DK1861389T3 - 7-(2-(4-(3-triflourmethylphenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl)isoquinoleinbesylatsalt - Google Patents

7-(2-(4-(3-triflourmethylphenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl)isoquinoleinbesylatsalt

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Publication number
DK1861389T3
DK1861389T3 DK06726092T DK06726092T DK1861389T3 DK 1861389 T3 DK1861389 T3 DK 1861389T3 DK 06726092 T DK06726092 T DK 06726092T DK 06726092 T DK06726092 T DK 06726092T DK 1861389 T3 DK1861389 T3 DK 1861389T3
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DK
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Prior art keywords
pyrid
trifluoromethylphenyl
tetrahydro
ethyl
besylate salt
Prior art date
Application number
DK06726092T
Other languages
Danish (da)
English (en)
Inventor
Corinne Barre
Olivier Monnier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1861389T3 publication Critical patent/DK1861389T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P17/00Drugs for dermatological disorders
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    • A61P17/06Antipsoriatics
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    • A61P19/00Drugs for skeletal disorders
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
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  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
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  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
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DK06726092T 2005-03-17 2006-03-15 7-(2-(4-(3-triflourmethylphenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl)isoquinoleinbesylatsalt DK1861389T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502611A FR2883285B1 (fr) 2005-03-17 2005-03-17 Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
PCT/FR2006/000566 WO2006097624A1 (fr) 2005-03-17 2006-03-15 Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

Publications (1)

Publication Number Publication Date
DK1861389T3 true DK1861389T3 (da) 2008-10-20

Family

ID=35285429

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06726092T DK1861389T3 (da) 2005-03-17 2006-03-15 7-(2-(4-(3-triflourmethylphenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl)isoquinoleinbesylatsalt

Country Status (34)

Country Link
US (1) US7795277B2 (ru)
EP (1) EP1861389B1 (ru)
JP (1) JP2008534450A (ru)
KR (1) KR20070115258A (ru)
CN (1) CN101137644A (ru)
AR (1) AR053448A1 (ru)
AT (1) ATE399161T1 (ru)
AU (1) AU2006224465B2 (ru)
BR (1) BRPI0607614A2 (ru)
CA (1) CA2599637A1 (ru)
CR (1) CR9352A (ru)
CY (1) CY1108366T1 (ru)
DE (1) DE602006001590D1 (ru)
DK (1) DK1861389T3 (ru)
EA (1) EA011560B1 (ru)
ES (1) ES2309957T3 (ru)
FR (1) FR2883285B1 (ru)
HR (1) HRP20080447T3 (ru)
IL (1) IL185537A (ru)
MA (1) MA29348B1 (ru)
MX (1) MX2007011021A (ru)
MY (1) MY138296A (ru)
NO (1) NO20075022L (ru)
NZ (1) NZ561027A (ru)
PL (1) PL1861389T3 (ru)
PT (1) PT1861389E (ru)
RS (1) RS50611B (ru)
SI (1) SI1861389T1 (ru)
TN (1) TNSN07317A1 (ru)
TW (1) TW200700410A (ru)
UA (1) UA90304C2 (ru)
UY (1) UY29425A1 (ru)
WO (1) WO2006097624A1 (ru)
ZA (1) ZA200707488B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
DK2091948T3 (da) 2006-11-30 2012-07-23 Probiodrug Ag Nye inhibitorer af glutaminylcyclase
CA2679446C (en) 2007-03-01 2016-05-17 Probiodrug Ag New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ(qc、ec2.3.2.5)の複素環阻害剤
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736053B1 (fr) 1995-06-28 1997-09-19 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
ATE271554T1 (de) * 1999-10-22 2004-08-15 Sanofi Synthelabo Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung
DE60220779T2 (de) * 2001-04-20 2008-03-06 Sanofi-Aventis Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
FR2823749B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
JP2008534450A (ja) 2008-08-28
SI1861389T1 (sl) 2008-10-31
FR2883285B1 (fr) 2007-05-18
ZA200707488B (en) 2008-12-31
CA2599637A1 (fr) 2006-09-21
UA90304C2 (en) 2010-04-26
MX2007011021A (es) 2008-03-18
EA200702004A1 (ru) 2008-02-28
ES2309957T3 (es) 2008-12-16
US7795277B2 (en) 2010-09-14
PL1861389T3 (pl) 2008-12-31
HRP20080447T3 (en) 2008-10-31
FR2883285A1 (fr) 2006-09-22
EA011560B1 (ru) 2009-04-28
MY138296A (en) 2009-05-29
CY1108366T1 (el) 2014-02-12
RS50611B (sr) 2010-06-30
NZ561027A (en) 2010-11-26
WO2006097624A1 (fr) 2006-09-21
EP1861389B1 (fr) 2008-06-25
NO20075022L (no) 2007-10-04
TW200700410A (en) 2007-01-01
AR053448A1 (es) 2007-05-09
IL185537A0 (en) 2008-01-06
PT1861389E (pt) 2008-09-11
UY29425A1 (es) 2006-10-31
IL185537A (en) 2011-08-31
EP1861389A1 (fr) 2007-12-05
ATE399161T1 (de) 2008-07-15
BRPI0607614A2 (pt) 2009-09-22
AU2006224465A1 (en) 2006-09-21
TNSN07317A1 (en) 2008-12-31
CN101137644A (zh) 2008-03-05
KR20070115258A (ko) 2007-12-05
AU2006224465B2 (en) 2011-10-13
US20080085917A1 (en) 2008-04-10
MA29348B1 (fr) 2008-03-03
CR9352A (es) 2008-02-20
DE602006001590D1 (de) 2008-08-07

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