetes mellitus using vardenafil
SK10782003A3 (sk) 2001-02-02 2003-12-02 Merck Patent Gmbh Farmaceutický prostriedok obsahujúci parazolo [4,3-d]pyrimidíny a endotelínové receptorové antagonisty alebo tienopyrimidíny a endotelínové receptorové antagonisty
US6338862B1 (en) * 2001-03-26 2002-01-15 Sarfaraz K Niazi Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors
ES2325880T3 (es) * 2001-06-08 2009-09-23 Ipsen Pharma Analogos quimericos de somatostatina-dopamina.
LV12979B (en) * 2001-09-07 2003-05-20 Ivars Kalvins Pharmaceutical composition

Also Published As

Publication number Publication date
KR20060031614A (ko) 2006-04-12
ES2374085T3 (es) 2012-02-13
EP1923073B1 (de) 2011-09-21
KR101233828B1 (ko) 2013-02-14
CY1107707T1 (el) 2013-04-18
DK1635838T3 (da) 2007-09-10
DE10325813A1 (de) 2005-01-05
WO2004108062A3 (de) 2005-03-10
CN1871010A (zh) 2006-11-29
CY1111918T1 (el) 2015-11-04
CN1871010B (zh) 2010-05-26
KR101176110B1 (ko) 2012-08-22
ATE361074T1 (de) 2007-05-15
EP1923073A3 (de) 2008-07-09
JP2010195821A (ja) 2010-09-09
US9278097B2 (en) 2016-03-08
JP2009280602A (ja) 2009-12-03
ES2287740T3 (es) 2007-12-16
PT1923073E (pt) 2011-10-04
ATE525074T1 (de) 2011-10-15
KR20120024807A (ko) 2012-03-14
JP4557970B2 (ja) 2010-10-06
EP1635838B1 (de) 2007-05-02
PL1635838T3 (pl) 2007-09-28
JP2006527177A (ja) 2006-11-30
DE502004003694D1 (de) 2007-06-14
JP5631053B2 (ja) 2014-11-26
SI1635838T1 (sl) 2007-10-31
JP5757677B2 (ja) 2015-07-29
PL1923073T3 (pl) 2012-02-29
EP1635838A2 (de) 2006-03-22
DE10325813B4 (de) 2007-12-20
WO2004108062A2 (de) 2004-12-16
EP1923073A2 (de) 2008-05-21
PT1635838E (pt) 2007-08-10
SI1923073T1 (sl) 2011-11-30
US20070004744A1 (en) 2007-01-04

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