DK1902054T3 - Pyrido[2,3-d]pyrimidinderivater, fremstilling og terapeutisk anvendelse heraf - Google Patents

Pyrido[2,3-d]pyrimidinderivater, fremstilling og terapeutisk anvendelse heraf

Info

Publication number
DK1902054T3
DK1902054T3 DK06778710T DK06778710T DK1902054T3 DK 1902054 T3 DK1902054 T3 DK 1902054T3 DK 06778710 T DK06778710 T DK 06778710T DK 06778710 T DK06778710 T DK 06778710T DK 1902054 T3 DK1902054 T3 DK 1902054T3
Authority
DK
Denmark
Prior art keywords
pyrido
preparation
therapeutic use
pyrimidine derivatives
pyrimidine
Prior art date
Application number
DK06778710T
Other languages
Danish (da)
English (en)
Inventor
Claude Muneaux
Pierre Casellas
Pierre Perreaut
Samir Jegham
Bernard Bourrie
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1902054T3 publication Critical patent/DK1902054T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK06778710T 2005-07-01 2006-06-29 Pyrido[2,3-d]pyrimidinderivater, fremstilling og terapeutisk anvendelse heraf DK1902054T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507032A FR2887882B1 (fr) 2005-07-01 2005-07-01 Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
PCT/FR2006/001518 WO2007003765A1 (fr) 2005-07-01 2006-06-29 DERIVES DE PYRIDO[2,3-d]PYRIMIDINE, LEUR PREPARATION, LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
DK1902054T3 true DK1902054T3 (da) 2009-06-15

Family

ID=36096420

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06778710T DK1902054T3 (da) 2005-07-01 2006-06-29 Pyrido[2,3-d]pyrimidinderivater, fremstilling og terapeutisk anvendelse heraf
DK08017944.3T DK2020410T3 (en) 2005-07-01 2006-06-29 Pyrido [2,3-d] pyrimidine derivatives, the preparation thereof and therapeutic use

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK08017944.3T DK2020410T3 (en) 2005-07-01 2006-06-29 Pyrido [2,3-d] pyrimidine derivatives, the preparation thereof and therapeutic use

Country Status (40)

Country Link
US (2) US7504406B2 (enExample)
EP (2) EP2020410B1 (enExample)
JP (1) JP4472009B2 (enExample)
KR (1) KR101298344B1 (enExample)
CN (2) CN102260258B (enExample)
AR (1) AR054812A1 (enExample)
AT (1) ATE423119T1 (enExample)
AU (1) AU2006264801B2 (enExample)
BR (1) BRPI0613020A2 (enExample)
CA (1) CA2610794C (enExample)
CR (1) CR9568A (enExample)
CY (2) CY1110457T1 (enExample)
DE (1) DE602006005246D1 (enExample)
DK (2) DK1902054T3 (enExample)
DO (1) DOP2006000145A (enExample)
EA (1) EA014312B1 (enExample)
EC (1) ECSP078011A (enExample)
ES (2) ES2450067T3 (enExample)
FR (1) FR2887882B1 (enExample)
HR (2) HRP20090236T1 (enExample)
IL (1) IL187900A0 (enExample)
JO (1) JO2550B1 (enExample)
MA (1) MA29561B1 (enExample)
ME (1) ME01813B (enExample)
MX (1) MX2007016239A (enExample)
MY (1) MY143089A (enExample)
NO (1) NO20080418L (enExample)
NZ (1) NZ564072A (enExample)
PA (1) PA8684801A1 (enExample)
PE (1) PE20070139A1 (enExample)
PL (2) PL1902054T3 (enExample)
PT (2) PT1902054E (enExample)
RS (2) RS50781B (enExample)
SI (2) SI2020410T1 (enExample)
TN (1) TNSN07440A1 (enExample)
TW (1) TWI321566B (enExample)
UA (1) UA92021C2 (enExample)
UY (1) UY29645A1 (enExample)
WO (1) WO2007003765A1 (enExample)
ZA (1) ZA200711032B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
CN102186845B (zh) 2008-10-17 2016-09-07 阿卡制药有限公司 S1p受体调节剂以及它们的用途
CA2739901A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
CN103204825B (zh) * 2012-01-17 2015-03-04 上海科州药物研发有限公司 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途
EP2638911A1 (en) 2012-03-14 2013-09-18 Sanofi Novel combinations for treating acute myeloid leukaemia or chronic myeloid leukaemia
CN103833771A (zh) * 2012-11-22 2014-06-04 天津滨江药物研发有限公司 作为蛋白激酶Mek抑制剂的苯并五元杂环化合物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) * 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
JPH04128276A (ja) 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd アミノベンゾサルタム誘導体およびその用途
FI971953A7 (fi) * 1994-11-14 1997-05-12 Warner Lambert Co Proteiinityrosiinikinaasin välittämää soluproliferaatiota inhiboivat 6 -aryyli-pyrido(2,3-d)pyrimidiinit ja naftyridiinit
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
WO2001055147A1 (en) * 2000-01-25 2001-08-02 Warner-Lambert Company PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
AP2002002643A0 (en) * 2000-03-06 2002-12-31 Warner Lambert Co 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
JP2004519422A (ja) 2000-08-04 2004-07-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ２−（４−ピリジル）アミノ−６−ジアルコキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン
AU2002324450A1 (en) * 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
WO2004063195A1 (en) 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections

Also Published As

Publication number Publication date
AR054812A1 (es) 2007-07-18
AU2006264801B2 (en) 2012-05-10
US8008310B2 (en) 2011-08-30
CY1114989T1 (el) 2016-12-14
NO20080418L (no) 2008-03-28
DE602006005246D1 (de) 2009-04-02
TWI321566B (en) 2010-03-11
JO2550B1 (en) 2010-09-05
NZ564072A (en) 2012-02-24
HK1122797A1 (en) 2009-05-29
WO2007003765A1 (fr) 2007-01-11
MX2007016239A (es) 2008-03-06
KR101298344B1 (ko) 2013-08-20
JP2008544975A (ja) 2008-12-11
BRPI0613020A2 (pt) 2010-12-14
ATE423119T1 (de) 2009-03-15
CA2610794C (fr) 2012-02-21
UA92021C2 (ru) 2010-09-27
FR2887882A1 (fr) 2007-01-05
ME01813B (me) 2014-09-20
RS53211B (sr) 2014-08-29
ES2450067T3 (es) 2014-03-21
EP1902054A1 (fr) 2008-03-26
IL187900A0 (en) 2008-03-20
JP4472009B2 (ja) 2010-06-02
US20090163522A1 (en) 2009-06-25
SI1902054T1 (sl) 2009-06-30
TW200745102A (en) 2007-12-16
DOP2006000145A (es) 2008-01-31
CA2610794A1 (fr) 2007-01-11
PE20070139A1 (es) 2007-03-07
AU2006264801A1 (en) 2007-01-11
ZA200711032B (en) 2009-04-29
UY29645A1 (es) 2007-01-31
SI2020410T1 (sl) 2014-04-30
PA8684801A1 (es) 2007-01-17
RS50781B (sr) 2010-08-31
EP2020410B1 (fr) 2013-12-18
ES2322101T3 (es) 2009-06-16
MA29561B1 (fr) 2008-06-02
CN101213196B (zh) 2011-09-07
TNSN07440A1 (en) 2009-03-17
DK2020410T3 (en) 2014-03-24
PL2020410T3 (pl) 2014-05-30
CN102260258A (zh) 2011-11-30
KR20080021714A (ko) 2008-03-07
PL1902054T3 (pl) 2009-07-31
US20080176874A1 (en) 2008-07-24
FR2887882B1 (fr) 2007-09-07
ECSP078011A (es) 2008-01-23
HRP20090236T1 (hr) 2009-05-31
CR9568A (es) 2008-02-20
HRP20140246T1 (hr) 2014-06-20
MY143089A (en) 2011-03-15
EP2020410A1 (fr) 2009-02-04
CN101213196A (zh) 2008-07-02
CY1110457T1 (el) 2015-04-29
EP1902054B1 (fr) 2009-02-18
PT1902054E (pt) 2009-04-22
EA014312B1 (ru) 2010-10-29
US7504406B2 (en) 2009-03-17
EA200800223A1 (ru) 2008-06-30
PT2020410E (pt) 2014-03-20
CN102260258B (zh) 2015-01-07

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