SI1635838T1 - Zaviralci fosfodiesteraze tipa 5 za profilakso in/ali terapijo pri portalni hipertenziji - Google Patents

Zaviralci fosfodiesteraze tipa 5 za profilakso in/ali terapijo pri portalni hipertenziji

Info

Publication number
SI1635838T1
SI1635838T1 SI200430378T SI200430378T SI1635838T1 SI 1635838 T1 SI1635838 T1 SI 1635838T1 SI 200430378 T SI200430378 T SI 200430378T SI 200430378 T SI200430378 T SI 200430378T SI 1635838 T1 SI1635838 T1 SI 1635838T1
Authority
SI
Slovenia
Prior art keywords
portal hypertension
portal
inhibitor
prevent
treat
Prior art date
Application number
SI200430378T
Other languages
English (en)
Inventor
Wolfgang Kreisel
Original Assignee
Universit Ntsklinikum Freiburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universit Ntsklinikum Freiburg filed Critical Universit Ntsklinikum Freiburg
Publication of SI1635838T1 publication Critical patent/SI1635838T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200430378T 2003-06-06 2004-06-03 Zaviralci fosfodiesteraze tipa 5 za profilakso in/ali terapijo pri portalni hipertenziji SI1635838T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10325813A DE10325813B4 (de) 2003-06-06 2003-06-06 Prophylaxe und/oder Therapie bei der portalen Hypertonie
PCT/EP2004/006014 WO2004108062A2 (de) 2003-06-06 2004-06-03 Prophylaxe und/oder therapie bei der portalen hypertonie
EP04739573A EP1635838B1 (de) 2003-06-06 2004-06-03 Phosphodiesterase-5-inhibitoren zur prophylaxe und/oder therapie der portalen hypertonie

Publications (1)

Publication Number Publication Date
SI1635838T1 true SI1635838T1 (sl) 2007-10-31

Family

ID=33494881

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200431750T SI1923073T1 (sl) 2003-06-06 2004-06-03 Kombinirano zdravilo ki vsebuje pde-5 inhibitor
SI200430378T SI1635838T1 (sl) 2003-06-06 2004-06-03 Zaviralci fosfodiesteraze tipa 5 za profilakso in/ali terapijo pri portalni hipertenziji

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200431750T SI1923073T1 (sl) 2003-06-06 2004-06-03 Kombinirano zdravilo ki vsebuje pde-5 inhibitor

Country Status (14)

Country Link
US (1) US9278097B2 (sl)
EP (2) EP1923073B1 (sl)
JP (3) JP4557970B2 (sl)
KR (2) KR101233828B1 (sl)
CN (1) CN1871010B (sl)
AT (2) ATE525074T1 (sl)
CY (2) CY1107707T1 (sl)
DE (2) DE10325813B4 (sl)
DK (2) DK1635838T3 (sl)
ES (2) ES2287740T3 (sl)
PL (2) PL1923073T3 (sl)
PT (2) PT1635838E (sl)
SI (2) SI1923073T1 (sl)
WO (1) WO2004108062A2 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1392314B1 (de) * 2001-05-09 2006-12-20 Bayer HealthCare AG NEUE VERWENDUNG VON 2-[2-Ethoxy-5-(4-methyl-piperazin-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE102004023069A1 (de) * 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
DE102004038328A1 (de) * 2004-08-06 2006-03-16 Bayer Healthcare Ag Neue Verwendungen von 2-Phenyl-substituierten Imidazotriazinon-Derivaten
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
DK1888074T3 (da) * 2005-06-10 2012-01-23 Dong A Pharm Co Ltd Middel til forebyggelsen og behandling af leversygdomme indeholdende pyrazolopyrimidinderivat
US20090186896A1 (en) * 2005-09-29 2009-07-23 Bayer Healthcare Ag PDE Inhibitors and Combinations Thereof for the Treatment of Urological Disorders
US8512258B2 (en) * 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
JP2010532319A (ja) * 2007-06-13 2010-10-07 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 聴覚障害の処置用のｐｄｅ阻害剤
WO2014088326A1 (ko) 2012-12-04 2014-06-12 주식회사 아리바이오 포스포디에스테라제 타입 5 저해제를 포함하는 신경세포의 아폽토시스 억제용 조성물
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
WO2019006248A1 (en) 2017-06-30 2019-01-03 Georgia State University Research Foundation, Inc. NON-INVASIVE METHODS FOR DETECTION OF HEPATIC FIBROSIS
CA3023014C (en) * 2017-11-06 2023-09-26 Stalicla Sa Pharmaceutical composition for treatment of autism
CN110811593A (zh) * 2019-11-07 2020-02-21 天津中医药大学第二附属医院 一种高血压中医证型采取肝血流动力学特点的判别方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2882843B2 (ja) * 1990-03-28 1999-04-12 日本化薬株式会社 門脈圧亢進症改善剤
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5973011A (en) * 1994-03-30 1999-10-26 Isis Pharma Gmbh Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
CZ20012627A3 (cs) 1999-01-20 2002-01-16 Arzneimittelwerk Dresden Gmbh Pouľití imidazo [1,5-a] pyrido [3,2-e]pyrazinonů jako léčiva
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
AU3210500A (en) * 1999-01-22 2000-08-07 Selectus Pharmaceuticals, Inc. Controlling heart rate or blood pressure in patients co-medicated with phosphodiesterase inhibitors for treatment of impotence
US6087362A (en) * 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
US20010003120A1 (en) * 1999-05-14 2001-06-07 M. D. Robert Hines Method for treating erectile dysfunction
FR2796945B1 (fr) * 1999-07-30 2002-06-28 Sod Conseils Rech Applic Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments
IL139073A0 (en) 1999-10-21 2001-11-25 Pfizer Treatment of neuropathy
TWI224966B (en) 1999-11-02 2004-12-11 Pfizer Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient
US20020103117A1 (en) 2000-02-03 2002-08-01 Ralph Knoell Use of protein kinase-inhibitor-alpha
DE10004858A1 (de) * 2000-02-03 2001-08-16 Schering Ag Verwendung von Proteinkinase-Inhibitor-alpha
US6476037B1 (en) 2000-03-23 2002-11-05 The Regents Of The University Of California L-arginine and phosphodiesterase (PDE) inhibitor synergism
EP1313478A2 (en) 2000-08-30 2003-05-28 Lilly Icos LLC Method for treatment of migraine using pde5 inhibitors
US20020028764A1 (en) * 2000-09-04 2002-03-07 Aarhus Amt. Treatment of acute and chronic liver disease
EP1329218A4 (en) 2000-10-25 2007-04-04 Takeda Pharmaceutical AGENTS FOR PREVENTIVE AND TREATING PORTAL HYPERTENSION
JP2002201128A (ja) * 2000-10-25 2002-07-16 Takeda Chem Ind Ltd 門脈圧亢進症予防・治療剤
CN1499969A (zh) 2001-01-31 2004-05-26 Ĭ��ר���ɷ����޹�˾ 含有吡唑并[4,3-d]嘧啶和硝酸酯或噻吩并嘧啶和硝酸酯的药物组合物
HUP0303005A3 (en) 2001-02-02 2005-05-30 Merck Patent Gmbh Pharmaceutical compositions comprising pyrazolo[4,3-d]pyrimidines or thienopyrimidines and endothelin receptor antagonists
AU2002226633A1 (en) * 2001-02-02 2002-08-12 Pfizer Limited Treatment of diabetes mellitus using vardenafil
US6338862B1 (en) * 2001-03-26 2002-01-15 Sarfaraz K Niazi Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors
US7579435B2 (en) * 2001-06-08 2009-08-25 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin-dopamine chimeric analogs
LV12979B (en) * 2001-09-07 2003-05-20 Ivars Kalvins Pharmaceutical composition

Also Published As

Publication number Publication date
JP5631053B2 (ja) 2014-11-26
EP1635838A2 (de) 2006-03-22
EP1923073B1 (de) 2011-09-21
DE502004003694D1 (de) 2007-06-14
JP2009280602A (ja) 2009-12-03
PL1923073T3 (pl) 2012-02-29
DE10325813A1 (de) 2005-01-05
JP2006527177A (ja) 2006-11-30
US9278097B2 (en) 2016-03-08
US20070004744A1 (en) 2007-01-04
JP2010195821A (ja) 2010-09-09
SI1923073T1 (sl) 2011-11-30
DE10325813B4 (de) 2007-12-20
PT1635838E (pt) 2007-08-10
ES2287740T3 (es) 2007-12-16
CY1111918T1 (el) 2015-11-04
DK1923073T3 (da) 2011-10-17
KR101176110B1 (ko) 2012-08-22
JP5757677B2 (ja) 2015-07-29
KR20060031614A (ko) 2006-04-12
WO2004108062A3 (de) 2005-03-10
EP1635838B1 (de) 2007-05-02
EP1923073A3 (de) 2008-07-09
CN1871010B (zh) 2010-05-26
PT1923073E (pt) 2011-10-04
CY1107707T1 (el) 2013-04-18
KR20120024807A (ko) 2012-03-14
ATE361074T1 (de) 2007-05-15
ATE525074T1 (de) 2011-10-15
CN1871010A (zh) 2006-11-29
EP1923073A2 (de) 2008-05-21
PL1635838T3 (pl) 2007-09-28
ES2374085T3 (es) 2012-02-13
JP4557970B2 (ja) 2010-10-06
KR101233828B1 (ko) 2013-02-14
DK1635838T3 (da) 2007-09-10
WO2004108062A2 (de) 2004-12-16

Similar Documents

Publication Publication Date Title
CY1107707T1 (el) Αναστολεις της φωσφοδιεστερασης-5 για την προφυλαξη και/ή τη θεραπεια της πυλαιας υπερτασης
BR0108452A (pt) Inibidores da oxidação parcial de ácido graxo no tratamento de insuficiência cardìaca congestiva
NO20010844L (no) Regulering av substrataktivitet
NO20033617L (no) Fremgangsmate for behandling av diabetes mellitus
IL160420A0 (en) Treating or preventing diabetes with cannabidiol
EP1500403A4 (en) MEANS FOR THE PREVENTION / TREATMENT OF DIABETES
BR0315630A (pt) Administração de combinação de uma indolinona com um agente quimioterapêutico para distúrbios de proliferação celular
TR200000129T2 (tr) Yepyeni spiroazabisiklik heterosiklik bileşikler.
NZ510920A (en) Use of (S)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) to treat acute and chronic mania in humans
DE60116642D1 (de) Verbindungen mit cytochrom p450ra1 hemmenden aktivität
MXPA04003547A (es) Tratamiento de sepsis mediante administracion de dosis bajas de inhibidor de via factor de tejido.
WO2007117981A3 (en) Selective hydroxamate based mmp inhibitors
NO980221L (no) Fremgangsmåte for behandling av tykktarmsadenomer
MXPA05012320A (es) Tratamientos de trastornos bipolares y sintomas asociados.
EP1438063A4 (en) MODULATION OF PHYSIOLOGICAL PROCESSES AND USEFUL MEANS
NO20051390L (no) Fremgangsmate for behandling av pasienter med massivt blodtap
NZ519722A (en) Treatment of diabetic ulcers
GEP20063822B (en) Diclofenac-based composition for the topical treatment of oropharyngeal cavity disorders
EP1447090B8 (de) Verwendung von Hyaluronidase zur Prophylaxe und Behandlung von Herz-Kreislauf-Erkrankungen
HUP0001097A2 (hu) COMT-inhibitorok alkalmazása cukorbetegséggel kapcsolatos érrendszeri rendellenességek megelőzésére alkalmas gyógyszerkészítmények előállítására
ZA200102727B (en) Method of treating sickle cell disease or thalassemia.
WO2003004046A3 (en) Use of xaa-pro peptidases for the treatment of substance p-related disorders
AU2003223528A8 (en) Treatment for type 1 diabetes before and after expression of predisposition markers.
NO20024545L (no) Fremgangsmåte for behandling av kongestiv hjertefeil
WO2005110059A3 (en) Treatment of severe community-acquired pneumonia by admistration of tissue factor pathway inhibitor (tfpi)