DK1897558T3 - Fast præparat af 2-hexadecyloxy-6-methyl-4h-3,1-benzoxazin-4-on - Google Patents
Fast præparat af 2-hexadecyloxy-6-methyl-4h-3,1-benzoxazin-4-onInfo
- Publication number
- DK1897558T3 DK1897558T3 DK06747305.8T DK06747305T DK1897558T3 DK 1897558 T3 DK1897558 T3 DK 1897558T3 DK 06747305 T DK06747305 T DK 06747305T DK 1897558 T3 DK1897558 T3 DK 1897558T3
- Authority
- DK
- Denmark
- Prior art keywords
- solid preparation
- cellulose
- melting point
- poorly water
- low melting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005170172 | 2005-06-09 | ||
PCT/JP2006/312078 WO2006132440A1 (ja) | 2005-06-09 | 2006-06-09 | 固形製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1897558T3 true DK1897558T3 (da) | 2013-12-09 |
Family
ID=37498616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06747305.8T DK1897558T3 (da) | 2005-06-09 | 2006-06-09 | Fast præparat af 2-hexadecyloxy-6-methyl-4h-3,1-benzoxazin-4-on |
Country Status (10)
Country | Link |
---|---|
US (2) | US20090208584A1 (da) |
EP (1) | EP1897558B1 (da) |
JP (1) | JP5044398B2 (da) |
CA (1) | CA2611451C (da) |
DK (1) | DK1897558T3 (da) |
ES (1) | ES2434072T3 (da) |
PL (1) | PL1897558T3 (da) |
PT (1) | PT1897558E (da) |
SI (1) | SI1897558T1 (da) |
WO (1) | WO2006132440A1 (da) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008136392A1 (ja) * | 2007-04-27 | 2008-11-13 | Ajinomoto Co., Inc. | 経口投与用製剤 |
US20100172991A1 (en) * | 2007-06-08 | 2010-07-08 | Henry Joseph Horacek | Extended Release Formulation and Methods of Treating Adrenergic Dysregulation |
JP2010529142A (ja) * | 2007-06-08 | 2010-08-26 | アドレネクス・ファーマシューティカルズ,インコーポレイテッド | アドレナリン調節異常症を治療する徐放性の製剤および方法 |
US8486452B2 (en) * | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
JP5352474B2 (ja) * | 2007-12-28 | 2013-11-27 | 沢井製薬株式会社 | 口腔内崩壊錠およびその製造方法 |
MX2011001150A (es) * | 2008-07-31 | 2011-03-29 | Takeda Pharmaceutical | Composicion farmaceutica solida. |
AR073380A1 (es) * | 2008-09-25 | 2010-11-03 | Takeda Pharmaceutical | Composicion farmaceutica solida. comprimido multicapa |
JP2010254623A (ja) | 2009-04-24 | 2010-11-11 | Takeda Chem Ind Ltd | ベンゾオキサジノン化合物の結晶 |
AU2010279171A1 (en) * | 2009-07-28 | 2012-03-01 | Takeda Pharmaceutical Company Limited | Tablet |
EP2366378A1 (en) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
ES2524896T3 (es) | 2010-06-16 | 2014-12-15 | Takeda Pharmaceutical Company Limited | Cristal de compuesto de amida |
EP2729145A4 (en) | 2011-07-07 | 2014-12-10 | Arqule Inc | PYRROLOCHINOLINYLPYRROLIDIN-2,5-DION FORMULATIONS AND METHOD FOR THEIR PREPARATION AND USE |
CN103889908B (zh) * | 2011-10-19 | 2016-04-06 | 日本曹达株式会社 | 尿石抑制剂 |
GB201122213D0 (en) * | 2011-12-23 | 2012-02-01 | Norgine Bv | Compositions |
WO2013092786A1 (en) | 2011-12-23 | 2013-06-27 | Norgine B.V. | Compositions comprising cetilistat |
AU2012101841A4 (en) * | 2011-12-23 | 2013-01-17 | Norgine Bv | Compositions comprising cetilistat |
US20150011549A1 (en) * | 2012-02-15 | 2015-01-08 | Takeda Pharmaceutical Company Limited | Tablet |
DE202012104963U1 (de) | 2012-12-19 | 2013-01-14 | Norgine B.V. | Cetilistat aufweisende Zusammensetzungen |
JP5686452B2 (ja) * | 2013-03-01 | 2015-03-18 | 塩野義製薬株式会社 | イルベサルタンを含有する錠剤 |
CN104971051A (zh) * | 2014-04-11 | 2015-10-14 | 刘小斌 | 一种赛利司他片及制备方法 |
CN106310287B (zh) * | 2015-06-25 | 2019-03-19 | 山东省药学科学院 | 新利司他药用组合物及其制备方法 |
Family Cites Families (40)
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GB224671A (en) | 1923-10-03 | 1924-11-20 | Ismay Annie Fownes | Improvements in and relating to wire-netting fencing |
JPS5116491B2 (da) | 1971-10-08 | 1976-05-25 | ||
US4623588A (en) * | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
CA2128044C (en) * | 1993-08-05 | 2007-02-20 | Klaus-Dieter Bremer | Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor |
JP2842244B2 (ja) * | 1993-09-21 | 1998-12-24 | 武田薬品工業株式会社 | イデベノン粒剤およびその製造法 |
JP3532999B2 (ja) * | 1995-03-24 | 2004-05-31 | 株式会社ロッテ | 新規なタンニン類およびこれを有効成分とするリパーゼ阻害剤 |
WO1997010224A1 (en) | 1995-09-13 | 1997-03-20 | Takeda Chemical Industries, Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
JPH10182436A (ja) * | 1996-10-31 | 1998-07-07 | Takeda Chem Ind Ltd | 固形医薬製剤 |
EP0839526A3 (en) * | 1996-10-31 | 1999-01-07 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with fast buccal disintegration or dissolution |
US6172095B1 (en) * | 1996-11-25 | 2001-01-09 | The Procter & Gamble Company | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
JP3926888B2 (ja) * | 1997-05-27 | 2007-06-06 | 株式会社カネカ | コレステロール低下剤 |
WO1999022735A1 (en) | 1997-10-30 | 1999-05-14 | Merck & Co., Inc. | Somatostatin agonists |
DE69942777D1 (de) * | 1998-07-28 | 2010-10-28 | Takeda Pharmaceutical | Leicht zerfallende feste Zubereitung |
BR9912980B1 (pt) * | 1998-08-14 | 2013-10-22 | Composição farmacêutica administrável oralmente, tablete de mascar contendo a mesma e utilização da mesma | |
US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
AR022204A1 (es) | 1999-01-08 | 2002-09-04 | Norgine Bv | Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende. |
JP2000273039A (ja) * | 1999-01-20 | 2000-10-03 | Taisho Pharmaceut Co Ltd | 口腔内崩壊性組成物 |
US6740339B1 (en) * | 1999-06-18 | 2004-05-25 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
AR025587A1 (es) * | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
AU7556800A (en) | 1999-10-07 | 2001-05-10 | Tadeka Chemical Industries, Ltd. | Amine derivatives |
AU780948C (en) | 1999-11-10 | 2006-09-14 | Takeda Pharmaceutical Company Limited | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
US6930185B2 (en) | 2000-04-28 | 2005-08-16 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
JP2001316249A (ja) * | 2000-05-11 | 2001-11-13 | Lion Corp | 錠剤型医薬組成物 |
CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
JP2001335469A (ja) * | 2000-05-26 | 2001-12-04 | Lion Corp | 固体製剤の製造方法 |
HU229292B1 (en) * | 2000-07-28 | 2013-10-28 | Hoffmann La Roche | New pharmaceutical composition |
US6967212B2 (en) * | 2001-05-30 | 2005-11-22 | Bristol-Myers Squibb Company | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
US20030027786A1 (en) * | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
US20050245571A1 (en) | 2001-10-19 | 2005-11-03 | Hidenori Abe | Amine derivative |
JP3624954B1 (ja) * | 2001-11-07 | 2005-03-02 | 藤沢薬品工業株式会社 | 分散不良薬物の溶出性を改善する方法 |
SI21301A (sl) * | 2002-09-11 | 2004-04-30 | LEK farmacevtska družba d.d. | Farmacevtska oblika z nadzorovanim sproščanjem |
US8372430B2 (en) * | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
US20060178359A1 (en) * | 2003-02-07 | 2006-08-10 | Mitsuru Shiraishi | Tricyclic compound, process for producing the same, and use |
US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
JP2005170172A (ja) | 2003-12-10 | 2005-06-30 | Ogura Clutch Co Ltd | 車両室内用遮蔽装置 |
WO2006110809A2 (en) * | 2005-04-12 | 2006-10-19 | Elan Pharma International, Limited | Nanoparticulate lipase inhibitor formulations |
-
2006
- 2006-06-09 US US11/921,664 patent/US20090208584A1/en not_active Abandoned
- 2006-06-09 CA CA2611451A patent/CA2611451C/en not_active Expired - Fee Related
- 2006-06-09 ES ES06747305T patent/ES2434072T3/es active Active
- 2006-06-09 JP JP2007520212A patent/JP5044398B2/ja not_active Expired - Fee Related
- 2006-06-09 WO PCT/JP2006/312078 patent/WO2006132440A1/ja active Application Filing
- 2006-06-09 SI SI200631694T patent/SI1897558T1/sl unknown
- 2006-06-09 EP EP06747305.8A patent/EP1897558B1/en not_active Not-in-force
- 2006-06-09 PT PT67473058T patent/PT1897558E/pt unknown
- 2006-06-09 DK DK06747305.8T patent/DK1897558T3/da active
- 2006-06-09 PL PL06747305T patent/PL1897558T3/pl unknown
-
2014
- 2014-02-26 US US14/190,528 patent/US20140178477A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5044398B2 (ja) | 2012-10-10 |
US20090208584A1 (en) | 2009-08-20 |
EP1897558A4 (en) | 2012-09-12 |
JPWO2006132440A1 (ja) | 2009-01-08 |
ES2434072T3 (es) | 2013-12-13 |
EP1897558A1 (en) | 2008-03-12 |
CA2611451A1 (en) | 2006-12-14 |
CA2611451C (en) | 2014-04-22 |
EP1897558B1 (en) | 2013-09-04 |
WO2006132440A1 (ja) | 2006-12-14 |
PT1897558E (pt) | 2013-11-06 |
PL1897558T3 (pl) | 2014-01-31 |
SI1897558T1 (sl) | 2014-03-31 |
US20140178477A1 (en) | 2014-06-26 |
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